Colorectal cancer and genetic alterations in the Wnt pathway. by Segditsas, S, Tomlinson, I

“…These mutations almost always cause loss of the C-terminal functions of the APC protein - probably involved in microtubule binding, cell polarity and chromosome segregation - and deletion of the SAMP repeats that are important for binding to axin and formation of the beta-catenin phosphorylation complex. …”

Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, S, Morgan, M, Bikoff, E, Robertson, E

“…Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the establishment of epithelial cell polarity and functional maturation of alveolar cells. …”

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil by Sellers, K, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo, A, Jarosz-Griffiths, H, Watson, I, Xia, W, Semenov, M, Morin, P, Hooper, N, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A, Harte, M, Simons, P, Srivastava, D, Killick, R

“…We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt–planar cell polarity (Wnt-PCP) pathway to drive tau pathology and neuronal death. …”

Phenotypic characterisation of the C. elegans latrophilin homolog, lat-1 by Mestek, L

“…The C.elegans lat-1 gene encodes the latrophilin vertebrate homolog; it is a member of the adhesion GPCR family and is structurally related to the flamingo/CELSR, an essential component of planar cell polarity pathway. This study aims to phenotypically characterise lat-1 mutants in C.elegans to provide insights into the physiological role of this important member of adhesion GPCRs. lat-1 mutants exhibit several morphological defects throughout development and during vulva development. …”

A microtubule interactome: complexes with roles in cell cycle and mitosis. by Hughes, J, Meireles, A, Fisher, K, Garcia, A, Antrobus, O, Wainman, A, Zitzmann, N, Deane, C, Ohkura, H, Wakefield, J

“…The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and altering their properties. …”

A microtubule interactome: complexes with roles in cell cycle and mitosis. by Hughes, J, Meireles, A, Fisher, K, Garcia, A, Antrobus, P, Wainman, A, Zitzmann, N, Deane, C, Ohkura, H, Wakefield, J

“…The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and altering their properties. …”

Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila by Pénélope Darnat, Angélique Burg, Jérémy Sallé, Jérôme Lacoste, Sophie Louvet-Vallée, Michel Gho, Agnès Audibert

“…The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear. …”
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Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development. by Peter Walentek, Isabelle Schneider, Axel Schweickert, Martin Blum

“…Wnt signaling has previously been involved in two steps, Wnt/ß-catenin mediated induction of Foxj1, a regulator of motile cilia, and Wnt/planar cell polarity (PCP) dependent cilia polarization to the posterior pole of cells. …”
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A novel GTP-binding protein–adaptor protein complex responsible for export of Vangl2 from the trans Golgi network by Yusong Guo, Giulia Zanetti, Randy Schekman

“…Planar cell polarity (PCP) requires the asymmetric sorting of distinct signaling receptors to distal and proximal surfaces of polarized epithelial cells. …”
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Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae. by Nusrat Sharmeen, Chris Law, Cunle Wu

“…Time-lapse single-cell imaging and quantitation shown here characterizes Ste50p involvement in the establishment of cell polarity. We found that Ste50p patches on the cell cortex mark the point of shmoo initiation, these patches could move, and remain associated with the growing shmoo tip in a pheromone concentration time-dependent manner until shmoo maturation. …”
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How cells determine the number of polarity sites by Jian-geng Chiou, Kyle D Moran, Daniel J Lew

“…The diversity of cell morphologies arises, in part, through regulation of cell polarity by Rho-family GTPases. A poorly understood but fundamental question concerns the regulatory mechanisms by which different cells generate different numbers of polarity sites. …”
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The Regulation of the Hippo Pathway by Intercellular Junction Proteins by Usama Sharif Ahmad, Jutamas Uttagomol, Hong Wan

“…However, several studies have shown that numerous cellular and non-cellular mechanisms such as cell polarity, contact inhibition, soluble factors, mechanical forces, and metabolism can convey external stimuli to the intracellular kinase cascade, promoting the activation of key components of the Hippo pathway and therefore regulating the subcellular localisation and protein activity of YAP/TAZ. …”
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Prickle isoform participation in distinct polarization events in the Drosophila eye. by Bomsoo Cho, Song Song, Joy Y Wan, Jeffrey D Axelrod

“…Planar cell polarity (PCP) signaling regulates several polarization events during development of ommatidia in the Drosophila eye, including directing chirality by polarizing a cell fate choice and determining the direction and extent of ommatidial rotation. …”
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Mechanical control of neural plate folding by apical domain alteration by Miho Matsuda, Jan Rozman, Sassan Ostvar, Karen E. Kasza, Sergei Y. Sokol

“…This apical domain heterogeneity was accompanied by biased cell orientation along the anteroposterior axis, especially at neural plate hinges, and required planar cell polarity signaling. Vertex models suggested that dispersed isotropically constricting cells can cause the elongation of adjacent cells. …”
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The Matrix Reloaded—The Role of the Extracellular Matrix in Cancer by Hans Raskov, Shruti Gaggar, Asma Tajik, Adile Orhan, Ismail Gögenur

“…In cancer, the ECM can be remodelled in response to environmental cues, and it controls a plethora of cellular functions, including metabolism, cell polarity, migration, and proliferation, to sustain and support oncogenesis. …”
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Pak1 kinase controls cell shape through ribonucleoprotein granules by Joseph O Magliozzi, James B Moseley

“…Pak1 (also called Shk1 and Orb2) prevents Sts5 association with P bodies by directly phosphorylating its intrinsically disordered region (IDR). Pak1 and the cell polarity kinase Orb6 both phosphorylate the Sts5 IDR but at distinct residues. …”
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Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae by Nusrat Sharmeen, Chris Law, Cunle Wu

“…Time-lapse single-cell imaging and quantitation shown here characterizes Ste50p involvement in the establishment of cell polarity. We found that Ste50p patches on the cell cortex mark the point of shmoo initiation, these patches could move, and remain associated with the growing shmoo tip in a pheromone concentration time-dependent manner until shmoo maturation. …”
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Developmental progression continues during embryonic diapause in the roe deer by Anna B. Rüegg, Vera A. van der Weijden, João Agostinho de Sousa, Ferdinand von Meyenn, Hubert Pausch, Susanne E. Ulbrich

“…Our results show that morphological rearrangements of the epiblast during diapause correlate with gene expression patterns and changes in cell polarity. Immunohistochemical staining further supports these findings. …”
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Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications by Wen-Ting Xu, Ling-Li Shi, Jie Xu, Haiqing Qian, Huifang Zhou, Li-Hong Wang

“…Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation. …”
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Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. by Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y Chuang, Regan F Volk, Katherine L Hofmann, Balyn Zaro, Pao-Tien Chuang

“…The Wnt5a signal is mediated by Vangl1/2 to trigger a cascade of noncanonical or planar cell polarity (PCP) signaling. In response to noncanonical Wnt signaling, lung cells undergo cytoskeletal reorganization and change focal adhesions. …”
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