What can modelling provide to cardiac physiology? by Smith, N, McCulloch, A, Paterson, D

Cardiac physiology investigated by new methods of imaging. by Neubauer, S

What can modelling provide to cardiac physiology? by Smith, N, Mcculloch, A, Paterson, D

Applying atomic force microscopy to studies in cardiac physiology. by Davis, J, Powell, T, Hill, H

White Paper: Uncertainty and variability in computational and mathematical models of cardiac physiology by Mirams, G, Pathmanathan, P, Gray, R, Challenor, P, Clayton, R

Elucidation of cardiac physiology in aortic valve replacement: what should we know? by Jin, X

“…Embracing genetic technology with classical cardiac physiology will create a new platform to yield a more in-depth understanding of the nature of myocardial adaptation to pressure and volume changes associated with valve disease, and myocardial responses to heart valve surgery. …”

Pharmacological manipulation of hypoxic signalling as a therapeutic target to improve metabolism and function in the type 2 diabetic heart by da Luz Sousa Fialho, M

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Role of nNOS in the automatic control of cardiac excitability in cardiac physiological and pathophysiological states by Heaton, D, Heaton, Daniel Anthony

Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction by Rosalia, Luca, Ozturk, Caglar, Shoar, Saeed, Fan, Yiling, Malone, Grainne, Cheema, Faisal H, Conway, Claire, Byrne, Robert A, Duffy, Garry P, Malone, Andrew, Roche, Ellen, Hameed, Aamir

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The isolated, buffer-perfused ferret heart: a new model for the study of cardiac physiology and metabolism. by Neubauer, S, Ingwall, J

“…The isolated, buffer-perfused ferret heart is a new model for the study of cardiac physiology and metabolism. Compared to the more commonly used isolated heart preparation, the rat heart, the ferret has a lower rate-pressure product due to lower heart rate, a remarkably low coronary flow and almost complete oxygen extraction. …”

Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study by Brent, B, Obonyo, N, Akech, S, Shebbe, M, Mpoya, A, Mturi, N, Berkley, J, Tulloh, R, Maitland, K

“…<strong>Design, Setting, and Participants</strong> A prospective, matched case-control study, the Cardiac Physiology in Malnutrition (CAPMAL) study, of 88 children with SAM (exposed) vs 22 severity-matched patients without SAM (unexposed) was conducted between March 7, 2011, and February 20, 2012; data analysis was performed from October 1, 2012, to March 1, 2016. …”

The pitfalls of in vivo cardiac physiology in genetically modified mice -- lessons learnt the hard way in the creatine kinase system by Lygate, CA

Investigating cardiac metabolism and the effect of novel metabolic modulation therapy on cardiac physiology and exercise capacity in aortic stenosis: a multi-parametric cardiac magnetic resonance study by Monga, S

“…However, this modulation did not show any measurable improvement in cardiac physiology or exercise capacity.</p> <p>Together, these data show that myocardial metabolic remodelling plays an important role in pathophysiology and progression of AS. …”

Improving interpretation of cardiac phenotypes and enhancing discovery with expanded knowledge in the gene ontology by Lovering, R, Roncaglia, P, Howe, D, Laulederkind, S, Khodiyar, V, Berardini, T, Tweedie, S, Foulger, R, Osumi-Sutherland, D, Campbell, N, Huntley, R, Talmud, P, Blake, J, Breckenridge, R, Riley, P, Lambiase, P, Elliott, P, Clapp, L, Tinker, A, Hill, D

“… <h4>Background</h4> <p>A systems biology approach to cardiac physiology requires a comprehensive representation of how coordinated processes operate in the heart, as well as the ability to interpret relevant transcriptomic and proteomic experiments. …”

Mathematical modelling of the ischaemic heart by Mulquiney, P, Smith, N, Clarke, K, Hunter, P

“…Recent advances in high performance computing combined with increasing knowledge of the kinetics of biochemical reactions and transport processes have allowed us to develop mathematical models that describe various aspects of cardiac physiology. These models include both single cell and three-dimensional tissue models that simulate important features of cardiac electrophysiology, mechanics, and metabolism. …”

Mathematical modelling of the ischaemic heart by Mulquiney, P, Smith, N, Clarke, K, Hunter, P

“…Recent advances in high performance computing combined with increasing knowledge of them kinetics of biochemical reactions and transport processes have allowed us to develop mathematical models that describe various aspects of cardiac physiology. These models include both single cell and three-dimensional tissue models that simulate important features of cardiac electrophysiology, mechanics, and metabolism. …”

Chaste: a test-driven approach to software development for biological modelling by Pitt-Francis, J, Pathmanathan, P, Bernabeu, M, Bordas, R, Cooper, J, Fletcher, A, Mirams, G, Murray, P, Osbourne, J, Walter, A, Chapman, S, Garny, A, van Leeuwen, I, Maini, P, Rodriguez, B, Waters, S, Whiteley, J, Byrne, H, Gavaghan, D

“…Current functionality has arisen from modelling in the fields of cancer, cardiac physiology and soft-tissue mechanics. It is released under the LGPL 2.1 licence. …”

The pathophysiology of heart failure: a tale of two old paradigms revisited. by Ashrafian, H, Williams, L, Frenneaux, M

“…In the search for novel strategies to improve on these outcomes, we must reacquaint ourselves with basic cardiac physiology at levels ranging from the molecular to the systemic in order to identify new targets for the treatment of HF. …”

The role of epicardial adipose tissue in cardiac biology: classic concepts and emerging roles by Antonopoulos, A, Antoniades, C

“…Further in-depth exploration of the molecular mechanisms regulating the cross-talk between the heart and EpAT is expected to enhance our understanding regarding the role of the latter in cardiac physiology and relevant disease mechanisms.…”

A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue by Ayagama, T, Bose, SJ, Capel, RA, Priestman, DA, Berridge, G, Fischer, R, Galione, A, Platt, FM, Kramer, H, Burton, RAB

“…The importance of lysosomes in cardiac physiology and pathology is well established, and evidence for roles in calcium signaling is emerging. …”