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Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.
Published 2015“…Recently, modelling frameworks have been devised for studying mechanisms underlying physiological variability in cardiac electrophysiology and pro-arrhythmic risk under a variety of conditions and for several animal species as well as human. …”
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Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility‚ interoperability‚ and data sharing
Published 2011“…As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. …”
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Visualization of the SyncAV<sup>®</sup> Algorithm for CRT Optimization by Non-invasive Imaging of Cardiac Electrophysiology: NICE-CRT Trial
Published 2023-07-01“…There is an unmet need to successfully transform its application into clinical routine. (2) Methods: Non-invasive imaging of cardiac electrophysiology was performed in different device programming settings of the SyncAV<sup>®</sup> algorithm in 14 heart failure patients with left bundle branch block and a PR interval ≤ 250 milliseconds to determine the shortest ventricular activation time. (3) Results: the best offset time (to be manually programmed) permitting automatic dynamic adjustment of the paced atrioventricular interval after every 256 heart beats was found to be 30 and 50 milliseconds, decreasing mean native QRS duration from 181.6 ± 23.9 milliseconds to 130.7 ± 10.0 and 130.1 ± 10.5 milliseconds, respectively (<i>p</i> = 0.01); this was followed by an offset of 40 milliseconds (decreasing QRS duration to 130.1 ± 12.2 milliseconds; <i>p</i> = 0.08). (4) Conclusions: The herein presented NICE-CRT study supports the current recommendation to program an offset of 50 milliseconds as default in patients with left bundle branch block and preserved atrioventricular conduction after implantation of a CRT device capable of SyncAV<sup>®</sup> optimization. …”
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KairoSight-3.0: A validated optical mapping software to characterize cardiac electrophysiology, excitation-contraction coupling, and alternans
Published 2023-09-01Subjects: “…Cardiac electrophysiology…”
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<i>POPDC1</i> Variants Cause Atrioventricular Node Dysfunction and Arrhythmogenic Changes in Cardiac Electrophysiology and Intracellular Calcium Handling in Zebrafish
Published 2024-02-01“…To investigate the impact of POPDC1 dysfunction on cardiac electrophysiology and intracellular calcium handling, homozygous <i>popdc1<sup>S191F</sup></i> and <i>popdc1</i> knock-out (<i>popdc1<sup>KO</sup></i>) zebrafish larvae and adult isolated <i>popdc1<sup>S191F</sup></i> hearts were studied by functional fluorescent analysis. …”
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Feasibility and safety of interventional electrophysiology and catheter ablation in the South African public sector: Challenges and opportunities for comprehensive cardiac electrophysiology in South Africa
Published 2022-12-01“…Conclusion A broad spectrum of catheter ablation procedures was performed with a high success rate and limited complications, thus demonstrating the feasibility of safe cardiac electrophysiology and catheter ablation in the South African public sector.…”
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Multiscale Modelling of β-Adrenergic Stimulation in Cardiac Electromechanical Function
Published 2021-07-01Subjects: Get full text
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Clinical Characteristics of Patients with Tetralogy of Fallot who Underwent an Invasive Procedure for Arrhythmias
Published 2021-12-01Subjects: Get full text
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A diagnostic dilemma: early repolarization syndrome associated with ventricular fibrillation
Published 2014-02-01Subjects: Get full text
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Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels
Published 2023-05-01Subjects: Get full text
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The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review
Published 2024-05-01Subjects: “…Cardiac electrophysiology…”
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Corrigendum: Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels
Published 2023-06-01Subjects: Get full text
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A computational modeling framework for pre-clinical evaluation of cardiac mapping systems
Published 2023-07-01Subjects: Get full text
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Mathematical modelling of drug-ion channel interactions for cardiac safety assessment
Published 2015Subjects:Thesis