Uncertainty characterisation in action potential modelling for cardiac drug safety by Johnstone, R

“…The CiPA initiative aims to replace the TQT study with a combination of in-vitro ion channel screening and mathematical mechanistic models of single-cell cardiac electrophysiology to predict a drug's proarrhythmic risk. …”

Nonlinear diffusion and thermo-electric coupling in a two-variable model of cardiac action potential by Gizzi, A, Loppini, A, Ruiz-Baier, R, Ippolito, A, Camassa, A, La Camera, A, Emmi, E, Di Perna, L, Garofalo, V, Cherubini, C, Filippi, S

“…Here, we investigate whether a generalized two-variable reaction-diffusion model of cardiac electrophysiology can highlight the dual nonlinear effects induced by thermo-electricity and diffusive nonlinearities under several simulated tests. …”

Slow recovery of excitability increases ventricular fibrillation risk as identified by emulation by Lawson, B, Burrage, K, Burrage, P, Drovandi, C, Bueno Orovio, A

“…These results exemplify the potential of emulation techniques in elucidating novel mechanisms of arrhythmia and further application to cardiac electrophysiology.…”

Ventricular SK2 upregulation following angiotensin II challenge: modulation by p21-activated kinase-1 by Yang, B, Jiang, Q, He, S, Li, T, Ou, X, Chen, T, Fan, X, Jiang, F, Zeng, X, Huang, CL-H, Tan, X, Lei, M

“…SK2 may then influence cardiac electrophysiology under conditions of cardiac hypertrophy and failure.…”

Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. by Burton, R, Schneider, J, Bishop, M, Hales, P, Bollensdorff, C, Robson, M, Wong, K, Morris, J, Quinn, T, Kohl, P

“…Pilot optical mapping experiments showed that TCA occlusion had variable acute effects on rabbit cardiac electrophysiology. CONCLUSION: Third coronary artery presence is common in rabbit and human hearts. …”

The cardiac L-type calcium current: existing models and methods of improvement by Agrawal, A

“…Arrhythmias can be initiated by unintended modulations of cardiac electrophysiology by pharmaceutical drugs. Therefore, in the past decade, drug regulatory bodies have implemented the use of cardiac models for cardiac safety assessment of novel drugs. …”

Investigations of electrophysiological mechanisms related to myocardial ischaemia in hypertrophic cardiomyopathy: implications for arrhythmic risk, ECG diagnosis, and antiarrhythmi... by Coleman, JA

“…Using multiscale modelling of cardiac electrophysiology, this thesis aimed to investigate the electrophysiological effects of myocardial ischaemia and ionic remodelling in HCM, to benefit arrhythmic risk predictions, the ECG diagnosis of ischaemia, and antiarrhythmic therapy.…”

Leadless Pacemaker Implantation in the Emergency Bradyarrhythmia Setting: Results from a Multicenter European Registry by Marco Schiavone, Annalisa Filtz, Alessio Gasperetti, Alexander Breitenstein, Pietro Palmisano, Gianfranco Mitacchione, Simone Gulletta, Gian Battista Chierchia, Elisabetta Montemerlo, Giovanni Statuto, Giulia Russo, Michela Casella, Francesco Vitali, Patrizio Mazzone, Daniel Hofer, Gianmarco Arabia, Fabrizio Tundo, Diego Ruggiero, Nicolai Fierro, Massimo Moltrasio, Matteo Bertini, Antonio Dello Russo, Ennio C. L. Pisanò, Paolo Della Bella, Giovanni Rovaris, Carlo de Asmundis, Mauro Biffi, Antonio Curnis, Claudio Tondo, Ardan M. Saguner, Giovanni B. Forleo

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miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2 by Qianqian Li, Qianqian Li, Ziguan Zhang, Shanshan Chen, Zhengrong Huang, Mengru Wang, Mengchen Zhou, Mengchen Zhou, Chenguang Yu, Xiangyi Wang, Yilin Chen, Dan Jiang, Dunfeng Du, Dunfeng Du, Dunfeng Du, Dunfeng Du, Yufeng Huang, Xin Tu, Zhishui Chen, Zhishui Chen, Zhishui Chen, Zhishui Chen, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao

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Left Atrial Anterior Wall Scar-Related Atrial Tachycardia in Patients after Catheter Ablation or Cardiac Surgery: Electrophysiological Characteristics and Ablation Strategy by Hao Wang, Siqi Xi, Jindong Chen, Tian Gan, Weiye Huang, Ben He, Liang Zhao

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Left ventricular electrical potential measured by the NOGA XP electromechanical mapping method as a predictor of response to cardiac resynchronization therapy by Jacek Wilczek, Jacek Wilczek, Tomasz Jadczyk, Tomasz Jadczyk, Wojciech Wojakowski, Wojciech Wojakowski, Krzysztof S. Gołba, Krzysztof S. Gołba

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Pathogenesis and Management of Brugada Syndrome: Recent Advances and Protocol for Umbrella Reviews of Meta-Analyses in Major Arrhythmic Events Risk Stratification by Hasina Masha Aziz, Michał P. Zarzecki, Sebastian Garcia-Zamora, Min Seo Kim, Piotr Bijak, Gary Tse, Hong-Hee Won, Paweł T. Matusik

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The prevalence of permanent pacemaker implantation after open-heart surgeries; eight years of experience in Tehran heart center by Kaveh Oraii Yazdani, Akbar Shafiee, Amirhossein Heidari, Hossein Ahmadi-Tafti, Ahmad Yaminisharif

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Body composition and mortality in a cohort study of Chinese patients with hypertrophic cardiomyopathy by Ke Zhou, Jie Xiang, Jie Xiang, Guo-yong Li, Xiao-bo Pu, Li Zhang

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The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing by Svetlana V. Tapilina, Alexandra D. Ivanova, Tatiana S. Filatova, Pavel A. Galenko-Yaroshevsky, Denis V. Abramochkin

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Personalization of biomechanical simulations of the left ventricle by in-vivo cardiac DTI data: Impact of fiber interpolation methods by Johanna Stimm, David A. Nordsletten, David A. Nordsletten, Javiera Jilberto, Renee Miller, Ezgi Berberoğlu, Sebastian Kozerke, Christian T. Stoeck, Christian T. Stoeck

“…Simulations of cardiac electrophysiology and mechanics have been reported to be sensitive to the microstructural anisotropy of the myocardium. …”
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Hypothermia-induced accelerated idioventricular rhythm after cardiac surgery; a case report by Saeid Hosseini, Soheila Salari, Sepideh Banar, Yousef Rezaei, Atieh Tajik, Ali Zahedmehr, Zahra Emkanjoo

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Generation of a Triadin KnockOut Syndrome Zebrafish Model by Vanilla Martina Vecchi, Marco Spreafico, Alessia Brix, Anna Santoni, Simone Sala, Anna Pistocchi, Anna Marozzi, Chiara Di Resta

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Association between albumin corrected anion gap and 30-day all-cause mortality of critically ill patients with acute myocardial infarction: a retrospective analysis based on the MI... by Linhao Jian, Zhixiang Zhang, Quan Zhou, Xiangjie Duan, Haiqin Xu, Liangqing Ge

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Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts by Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini

“…Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrophysiology and cardiomyopathy in mice.…”
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