CEACAM6’s Role as a Chemoresistance and Prognostic Biomarker for Pancreatic Cancer: A Comparison of CEACAM6’s Diagnostic and Prognostic Capabilities with Those of CA19-9 and CEA... by Benediktas Kurlinkus, Marija Ger, Algirdas Kaupinis, Eugenijus Jasiunas, Mindaugas Valius, Audrius Sileikis

“…Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) was discovered as a possible promising pancreatic cancer biomarker. …”
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LC-MS Fingerprinting Development for Standardized Precipitate from <em>Agastache mexicana</em>, Which Induces Antihypertensive Effect through NO Production and Calcium Channel Bloc... by Karla Catalina Cruz-Torres, Samuel Estrada-Soto, Luis Arias-Durán, Gabriel Navarrete-Vázquez, Julio César Almanza-Pérez, Beatriz Mora-Ramiro, Irene Perea-Arango, Emanuel Hernández-Núñez, Rafael Villalobos-Molina, Gabriela Carmona-Castro, Irma-Martha Medina-Díaz, Gabriela Ávila-Villarreal

“…On the other hand, human umbilical vein cells treated with 10 µg/mL of PP<i>Am</i> showed a significant reduction (<i>p</i> < 0.05) in intracellular adhesion molecule-1, compared to the control, but not on vascular cell adhesion molecule-1. In conclusion, PP<i>Am</i> induces a significant antihypertensive effect in acute- and subacute-period treatments, due to its direct vasorelaxant action on rat aortic rings through NO production and Ca²⁺ channel blockade.…”
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Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease by Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu’uhevaha J. Kaitu’u-Lino, Kenji Onda, Natalie J. Hannan

“…Both drugs could mitigate expression of the endothelial dysfunction markers, vascular cell adhesion molecule-1 and endothelin-1 (via qPCR). Neither esomeprazole MH nor MTH quenched cytotrophoblast reactive oxygen species production in response to sodium azide (ROS assay). …”
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Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate by Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, Kazuhisa Honma, Yuichi Nagashima, Genki Hichiwa, Kazuto Shimoya, Satoshi Abe, Takashi Moriwaki, Yasufumi Murakami, Xu Gao, Hiroyuki Kugoh, Mitsuo Oshimura, Yuji Ito, Yasuhiro Kazuki

“…In this study, we investigated 377 clones of fully human mAbs against a tumor antigen, epithelial cell adhesion molecule (EpCAM), to determine their antigen binding properties. …”
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Endometrial cancer prognosis correlates with the expression of L1CAM and miR34a biomarkers by Giacomo Corrado, Valentina Laquintana, Rossella Loria, Mariantonia Carosi, Laura de Salvo, Isabella Sperduti, Ashanti Zampa, Lucia Cicchillitti, Giulia Piaggio, Giuseppe Cutillo, Rita Falcioni, Enrico Vizza

“…Abstract Background Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several human carcinomas and has recently been described as a new marker for endometrial and ovarian carcinomas. …”
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Association of CD4-positive cell infiltration with response to vedolizumab in patients with ulcerative colitis by Haruka Miyazaki, Namiko Hoshi, Tsukasa Ishida, Chiharu Nishioka, Sachiko Ouchi, Daisuke Shirasaka, Tomoo Yoshie, Yoshinori Munetomo, Yoshio Sakamoto, Tatsuya Osuga, Saori Matsui, Toshiki Hyodo, Tamami Denda, Daisuke Watanabe, Makoto Ooi, Yuzo Kodama

“…Vedolizumab, a humanized monoclonal antibody against alpha 4 beta 7 (α4β7) integrin, suppresses immune cell migration by blocking the interaction between α4β7 integrin and mucosal addressin cell adhesion molecule 1. Reports about histological features that predict vedolizumab efficacy are scarce. …”
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Aloe Vera/Collagen Mixture Induces Integrin α1β1 and PECAM-1 Genes Expression in Human Adipose-Derived Stem Cells by Faraz Sigaroodi, Hajar Shafaei, Mohammad Karimipour, Mohammad Amin Dolatkhah, Abbas Delazar

“…We aimed to evaluate the effect of Aloe vera/ Collagen blended on cell viability, cell attachment, and angiogenic potential by determining of integrin α1β1 and platelet endothelial cell adhesion molecule (PECAM-1) genes expression in human adipose-derived stem cells (hASCs). …”
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CircDDX17 inhibits invasive progression of pituitary adenomas by sponging miR-1279 and regulating CADM2 expression by Xiao Yue, Fengming Lan, Weiping Liu

“…In the present study, we investigated the role of circDDX17 in pituitary adenomas (PAs).MethodsReverse transcription–quantitative PCR was performed to detect the expression of Circular RNA DDX17 (circDDX17), microRNA-1279 (miR-1279), and cell adhesion molecule 2 (CADM2) in PA tissues. Cell abilities of migration and invasion were examined by wound healing and transwell assays. …”
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Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway by Wenhai Guo, Danping Huang, Shaodong Li

“…Results: Under H2O2 stimulation, HMEC-1 and ECV-304 cell proliferation and the SIRT1/Nrf2/HO-1 pathway protein expression were significantly reduced, whereas cytotoxicity, apoptosis, cell adhesion molecule expression, pro-inflammatory and oxidative stress factors production were apparently encouraged, which were partially countered by lycopene intervention in a dose-dependent manner. …”
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Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells by Cai Shao-xi, Zeng Guo-fang, Wu Guang-Jer

“…<p>Abstract</p> <p>Background</p> <p>Conflicting research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as both a tumor promoter and a tumor suppressor in the development of breast cancer. …”
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A novel minimally-invasive method to sample human endothelial cells for molecular profiling. by Stephen W Waldo, Daniel A Brenner, James M McCabe, Mark Dela Cruz, Brian Long, Venkata A Narla, Joseph Park, Ameya Kulkarni, Elizabeth Sinclair, Stephen Y Chan, Suzaynn F Schick, Namita Malik, Peter Ganz, Priscilla Y Hsue

“…Quantitative PCR demonstrated higher expression of von Willebrand Factor (vWF, P<0.001), nitric oxide synthase 3 (NOS3, P<0.001) and vascular cell adhesion molecule 1 (VCAM-1, P<0.003) in the endothelial population compared to similarly isolated leukocytes. …”
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Therapeutic effect of folic acid combined with decitabine on diabetic mice by Gang Du, Yong Yan, Jun-Feng Gao, Chun-Yan Guo, Xiao Shen, Xun-Wen Lei

“…The platelet endothelial cell adhesion molecule-1 (CD31) and vascular endothelial growth factor receptor (VEGFR) protein were detected by Western blot. …”
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Evaluation of CAMD1 Gene Promoter Hypermethylation in Human Papillomavirus Positive Cytological Samples of Cervical Cancer by Farzaneh Jalili, Golnaz Asaadi Tehrani, Sina Mirzaahamdi

“…This study aimed to investigate cell adhesion molecule 1 (CADM1), promoter methylation in HPV serological positive samples in the Iranian population. …”
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Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp by Christopher J. Coates, Igor Kraev, Andrew F. Rowley, Sigrun Lange

“…Three deiminated proteins specific to parasitized crab haemolymph were actin, Down syndrome cell adhesion molecule (DSCAM), and nitric oxide synthase – factors that contribute to innate immunity. …”
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Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect by Yu-De Chu, Li-Chun Cheng, Siew-Na Lim, Ming-Wei Lai, Chau-Ting Yeh, Wey-Ran Lin

“…The study also identified CEA cell adhesion molecule-6 (CEACAM6) as a downstream effector of ALDOB that controlled CRC cell proliferation and chemoresistance. …”
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Antibodies against electronegative LDL inhibit atherosclerosis in LDLr-/- mice by D.M. Grosso, S. Ferderbar, A.C.B.A. Wanschel, M.H. Krieger, M.L. Higushi, D.S.P. Abdalla

“…The passive immunization with anti-LDL(-) monoclonal IgG2b, polyclonal antibody and its derived Fab significantly reduced the cross-sectional area of atherosclerotic lesions at the aortic root of LDLr-/- mice (28.8 ± 9.7, 67.3 ± 17.02, 56.9 ± 8.02 µm² (mean ± SD), respectively) compared to control (124.9 ± 13.2 µm²). Vascular cell adhesion molecule-1 protein expression, quantified by the KS300 image-analyzing software, on endothelium and the number of macrophages in the intima was also decreased in aortas of mice treated with anti-LDL(-) monoclonal antibody (3.5 ± 0.70 per field x 10) compared to controls (21.5 ± 3.5 per field x 10). …”
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The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression by Sanith Cheriyamundath, Anmol Kumar, Nancy Gavert, Thomas Brabletz, Avri Ben-Ze’ev

“…We identified the cell adhesion molecule L1CAM (L1) as a target of β-catenin-TCF transactivation in CRC cells. …”
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice by Yang Yun, Xuejiao Wang, Jingyi Xu, Jingyu Chen, Xueru Wang, Pingting Yang, Ling Qin

“…The increased expression of adhesion molecules (P-selectin and vascular cell adhesion molecule-1 (VCAM-1)), leukocyte recruitment, blood-brain barrier (BBB) leakage were significantly decreased. …”
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N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. by Eric Haÿ, Alexandra Nouraud, Pierre J Marie

“…Recent studies indicate that the cell-cell adhesion molecule N-cadherin interacts with the Wnt co-receptors LRP5/6 to regulate osteoblast differentiation and bone accrual. …”
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Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review an... by Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim

“…The pooled data indicated that vitamin E supplementation significantly decreased intercellular adhesion molecule-1 [standardized mean difference (SMD): −1.35; 95% confidence interval (CI): −2.57, −0.13; <i>p</i> = 0.03, I² = 89%], vascular cell adhesion molecule-1 (SMD: −1.08; 95% CI: −2.05, −0.11; <i>p</i> = 0.03, I² = 81%), C-reactive protein (SMD: −0.41; 95% CI: −0.75, −0.07; <i>p</i> = 0.02, I² = 64%), and malondialdehyde (SMD: −0.76; 95% CI: −1.26, −0.25; <i>p</i> = 0.003, I² = 77%) levels, but not interleukin-6 levels compared to those in the control group. …”
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