The stem cell movement. by Smart, N, Riley, P

“…This review focuses on existing insights into the trafficking of stem cells in the context of cardiac regenerative therapy, with particular focus on the wide variety of potential sources of cells, critical factors that may regulate their migration, and how extrapolating from embryonic stem/progenitor cell behavior during cardiogenesis may reveal pathways implicit in the adult heart postinjury.…”

Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development by Ricardo A. DeMoya, Rachel E. Forman-Rubinsky, Deon Fontaine, Joseph Shin, Simon C. Watkins, Cecilia W. Lo, Michael Tsang

“…These studies highlight the conserved role of Sap130a and Hdac1 in zebrafish cardiogenesis.…”
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Microwell-mediated Control of Embryoid Body Size Regulates Embryonic Stem Cell Fate Via Differential Expression of WNT5a and WNT11 by Khademhosseini, Ali, Hwang, Yu-Shik, Chung, Bong Geun, Moeller, Hannes-Christian, Ortmann, Daniel, Hattori, Nobuaki

“…We determined that cardiogenesis was enhanced in larger EBs (450 μm in diameter), and in contrast, endothelial cell differentiation was increased in smaller EBs (150 μm in diameter). …”
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Dissecting the upstream regulation of the GATA genes during heart development by Wennington, C

“…Here, I have investigated the upstream regulation of the cardiac GATA factors during cardiogenesis in zebrafish by interrogating their cis-regulatory genomic landscapes. …”

Semaphorins in immune cell function, inflammatory and infectious diseases by Rony Thomas, Xi Yang

“…Emerging evidence indicates the relevance of semaphorins outside the nervous system, including angiogenesis, cardiogenesis, osteoclastogenesis, tumour progression, and, more recently, the immune system. …”
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Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human by Hui Liu, Yingying Ma, Jiaxin Yu, Xiang Chen, Shuyuan Wang, Yijie Jia, Na Ding, Xiaoyan Jin, Yunpeng Zhang, Juan Xu, Xia Li

“…Cardiogenesis is an extremely complicated process involved with DNA regulatory elements, and trans factors regulate gene expression pattern spatiotemporally. …”
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On the Morphology of the Drosophila Heart by Barbara Rotstein, Achim Paululat

“…The circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to name a few examples. …”
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In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease by Francesco Nappi

“…Single-cell transcriptomics data have revealed the expression of genes associated with CHD in specific cell types, and emerging evidence suggests that genetic mutations disrupt multicellular genes essential for cardiogenesis. Metrics and units are being tracked in whole-genome sequencing studies.…”
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MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration by Ashley M. Fuller, Li Qian

“…Here, we discuss findings attesting to the critical role of miRNAs in cardiogenesis and cardiac regeneration, and present evidence regarding the therapeutic potential of miRNAs for cardiovascular diseases.…”
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The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research by Julia Christina Gross, Julia Christina Gross, Laura Cecilia Zelarayán, Laura Cecilia Zelarayán

“…In this regard, the role of activated Wnt signaling in cardiogenesis is well defined. However, the knowledge about signaling transmission has been challenged. …”
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Extracellular Vesicles in Atherosclerosis: State of the Art by Wioletta Olejarz, Karol Sadowski, Klaudia Radoszkiewicz

“…Importantly, EVs derived from stem/progenitor cells are essential mediators of cardiogenesis and cardioprotection and may be used in regenerative medicine and tissue engineering.…”
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Calreticulin and the Heart by Jody Groenendyk, Wen-An Wang, Alison Robinson, Marek Michalak

“…The protein supports Ca²⁺-dependent signaling events that are critical to cardiomyocyte differentiation and cardiogenesis. The increased expression of calreticulin and endoplasmic reticulum/sarcoplasmic reticulum Ca²⁺ capacity produces cardiomyocytes with enhanced efficiency, and detrimental mechanical stretching of cardiac fibroblasts, leading to cardiac pathology. …”
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Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart by Shang Wang, Irina V. Larina

“…In vertebrates, the coordinated beat of the early heart tube drives cardiogenesis and supports embryonic growth. How the heart pumps at this valveless stage marks a fascinating problem that is of vital significance for understanding cardiac development and defects. …”
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Progress on the role of cardiac-specific microRNA in myocardial infarction by WANG Qiang-li, ZHAO Yue, GUO Hai-dong, WANG Ying

“…Cardiac-specific miRNAs, such as miR-1, miR-133, miR499 and miR208, are widely involved in cardiogenesis, physiology and pathology of heart. Cardiac-specific miRNAs are not only involved in cardiomyocyte differentiation in early cardiogenic stages and cardiomyocyte proliferation in the late cardiogenic stages, but also in cell damage or protection, fibrosis, and ventricular remodeling in myocardial infarction (MI) after birth. …”
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The history of RNAi and microRNA discovery by Tan, GC

“…These processes include the regulation of developmental timing and signalling pathways, apoptosis, metabolism, myogenesis and cardiogenesis, brain development, and human pathologies like viral diseases, genetic disorders and cancer (Shi et al. 2008).…”
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Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies by Maha Alser, Samar Shurbaji, Huseyin C. Yalcin

“…Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. …”
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GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. by Peterkin, T, Gibson, A, Patient, R

“…Endoderm is critical for heart formation in several vertebrates including Xenopus, and separate perturbation of GATA-6 expression in the deep anterior endoderm and in the overlying heart mesoderm shows that GATA-6 is required in both for cardiogenesis. The GATA-6 requirement in cardiac mesoderm was confirmed in zebrafish, an organism in which endoderm is thought not to be necessary for heart formation. …”

Mutational analysis of the <it>PITX2 </it>coding region revealed no common cause for transposition of the great arteries (dTGA) by Goldmuntz Elizabeth, Rüdiger Heinz-Juergen, Schön Karin, Roeth Ralph, Niesler Beate, Muncke Nadja, Goodship Judith, Rappold Gudrun

“…<p>Abstract</p> <p>Background</p> <p>PITX2 is a bicoid-related homeodomain transcription factor that plays an important role in asymmetric cardiogenesis. Loss of function experiments in mice cause severe heart malformations, including transposition of the great arteries (TGA). …”
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Quantitative ontogenetic assessment of connective tissue cell dynamics in the ventricular rat myocardium by Gorbunov A.A., Tverdokhleb I.V.

“…At every stage of cardiogenesis the dynamics in quantitative changes in myocardial connective tissue component correlated with myocardiocyte differentia-tion and microvasculature formation.…”
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Protocol to measure calcium spikes in cardiomyocytes obtained from human pluripotent stem cells using a ready-to-use media by Veronica Astro, Gustavo Ramirez-Calderon, Antonio Adamo

“…Summary: The derivation of cardiomyocytes from human pluripotent stem cells (hPSCs) is a powerful tool to investigate early cardiogenesis and model diseases in vitro. Here, we present an optimized protocol to obtain contracting hPSCs-derived cardiomyocytes using a ready-to-use kit. …”
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