MicroRNA-155 mediates multiple gene regulations pertinent to the role of human adipose-derived mesenchymal stem cells in skin regeneration by Hady Shahin, Hady Shahin, Hady Shahin, Luigi Belcastro, Jyotirmoy Das, Jyotirmoy Das, Marina Perdiki Grigoriadi, Rolf B. Saager, Ingrid Steinvall, Folke Sjöberg, Pia Olofsson, Moustafa Elmasry, Ahmed T. El-Serafi, Ahmed T. El-Serafi

“…Pathway enrichment analysis highlighted cell signalling-associated pathways and immunomodulatory pathways. miRNA-target modelling revealed regulations related to genes encoding for 16 upregulated proteins. miR-155-5p was predicted to regulate Fibroblast growth factor 2 and 7, C-C motif chemokine ligand 2 and Vascular cell adhesion molecule 1. Transfecting human AD-MSCs cell line with anti-miR-155 showed transient gene silencing of the four proteins at 24 h post-transfection.Discussion: This study proposes a positive miR-155-mediated gene regulation of key factors involved in wound healing. …”
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Liver X Receptor Activation Attenuates Oxysterol-Induced Inflammatory Responses in Fetoplacental Endothelial Cells by Meekha George, Magdalena Lang, Chaitanya Chakravarthi Gali, Joshua Adekunle Babalola, Carmen Tam-Amersdorfer, Anika Stracke, Herbert Strobl, Robert Zimmermann, Ute Panzenboeck, Christian Wadsack

“…Primary fpEC in culture treated with 7-ketoC or 7β-OHC, induced the activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NFκB) signaling, which resulted in the expression of pro-inflammatory cytokines (IL-6, IL-8) and intercellular cell adhesion molecule-1 (ICAM-1). Liver-X receptor (LXR) activation is known to repress inflammation. …”
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Progesterone modulates the DSCAM-AS1/miR-130a/ESR1 axis to suppress cell invasion and migration in breast cancer by Neelima Yadav, Roma Sunder, Sanket Desai, Bhasker Dharavath, Pratik Chandrani, Mukul Godbole, Amit Dutt

“…Results We identified a significant downregulation in the expression of a long non-coding RNA, Down syndrome cell adhesion molecule antisense DSCAM-AS1, in response to progesterone treatment in breast cancer. …”
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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition by Liping Teng, Maria Maqsood, Min Zhu, Yuting Zhou, Mingzhu Kang, Juan Zhou, Jinghua Chen

“…The levels of tumor necrosis factor-α (TNF-α), macrophage mannose receptor (MMR/CD206), platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), and vascular endothelial growth factor (VEGF) were detected by immunohistochemistry. …”
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Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia by Yixia Xie, Baowei Hu, Yue Gao, Yaxin Tang, Guohe Chen, Jiayuan Shen, Zhikai Jiang, He Jiang, Jiwei Han, Junyan Yan, Lifang Jin

“…Ductular reactions in G6pc−/− mice were tested based on the expression of cholangiocytic markers cytokeratin 19 (CK19) and epithelial cell adhesion molecule (EpCAM). Yes-associated protein 1 (Yap) signalling activity was measured using western blot (WB) analysis and quantitative real-time polymerase chain reaction (qRT-PCR). …”
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Lack of LTβR Increases Susceptibility of IPEC-J2 Cells to Porcine Epidemic Diarrhea Virus by Tawfeek Altawaty, Lulu Liu, Hongyong Zhang, Cong Tao, Shaohua Hou, Kui Li, Yanfang Wang

“…Furthermore, we found that PEDV-infected LTβR^{−/−} null IPEC-J2 cells exhibited significant suppression of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) target genes (interleukin (IL)-6 and IL-8) and mucosal barrier integrity-related genes (vascular cell adhesion molecule 1 (VCAM1) and IL-22), which may explain why LTβR^{−/−} cells are more susceptible to PEDV infection. …”
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Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1 by Anzhelika Vorobyeva, Ekaterina Bezverkhniaia, Elena Konovalova, Alexey Schulga, Javad Garousi, Olga Vorontsova, Ayman Abouzayed, Anna Orlova, Sergey Deyev, Vladimir Tolmachev

“…The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic target. …”
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LincRNA-P21 knockdown facilitates esophageal squamous cell carcinoma cell progression by upregulating cadherin 5 via YTH domain containing 1 by Wang Jianjun, Zhu Li, Zhang Quan, Xia Tian, Yao Wenjian, Wei Li

“…In this study, we investigate whether lincRNA-P21 exerts its functions by regulating the cell adhesion molecule cadherin 5 (CDH5) in ESCC. Moreover, the RNA binding protein (RBP) mediators of lincRNA-P21 and CDH5 are further examined. …”
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Role of the Autism Risk Gene <i>Shank3</i> in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses by Hsiu-Wen Chang, Ming-Jen Hsu, Li-Nien Chien, Nai-Fang Chi, Meng-Chieh Yu, Hsiu-Chen Chen, Yuan-Feng Lin, Chaur-Jong Hu

“…Shank3 downregulation suppressed tumor necrosis factor-α-induced fatty acid synthase expression; vascular cell adhesion molecule 1 expression; and downstream signaling pathways involving p38, Jun N-terminal kinase, and nuclear factor-κB. …”
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Mechanism of Multi-Organ Injury in Experimental COVID-19 and Its Inhibition by a Small Molecule Peptide by Michael J. Paidas, Natarajan Sampath, Emma A. Schindler, Daniela S. Cosio, Chima Obianuju Ndubizu, Nagarajarao Shamaladevi, Jaclyn Kwal, Suset Rodriguez, Anis Ahmad, Norma Sue Kenyon, Arumugam R. Jayakumar

“…Furthermore, our newly created drug (a 15 amino acid synthetic peptide, known as SPIKENET) that was designed to prevent the binding of spike glycoproteins with their receptor(s), angiotensin- converting enzyme 2 (ACE2), and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) (SARS-CoV-2 and MHV-1, respectively), ameliorated animal death and reversed altered levels of AQPs and oxidative stress post-MHV-1 infection. …”
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Effects of Next-Generation Low-Energy Extracorporeal Shockwave Therapy on Erectile Dysfunction in an Animal Model of Diabetes by Hyun Cheol Jeong, Seung Hwan Jeon, Zhu Guan Qun, Kang Sup Kim, Sae Woong Choi, Fahad Bashraheel, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U-Syn Ha, Sung Hoo Hong, Ji Youl Lee, Du Geon Moon, Sae Woong Kim

“…After ESWT treatment, vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), platelet endothelial cell adhesion molecule-1, cyclic guanosine monophosphate, and neuronal nitric oxide synthase (nNOS) expression levels were restored to levels in the DM group (p＜0.05). …”
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mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth by Vita Golubovskaya, John Sienkiewicz, Jinying Sun, Yanwei Huang, Liang Hu, Hua Zhou, Hizkia Harto, Shirley Xu, Robert Berahovich, Walter Bodmer, Lijun Wu

“…The epithelial cell adhesion molecule (EpCAM) is often overexpressed in many types of tumors, including colorectal cancer. …”
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Expression of Colorectal Cancer Antigenic Protein Fused to IgM Fc in Chinese Cabbage (<i>Brassica rapa</i>) by Ye-Rin Lee, Chae-Yeon Lim, Sohee Lim, Se Ra Park, Jong-Pil Hong, Jinhee Kim, Hye-Eun Lee, Kisung Ko, Do-Sun Kim

“…The epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen and a potential target for tumor vaccine. …”
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Beneficial Effects of Tacrolimus on Brain-Death-Associated Right Ventricular Dysfunction in Pigs by Asmae Belhaj, Laurence Dewachter, Astrid Monier, Gregory Vegh, Sandrine Rorive, Myriam Remmelink, Mélanie Closset, Christian Melot, Jacques Creteur, Isabelle Salmon, Benoît Rondelet

“…BD induced increased expression of the pro-inflammatory IL-6-to-IL-10 ratio, their related receptors, and vascular cell adhesion molecule-1 in both the RV and LV. These changes were prevented by tacrolimus. …”
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Capmatinib suppresses LPS-induced interaction between HUVECs and THP-1 monocytes through suppression of inflammatory responses by Hyung Sub Park, A.M. Abd El-Aty, Ji Hoon Jeong, Taeseung Lee, Tae Woo Jung

“…Results: This study found that CAP treatment ameliorated cell adhesion between THP-1 monocytes and HUVECs and the expression of adhesive molecules, such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Moreover, phosphorylation of inflammatory markers, such as NFκB and IκB as well as TNFα and monocyte chemoattractant protein-1 (MCP-1) released from HUVECs and THP-1 monocytes, was prevented by CAP treatment. …”
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Optimization of the Enrichment of Circulating Tumor Cells for Downstream Phenotypic Analysis in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-1 Immunotherapy by Maria A Papadaki, Afroditi I Sotiriou, Christina Vasilopoulou, Maria Filika, Despoina Aggouraki, Panormitis G Tsoulfas, Christina A Apostolopoulou, Konstantinos Rounis, Dimitrios Mavroudis, Sofia Agelaki

“…Samples were immunofluorescently stained for a) cytokeratins (CK)/epithelial cell adhesion molecule (EpCAM)/leukocyte common antigen (CD45), and b) CK/programmed cell death ligand-1 (PD-L1)/ indoleamine-2,3-dioxygenase (IDO). …”
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P-Cadherin Is Expressed by Epithelial Progenitor Cells and Melanocytes in the Human Corneal Limbus by Naresh Polisetti, Lyne Sharaf, Gottfried Martin, Günther Schlunck, Thomas Reinhard

“…These data suggest that P-cad is a critical cell–cell adhesion molecule, connecting LEPC and LM, which may play an important role in the long-term maintenance of LEPC at the limbal stem cell niche; moreover, these findings led to further improvement of cell enrichment protocols to enhance the yield of LEPC.…”
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Plasma TRAIL and ANXA1 in diagnosis and prognostication of pulmonary arterial hypertension by Mattias Arvidsson, Abdulla Ahmed, Joanna Säleby, Salaheldin Ahmed, Roger Hesselstrand, Göran Rådegran

“…In both single (p < 0.05) and multivariable Cox regression models Annexin A1 (ANXA1) [hazard ratio, HR: 1.0367; (95% CI: 1.0059–1.0684; p = 0.044)] and carcinoembryonic antigen‐related cell adhesion molecule 8 [HR: 1.0603; (95% CI: 1.0004–1.1237; p = 0.0483)] were significant predictors of survival, adjusted for age, female sex and ESC/ERS‐initial risk score. …”
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Cardiovascular disease protein biomarkers are associated with kidney function: The Framingham Heart Study. by Amena Keshawarz, Shih-Jen Hwang, Gha Young Lee, Zhi Yu, Chen Yao, Anna Köttgen, Daniel Levy

“…MR suggested putatively causal relations of melanoma cell adhesion molecule (MCAM; -0.011±0.003 mL/min/1.73m2, p = 5.11E-5) and epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1; -0.006±0.002 mL/min/1.73m2, p = 0.0001) concentration with eGFR.…”
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Accumulation of Inflammatory Mediators in the Normal Pericardial Fluid by Mohammad M. El-Diasty, Javier Rodríguez, Luis Pérez, Sonia Eiras, Angel L. Fernández

“…Levels of interleukin 1α (IL-1α); interleukin 1β (IL-1β); interleukin 2 (IL-2) interleukin 4 (IL-4); interleukin 6 (IL-6); interleukin 8 (IL8); interleukin 10 (IL10); tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1) epidermal growth factor (EGF), soluble E-selectin, L-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) were determined in both pericardial fluid and serum samples. …”
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