Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock by Marta Reina-Couto, Marisa Santos-Oliveira, Patrícia Pereira-Terra, Carolina Silva-Pereira, Janete Quelhas-Santos, Álvaro Duarte, Sandra Martins, Paula Serrão, Cláudia Camila Dias, Manuela Morato, João T. Guimarães, Roberto Roncon-Albuquerque, José-Artur Paiva, António Albino-Teixeira, Teresa Sousa

“…Serum intercellular-adhesion molecule-1, vascular cell-adhesion molecule-1, E-selectin, tumor necrosis factor-α, IL-1β, and IL-6 were measured by multiplex immunoassays. …”
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Aerobic Exercise Training Inhibits Neointimal Formation via Reduction of PCSK9 and LOX-1 in Atherosclerosis by Wei Li, Heegeun Park, Erling Guo, Wooyeon Jo, Kyu Min Sim, Sang Ki Lee

“…Fourth, aerobic exercise training significantly decreased the expression of PCSK9, the lectin-like oxidized LDL receptor-1 (LOX-1), and vascular cell adhesion molecule-1 (VCAM-1) in balloon-induced common carotid arteries of high-fat-diet rats compared to the BIC. …”
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Pure and mixed clear cell carcinoma of the endometrium: A molecular and immunohistochemical analysis study by Casper Reijnen, Stéphanie W. Vrede, Astrid Eijkelenboom, Ruud Draak, Sanne Sweegers, Marc P. L. M. Snijders, Puck vanGestel, Johanna M. A. Pijnenborg, Johan Bulten, Heidi V. N. Küsters‐Vandevelde

“…Immunohistochemistry was performed for estrogen receptor, progesterone receptor, L1 cell adhesion molecule, MSH6, and PMS2. Results The following molecular subgroups were identified for pure and mixed uterine CCCs, respectively: POLE mutated 0% (0/18) and 6% (1/18); MSI in 6% (1/18) and 50% (9/18); TP53 wildtype in 56% (10/18) and 22% (4/18); TP53 mutated in 39% (7/18) and 22% (4/18) (p = 0.013). …”
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Effects of the synbiotic composed of mangiferin and Lactobacillus reuteri 1–12 on type 2 diabetes mellitus rats by Fanying Meng, Fan Zhang, Meng Meng, Qiuding Chen, Yaqin Yang, Wenbo Wang, Haina Xie, Xue Li, Wen Gu, Jie Yu

“…Also, SML regulated biochemical parameters such as short chain fatty acids (SCFAs), lipopolysaccharides (LPS), intercellular cell adhesion molecule-1 (ICAM-1), and tumor necrosis factor-α (TNF-α). …”
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Phenolic Profile and Fingerprint Analysis of <i>Akebia quinata</i> Leaves Extract with Endothelial Protective Activity by Dan Gao, Chong-Woon Cho, Jin-Hyeok Kim, Haiying Bao, Hyung-Min Kim, Xiwen Li, Jong-Seong Kang

“…We found that <i>A. quinata</i> leaves extract pretreatment of 10 μg/mL significantly attenuated LPS-induced protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1. Furthermore, this extract also suppressed LPS-induced phosphorylation of nuclear factor-κB p65. …”
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Anti-EpCAM Functionalized I-131 Radiolabeled Biomimetic Nanocarrier Sodium/Iodide-Symporter-Mediated Breast-Cancer Treatment by Suphalak Khamruang Marshall, Yada Panrak, Naritsara Makchuchit, Passara Jaroenpakdee, Boonyisa Saelim, Maneerat Taweesap, Verachai Pachana

“…The PLGA nanoparticle was coated in human red blood cell membranes and labeled with epithelial cell adhesion molecule (EpCAM) antibody to enable it to target EpCAM overexpression by breast-cancer cells. …”
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Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B by Hirohito Ogawa, Daisuke Fujikura, Hikaru Namba, Nobuko Yamashita, Tomoyuki Honda, Masao Yamada

“…We then determined that nectin cell adhesion molecule 2 (nectin-2) mediated virus entry and that HHV-6B-insensitive T-cells transduced with nectin-2 were transformed into virus-permissive cells. …”
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Cardiotonic Pills Plus Recombinant Human Prourokinase Ameliorates Atherosclerotic Lesions in LDLR–/– Mice by Jing-Na Deng, Jing-Na Deng, Jing-Na Deng, Jing-Na Deng, Jing-Na Deng, Jing-Na Deng, Quan Li, Quan Li, Quan Li, Quan Li, Quan Li, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Huan Li, Huan Li, Huan Li, Huan Li, Huan Li, Huan Li, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Gao Li, Bai-He Hu, Bai-He Hu, Bai-He Hu, Bai-He Hu, Bai-He Hu, Xin Chang, Xin Chang, Xin Chang, Xin Chang, Xin Chang, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han

“…In addition, we observed that systemic inflammation was inhibited, manifested downregulation of plasma macrophage inflammatory protein-1α and intercellular cell adhesion molecule-1.ConclusionCP plus proUK effectively attenuated atherosclerosis plaque in LDLR–/– mice, which is associated with normalizing the lipid metabolism in the liver and aorta, reducing phagocytosis of receptor-mediated modified-LDL uptake and inhibiting systemic inflammation.…”
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Microvascular Dysfunction and Whole‐Brain White Matter Connectivity: The Maastricht Study by Magdalena Beran, April C.E. van Gennip, Coen D.A. Stehouwer, Jacobus F.A. Jansen, Monideepa D. Gupta, Alfons J.H.M. Houben, Tos T.J.M. Berendschot, Carroll A.B. Webers, Anke Wesselius, Casper G. Schalkwijk, Walter H. Backes, Joost J.A. de Jong, Carla J.H. van der Kallen, Marleen M.J. van Greevenbroek, Sebastian Köhler, Jet M.J. Vonk, Mirjam I. Geerlings, Miranda T. Schram, Thomas T. van Sloten

“…Measures of microvascular function included urinary albumin excretion, central retinal arteriolar and venular calibers, composite scores of flicker light–induced retinal arteriolar and venular dilation, and plasma biomarkers of endothelial dysfunction (intercellular adhesion molecule‐1, vascular cell adhesion molecule‐1, E‐selectin, and von Willebrand factor). …”
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V-set and immunoglobulin domain containing 1 (VSIG1) as an emerging target for epithelial–mesenchymal transition of gastric cancer by Catalin-Bogdan Satala, Ioan Jung, Zsolt Kovacs, Raluca-Ioana Stefan-Van Staden, Calin Molnar, Tivadar Bara, Andrei-Ionut Patrichi, Simona Gurzu

“…Abstract V-set and Immunoglobulin domain containing 1 (VSIG1) is a cell–cell adhesion molecule which role in the genesis and evolution of gastric cancer (GC) is not understood. …”
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Red-Osier Dogwood Extracts Prevent Inflammatory Responses in Caco-2 Cells and a Caco-2 BBe1/EA.hy926 Cell Co-Culture Model by Qian Jiang, Hua Zhang, Runqiang Yang, Qianru Hui, Yuhuan Chen, Lili Mats, Rong Tsao, Chengbo Yang

“…The results showed that RDE supplementation significantly prevented interleukin-8 (IL-8) production and suppressed the gene expression of IL-8, tumor necrosis factor-alpha (TNF-&#945;), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and cyclooxygenase 2 (COX-2) in the TNF-&#945; inflamed Caco-2 cells. …”
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Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis by Wei-Chih Chen, Nien-Jung Chen, Hsin-Pai Chen, Wen-Kuang Yu, Vincent Yi-Fong Su, Hao Chen, Huai-Hsuan Wu, Kuang-Yao Yang

“…Nintedanib also decreased the activation of endothelial cells by the decreased expression of vascular cell adhesion molecule 1 (VCAM-1). The effect of nintedanib on regulating neutrophil chemotaxis was also confirmed by a mouse model with adoptive neutrophil transfer in vivo. …”
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Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer Cells by Darko Castven, Carolin Czauderna, Diana Becker, Sharon Pereira, Jennifer Schmitt, Arndt Weinmann, Viral Shah, Jovana Hajduk, Friederike Keggenhoff, Harald Binder, Tobias Keck, Stefanie Heilmann‐Heimbach, Marcus A. Wörns, Snorri S. Thorgeirsson, Kai Breuhahn, Peter R. Galle, Jens U. Marquardt

“…Resistant cells showed induction in sphere forming in vitro and tumor‐initiating capacity in vivo as well as increased number of side population and epithelial cell adhesion molecule‐positive cells. Conversely, sensitive cell lines showed consistent reduction of TIC properties. …”
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Sensory neuron transient receptor potential vanilloid-1 channel regulates angiogenesis through CGRP in vivo by Zhanfeng Zhu, Zhanfeng Zhu, Yixuan Jiang, Yixuan Jiang, Zixia Li, Yu Du, Yu Du, Qinyi Chen, Qinyi Chen, Qiang Guo, Yu Ban, Yu Ban, Ping Gong, Ping Gong

“…Meanwhile, TRPV1 activation upregulated the mRNA and protein expression of vascular endothelial growth factor A (VEGF-A), cell adhesion molecule-1 (CD31), and CGRP. Immunostaining revealed the co-localization of TRPV1 and CGRP in dorsal root ganglia (DRG) sensory neurons. …”
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Age-Dependent Surface Receptor Expression Patterns in Immature Versus Mature Platelets in Mouse Models of Regenerative Thrombocytopenia by Anita Pirabe, Sabine Frühwirth, Laura Brunnthaler, Hubert Hackl, Anna Schmuckenschlager, Waltraud C. Schrottmaier, Alice Assinger

“…Our findings indicate that aged mice show an upregulated expression of the platelet endothelial cell adhesion molecule-1 (CD31), tetraspanin-29 (CD9), and Toll-like receptor 2 (TLR2) compared to their younger counterparts. …”
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Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer’s disease by Min-Seok Kim, Kwangmin Cho, Mi-Hyang Cho, Na-Young Kim, Kyunggon Kim, Dong-Hou Kim, Seung-Yong Yoon

“…Specifically, Aβ oligomers disassemble the MHC-I-β2-microglobulin (β2M) complex, leading to reduced interactions with neural cell adhesion molecule 1 (NCAM1), a novel interactor of neuronal MHC-I, and decreased signaling. …”
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Screening and validation of differentially expressed genes in polymyositis by Linmang Qin, Haobo Lin, Guangfeng Zhang, Jieying Wang, Tianxiao Feng, Yunxia Lei, Yuesheng Xie, Ting Xu, Xiao Zhang

“…Gene Ontology (GO) analysis implicated Type I interferon (IFN-Ⅰ) signaling, while KEGG pointed to cell adhesion molecule activation and oxidative phosphorylation inhibition. …”
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Relationship between patterns of immunohistochemical conventional neuroendocrine markers and efficacy of immune check point inhibitors in patients with extensive disease small cell... by Yuko Iida, Kazushige Wakuda, Takuya Kawata, Meiko Morita, Motoki Sekikawa, Kosei Doshita, Michitoshi Yabe, Hiroaki Kodama, Keita Miura, Noboru Morikawa, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Akira Ono, Hirotsugu Kenmotsu, Tateaki Naito, Haruyasu Murakami, Yasuhiro Gon, Toshiaki Takahashi

“…There have been few reports on the efficacy of ICIs based on conventional immunohistochemical neuroendocrine (NE) markers (synaptophysin, chromogranin A, and neural cell adhesion molecule [NCAM]). In the present study, we aimed to analyze the relationship between the expression of immunohistochemical NE markers and the efficacy of ICIs in patients with extensive disease (ED)‐SCLC, to assess whether conventional NE markers are predictive of ICIs. …”
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E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes by Dana Mihaela Ciobanu, Cornelia Bala, Adriana Rusu, Gabriel Cismaru, Gabriela Roman

“…E-selectin is an endothelial cell adhesion molecule involved in vascular inflammation. …”
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Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload–Induced Heart Failure by Ane M. Salvador, Tania Nevers, Francisco Velázquez, Mark Aronovitz, Bonnie Wang, Ana Abadía Molina, Iris Z. Jaffe, Richard H. Karas, Robert M. Blanton, Pilar Alcaide

“…BackgroundLeft ventricular dysfunction and heart failure are strongly associated in humans with increased circulating levels of proinflammatory cytokines, T cells, and soluble intercellular cell adhesion molecule 1 (ICAM1). In mice, infiltration of T cells into the left ventricle contributes to pathological cardiac remodeling, but the mechanisms regulating their recruitment to the heart are unclear. …”
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