Design and characteristics of the prophylactic intra‐operative ventricular arrhythmia ablation in high‐risk LVAD candidates (PIVATAL) trial by David T. Huang, Igor Gosev, Katherine L. Wood, Hima Vidula, William Stevenson, Frank Marchlinski, Gregory Supple, Sandip K. Zalawadiya, J. Peter Weiss, Roderick Tung, Wendy S. Tzou, Joshua D. Moss, Krishna Kancharla, Sunit‐Preet Chaudhry, Parin J. Patel, Arfaat M. Khan, Claudio Schuger, Guy Rozen, Michael S. Kiernan, Gregory S. Couper, Marzia Leacche, Ezequiel J. Molina, Anand D. Shah, Michael Lloyd, Jakub Sroubek, Edward Soltesz, Kalyanam Shivkumar, Casey White, Sinan Tankut, Brent A. Johnson, Scott McNitt, Valentina Kutyifa, Wojciech Zareba, Ilan Goldenberg

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Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation by Susanne Rehnelt, Daniela Malan, Krisztina Juhasz, Benjamin Wolters, Leo Doerr, Matthias Beckler, Ralf Kettenhofen, Heribert Bohlen, Tobias Bruegmann, Philipp Sasse

“…Taken together, we present a scalable approach for preclinical frequency-dependent screening of drug effects on cardiac electrophysiology. Importantly, we show that the recording and analysis can be fully automated and the technology is readily available using commercial products.…”
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Identification of the Ectopic Foci of Focal Atrial Tachycardia (FAT) by Using Electrocardiogram (ECG) Signal Analysis by Fatemeh Mohammadi, Ali Sheikhani, Farbod Razzazi, Alireza Ghorbani Sharif

“…Background and Aim: Cardiac electrophysiology study (EPS) is the study of the electrical system of the heart. …”
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Racial Disparity in Referral for Catheter Ablation for Atrial Fibrillation at a Single Integrated Health System by Jessica M. Duke, Lutfiyya N. Muhammad, Jing Song, Yoshihiro Tanaka, Celeste Witting, Sadiya S. Khan, Rod S. Passman

“…Logistic regression models adjusted for socioeconomic and health factors were constructed to determine the association between race and ethnicity and binary dependent variables including referrals and visits to general cardiology and cardiac electrophysiology (EP) and AFCA. Of 5445 patients analyzed, 4652 were non‐Hispanic White (NHW) and 793 were non‐Hispanic Black (NHB). …”
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Electrophysiological mapping of the epicardium via 3D‐printed flexible arrays by Terrence Pong, Kevin J. Cyr, Cody Carlton, Joy Aparicio‐Valenzuela, Hanjay Wang, Meghedi Babakhanian, Alessandro Maiuolo, Haley Lucian, Paul J. Wang, Y. Joseph Woo, Anson M. Lee

“…Abstract Cardiac electrophysiology mapping and ablation are widely used to treat heart rhythm disorders such as atrial fibrillation (AF) and ventricular tachycardia (VT). …”
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Predictors of morbidity and in‐hospital mortality following procedure‐related cardiac tamponade by Saurabh Deshpande, Hiroyuki Swatari, Raheel Ahmed, George Collins, Mohammed Y. Khanji, Virend K. Somers, Anwar A. Chahal, Deepak Padmanabhan

“…We assessed CT following common cardiac electrophysiology (EP) procedures to facilitate risk prediction of associated morbidity and in‐hospital mortality. …”
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Enabling unstructured-mesh computation on massively tiled AI processors: An example of accelerating in silico cardiac simulation by Luk Burchard, Kristian Gregorius Hustad, Johannes Langguth, Johannes Langguth, Xing Cai, Xing Cai

“…Graphcore IPUs are chosen as the target hardware platform, to which we port an existing monodomain solver that simulates cardiac electrophysiology over realistic 3D irregular heart geometries. …”
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Revealing mechanism of Methazolamide for treatment of ankylosing spondylitis based on network pharmacology and GSEA by Tao Sun, Manzhi Wang, Weiqiang Liang, Ping Gao, Qiang Liu, Xinfeng Yan

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Atrial fibrillation prevalence and management patterns in a Middle Eastern community in the United States: A retrospective study by Mohamad Raad, Christopher Lewis, Mohamed Ramzi Almajed, Tarek Makki, Marwan Refaat, Arfaat Khan, Marc Lahiri

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Transseptal Puncture Guided by Three-Dimensional Electroanatomical Mapping: Early Experience Using a Simplified Approach in Adults with Congenital Heart Disease by Fu Guan, Matthias Gass, Florian Berger, Deniz Akdis, Firat Duru, Thomas Wolber

“…Aims: The widespread use of three-dimensional (3D) mapping systems and echocardiography in the field of cardiac electrophysiology has made it possible to perform transseptal punctures (TSP) with low or no fluoroscopy. …”
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Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology by Kobina Essandoh, Julie M. Philippe, Paul M. Jenkins, Paul M. Jenkins, Matthew J. Brody, Matthew J. Brody

“…Recent work has begun to uncover functions of S-acylation in the heart, particularly in the regulation of cardiac electrophysiology, including modification of the sodium-calcium exchanger, phospholemman and the cardiac sodium pump, as well as the voltage-gated sodium channel. …”
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Safety of Lumason® (SonoVue®) in special populations and critically ill patients by A. Filippone, M. A. Kirchin, J. Monteith, M. L. Storto, A. Spinazzi

“…No detrimental effects of Lumason® on cardiac electrophysiology were observed in patients with coronary artery disease (CAD), and no significant effects on pulmonary hemodynamics were noted in patients with pulmonary hypertension or congestive heart failure. …”
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The effect of virtual interactive nurse-led support group intervention on fatigue, shock anxiety, and acceptance of implantable cardioverter defibrillator patients: a randomized tr... by Masoume Rambod, Samira Rohaninasab, Nilofar Pasyar, Mohammad Hossein Nikoo

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Clinical and Non-Clinical Cardiovascular Disease Associated Pathologies in Parkinson’s Disease by Bonn Lee, Charlotte Edling, Shiraz Ahmad, Fiona E. N. LeBeau, Gary Tse, Kamalan Jeevaratnam

“…For future reference, research that can integrate cardiac electrophysiology and pathological alterations is required.…”
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3D reconstruction of ablation lesions from in-vitro preparations using MRI by Pollnow Stefan, Noshadi Areg, Kircher Michael, Guthausen Gisela, Oerther Thomas, Dössel Olaf

“…Wet lab experiments provide the opportunity to investigate cardiac electrophysiology under reproducible conditions. To evaluate the electrophysiological changes of ablated myocardium in these studies it is necessary to consider the three-dimensional (3D) geometry of the lesions. …”
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Personalized Management of Sudden Death Risk in Primary Cardiomyopathies: From Clinical Evaluation and Multimodality Imaging to Ablation and Cardioverter-Defibrillator Implant by Davide Lazzeroni, Antonio Crocamo, Valentina Ziveri, Maria Francesca Notarangelo, Davide Rizzello, Matteo Spoladori, Davide Donelli, Giovanna Cacciola, Diego Ardissino, Giampaolo Niccoli, Giovanni Peretto

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Modelling of patient-specific Purkinje activation based on measured ECGs by Kahlmann Willi, Poremba Emanuel, Potyagaylo Danila, Dössel Olaf, Loewe Axel

“…While it cannot be imaged in-vivo, it plays an important role for personalizing computer simulations of cardiac electrophysiology. Here, we present a new method to automatically model and customize the Purkinje system based on the measured electrocardiogram (ECG) of a patient. …”
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Designing Very Fast and Accurate Convolutional Neural Networks With Application in ICD and Smart Electrocardiograph Devices by Alireza Keyanfar, Reza Ghaderi, Soheila Nazari, Behzad Hajimoradi, Leila Kamalzadeh

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Incidence of Cancer Treatment–Induced Arrhythmia Associated With Novel Targeted Chemotherapeutic Agents by Andrew C. Nickel, Akshar Patel, Nabil F. Saba, Angel R. Leon, Mikhael F. El‐Chami, Faisal M. Merchant

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Modulation of renal sympathetic innervation: recent insights beyond blood pressure control by Linz, Dominik, Hohl, Mathias, Elliott, Adrian D, Lau, Dennis H, Mahfoud, Felix, Esler, Murray D, Sanders, Prashanthan, Böhm, Michael

“…Beyond its effects on blood pressure, sympathetic modulation by RDN has been shown to have profound effects on cardiac electrophysiology and cardiac arrhythmogenesis. RDN can display anti-arrhythmic effects in a variety of animal models for atrial fibrillation and ventricular arrhythmias. …”
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