Suppressing Kaposi’s Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme by Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu

“…In this study, we engineered ribozymes derived from ribonuclease P (RNase P) catalytic RNA with targeting against the mRNA encoding KSHV immediate early replication and transcription activator (RTA), which is vital for KSHV gene expression. …”
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Rational Design of an Orthogonal Pair of Bimolecular RNase P Ribozymes through Heterologous Assembly of Their Modular Domains by Yuri Nozawa, Megumi Hagihara, Md Sohanur Rahman, Shigeyoshi Matsumura, Yoshiya Ikawa

“…Bimolecular forms of bacterial RNase P ribozymes consisting of S-domain and C-domain RNAs are attractive as platforms for catalytic RNA nanostructures, but their S-domain/C-domain assembly was not optimized for this purpose. …”
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Ribozymes as therapeutic tools for genetic disease. by Phylactou, L, Kilpatrick, M, Wood, M

“…It also provided the platform to develop those catalytic RNA molecules, called ribozymes, as trans -acting tools for RNA manipulation. …”

What RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental Attention by Charles W. Carter

“…A coherent structural basis for that scenario was articulated nearly a decade before the demonstration of catalytic RNA. Parallel hierarchical catalytic repertoires for increasingly highly conserved sequences from the two synthetase classes now increase the likelihood that they arose as translation products from opposite strands of a single gene. …”
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RiboaptDB: A Comprehensive Database of Ribozymes and Aptamers by Thodima Venkata, Pirooznia Mehdi, Deng Youping

“…<p>Abstract</p> <p>Background</p> <p>Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that have been selected from vast populations of random sequences, through a combinatorial approach known as SELEX. …”

The Dynamic Network of RNP RNase P Subunits by Athanasios-Nasir Shaukat, Eleni G. Kaliatsi, Ilias Skeparnias, Constantinos Stathopoulos

“…In all organisms, the cleavage activity of a single phosphodiester bond adjacent to the first nucleotide of the acceptor stem is indispensable for cell viability and lies within an essential catalytic RNA subunit. Although RNase P is a ribozyme, its kinetic efficiency in vivo, as well as its structural variability and complexity throughout evolution, requires the presence of one protein subunit in bacteria to several protein partners in archaea and eukaryotes. …”
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Mechanism of U6 snRNA oligouridylation by human TUT1 by Seisuke Yamashita, Kozo Tomita

“…Abstract U6 snRNA is a catalytic RNA responsible for pre-mRNA splicing reactions and undergoes various post-transcriptional modifications during its maturation process. …”
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A RNase P Ribozyme Inhibits Gene Expression and Replication of Hepatitis B Virus in Cultured Cells by Bin Yan, Yujun Liu, Yuan-Chuan Chen, Fenyong Liu

“…Sequence-specific ribozymes derived from ribonuclease P (RNase P) catalytic RNA are being explored for gene targeting applications. …”
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Investigating a new generation of ribozymes in order to target HCV. by Michel V Lévesque, Dominique Lévesque, Francis P Brière, Jean-Pierre Perreault

“…The former switches cleavage activity "on" solely in the presence of the desired RNA substrate, while the latter was the first catalytic RNA reported to function naturally in human cells, specifically in hepatocytes. …”
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Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis by Matzov, Donna, Taoka, Masato, Nobe, Yuko, Yamauchi, Yoshio, Halfon, Yehuda, Asis, Nofar, Zimermann, Ella, Rozenberg, Haim, Bashan, Anat, Bhushan, Shashi, Isobe, Toshiaki, Gray, Michael W., Yonath, Ada, Shalev-Benami, Moran

“…The rRNA is substantially enriched in post-transcriptional modifications that are spread far beyond the catalytic RNA core, contributing to the stabilization of this highly fragmented ribosome species. …”
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Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor by Tobias Göppel, Joachim H. Rosenberger, Bernhard Altaner, Ulrich Gerland

“…However, it does not explain the origin of the catalytic RNA molecules. How could the transition from a pre-RNA to an RNA world occur? …”
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Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation by Anzhalika Sidarovich, Cindy L Will, Maria M Anokhina, Javier Ceballos, Sonja Sievers, Dmitry E Agafonov, Timur Samatov, Penghui Bao, Berthold Kastner, Henning Urlaub, Herbert Waldmann, Reinhard Lührmann

“…The U2/U6 RNA network in B028 complexes differs from that of the Bact complex, consistent with the idea that the catalytic RNA core forms stepwise during the B to Bact transition and is likely stabilized by the Prp19/CDC5L complex and related proteins. …”
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Experimental promoter identification of a foodborne pathogen Salmonella enterica subsp. enterica serovar Typhimurium with near single base-pair resolution by Sang-Mok Lee, Hoa Thi Le, Assiya Taizhanova, Linh Khanh Nong, Joon Young Park, Eun-Jin Lee, Bernhard O. Palsson, Donghyuk Kim

“…Typhimurium LT2 (LT2), the ChIP-exo experiment was conducted to accurately determine the binding sites of catalytic RNA polymerase subunit RpoB and major sigma factors (RpoD, RpoN, RpoS, and RpoE) during exponential phase. …”
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AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors by Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N’Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate

“…Each one connects to an enhanced specific expression of the catalytic RNA Pol2 A subunit, among 12 different subunits. …”
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7.342 The RNA Revolution: At the Frontiers of Cell Biology and Molecular Medicine, Fall 2016 by Garg, Salil, Ward, Amanda

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Hammerhead ribozymes reduce central nervous system (CNS)-derived neuronal nitric oxide synthase messenger RNA in a human cell line. by Maniotis, D, Wood, M, Phylactou, L

“…Catalytic RNA molecules (ribozymes) have been widely used specifically to suppress gene expression. …”