Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells by Onder, Tamer T

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Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro by March, Sandra, Hui, Elliot E., Underhill, Gregory, Khetani, Salman R., Bhatia, Sangeeta N.

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VCAM-1 targeted alpha-particle therapy for early brain metastases by Corroyer-Dulmont, A, Valable, S, Falzone, N, Frelin-Labalme, A-M, Tietz, O, Toutain, J, Sarmiento Soto, M, Divoux, D, Chazaviel, L, Pérès, EA, Sibson, NR, Vallis, KA, Bernaudin, M

“…The therapeutic challenge is to deliver molecularly targeted therapy at an early stage when relatively few metastatic tumor cells have invaded the brain. Vascular cell adhesion molecule 1 (VCAM-1), overexpressed by nearby endothelial cells during the early stages of BM development, is a promising target. …”

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease. by Campbell, D, Neal, B, Chalmers, J, Colman, SA, Jenkins, A, Kemp, B, Patel, A, MacMahon, S, Woodward, M

“…Plasma levels of C-reactive protein (CRP), soluble vascular cell adhesion molecule 1 (sVCAM-1), homocysteine, amino-terminal-pro-B-type natriuretic peptide (NT-proBNP), and renin were not associated with ICH risk. …”

Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis. by Antoniades, C, Tousoulis, D, Marinou, K, Papageorgiou, N, Bosinakou, E, Tsioufis, C, Stefanadi, E, Latsios, G, Tentolouris, C, Siasos, G, Stefanadis, C

“…Patients in INS group had higher levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein (MCP-1) and vascular cell adhesion molecule (sVCAM-1), compared to TABL. However, TNF-alpha was negatively correlated with protein C (PrtC) only in INS (r = - 0.726, p = 0.01) but not in TABL group (r = - 0.066, p = 0.738). …”

Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction. by Tousoulis, D, Antoniades, C, Bosinakou, E, Kotsopoulou, M, Tsoufis, C, Marinou, K, Charakida, M, Stefanadi, E, Vavuranakis, M, Latsios, G, Stefanadis, C

“…RESULTS: Patients with UA had significantly higher levels of interleukin-6 (IL-6), soluble vascular cells adhesion molecule (sVCAM-1) and von Willebrand factor (vWF) (p<0.05 vs controls), and lower levels of antithrombin III (ATIII) (p<0.01 vs controls) and protein C (PrtC) (p<0.05 vs controls). …”

A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content by McAteer, M, Mankia, K, Ruparelia, N, Jefferson, A, Nugent, H, Stork, L, Channon, K, Schneider, J, Choudhury, R

“…We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. …”

Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. by Papageorgiou, N, Tousoulis, D, Psaltopoulou, T, Giolis, A, Antoniades, C, Tsiamis, E, Miliou, A, Toutouzas, K, Siasos, G, Stefanadis, C

“… BACKGROUND/OBJECTIVES: Inter-cellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and tumor necrosis factor-α (TNF-α), are implicated in atherogenesis. …”

Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint. by Marinova-Mutafchieva, L, Taylor, P, Funa, K, Maini, R, Zvaifler, N

“…They were retained through multiple passages and persistently displayed surface vascular cell adhesion molecule 1. Immunohistochemical analysis of cultured RA FLS (passages 3, 4, and 6; n = 6) revealed that 11.6% were BMPR-positive, while only 2.0% of osteoarthritis FLS (passage 4; n = 3) were BMPR-positive, and 1 normal synovial culture had no BMPR-positive cells. …”

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. by Fan, L, Douglas, G, Bendall, J, McNeill, E, Crabtree, M, Hale, AB, Mai, A, Li, J, McAteer, M, Schneider, J, Choudhury, R, Channon, K

“…Nox2 transgenic aortas had increased endothelial ROS production, endothelial vascular cell adhesion molecule-1 expression, matrix metalloproteinase activity, and CD45(+) inflammatory cell infiltration. …”

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection by Fan, L, Douglas, G, Bendall, J, McNeill, E, Crabtree, M, Hale, AB, Li, J, McAteer, M, Schneider, J, Choudhury, R, Channon, K

“…Nox2 transgenic aortas had increased endothelial ROS production, endothelial vascular cell adhesion molecule-1 expression, matrix metalloproteinase activity, and CD45+ inflammatory cell infiltration. …”

Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin... by Tousoulis, D, Antoniades, C, Marinou, K, Vasiliadou, C, Bouras, G, Stefanadi, E, Latsios, G, Siasos, G, Toutouzas, K, Stefanadis, C

“…Forearm vasodilatory response to reactive hyperemia, plasma total homocysteine (tHcy), oxidized LDL (ox-LDL), ET-1 and soluble vascular cell adhesion molecule (sVCAM-1), were evaluated at baseline and 4 hours post methionine loading (4hPML). …”

A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content. by McAteer, M, Mankia, K, Ruparelia, N, Jefferson, A, Nugent, H, Stork, L, Channon, K, Schneider, J, Choudhury, R

“…We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. …”

MuSK antibody positive myasthenia gravis plasma modifies MURF-1 expression in C2C12 cultures and mouse muscle in vivo. by Benveniste, O, Jacobson, L, Farrugia, M, Clover, L, Vincent, A

“…We also looked at expression of neural cell adhesion molecule (NCAM, CD56) that is upregulated after denervation in vivo. …”

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism by Jiang, C, Hopfner, F, Katsikoudi, A, Hein, R, Catli, C, Evetts, S, Huang, Y, Wang, H, Ryder, JW, Kuhlenbäumer, G, Deuschl, G, Padovani, A, Berg, D, Borroni, B, Hu, MT, Davis, JJ, Tofaris, GK

“…We developed poly(carboxybetaine-methacrylate) coated beads to isolate L1 cell adhesion molecule (L1CAM)-positive extracellular vesicles with characteristics of exosomes and used mass spectrometry or multiplexed electrochemiluminescence to measure exosomal proteins.…”

Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging by Chan, J, Monaco, C, Wylezinska-Arridge, M, Tremoleda, J, Cole, J, Goddard, J, Cheung, M, Bhakoo, K, Gibbs, R

“…</p><p> METHODS: DT-MPIO were used to detect and characterize inflammatory markers, vascular cell adhesion molecule 1 (VCAM-1). and P-selectin on (1) tumor necrosis factor-α-treated cells by immunocytochemistry and (2) aortic root plaques of apolipoprotein-E deficient mice by in vivo MRI. …”

Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. by Antoniades, C, Tousoulis, D, Tountas, C, Tentolouris, C, Toutouza, M, Vasiliadou, C, Tsioufis, C, Toutouzas, P, Stefanadis, C

“…We examined the effect of vitamin C on endothelial function and levels of soluble vascular cell adhesion molecule (sVCAM-1), interleukin-6 (IL-6) and tumour necrosis factor (TNF-alpha), in DM patients with or without CAD and in non-diabetic subjects. …”

A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-... by Marinova-Mutafchieva, L, Williams, R, Mauri, C, Mason, L, Walmsley, M, Taylor, P, Feldmann, M, Maini, R

“…RESULTS: Anti-TNFalpha significantly reduced the numbers of cells expressing TNFalpha, interleukin-1beta (IL-1beta), very late activation antigen 4 (VLA-4), vascular cell adhesion molecule 1 (VCAM-1), and numbers of CD4+ T cells and macrophages in the joint. …”

L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. by Dou, X, Menkari, C, Mitsuyama, R, Foroud, T, Wetherill, L, Hammond, P, Suttie, M, Chen, X, Chen, S, Charness, M

“…Ethanol causes fetal alcohol spectrum disorders (FASD) partly by inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule. Ethanol interacts with an alcohol binding pocket in the L1 extracellular domain (ECD), and dephosphorylation of S1248 in the L1 cytoplasmic domain (CD) renders L1 adhesion insensitive to inhibition by ethanol (L1 insensitive). …”

Diagnostic strategy for the assessment of rheumatoid vasculitis. by Voskuyl, A, Hazes, J, Zwinderman, A, Paleolog, E, van der Meer, F, Daha, MR, Breedveld, F

“…The following markers were evaluated: circulating immune complexes, complement components C3 and C4, class-specific rheumatoid factors (IgM RF, IgG RF, IgA RF), antineutrophil cytoplasmic antibodies, antinuclear antibodies, antiendothelial antibodies, circulating intercellular adhesion molecule-1 and -3, circulating vascular cell adhesion molecule and E-selectin, cellular fibronectin, von Willebrand factor antigen, and C reactive protein. …”