Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies by Elena Meseguer, Devy Diallo, Julien Labreuche, Hugo Charles, Sandrine Delbosc, Gabrielle Mangin, Linsay Monteiro Tavares, Giuseppina Caligiuri, Antonino Nicoletti, Pierre Amarenco

“…Biomarkers were related to hemostasis (u-plasminogen activator/urokinase (uPA/urokinase), serpin E1/PAI-1, serpin C1/antithrombin-III, kallikrein 6/neurosin, alpha 2-macroglobulin), inflammation[myloperoxidase (MPO), chemokine ligand 2/monocyte chemoattractant protein-1 chemokine (CCL2/MCP-1), adiponectin, resistin, cell-free DNA (cDNA), CD40 Ligand (CD40L)], endothelium activation (Vascular cell adhesion protein 1 (VCAM-1) intercellular adhesion molecule 1 (ICAM-1), platelet endothelial cell adhesion molecule 1 (CD31/PECAM-1)], and tissue remodeling (total cathepsin S, osteopontin, cystatin C, neuropilin-1, matrix metallopeptidase 2 (MMP-2), matrix metallopeptidase 3 (MMP-3), matrix metallopeptidase 9 (MMP-9), matrix metallopeptidase 13 (MMP-13)]. …”
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Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons by Matias Ryding, Mattias Gamre, Mette S. Nissen, Anna C. Nilsson, Justyna Okarmus, Anne A. E. Poulsen, Morten Meyer, Morten Blaabjerg

“…Anti-IgLON5 disease is a progressive neurological disorder associated with autoantibodies against a neuronal cell adhesion molecule, IgLON5. In human postmortem brain tissue, the neurodegeneration and accumulation of hyperphosphorylated tau (p-tau) are found. …”
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Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE−/− mice by Bao-Li Zhang, Peng Yu, En-Yong Su, Chun-Yu Zhang, Shi-Yao Xie, Xue Yang, Yun-Zeng Zou, Ming Liu, Ming Liu, Hong Jiang, Hong Jiang

“…Treatment significantly reduced lesion formation, macrophage infiltration in lesions, protein levels of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, and pyroptosis-related proteins such as activated caspase-1, activated GSDMD, cleaved interleukin(IL)-1β, and high mobility group box 1 in aortas. …”
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Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice by Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Shougang Zhuang, Feng Liu

“…Furthermore, AZ505 was effective in suppressing the phosphorylation of STAT3 and NF-κB, two transcriptional factors associated with kidney inflammation, attenuating the expression of monocyte chemoattractant protein-1 and intercellular cell adhesion molecule-1 and reducing infiltration of F4/80+ macrophages to the injured kidney. …”
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Effect of Varying Expression of EpCAM on the Efficiency of CTCs Detection by SERS-Based Immunomagnetic Optofluidic Device by Marta Czaplicka, Krzysztof Niciński, Ariadna Nowicka, Tomasz Szymborski, Izabela Chmielewska, Joanna Trzcińska-Danielewicz, Agnieszka Girstun, Agnieszka Kamińska

“…Magnetic nanospheres (Fe₂O₃) were coated with SERS-active metal and then modified with <i>p</i>-mercaptobenzoic acid (<i>p</i>-MBA) which works simultaneously as a Raman reporter and linker to an antiepithelial-cell-adhesion-molecule (anti-EpCAM) antibodies. The newly developed laser-induced SERS-active silicon substrate with a very strong enhancement factor (up to 10⁸) and high stability and reproducibility provide the additional extra-enhancement in the sandwich plasmonic configuration of immune assay which finally leads to increase the efficiency of detection. …”
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Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa by Sidney Hanser, Peter Modupi Mphekgwana, Mpho Matthias Moraba, Lourens Erasmus, Marlise van Staden

“…C-reactive protein (CRP), L-selectin, soluble intercellular adhesion molecule (sICAM-1), and soluble vascular cell adhesion molecule (sVCAM-1) in serum samples were tested. …”
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The effects of asthma on the oxidative stress, inflammation, and endothelial dysfunction in children with pneumonia by Ali Arjmand Shabestari, Fatemeh Imanparast, Pegah Mohaghegh, Habibeh Kiyanrad

“…Fasting blood samples were taken to the assay of serum malondialdehyde (MDA), total antioxidant capacity (TAC), tumor necrosis factor-alpha (TNF-α), soluble vascular cell adhesion molecule-1 (sVCAM-1), and plasminogen activator inhibitor-1 (PAI-1). …”
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Deciphering the Role of miR-200c-3p in Type 1 Diabetes (Subclinical Cardiovascular Disease) and Its Correlation with Inflammation and Vascular Health by Sherin Bakhashab, Megan Li Yuen Yeoh, David J. Coulson, Samuel Christian Steel, Sabina L. Ray, Jolanta U. Weaver

“…There was a significant negative correlation between the expression of miR-200c-3p and HbA1c, interleukin-7 (IL-7), vascular endothelial growth factor-C (VEGF-C), and soluble vascular cell adhesion molecule-1, and a positive correlation with CD45^dimCD34⁺VEGFR-2⁺, CD45^dimCD34⁺CD133⁺ and PACs. …”
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Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography by LaFramboise William A, Dhir Rajiv, Kelly Lori A, Petrosko Patricia, Krill-Burger John M, Sciulli Christin M, Lyons-Weiler Maureen A, Chandran Uma R, Lomakin Aleksey, Masterson Robert V, Marroquin Oscar C, Mulukutla Suresh R, McNamara Dennis M

“…</p> <p>Results</p> <p>Significant differences were detected in circulating proteins from patients requiring revascularization including increased apolipoprotein B100 (APO-B100), C-reactive protein (CRP), fibrinogen, vascular cell adhesion molecule 1 (VCAM-1), myeloperoxidase (MPO), resistin, osteopontin, interleukin (IL)-1β, IL-6, IL-10 and N-terminal fragment protein precursor brain natriuretic peptide (NT-pBNP) and decreased apolipoprotein A1 (APO-A1). …”
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TREATMENT RESPONSE PREDICTION IN PATIENTS WITH RHEUMATOID ARTHRITIS. Review by D.L. Fedkov, M.O. Komkina

“…Based on the results of several studies, predictors of response to methotrexate were high Disease Activity Score (DAS), concentration of myeloid-related proteins 8/14, high P-glycoprotein levels, low serum calprotectin and leptin levels, baseline serum concentration of tumor necrosis factor (TNF)-α, TNF receptor I, interleukin (IL)-1β, soluble CD163, numbers of CD14+highCD16, vascular cell adhesion molecule, lower expression of hsa-miR-132-3p, hsa-miR-146a-5p, and hsa-miR-155-5p. …”
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The role of transforming growth factor- in hypertension-induced cerebrovascular remodeling by Randa S. Eshaq, Minsup Lee, Wendy Leskova, Norman Harris, Jonathan Alexander

“…The EC junctional proteins platelet endothelial cell adhesion molecule-1 (PECAM-1) and vascular endothelial-cadherin (VE-cadherin), were significantly decreased in SHR. …”
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Recombinant hirudin attenuates pulmonary hypertension and thrombosis in acute pulmonary embolism rat model by Xiang Wei, Yanfen Zou, Shunli Dong, Yi Chen, Guoping Li, Bin Wang

“…Moreover, R-hirudin ameliorated histopathological injuries and reduced apoptotic cells and Matrix metalloproteinase-9 (MMP9), vascular cell adhesion molecule-1 (VCAM-1), p-Extracellular signal-regulated kinase (ERK)1/2/ERK1/2, and p-P65/P65 expression in lung tissues. …”
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Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia by Lei Liu, Rencheng Wang, Ran Xu, Yuening Chu, Weirong Gu

“…Moreover, procyanidin B2 alleviated endothelial dysfunction and impaired angiogenesis induced by sFlt-1, including increasing the migration, invasion and angiogenesis of endothelial cells and decreasing the expression of vascular cell adhesion molecule-1 (VCAM-1) and leukocyte adhesion on HUVECs. …”
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Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema by Xiaoxia Jin, Tong Wang, Yingjun Liao, Jingjing Guo, Gaoyang Wang, Fenghong Zhao, Yaping Jin

“…Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1&#946; (IL-1&#946;), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains. …”
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Improving vasculoprotective effects of MSCs in coronary microvessels – benefits of 3D culture, sub-populations and heparin by Kobkaew Bumroongthai, Dean P. J. Kavanagh, Paul Genever, Neena Kalia

“…Therapeutic benefit could mechanistically be explained by reductions in coronary endothelial oxidative stress and intercellular adhesion molecule-1 (ICAM-1)/vascular cell adhesion molecule-1 (VCAM-1) expression. However, since this was noted by both 2D and 3D cultured MSCs-Y201, therapeutic benefit is likely explained by the fact that 3D cultured MSCs-Y201 were the most potent sub-population at reducing serum levels of several pro-inflammatory cytokines.ConclusionThis novel study highlights the importance of not only 3D culture, but also of a specific CD317neg MSC sub-population, as being critical to realising their full coronary vasculoprotective potential in the injured heart. …”
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High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense by Rangel Silvares R, Nunes Goulart da Silva Pereira E, Eduardo Ilaquita Flores E, Lino Rodrigues K, Ribeiro Silva A, Gonçalves-de-Albuquerque CF, Daliry A

“…Reverse transcription polymerase chain reaction was used to analyze eNOs, IL-6, vascular cell adhesion molecule (VCAM), NADPH oxidase subunit 47 (N47), catalase, and receptor for AGE (RAGE) gene expression.Results: Wistar rats fed a HFD showed negligible alteration in renal function, decrease in catalase mRNA transcripts and catalase enzyme activity compared to control (CTL) animals. …”
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Role of L-selectin and ICAM-1 adhesion molecules in children with asthma by P. V. Berezhansky, N. S. Tataurschikova, T. G. Fedoskova, O. I. Letyaeva, A. S. Rusanova, I. N. Grigorieva, A. A. Kameleva, A. E. Dobrenkaya, A. I. Vasilkova

“…Increased amounts of vascular adhesion molecules in respiratory tract It has been proven are proven to be an important component of pathogenesis in bronchial asthma.Maximal expression of vascular cell adhesion molecule 1 (VCAM-1) and ICAM-1 in the persons prone to allergic diseases may occur after undetermined time period, and it immediately causes pronounced degranulation of eosinophils in respiratory tract and capillary bed. …”
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Circ_0035796 depletion inhibits transforming growth factor-β1-induced pulmonary fibrosis in a miR-150-5p/L1CAM-dependent manner by Juan Li, Xiaohong Chen, Baohong Zhang, Chenlu Wang

“…The expression of circ_0035796, microRNA-150-5p (miR-150-5p) and L1 cell adhesion molecule (L1CAM) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). …”
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SOLUBLE ADHESION MOLECULES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME by T. E. Pankratenko, O. V. Moskalets, T. Yu. Abaseeva

“…Many studies showed that the biomarkers of endothelial activation/dysfunction including intercellular adhesion molecule type 1 (ICAM-1) and vascular cell adhesion molecule type 1 (VCAM-1) were associated with severe disease and could predict complications and clinical outcomes in different disorders. …”
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Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats by Ashmeetha Manilall, Lebogang Mokotedi, Sulè Gunter, Regina Le Roux, Serena Fourie, Colleen A. Flanagan, Aletta M. E. Millen

“…Results Collagen inoculation increased LV relative mRNA expression of vascular cell adhesion molecule 1 (VCAM1), pentraxin 3 (PTX3), and inducible nitric oxide synthase (iNOS) compared to controls, indicating local microvascular inflammation. …”
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