Extracting quantitative relationships between cell motility and molecular activities (Analytical approaches and implications) by Yuichi SAKUMURA, Katsuyuki KUNIDA

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Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility by Akira Takeda, Daichi Kobayashi, Keita Aoi, Naoko Sasaki, Yuki Sugiura, Hidemitsu Igarashi, Kazuo Tohya, Asuka Inoue, Erina Hata, Noriyuki Akahoshi, Haruko Hayasaka, Junichi Kikuta, Elke Scandella, Burkhard Ludewig, Satoshi Ishii, Junken Aoki, Makoto Suematsu, Masaru Ishii, Kiyoshi Takeda, Sirpa Jalkanen, Masayuki Miyasaka, Eiji Umemoto

“…Here we demonstrate that lysophosphatidic acid (LPA) produced by LN fibroblastic reticular cells (FRCs) acts locally to LPA2 to induce T-cell motility. In vivo, either specific ablation of LPA-producing ectoenzyme autotaxin in FRCs or LPA2 deficiency in T cells markedly decreased intranodal T cell motility, and FRC-derived LPA critically affected the LPA2-dependent T-cell motility. …”
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Live imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated by Mikiko Inaki, Smitha Vishnu, Kenji Matsuno

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Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase by Mirca S. Saurty-Seerunghen, Thomas Daubon, Léa Bellenger, Virgile Delaunay, Gloria Castro, Joris Guyon, Ahmed Rezk, Sylvie Fabrega, Ahmed Idbaih, Fabien Almairac, Fanny Burel-Vandenbos, Laurent Turchi, Eric Duplus, Thierry Virolle, Jean-Michel Peyrin, Christophe Antoniewski, Hervé Chneiweiss, Elias A. El-Habr, Marie-Pierre Junier

“…Abstract Cell motility is critical for tumor malignancy. Metabolism being an obligatory step in shaping cell behavior, we looked for metabolic weaknesses shared by motile cells across the diverse genetic contexts of patients’ glioblastoma. …”
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Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility by Tobias X Dong, Shivashankar Othy, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo, Sabrina Leverrier, Ying Yu, Ian Parker, Joseph L Dynes, Michael D Cahalan

Subjects: “…cell motility…”
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A novel function of AAA-ATPase p97/VCP in the regulation of cell motility by Khong, Nicole Zi Jia, Lai, Soak-Kuan, Koh, Cheng-Gee, Geifman-Shochat, Susana, Li, Hoi-Yeung

“…Here, we report a novel function of p97/VCP in actin regulation and cell motility. We found that loss of p97/VCP promotes stabilization of F-actin, which cannot be reversed by actin-destabilizing agent, Cytochalasin D. …”
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GSK3β interacts with CRMP2 and Notch1 and controls T-cell motility by Mobashar Hussain Urf Turabe Fazil, Prasannan, Praseetha, Wong, Brandon Han Siang, Kottaiswamy, Amuthavalli, Nur Syazwani Mohamed Salim, Sze, Siu Kwan, Verma, Navin Kumar

“…We therefore conclude that GSK3β controls T-cell motility through interactions with CRMP2 and Notch1, which has important implications in adaptive immunity, T-cell mediated diseases and LFA-1-targeted therapies.…”
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Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. by Coutts, A, Pires, I, Weston, L, Buffa, F, Milani, M, Li, J, Harris, A, Hammond, E, La Thangue, N

“…Moreover, the enhanced cell motility and invasion that occurs during hypoxia requires JMY, as depleting JMY under hypoxic conditions causes decreased cell motility. …”

A random cell motility gradient downstream of FGF controls elongation of amniote embryos by Benazeraf, B, Francois, P, Baker, R, Little, C, Pourquie, O

“…We propose that the gradient of random cell motility downstream of FGF signalling in the PSM controls posterior elongation in the amniote embryo. …”

CD24 is upregulated in inflammatory bowel disease and stimulates cell motility and colony formation. by Ahmed, M, Jackson, D, Seth, R, Robins, A, Lobo, D, Tomlinson, I, Ilyas, M

“…This may be regulated by Wnt signaling and can confer enhanced colony forming ability and enhanced cell motility-features that may be important in tissue healing in the colon.…”

A random cell motility gradient downstream of FGF controls elongation of amniote embryos by Benazeraf, B, Francois, P, Baker, R, Little, C, Pourquie, O

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α by Coutts, A, Pires, I, Weston, L, Buffa, F, Milani, M, Li, J, Harris, A, Hammond, E, La Thangue, N

“…Moreover, the enhanced cell motility and invasion that occurs during hypoxia requires JMY, as depleting JMY under hypoxic conditions causes decreased cell motility. …”

Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. by Ruocco, MG, Pilones, K, Kawashima, N, Cammer, M, Huang, J, Babb, J, Liu, M, Formenti, S, Dustin, M, Demaria, S

A random cell motility gradient downstream of FGF controls elongation of an amniote embryo. by Bénazéraf, B, Francois, P, Baker, R, Denans, N, Little, C, Pourquié, O

“…We propose that the gradient of random cell motility downstream of FGF signalling in the PSM controls posterior elongation in the amniote embryo. …”

Integrative analysis of T cell motility from multi-channel microscopy data using TIAM. by Mayya, V, Neiswanger, W, Medina, R, Wiggins, C, Dustin, M

“…Integrative analytical approaches are needed to study and understand T cell motility as it is a highly coordinated and complex process. …”

Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells by Subhaya Bose, Kinjal Dasbiswas, Arvind Gopinath

Subjects: “…cell motility…”
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Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo by Elizabeth R Jerison, Stephen R Quake

Subjects: “…cell motility…”
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Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions by Daniel Schindler, Ted Moldenhawer, Carsten Beta, Wilhelm Huisinga, Matthias Holschneider

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Cell_motility: a cross-platform, open source application for the study of cell motion paths by Gevaert Kris, Ampe Christophe, Monsieur Geert, Martens Lennart, Vandekerckhove Joël

“…</p> <p>Results</p> <p>We here present the cell_motility software, an open source Java application under the GNU-GPL license that provides a clear and concise analysis workbench for large amounts of cell motion data. …”
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Two-component system ArcBA modulates cell motility and biofilm formation in Dickeya oryzae by Mingfa Lv, Mingfa Lv, Sixuan Ye, Ming Hu, Yang Xue, Zhibin Liang, Xiaofan Zhou, Xiaofan Zhou, Lianhui Zhang, Lianhui Zhang, Jianuan Zhou

“…Phytopathogen Dickeya oryzae is a causal agent of rice foot rot disease and the pathogen has an array of virulence factors, such as phytotoxin zeamines, plant cell wall degrading enzymes, cell motility, and biofilms, collectively contributing to the bacterial pathogenesis. …”
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