Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers by Hong-Beom Park, Ju-Won Kim, Kwang-Hyun Baek

“…The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. …”
Get full text

Dysregulation of Rho GTPases in Human Cancers by Haiyoung Jung, Suk Ran Yoon, Jeewon Lim, Hee Jun Cho, Hee Gu Lee

“…Rho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. …”
Get full text

The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning by Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P. Harmston, Nicholas S. Tolwinski

“…PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion. Here, we examine two roles of Otk-1 and Otk-2 in patterning and neurogenesis. …”
Get full text

Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells by Takehiko Ueyama

“…The small GTPases of the Rho-family (Rho-family GTPases) have various physiological functions, including cytoskeletal regulation, cell polarity establishment, cell proliferation and motility, transcription, reactive oxygen species (ROS) production, and tumorigenesis. …”
Get full text

Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division by Felipe Mora-Bermúdez, Fumio Matsuzaki, Wieland B Huttner

“…Thus, our study identifies a novel link between cell polarity, astral microtubules, and spindle orientation in morphogenesis.…”
Get full text

Undervalued ubiquitous proteins by Brücher Björn L.D.M., Jamall Ijaz S.

“…UPs are fundamental for cellular homeostasis and phylogenetic development as well as for the integrity of the cytoskeleton and for the stability of cells and tissues in regards to intercellular signaling, cell shape and mobility, apoptosis, wound healing, and cell polarity. Corresponding enzymes are used by microorganisms to gain entry into the host by degradation of UPs and play a role to cleave peptide bonds for killing disease-causing life forms along for the creation of the precancerous niche (PCN) during carcinogenesis, cancer invasion, and in metastasis. …”
Get full text

Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier” by Susanne M. Krug, Michael Fromm

“…This Special Issue covers numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, the function of and regulation by proteins of the tricellular TJ, the TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJs as sensors and reactors to environmental conditions, and last, but not least, TJ proteins and cancer. …”
Get full text

Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States by Laura Bornes, Guillaume Belthier, Jacco van Rheenen

“…Epithelial-to-mesenchymal transition (EMT) is a cellular program which leads to cells losing epithelial features, including cell polarity, cell–cell adhesion and attachment to the basement membrane, while gaining mesenchymal characteristics, such as invasive properties and stemness. …”
Get full text

Apical vesicles: Social networking at the pollen tube tip by Xun Weng, Hao Wang

“…It is regarded as an ideal model cell system in plants to study polar cell growth and cell polarity. The rapid pollen tube growth is empowered by exocytosis of large amounts of secretion vesicles that contain proteins, lipids and cell wall materials to the apex. …”
Get full text

Chemophoresis engine: A general mechanism of ATPase-driven cargo transport. by Takeshi Sugawara, Kunihiko Kaneko

“…Cell polarity regulates the orientation of the cytoskeleton members that directs intracellular transport for cargo-like organelles, using chemical gradients sustained by ATP or GTP hydrolysis. …”
Get full text

The Current Trends of Biosensors in Tissue Engineering by Yi-Chen Ethan Li, I-Chi Lee

“…Key developments in the cell/tissue-based biosensors, biomolecular sensing strategies, and the expansion of several biochip approaches such as organs-on-chips, paper based-biochips, and flexible biosensors are available. Cell polarity and cell behaviors such as proliferation, differentiation, stimulation response, and metabolism detection are included. …”
Get full text

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex by Melis Dilara Arslanhan, Dila Gulensoy, Elif Nur Firat-Karalar

“…The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in organisms. …”
Get full text

Functional characterization of FBXL7 as a novel player in human cancers by Yue Wang, Xiao Shen, Longyuan Gong, Yongchao Zhao, Xiufang Xiong

“…FBXL7 promotes polyubiquitylation and degradation of diverse substrates and is involved in many biological processes, including apoptosis, cell proliferation, cell migration and invasion, tumor metastasis, DNA damage, glucose metabolism, planar cell polarity, and drug resistance. In this review, we summarize the downstream substrates and upstream regulators of FBXL7. …”
Get full text

Advances in prognostic and therapeutic targets for hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The hippo signaling pathway by Geofrey Mahiki Mranda, Zhi-Ping Xiang, Jun-Jian Liu, Tian Wei, Yinlu Ding

“…Consequently, the Hippo signaling pathway executing a pivotal role in organogenesis, hemostasis, and regeneration of tissues, regulates liver cells proliferation, and apoptosis. Cell polarity or adhesion molecules and cellular metabolic status are some of the biological activators of the pathway. …”
Get full text

Lateral Root Initiation and the Analysis of Gene Function Using Genome Editing with CRISPR in <i>Arabidopsis</i> by Nick Vangheluwe, Tom Beeckman

“…Furthermore, we highlight the potential of genome editing technology to analyse gene function in lateral root initiation, which provides an excellent model to answer fundamental developmental questions such as coordinated cell division, growth axis establishment as well as the specification of cell fate and cell polarity.…”
Get full text

Endothelial DLC1 is dispensable for liver and kidney function in mice by Ying Tan, Su Hao Lo

“…DLC1 is a focal adhesion molecule that regulates cell polarity, proliferation, migration, and survival. …”
Get full text

Integrated transcriptomics contrasts fatty acid metabolism with hypoxia response in β-cell subpopulations associated with glycemic control by Mario A Miranda, Juan F Macias-Velasco, Heather Schmidt, Heather A Lawson

“…We identify β-cell subpopulations associated with basal insulin secretion, hypoxia response, cell polarity, and stress response. Network analysis associates fatty acid metabolism and basal insulin secretion with hyperglycemic-obesity, while expression of Pdyn and hypoxia response is associated with normoglycemic-obesity. …”
Get full text

Diffusive coupling of two well-mixed compartments elucidates elementary principles of protein-based pattern formation by Fridtjof Brauns, Jacob Halatek, Erwin Frey

“…This reveals a close relation between cell polarity oscillatory patterns in cells. Critically, our findings suggest that the design principles of intracellular pattern formation are found in characteristic features in these phase portraits (nullclines and fixed points). …”
Get full text

Rare Inherited Cholestatic Disorders and Molecular Links to Hepatocarcinogenesis by Rebecca Jeyaraj, Deirdre Kelly

“…Specifically, chronic bile-induced damage (caused by <i>ABCB11</i> changes), disruption of intercellular junction formation (caused by <i>TJP2</i> changes) and loss of normal apical–basal cell polarity (caused by <i>VPS33B</i> changes) will be discussed as possible mechanisms for HCC development.…”
Get full text

Characterization of candidate genes governing complex multicellularity in Neurospora crassa by Wong, Jie Yun

“…Another candidate protein, Spz1, was shown to interact with proteins known to function in cell polarity through its coiled- coil domain. Altogether, the results from this study provide clues on the extant of genes required for CM.…”
Get full text