IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells by Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu

“…STAT3 and NF-κB signaling and expression of the Th17 cell polarization-related cytokines were also decreased in IL-27Rα−/− bone-marrow-derived dendritic cells(BMDC) stimulated with inactivated SPY1. …”
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Comprehensive analysis of different tumor cell-line produced soluble mediators on the differentiation and functional properties of monocyte-derived dendritic cells by Sára Burai, Ramóna Kovács, Tamás Molnár, Márta Tóth, Tímea Szendi-Szatmári, Viktória Jenei, Zsuzsanna Bíró-Debreceni, Shlomie Brisco, Margit Balázs, Attila Bácsi, Gábor Koncz, Anett Mázló

“…We investigated the impact of tumor cell-derived conditioned media on the differentiation of DCs from CD14+ monocytes, sequentially determining the phenotype, cytokine production, phagocytic, and the T cell polarizing capacity of moDCs. We completed our observations by analyzing our data with bioinformatic tools to provide objective correlations between phenotypical and functional properties of different tumor-educated moDCs. …”
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The Regulatory Role of T Cell Responses in Cardiac Remodeling Following Myocardial Infarction by Tabito Kino, Mohsin Khan, Sadia Mohsin

“…Paracrine factors secreted by stem cells polarize T cell subsets partially by exogenous ubiquitination, which can induce differentiation of T cell subset to promote tissue repair after myocardial infarction (MI). …”
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Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells. by G Nicholas Llewellyn, Ian B Hogue, Jonathan R Grover, Akira Ono

“…However, despite the importance of understanding virus spread in vivo, little is known about the HIV-1 life cycle, particularly its late phase, in polarized T cells. Polarized T cells form two ends, the leading edge at the front and a protrusion called a uropod at the rear. …”
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Capacity Decay Mechanism of the LCO + NMC532/Graphite Cells Combined with Post-Mortem Technique by Linjing Zhang, Jiuchun Jiang, Weige Zhang

“…The changes of differential capacity curves of the full cells show that the loss of active materials, loss of lithium ions and cell polarization are the main factors contributing to capacity loss. …”
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Apparent defect in yeast bud-site selection due to a specific failure to splice the pre-mRNA of a regulator of cell-type-specific transcription. by Shanshan Tuo, Kenichi Nakashima, John R Pringle

“…The yeast Saccharomyces cerevisiae normally selects bud sites (and hence axes of cell polarization) in one of two distinct patterns, the axial pattern of haploid cells and the bipolar pattern of diploid cells. …”
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Recovery of Vibrio cholerae polarized cellular organization after exit from a non-proliferating spheroplast state. by Anthony Goudin, Jean-Luc Ferat, Christophe Possoz, François-Xavier Barre, Elisa Galli

“…Taken together, these results confirm the interest of L-arabinose-induced V. cholerae spheroplasts to study how cell shape is generated and shed light on the de novo establishment of the intracellular organization and cell polarization in V. cholerae.…”
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Quantifying Mass Transfer Rates in Redox Flow Batteries by Milshtein, Jarrod D, Tenny, Kevin M, Barton, John L, Drake, Javit, Darling, Robert M, Brushett, Fikile R

“…We then engage a single electrolyte flow cell study, with a model iron chloride electrolyte, to experimentally measure cell polarization as a function of flow field and flow rate. …”
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The octupole microelectrode for dielectrophoretic trapping of single cells-design and simulation by Ibrahim, Siti Noorjannah, Alkaisi, Maan M.

“…Study on the microelectrode factor is essential, as the geometry and the numbers of microelectrode can influence particles and/or cells polarization. This paper presents one of the three new microelectrode designs, called the octopule microelectrode, in a study on the microelectrode factor of the DEP trapping force. …”
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Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. by Mor, A, Dustin, M, Philips, MR

“…Inside-out signaling flows through Rap1 to regulator of adhesion and cell polarization enriched in lymphoid tissues (RAPL) and Rap1-GTP interacting adapter molecule (RIAM) that act in conjunction with the cytoskeleton on the cytosolic domain of LFA-1 to increase adhesion of the ectodomain. …”

New Phage-Derived Antibacterial Enzyme PolaR Targeting <i>Rothia</i> spp. by Paulina Miernikiewicz, Jakub Barylski, Aleksandra Wilczak, Anna Dragoš, Izabela Rybicka, Sophia Bałdysz, Aleksander Szymczak, Iztok Dogsa, Kostiantyn Rokush, Marek Adam Harhala, Jarosław Ciekot, Stanisław Ferenc, Jan Gnus, Wojciech Witkiewicz, Krystyna Dąbrowska

“…PolaR had no cytotoxic or antiproliferative effects on mammalian cells. PolaR is the first described endolysin selectively targeting <i>Rothia</i> species, with a high potential to combat infections caused by <i>Rothia mucilaginosa</i> and <i>Rothia dentocariosa</i>, and possibly other bacterial groups. …”
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Exome sequencing findings in children with annular pancreas by Georgia Pitsava, Nathan Pankratz, John Lane, Wei Yang, Shannon Rigler, Gary M. Shaw, James L. Mills

“…Conclusion IQGAP1 and NRCAM are crucial in cell polarization and migration. Mutations result in decreased motility which could possibly cause the ventral bud to not migrate normally. …”
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Pathogenic Th2 Cytokine Profile Skewing by IFN-γ-Responding Vitiligo Fibroblasts via CCL2/CCL8 by Rong Jin, Miaoni Zhou, Fuquan Lin, Wen Xu, Aie Xu

“…In vitro IFN-γ stimulation was performed to verify the JAK-STAT pathway by qPCR and Western blot. T cell polarization with chemokines was measured by flow cytometry. …”
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Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk by Seungkuk Ahn, Upnishad Sharma, Krishna Chaitanya Kasuba, Nico Strohmeyer, Daniel J. Müller

“…However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate. To overcome this limitation, a simple and scalable method to engineer biomimetic 3D fibrillar fibronectin matrices is introduced and how they are sensed by fibroblasts from the onset of attachment is characterized. …”
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Optimization Design of Rib Width and Performance Analysis of Solid Oxide Electrolysis Cell by Meiting Guo, Xiao Ru, Zijing Lin, Guoping Xiao, Jianqiang Wang

“…An analytical expression considering the influence of total cell polarization loss, the pitch width and the contact resistance is further developed for the benefit of the engineering society. …”
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Raman Microspectroscopy Identifies Biochemical Activation Fingerprints in THP-1- and PBMC-Derived Macrophages by Nora Feuerer, Daniel A. Carvajal Berrio, Florian Billing, Sören Segan, Martin Weiss, Ulrich Rothbauer, Julia Marzi, Katja Schenke-Layland

“…In MDMs, we identified that nucleic acid and non-membrane-associated intracellular lipid composition were also affected. (4) Our results show that it is crucial to carefully choose the right cell type for an in vitro model as the nature of the cells itself may impact immune cell polarization or activation results. Moreover, we demonstrated that RM is a sensitive tool for investigating cell-specific responses to activation stimuli and monitoring molecular changes in subcellular structures.…”
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Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions by Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Andrés Alcover, Vincenzo Di Bartolo

“…We highlight the importance of this fine-tuned crosstalk in three key stages of T cell biology involving cell polarization: T cell migration in response to chemokines, immunological synapse formation in response to antigen cues, and effector functions. …”
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Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease by Dan Wang, Zikun Zhang, Zekun Si, Yanlin Yang, Shuangshuang Li, Yaoming Xue

“…This study aimed to evaluate the potential benefits of dapagliflozin (Dap) on DKD, as well as its influence on shifting renal T‐cell polarization and related cytokine secretion. We treated male db/db mice with Dap or voglibose (Vog) and measured blood and kidney levels of Th17 and Treg cells using flow cytometry. …”
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Fibroblasts and Endothelial Cells in Three-Dimensional Models: A New Tool for Addressing the Pathogenesis of Systemic Sclerosis as a Prototype of Fibrotic Vasculopathies by Caterina Bodio, Alessandra Milesi, Paola Adele Lonati, Cecilia Beatrice Chighizola, Alessandro Mauro, Luca Guglielmo Pradotto, Pier Luigi Meroni, Maria Orietta Borghi, Elena Raschi

“…Fibroblasts formed a tissue-like texture with the deposition of a new extracellular matrix (ECM) and ECs assembled tube-shaped structures with cell polarization. The fine-tuned dynamic modular system allowing 3D fibroblast/EC culture connection represents a valuable model of the in vivo interplay between the main players in fibrotic vasculopathy as SSc. …”
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Benchmarking Electrolytes for the Solid Oxide Electrolyzer Using a Finite Element Model by Sriram Srinivas, Shankar Raman Dhanushkodi, Ramesh Kumar Chidambaram, Dorota Skrzyniowska, Anna Korzen, Jan Taler

“…Our models show a <i>R</i>² value of over 0.996 in predicting the cell-polarization curves and electrochemical properties at the given operating conditions. …”
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