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The reaction kinetics and three-dimensional architecture of a catalytic RNA
Published 2005Get full text
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Quasispecies-like behavior observed in catalytic RNA populations evolving in a test tube
Published 2010-03-01“…This is the first time this has been seen with a catalytic RNA. Extensive genotypic sampling from two replicate lineages was gathered and phylogenetic networks were constructed to elucidate the structure of the evolving RNA populations. …”
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Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
Published 2022-11-01Get full text
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Synthetic nucleic acids as inhibitors of gene expression : mechanisms, applications and therapeutics implications /
Published 2004Subjects: “…Catalytic RNA…”
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Development of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage
Published 2019Subjects: Get full text
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Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability
Published 2014-12-01Subjects: “…catalytic RNA…”
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Artificial RNA Motifs Expand the Programmable Assembly between RNA Modules of a Bimolecular Ribozyme Leading to Application to RNA Nanostructure Design
Published 2017-10-01Subjects: “…catalytic RNA…”
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An RNA Triangle with Six Ribozyme Units Can Promote a <i>Trans</i>-Splicing Reaction through Trimerization of Unit Ribozyme Dimers
Published 2021-03-01Subjects: “…catalytic RNA…”
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Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers
Published 2018-05-01“…Although tremendous progress has been made to establish catalytic RNA as a new class of biologics for cancer management, a lot of extracellular and intracellular barriers still pose a long-lasting challenge on the way to clinical approval. …”
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Structure Determination of Catalytic RNAs and Investigations of Their Metal Ion-Binding Properties
Published 2005-11-01“…A large part of our work is devoted to the structure determination of catalytic RNA molecules, i.e. ribozymes, by NMR. Based on the three-dimensional structure, further experiments are carried out to understand in detail the effects of different metal ions on the local and global structure, as well as catalysis itself. …”
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Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes
Published 2022-06-01“…Complex biochemical systems exhibit traits that appear to be highly adapted. Studies of catalytic RNA demonstrate that adaptive traits, such as increased specificity and error tolerance, could originate as evolutionary by-products.…”
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Viroids and the Origin of Life
Published 2021-03-01“…They are often ribozymes, characterized by catalytic RNA. They can perform many basic functions of life and may have played a role in evolution since the beginning of life on Earth. …”
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Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P
Published 2023-12-01“…S. cerevisiae RNase P comprises a catalytic RNA component and nine proteins. The assembly and maturation of S. cerevisiae RNase P involves an abundant and catalytically active precursor form, which includes all components except for proteins Rpr2 and Pop3. …”
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Ribozymes and siRNA for the treatment of diseases of the nervous system.
Published 2003“…Naturally occurring catalytic RNA molecules (ribozymes), their synthetic DNA counterparts (deoxyribozymes or DNAzymes), as well as the exciting, emerging technology of small interfering RNA which utilizes the highly conserved cellular RNA interference pathway, are being developed for therapeutic gene silencing purposes. …”
Journal article