The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK by Chau, Ling Tham, Harith, Hanis Hazeera, Kok, Wai Lam, Yi, Joong Chong, Cheema, Manraj Singh, Sulaiman, Mohd Roslan, Lajis, Nordin, Ahmad Israf, Daud

“…BHMC concentration-dependently reduced endothelial hyperpermeability, leukocyte-endothelial cell adhesion and monocyte transendothelial migration through inhibition of the protein expression of adhesion molecules (Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) and secretion of chemokines (Monocyte Chemotactic Protein-1) at the transcriptional level. …”
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SHAPE OF CALCIUM PHOSPHATE BIONS DEFINES A PROATHEROSCLEROTIC SHIFT IN CYTOKINE SECRETION PROFILE OF ENDOTHELIAL CELLS by A. G. Kutikhin, E. A. Velikanova, D. K. Shishkova

“…Upon the collection of cell culture supernatant (n=11 wells per group), the levels of proatherosclerotic cytokines (interleukin (IL)-1ß, IL-6, IL-8, IL-10, IL-12, IL-23, tumor necrosis factor (TNF)-a, interferon (IFN)-y, and soluble vascular cell adhesion molecule (sVCAM)-1) were measured utilizing an enzyme-linked immunosorbent assay.Results. …”
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Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes. by Khamis Mustafa, Ying Han, Dan He, Ying Wang, Nan Niu, Pedro A Jose, Yinong Jiang, Jeffrey B Kopp, Hewang Lee, Peng Qu

“…Moreover, PARP inhibition decreased oxLDL-mediated protein expression of a NF-κB target gene, VCAM1, encoding vascular cell adhesion molecule-1. This finding indicates an important role for NF-κB activity in PARP-mediated activation of the NLRP3 inflammasome. …”
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Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Current Insights into the Disease Pathophysiology, Diagnosis and Management by Wojciech Ambrosius, Sławomir Michalak, Wojciech Kozubski, Alicja Kalinowska

“…Its function is not fully understood but this glycoprotein may act as a cell surface receptor or cell adhesion molecule. The specific outmost location of myelin makes it a potential target for autoimmune antibodies and cell-mediated responses in demyelinating processes. …”
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The effects of exercise training on circulating adhesion molecules in adults: A systematic review and meta-analysis. by Mousa Khalafi, Michael E Symonds, Mohammad Hossein Sakhaei, Faeghe Ghasemi

“…<h4>Introduction</h4>The current meta-analysis investigated the effects of exercise training on circulating adhesion molecules i.e. soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in adults.<h4>Method</h4>PubMed, Web of Science, Scopus and Embase were searched to identify original articles, published in English languages journal from inception up to 31 August 2023 that compared the effects of exercise training with non-exercising control on sICAM-1 and sVCAM-1 in adults. …”
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H-Type Hypertension among Black South Africans and the Relationship between Homocysteine, Its Genetic Determinants and Estimates of Vascular Function by Jacomina P. du Plessis, Leandi Lammertyn, Aletta E. Schutte, Cornelie Nienaber-Rousseau

“…Plasma Hcy and cardiovascular measures (systolic and diastolic BP (SBP, DBP), pulse pressure, heart rate (HR), carotid-radialis pulse wave velocity (cr-PWV), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1) were quantified. Five Hcy-related polymorphisms (<i>cystathionine β-synthase</i> (<i>CBS</i> 844ins68, T833C, G9276A); <i>methylenetetrahydrofolate reductase</i> (<i>MTHFR</i> C677T) and <i>methionine synthase</i> (<i>MTR</i> A2756G)) were genotyped. …”
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Evaluation of the differences in proteomics of high‐quality bovine colostrum and low‐quality bovine colostrum by Yiğit Kaçar, Hasan Batmaz

“…Expressions in colostrum of glycosylation‐dependent cell adhesion molecule‐1, cofilin‐1, alpha‐S2‐casein, alpha‐lactalbumin, alpha‐1B‐glycoprotein, actin_cytoplasmic‐1, nucleobindin‐1, cathelicidin‐4, inter‐alpha‐trypsin inhibitor heavy chain H4, chitinase‐3‐like protein 1 and monocyte differentiation antigen CD14 were lower, whereas tetranectin, secreted frizzled‐related protein‐1 (SFRP1), perilipin‐2, coatomer subunit epsilon (COPE), butyrophilin subfamily 1 member A1, polyubiquitin‐B, lactadherin and albumin levels were higher in high‐quality colostrum than low‐quality colostrum. …”
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PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction by Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu

“…Cell biological studies unravel that PHACTR1 mediates endothelial inflammation and monocyte adhesion by activating NF-κB dependent intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) expression. In addition, overexpression of PHACTR1 also reduces the generation of nitric oxide (NO) by inhibiting Akt/eNOS activation. …”
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IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3 by Ying Zhu, Langyue He, Yue Zhu, Huici Yao, Jianfeng Jiang, Hongyan Lu

“…Immunohistochemistry was used to measure platelet endothelial cell adhesion molecule-1 (PECAM-1) level, flow cytometry to quantify Treg numbers, and Western blot to assess vascular endothelial growth factor (VEGFA), angiopoietin-1 (Ang-1), forkhead box protein P3 (FOXP3), and IRF4 protein levels. …”
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Anti-atherosclerotic effects of sitagliptin in patients with type 2 diabetes mellitus by Omoto S, Taniura T, Nishizawa T, Tamaki T, Shouzu A,Nomura S

“…Levels of soluble P-selectin (sP-selectin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), MCP-1, sRAGEs, and adiponectin were measured by ELISA at baseline and after 3 and 6 months of treatment. …”
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Increased Expression of lncRNA UCA1 and HULC Is Required for Pro-inflammatory Response During LPS Induced Sepsis in Endothelial Cells by Ying Chen, Yao Fu, Yan-fei Song, Nan Li

“…Expression of pro-inflammatory mediators IL6, ICAM1, and VCAM1 (which encodes interleukin-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1, respectively) were determined following LPS treatment of human dermal microvascular endothelial cells (HMECs) for 24 h to confirm sepsis induction. …”
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METCAM Is a Potential Biomarker for Predicting the Malignant Propensity of and as a Therapeutic Target for Prostate Cancer by Jui-Chuang Wu, Guang-Jer Wu

“…We have discovered that METCAM, a cell adhesion molecule in the Ig-like superfamily, has great potential regarding its use as a biomarker for differentiating prostate cancer from BPH, predicting the malignant propensity of prostate cancer at the early premalignant stage, and differentiating indolent prostate cancers from aggressive cancers. …”
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Composite Hydrogel Dressings with Enhanced Mechanical Properties and Anti-Inflammatory Ability for Effectively Promoting Wound Repair by Feng Y, Qin S, Li H, Yang Y, Zheng Y, Liu H, Yap WY, Zhou X, Wen J

“…Additional in vivo tests supported the findings that the full-thickness wound treated with the composite hydrogels showed quicker epithelial tissue regeneration, fewer inflammatory cells, more collagen deposition, and greater levels of platelet endothelial cell adhesion molecule (CD31) expression.Conclusion: These above results might offer a practical and affordable product or method of skin wound therapy in a medical context.Keywords: hydrogel dressing, tannins, multiple-crosslinking, anti-inflammatory, full-thickness wound healing…”
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The Force-Dependent Mechanism of an Integrin α4β7–MAdCAM-1 Interaction by Youmin Su, Zhiqing Luo, Dongshan Sun, Bishan Yang, Quhuan Li

“…The interaction between integrin α4β7 and mucosal vascular addressin cell-adhesion molecule-1 (MAdCAM-1) facilitates the adhesion of circulating lymphocytes to the surface of high endothelial venules in inflammatory bowel diseases (IBDs). …”
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The Role of Palmitic Acid in the Co-Toxicity of Bacterial Metabolites to Endothelial Cells by Choroszy M, Środa-Pomianek K, Wawrzyńska M, Chmielarz M, Bożemska E, Sobieszczańska B

“…The expression of vascular cell adhesion molecule VCAM-1, E-selectin, and occludin, an essential tight junction protein, in HUVECs treated with these metabolites was evaluated in Western blot.Results: PA, combined with LPS and IS, did not influence HUVECs viability but induced stress on actin fibers and focal adhesion complexes. …”
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Antenatal and postpartum immunological markers levels in women with HIV infection and malnutrition in a low resource setting: A pilot study by Panashe Chandiwana, Privilege T Munjoma, Arthur J Mazhandu, Lovemore R Mazengera, Benjamin Misselwitz, Sebastian B U Jordi, Bahtiyar Yilmaz, Kerina Duri

“…IL-8 (q < 0.05) levels significantly increased in HIV-infected women from pregnancy to 14 weeks PP. Vascular Cell Adhesion Molecule 1 (VCAM-1) ( q < 0.05) and interleukin-1 receptor antagonist (IL-1RA) ( q < 0.05) were significantly lower in malnourished women in pregnancy and 14 weeks PP, respectively. …”
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Nck1, But Not Nck2, Mediates Disturbed Flow‐Induced p21‐Activated Kinase Activation and Endothelial Permeability by Mabruka Alfaidi, Umesh Bhattarai, A. Wayne Orr

“…A single point mutation into individual Nck1 SH3 domains suggests a role for the first domain of Nck1 in PAK recruitment to platelet endothelial cell adhesion molecule‐1 and activation in response to shear stress. …”
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Identification of the Key Genes and Potential Therapeutic Compounds for Abdominal Aortic Aneurysm Based on a Weighted Correlation Network Analysis by Lin Li, Kejia Kan, Prama Pallavi, Michael Keese

“…Three hub modules and 144 hub genes were identified by WGCNA. asparagine synthetase (ASNS), axin-related protein 2 (AXIN2), melanoma cell adhesion molecule (MCAM), and the testis-specific Y-encoded-like protein 1 (TSPYL1) were obtained as intersecting hub genes and the diagnostic values were confirmed with ROC curves. …”
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Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats by Zhifeng Wu, Yongming Yang, Ming Wang

“…In addition, a rat fracture healing model was constructed, and BMSCs-si-p75NTR were injected, following which the fracture condition was observed using micro-CT imaging, and the expression of platelet/endothelial cell adhesion molecule-1 (CD31) was assessed. Results The results showed that BMSCs were successfully isolated, p75NTR inhibited apoptosis and the osteogenic differentiation of BMSCs, while si-p75NTR led to a decrease in sortilin expression in BMSCs, increased proliferation and migration in HUVECs, and upregulation of HIF-1α and VEGF expression. …”
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Levels of VCAM-1 and ICAM-1 in serum of active and inactive Systemic Lupus Erythematosus patients as biochemical markers for risk of cardiovascular disease by Hajer Walid, Ghid H Abdulhadi, Mohammad H Munshid

“…Objectives: This study attempted to investigate a potential association between circulating vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) as risk factors for atherosclerosis and their relationship to cardiovascular risk. …”
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