NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer’s Disease by Idoia Blanco-Luquin, Blanca Acha, Amaya Urdánoz-Casado, Eva Gómez-Orte, Miren Roldan, Diego R. Pérez-Rodríguez, Juan Cabello, Maite Mendioroz

“…Neural progenitor cells (NPCs) were differentiated for 29 days and Aβ peptide 1–42 was added. mRNA expression of Neuronal Differentiation 1 (<i>NEUROD1</i>), Neural Cell Adhesion Molecule 1 (<i>NCAM1</i>), Tubulin Beta 3 Class III (<i>TUBB3</i>), RNA Binding Fox-1 Homolog 3 (<i>RBFOX3</i>), Calbindin 1 (<i>CALB1</i>), and Glial Fibrillary Acidic Protein (<i>GFAP</i>) was determined by RT-qPCR to characterize the culture and framed within the multistep process of AHN. …”
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Effects of a high-fat meal on inflammatory and endothelial injury biomarkers in accordance with adiposity status: a cross-sectional study by Maria das Graças Coelho de Souza, Priscila Alves Maranhão, Diogo Guarnieri Panazzolo, José Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar

“…Blood samples were collected at five-time points: before (fasting state) and 30, 60, 120, and 180 min after HFM intake to determine levels of adipokines (adiponectin, leptin), non-esterified fatty acid (NEFA), inflammatory [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)] and endothelium damage [soluble E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor-1 (PAI-1)] biomarkers. …”
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Consumption of the cell-free or heat-treated fractions of a pitched kefir confers some but not all positive impacts of the corresponding whole kefir by Benjamin C. T. Bourrie, Andrew J. Forgie, Tingting Ju, Caroline Richard, Paul D. Cotter, Paul D. Cotter, Paul D. Cotter, Benjamin P. Willing

“…Plasma vascular cell adhesion molecule 1 (VCAM-1) was lowered by both whole kefir and heat-treated kefir in male mice but not females, while c-reactive protein (CRP) was unchanged across all high fat diet fed groups in males and females.ConclusionThese results indicate that some of the metabolic benefits of consumption of this kefir do not require whole kefir while also indicating that there are multiple compounds or components responsible for the different benefits observed.…”
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Skeletal muscle mTORC1 regulates neuromuscular junction stability by Martina Baraldo, Alessia Geremia, Marco Pirazzini, Leonardo Nogara, Francesca Solagna, Clara Türk, Hendrik Nolte, Vanina Romanello, Aram Megighian, Simona Boncompagni, Marcus Kruger, Marco Sandri, Bert Blaauw

“…Unexpectedly, reduced mTOR signalling in muscle fibres is accompanied by the appearance of markers of fibre denervation, like the increased expression of the neural cell adhesion molecule (NCAM). Both muscle‐specific deletion of mTOR or Raptor, or the use of rapamycin, was sufficient to induce 3–8% of NCAM‐positive fibres (P < 0.01), muscle fibrillation, and neuromuscular junction (NMJ) fragmentation in 24% of examined fibres (P < 0.001). …”
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IgLON5 deficiency produces behavioral alterations in a knockout mouse model by Jon Landa, Ana Beatriz Serafim, Mercedes Alba, Estibaliz Maudes, Laura Molina-Porcel, Laura Molina-Porcel, Anna Garcia-Serra, Francesco Mannara, Josep Dalmau, Josep Dalmau, Josep Dalmau, Josep Dalmau, Francesc Graus, Lidia Sabater, Lidia Sabater

“…BackgroundAnti-IgLON5 disease is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule of unknown function that is highly expressed in the brain. …”
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Endothelial, Immunothrombotic, and Inflammatory Biomarkers in the Risk of Mortality in Critically Ill COVID-19 Patients: The Role of Dexamethasone by Chrysi Keskinidou, Alice G. Vassiliou, Alexandros Zacharis, Edison Jahaj, Parisis Gallos, Ioanna Dimopoulou, Stylianos E. Orfanos, Anastasia Kotanidou

“…In the cohort who had received one dexamethasone dose, non-survivors had higher ICU admission levels of only soluble (s) vascular cell adhesion molecule-1 (VCAM-1), soluble urokinase-type plasminogen activator receptor (suPAR) and presepsin. …”
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TET Family Members Are Integral to Porcine Oocyte Maturation and Parthenogenetic Pre-Implantation Embryogenesis by Fan Chen, Ming-Guo Li, Zai-Dong Hua, Hong-Yan Ren, Hao Gu, An-Feng Luo, Chang-Fan Zhou, Zhe Zhu, Tao Huang, Yan-Zhen Bi

“…RNA sequencing analysis revealed differentially expressed genes in Bobcat339-treated embryos at the 4-cell stage, which were significantly enriched in cell proliferation, cell component related to mitochondrion, and cell adhesion molecule binding. Our results indicated that TET proteins are essential for porcine oocyte maturation and early embryogenesis, and they act by mediating 5mC/5hmC levels and gene transcription.…”
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Scutellaria barbata attenuates diabetic retinopathy by preventing retinal inflammation and the decreased expression of tight junction protein by Xi-Yu Mei, Ling-Yu Zhou, Tian-Yu Zhang, Bin Lu, Li-Li Ji

“…SE also decreased the increased retinal expression of intercellular cell adhesion molecule-1 (ICAM-1). SE reduced the increased phosphorylation of nuclear factor kappa B (NFκB) p65 and its subsequent nuclear translocation in retinas from STZ-induced diabetic mice. …”
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Direct Pro-Inflammatory Effect of C-Reactive Protein on Human Pulmonary Artery Endothelial Cells by H.J. Parekh, H.B. Nguyen, S.L. Hall, M. Rehage, J. Anholm, L. Specht, T.A. Linkhart

“…Expression of vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 was assessed by flow cytometry. …”
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Lung Cancer Stem Cell Markers as Therapeutic Targets: An Update on Signaling Pathways and Therapies by Yue Zheng, Laduona Wang, Limei Yin, Zhuoran Yao, Ruizhan Tong, Jianxin Xue, Jianxin Xue, You Lu, You Lu

“…Potential lung cancer stem cell markers mainly include surface biomarkers such as CD44, CD133, epithelial cell adhesion molecule, and ATP-binding cassette subfamily G member 2, along with intracellular biomarkers such as aldehyde dehydrogenase, sex-determining region Y-box 2, NANOG, and octamer-binding transcription factor 4. …”
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Urinary HER2, TWEAK and VCAM-1 levels are associated with new-onset proteinuria in paediatric lupus nephritis by Michelle A Petri, Emily von Scheven, Marisa S Klein-Gitelman, Patricia Costa-Reis, Kelly Maurer, Kathleen E Sullivan, Daniella Levy Erez, Xue Zhao, Walter Faig, Jon Burnham, Kathleen O'Neil

“…Urine was analysed for human epidermal growth factor receptor 2 (HER2), tumour necrosis factor-like weak inducer of apoptosis and vascular cell adhesion molecule-1 (VCAM-1) by ELISA. We defined active disease as either a rise in serum creatinine ≥0.3 mg/dL from baseline or a rise in renal Systemic Lupus Erythematosus Disease Activity Index score from the previous visit. …”
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Prognostic Significance of Integrin Subunit Alpha 2 (ITGA2) and Role of Mechanical Cues in Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma (PDAC) by Alessandro Gregori, Cecilia Bergonzini, Mjriam Capula, Giulia Mantini, Fatemeh Khojasteh-Leylakoohi, Annalisa Comandatore, Ghazaleh Khalili-Tanha, Alireza Khooei, Luca Morelli, Amir Avan, Erik H. Danen, Thomas Schmidt, Elisa Giovannetti

“…This study combined biomechanical and pharmacological approaches to evaluate the role of the cell-adhesion molecule ITGA2, a key regulator of ECM, in PDAC resistance to gemcitabine. …”
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Injecting drug use and hepatitis C virus infection independently increase biomarkers of inflammatory disease risk which are incompletely restored by curative direct-acting antivira... by Anna C. Hearps, Anna C. Hearps, Nikil Vootukuru, Nikil Vootukuru, Salimeh Ebrahimnezhaddarzi, Brendan L. Harney, Brendan L. Harney, Brendan L. Harney, Irene Boo, Long Nguyen, Damian Pavlyshyn, Paul M. Dietze, Paul M. Dietze, Heidi E. Drummer, Heidi E. Drummer, Heidi E. Drummer, Alexander J. Thompson, Anthony Jaworowski, Anthony Jaworowski, Margaret E. Hellard, Margaret E. Hellard, Margaret E. Hellard, Margaret E. Hellard, Margaret E. Hellard, Rachel Sacks-Davis, Rachel Sacks-Davis, Rachel Sacks-Davis, Joseph S. Doyle, Joseph S. Doyle

“…CXCL10, sTNF-RII, vascular cell adhesion molecule-1 and lipopolysaccharide binding protein (LBP) were additionally elevated in PWID with viremic HCV infection as compared to HCV- PWID. …”
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A clinically feasible circulating tumor cell sorting system for monitoring the progression of advanced hepatocellular carcinoma by Xiu-Yan Huang, Feng Li, Ting-Ting Li, Jun-Tao Zhang, Xiang-Jun Shi, Xin-Yu Huang, Jian Zhou, Zhao-You Tang, Zi-Li Huang

“…In this study, epithelial cell adhesion molecule (EpCAM)/vimentin/Glypican-3 (GPC3) antibody-modified lipid magnetic spheres (LMS) were used to capture tumor cells with epithelial phenotype, mesenchymal phenotype and GPC3 phenotype, respectively, in order to capture more CTCs with a more comprehensive phenotype for monitoring tumor metastasis. …”
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CEACAM7 expression contributes to early events of pancreatic cancer by Anupam Dhasmana, Swati Dhasmana, Sudhir Kotnala, Partha Laskar, Sheema Khan, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

“…Considering this alarming unmet clinic need, our team has identified a novel oncogenic protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), that can be useful for spotting early events of PDAC. …”
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Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia by Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra

“…Merging the two cohorts, we found that semaphorin 6B (SEMA6B) alone and three other protein combinations (SEMA6B+secreted frizzle protein 3 [SFRP3], SEMA6B+COMM domain containing 7 [COMMD7], and vascular cell adhesion molecule 1 [VCAM1]+BMX nonreceptor tyrosine kinase [BMX]) had AUROCs ≥ 0.90 in both cohorts, with high positive‐ and negative‐predictive values. …”
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The Influence of Prenatal Exposure to Quetiapine Fumarate on the Development of Dopaminergic Neurons in the Ventral Midbrain of Mouse Embryos by Walaa F. Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Ebtisam Abdulah Alosimi, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Charlotte A. E. Hauser, Hossam H. Tayeb, Abdulhakeem S. Alamri, Abdulwahab Alamri, Bassem M. Raafat, Khaled A. Alswat, Yusuf S. Althobaiti, Yousif A. Asiri

“…The results revealed that exposure to QEPF during early brain development decreased the effects of the dopaminergic lineage-related genes <i>Tyrosine hydroxylase</i><i>(Th)</i>, <i>Dopamine receptor D1</i> (<i>Drd1</i>), <i>Dopamine transporter</i> (<i>Dat</i>), <i>LIM homeobox transcription factor 1 alfa</i> (<i>Lmx1a)</i>, and <i>Cell adhesion molecule L1</i> (<i>Chl1)</i>, and the senescent dopaminergic gene <i>Pituitary homeobox 3</i> (<i>Pitx3)</i>. …”
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The effect of growth hormone on ovarian function recovery in a mouse model of ovarian insufficiency by Su Mi Kim, Su Mi Kim, Jung Young Yoo, Jung Young Yoo, Yeon Hee Hong, Yeon Hee Hong, Jaewang Lee, Ji Hyang Kim, Jung Ryeol Lee, Jung Ryeol Lee

“…Many genes involved in angiogenesis, especially Leptin (Lep), platelet endothelial cell adhesion molecule 1 (Pecam-1), and angiogenin (Ang) were up-regulated in the GH treatment groups.ConclusionGH treatment may promote the recovery of ovarian function in ovarian insufficiency induced by the administration of CP via decreasing apoptosis and stromal fibrosis and upregulating Lep, Pecam-1, and Ang genes.…”
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Effects of Acute Fructose Loading on Markers of Inflammation—A Pilot Study by Camilla Olofsson, Monica Eriksson, Ann-Christin Bragfors Helin, Björn Anderstam, Nicola Orsini, Peter Stenvinkel, Neda Rajamand Ekberg

“…The levels of glucose, insulin, insulin-like growth factor binding protein-1 (IGFBP-1) and inflammatory markers: Interleukin-6 (IL-6), Monocyte chemoattractant protein-1 (MCP-1), Interleukin-18 (IL-18), Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and bacterial lipopolysaccharides (LPS) were analyzed in blood. …”
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The Inflammatory Profile of CTEPH-Derived Endothelial Cells Is a Possible Driver of Disease Progression by Valérie F. E. D. Smolders, Kirsten Lodder, Cristina Rodríguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H. A. Quax, Marie José Goumans, Kondababu Kurakula

“…Basal mRNA levels of interleukin (IL)-8, IL-1β, monocyte chemoattractant protein-1 (MCP-1), C-C motif chemokine ligand 5 (CCL5), and vascular cell adhesion molecule-1 (VCAM-1) were upregulated in CTEPH-ECs compared to the control cells. …”
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