Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation by Lulan Chen, Yue He, Xiangdong Wang, Junbo Ge, Hua Li

“…Abstract Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac electrophysiological signals, such as action potentials, to maintain normal heart excitability and contraction. …”
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Cardiac biophysical detailed synergetic modality rendering and visible correlation by Fei Yang, Fei Yang, Xiaoxi Wei, Bo Chen, Chenxi Li, Dong Li, Shugang Zhang, Weigang Lu, Lei Zhang

“…To realistically represent the three-dimensional synergetic biological modality of the heart, this paper proposes a WebGL-based cardiac synergetic modality rendering framework to visualize the cardiac physical volume data and present synergetic correspondence rendering of the cardiac electrophysiological modality. By constructing the biological detailed interactive histogram, users can implement local details rendering for the heart, which could reveal the cardiac biology details more clearly. …”
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Effect Of Vitamin D Status On Invasive Electrophysiologic Parameters and Atrial Fibrillation Inducibility by Müjgan Tek, Basri Amasyalı, Mehmet Serkan Çetin, Aksüyek Savaş Çelebi, Erdem Diker, Berkten Berkalp

“…DISCUSSION AND CONCLUSION: Baseline VitD levels were not associated with cardiac electrophysiologic parameters and AF inducibility. To demonstrate the role of VitD in cardiac conduction system and AF inducibility thoroughly, further studies such as addressing VitD replacement are warranted.…”
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Cerebral Seizures in an Adolescent with Jervell and Lange-Nielsen Syndrome: It May Not Be Epilepsy by Joachim Levaux, Nesrine Farhat, Lieve Van Casteren, Saskia Bulk, Marie-Christine Seghaye

“…For any patient with known or unknown LQTS who presents seizures with resistance to anti-convulsive therapy, a cardiac electrophysiological investigation should be performed promptly to ensure etiological diagnosis and optimize treatment.…”
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Aliskiren, at low doses, reduces the electrical remodeling in the heart of the TGR(mRen2)27 rat independently of blood pressure by Walmor De Mello, Marielis Rivera, Andres Rabell, Yamil Gerena

“…Methods: The influence of chronic administration of low doses of aliskiren (5 mg/kg/day, i.p.) for a period of eight weeks on cardiac electrophysiological and structural remodeling was investigated in transgenic (TGR)(mRen-2)27 rats. …”
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Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar. by Suran Galappaththige, Richard A Gray, Caroline Mendonca Costa, Steven Niederer, Pras Pathmanathan

“…The aim of this paper is to understand and demonstrate the credibility assessment process for PSMs using patient-specific cardiac electrophysiological (EP) modeling as an exemplar. We first review approaches used to generate cardiac PSMs and consider how verification, validation, and uncertainty quantification (VVUQ) apply to cardiac PSMs. …”
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Effect of sildenafil citrate on the cardiovascular system by K. Shinlapawittayatorn, S. Chattipakorn, N. Chattipakorn

“…In the past few years, the cardiac electrophysiological effects of sildenafil citrate have been investigated extensively in both animal and clinical studies. …”
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Modernised classification of cardiac anti-arrhytmic drugs by Lei, M, Wu, L, Terrar, D, Huang, C

“…Amongst his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918-2016) provided a classification of anti-arrhythmic drugs that remains central to their clinical use. …”

CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. by Lu, C, Hao, G, Nikiforova, N, Larsen, H, Liu, K, Crabtree, M, Li, D, Herring, N, Paterson, D

“…Moreover, dysregulation of this adaptor protein in sympathetic neurons might further amplify the negative cardiac electrophysiological properties seen with CAPON mutations.…”

A protocol for transverse cardiac slicing and optical mapping in murine heart by He, S, Wen, Q, O'Shea, C, Mu-U-Min, R, Kou, K, Grassam-Rowe, A, Liu, Y, Fan, Z, Tan, X, Ou, X, Camelliti, P, Pavlovic, D, Lei, M

“…Thin living tissue slices have recently emerged as a new tissue model for cardiac electrophysiological research. Slices can be produced from human cardiac tissue, in addition to small and large mammalian hearts, representing a powerful in vitro model system for preclinical and translational heart research. …”

Scalable multi-parametric imaging of excitable tissue by Lee, P

“…<p>The field of cardiac electrophysiological imaging has advanced tremendously in the past three decades with developments in fluorescent dyes, photodetectors, optical filters, illumination sources, computers and electronics. …”

mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study by Walmsley, J, Rodriguez, JF, Mirams, GR, Burrage, K, Efimov, IR, Rodriguez, B

“…Our goal is to investigate whether the information contained in mRNA measurements can be used to predict cardiac electrophysiological remodeling in heart failure using computational modeling. …”

Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodel... by Attila Oláh, Bálint András Barta, Alex Ali Sayour, Mihály Ruppert, Eszter Virág-Tulassay, Julianna Novák, Zoltán V. Varga, Péter Ferdinandy, Béla Merkely, Tamás Radovits

“…After exercised animals completed a 12-week-long swim training protocol, echocardiography and in vivo cardiac electrophysiologic investigation were performed. Additionally, atrial histological and gene expression analyses were carried out. …”
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Rationale and design of the BECA project: Smartwatch-based activation of the chain of survival for out-of-hospital cardiac arrest by Roelof G. Hup, Emma C. Linssen, Marijn Eversdijk, Bente Verbruggen, Marieke A.R. Bak, Mirela Habibovic, Willem J. Kop, Dick L. Willems, Lukas R.C. Dekker, Reinder Haakma, Carlijn A. Vernooij, Tom A. Kooy, Hanno L. Tan, Rik Vullings

“…For this, the product will be worn by patients at high risk for out-of-hospital cardiac arrest, by volunteers who will temporarily interrupt blood flow in their arm by inflating a blood pressure cuff, and by patients who undergo cardiac electrophysiologic and implantable cardioverter defibrillator testing procedures. …”
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Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model by Yashwant Ayalasomayajula, Anagha Hesaraghatta, Neha Dantuluri, Jenna Yassine, Faizan Saleem, Hussein Mansour, Chayapatou Chayawatto, Nishank Rangarajan, Sashank Rangarajan, Smrithi Krishnan, Siva Kumar Panguluri

“…In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. …”
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BIOMARKERS ROLE IN THE DEVELOPMENT OF SINUS NODE DYSFUNCTION by L. M. Vasilets, A. V. Tuev, O. V. Khlynova, V. V. Vustina, E. A. Ratanova

“…In all participants, the measurement of serum levels of inflammation markers, cardiac electrophysiological testing, and long-term electrocardiography monitoring were performed. …”
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Deletion of <i>Trpm4</i> Alters the Function of the Na_v1.5 Channel in Murine Cardiac Myocytes by Lijo Cherian Ozhathil, Jean-Sébastien Rougier, Prakash Arullampalam, Maria C. Essers, Daniela Ross-Kaschitza, Hugues Abriel

“…While the expression and clinical variant studies further stress the importance of TRPM4 in cardiac function, the cardiac electrophysiological phenotypes in <i>Trpm4</i> knockdown mouse models remain incompletely characterized. …”
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The Effects of Vagus Nerve Stimulation on Ventricular Electrophysiology and Nitric Oxide Release in the Rabbit Heart by Emily Allen, Emily Allen, Pott Pongpaopattanakul, Pott Pongpaopattanakul, Reshma A. Chauhan, Reshma A. Chauhan, Kieran E. Brack, Kieran E. Brack, G. André Ng, G. André Ng

“…Vagus nerve stimulation (VNS) has been shown to reduce the susceptibility of the heart to ventricular fibrillation, however the precise underlying mechanisms are not well understood and the detailed stimulation parameters needed to improve patient outcomes clinically are currently inconclusive.Objective: To investigate NO release and cardiac electrophysiological effects of electrical stimulation of the vagus nerve at varying parameters using the isolated innervated rabbit heart preparation.Methods: The right cervical vagus nerve was electrically stimulated in the innervated isolated rabbit heart preparation (n = 30). …”
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Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes‐related ventricular arrhythm... by Yao‐Chang Chen, Yen‐Yu Lu, Wen‐Shiann Wu, Yung‐Kuo Lin, Yi‐Ann Chen, Shih‐Ann Chen, Yi‐Jen Chen

“…Accumulation of advanced glycation end products closely correlates with cardiovascular complications through mitochondrial dysfunction or oxidative stress and evoke proliferative, inflammatory, and fibrotic reactions, which might impair cardiac electrophysiological characteristics and increase the incidence of cardiac arrhythmia. …”
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The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose by Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher

“…Loperamide’s inhibition of the I_Na channel and hERG-mediated IKr are the most likely basis for this cardiac electrophysiological toxicity at overdose exposures. …”
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