Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42 by Yuan Tian, Peipei Zhang, Yajun Mou, Wenxiu Yang, Junhong Zhang, Qing Li, Xiaowei Dou

“…Intriguingly, silencing Notch4 in TNBC cells suppressed metastasis via downregulating Cdc42 expression, a key molecular for cell polarity formation. Notably, downregulation of Cdc42 expression affected Vimentin distribution, but not Vimentin expression to inhibit EMT shift. …”
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Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy by Ning Ma, Erqian Xu, Qing Luo, Guanbin Song

“…As a key molecule in regulating cell migration, Rac1 participates in signal transduction from the external cell to the actin cytoskeleton and promotes the establishment of cell polarity which plays an important role in cancer cell invasion/metastasis. …”
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Life and Death of Fungal Transporters under the Challenge of Polarity by Sofia Dimou, George Diallinas

“…We discuss these findings in relation to adaptation to challenges imposed by cell polarity in fungi as well as in other eukaryotes and provide a rationale of why transporters and possibly other housekeeping membrane proteins ‘avoid’ routes of polar trafficking.…”
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The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen by Federica Mangione, Enrique Martín-Blanco

“…Keywords: Drosophila, Ds/Ft/Fj pathway, planar cell polarity, axial orientation, cells alignment…”
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RhoA Promotes Synovial Proliferation and Bone Erosion in Rheumatoid Arthritis through Wnt/PCP Pathway by Ning Chen, Chao-Yue Diao, Xin Huang, Wei-Xing Tan, Ya-Bing Chen, Xin-Yu Qian, Jie Gao, Dong-Bao Zhao

“…Ras homolog gene family member A (RhoA) plays a major role in the Wnt/planar cell polarity (PCP) pathway, which is significantly activated in patients with rheumatoid arthritis (RA). …”
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Regulation of Epithelial-Mesenchymal Transitions by Alternative Splicing: Potential New Area for Cancer Therapeutics by Ling Li, Jinxia Zheng, Sebastian Oltean

“…The epithelial-mesenchymal transition (EMT) is a complicated biological process in which cells with epithelial phenotype are transformed into mesenchymal cells with loss of cell polarity and cell–cell adhesion and gain of the ability to migrate. …”
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Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. by Cristante, E, McArthur, S, Mauro, C, Maggioli, E, Romero, I, Wylezinska-Arridge, M, Couraud, P, Lopez-Tremoleda, J, Christian, H, Weksler, B, Malaspina, A, Solito, E

“…Analysis in vitro confirms that treatment of cerebrovascular endothelial cells with recombinant ANXA1 restores cell polarity, cytoskeleton integrity, and paracellular permeability through inhibition of the small G protein RhoA. …”

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. by Wang, Y, Bu, F, Royer, C, Serres, S, Larkin, JR, Soto, MS, Sibson, N, Salter, V, Fritzsche, F, Turnquist, C, Koch, S, Zak, J, Zhong, S, Wu, G, Liang, A, Olofsen, P, Moch, H, Hancock, D, Downward, J, Goldin, R, Zhao, J, Tong, X, Guo, Y, Lu, X

“…Hence, ASPP2 is a key regulator of epithelial plasticity that connects cell polarity to the suppression of WNT signalling, EMT and tumour metastasis.…”

Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. by Brown, K, Freeman, M

“…This pattern is established during disc development, when clusters rotate through 90 degrees, a process dependent on planar cell polarity and rotation-specific factors such as Nemo and Scabrous. …”

A microtubule interactome: complexes with roles in cell cycle and mitosis by Hughes, J, Meireles, A, Fisher, K, Garcia, A, Antrobus, P, Wainman, A, Zitzmann, N, Deane, C, Ohkura, H, Wakefield, J

“…The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and altering their properties. …”

Hepatic spheroids used as an in vitro model to study malaria relapse by Chua, ACY, Ananthanarayanan, A, Ong, JJY, Wong, JY, Yip, A, Singh, NH, Qu, Y, Dembele, L, McMillian, M, Ubalee, R, Davidson, S, Tungtaeng, A, Imerbsin, R, Gupta, K, Andolina, A, Lee, F, Tan, KSW, Nosten, F, Russell, B, Lange, A, Diagana, TT, Rénia, L, Yeung, BKS, Yu, H, Bifani, P

“…We demonstrated that this hepatic spheroid model was capable of maintaining long term viability, hepatocyte specific functions and cell polarity which enhanced permissiveness and thus, permitting for the complete development of both P. cynomolgi and P. vivax liver stage parasites in the infected spheroids. …”

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications by Akoumianakis, I, Polkinghorne, M, Antoniades, C

“…WNT signalling includes the β-catenin canonical pathway and the non-canonical pathways, namely the planar cell polarity and the calcium-dependent pathways. Advances over the past decade have linked non-canonical WNT signalling with key mechanisms of atherosclerosis, including oxidative stress, endothelial dysfunction, macrophage activation and vascular smooth muscle cell phenotype regulation. …”

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. by Juan Cabello, Lukas J Neukomm, Ufuk Günesdogan, Katharina Burkart, Steve J Charette, Günter Lochnit, Michael O Hengartner, Ralf Schnabel

“…Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance of cell movements during gastrulation, and the induction of cell polarity. Wnt can induce polar changes in cellular morphology by a remodelling of the cytoskeleton. …”
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Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle by Ieva Antanavičiūtė, Paulius Gibieža, Rytis Prekeris, Vytenis Arvydas Skeberdis

“…Inherited MBs affect cell polarity, modulate intra- and intercellular communication, enhance pluripotency of stem cells, and increase tumorigenic potential of cancer cells. …”
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Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae by Dilara Kocakaplan, Hüseyin Karabürk, Cansu Dilege, Idil Kirdök, Seyma Nur Bektas, Ayse Koca Caydasi

“…Mitotic exit in budding yeast is dependent on correct orientation of the mitotic spindle along the cell polarity axis. When accurate positioning of the spindle fails, a surveillance mechanism named the spindle position checkpoint (SPOC) prevents cells from exiting mitosis. …”
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Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation by Isabella Lin, Angela Wei, Zain Awamleh, Meghna Singh, Aileen Ning, Analeyla Herrera, REACH Biobank and Registry, Bianca E. Russell, Rosanna Weksberg, Valerie A. Arboleda

“…The data showed a broad activation of canonical Wnt signaling at the transcriptional and protein levels and upregulation of VANGL2, which encodes a planar cell polarity pathway protein that acts through noncanonical Wnt signaling to direct tissue patterning and cell migration. …”
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Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology by Jasna Lojk, Janja Marc

“…We will describe the role of the two most known non-canonical pathways (Wnt/planar cell polarity pathways and Wnt/Ca²⁺ pathway), as well as other signalling pathways with a strong role in bone biology that communicate with the Wnt signalling pathway through non-canonical Wnt signalling. …”
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Research progress of the role of non-canonical Wnt signaling pathway in ovarian cancer and its potential therapeutic implications by ZHOU Wanzhen, TENG Yincheng

“…Wnt signaling pathway includes canonical Wnt/β-catenin pathway and non-canonical pathway, and the latter mainly includes Wnt/planar cell polarity (Wnt/PCP) pathway and Wnt/Ca2+ pathway. …”
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Two subtypes of GTPase-activating proteins coordinate tip growth and cell size regulation in Physcomitrium patens by Jingtong Ruan, Linyu Lai, Hongxin Ou, Peishan Yi

“…Abstract The establishment of cell polarity is a prerequisite for many developmental processes. …”
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Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility by Hervé Alégot, Pierre Pouchin, Olivier Bardot, Vincent Mirouse

“…Early elongation is associated with apical constriction at the poles and with oriented cell rearrangements, but without any visible planar cell polarization of the apical domain. Thus, a morphogen gradient can trigger tissue elongation through a control of cell pulsing and without a planar cell polarity requirement.…”
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