Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics by Tatiana J. Carneiro, Ana L. M. Batista Carvalho, Martin Vojtek, Inês F. Carmo, Maria Paula M. Marques, Carmen Diniz, Ana M. Gil

“…Supported by cytotoxic, microscopic and biochemical characterization of both lines, Nuclear Magnetic Resonance (NMR) metabolomics was employed to characterize cell polar extracts for the two cell lines, as a function of time (0, 24 and 48 h), and identify statistically relevant differences both between sensitive and resistant cells and their time course behavior. …”
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The role of activated androgen receptor in cofilin phospho-regulation depends on the molecular subtype of TNBC cell line and actin assembly dynamics. by Lubna Tahtamouni, Ahmad Alzghoul, Sydney Alderfer, Jiangyu Sun, Mamoun Ahram, Ashok Prasad, James Bamburg

“…Androgens enhanced cell polarization in all lines, stimulated wound healing and transwell migration rates and increased N/E-cadherin mRNA ratios while reducing cell adhesion in BT549 and MDA-MB-453 cells. …”
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Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/... by Xinyu Zhang, Lingling Li, Jianxin Chen, Mengyuan Hu, Yali Zhang, Xuya Zhang, Yi Lu

“…Specifically, ECS reduced the expression of inflammatory factors in the hippocampus, inhibited M1 microglial cell polarization, and alleviated depression through the regulation of the NF-κB-NLRP3 inflammation pathway.Conclusion: Based on experimental and network analysis, this study revealed for the first time that ECS exerted antidepression effect via anti-neuroinflammation. …”
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ROLE OF CXCR3 CHEMOKINE RECEPTOR AND ITS LIGANDS IN CERTAIN DISEASES by N. A. Arsentieva, A. V. Semenov, D. A. Zhebrun, E. V. Vasilyeva, Areg A. Totolian

“…IFNγ-induced ligands of the CXCR3 are proinflammatory chemokines, they mainly recruit activated T cells and exert an effect on T cell polarization. Due to wide spectrum of biological activity, the ligands of CXCR3 receptor are involved in pathogenesis of various disorders, such as inflammation, infection, cancer, allergies and autoimmune disorders. …”
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Milk-Derived Small Extracellular Vesicles Promote Osteogenic Differentiation and Inhibit Inflammation via microRNA-21 by Runyuan Liu, Shuo Liu, Saixuan Wu, Meng Xia, Wanqing Liu, Lina Wang, Ming Dong, Weidong Niu

“…The evaluation of RAW 264.7 cell polarization and the assessment of inflammatory factor expression were conducted through qRT-PCR. …”
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Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance by Tamara Carnac

“…Acetylcholine activation of the α7 subunit of the nicotinic acetylcholine receptor (α7 nAChR) on the cell surface of immune cells leads to PI3K/Akt pathway activation and can control immune cell polarization. Dysregulation of this pathway due to dysfunction of the prenatal autonomic nervous system could lead to impaired fetal immune tolerance mechanisms and a greater vulnerability to Maternal Immune Activation (MIA) resulting in neurodevelopmental abnormalities. …”
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Superficial groove structure in the size of focal adhesion can clarify cell-type-specific differences in force-dependent substrate mechanosensing by Kazuaki NAGAYAMA, Tatsuya HANZAWA, Akiko SATO

“…PASM and A7r5 cells including thick bundles of actin fibers with elongated FAs showed pronounced cell polarization and directional migration on the 1 and 5 μm wide grooves. …”
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Pancancer network analysis reveals key master regulators for cancer invasiveness by Mahesh Jethalia, Siddhi P. Jani, Michele Ceccarelli, Raghvendra Mall

“…Downstream pathway analysis of MRs specific to INV-H phenotype resulted in the identification of several enriched pathways, including Epithelial into Mesenchymal Transition, TGF-β signaling pathway, regulation of Toll-like receptors, cytokines, and inflammatory response, and selective expression of chemokine receptors during T-cell polarization. Most of these pathways have connotations of inflammatory immune response and feasibility for metastasis. …”
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Oral Excretion Kinetics of Food-Additive Silicon Dioxides and Their Effect on In Vivo Macrophage Activation by Ri-Ye Kwon, Su-Min Youn, Soo-Jin Choi

“…Moreover, no in vivo monocyte uptake, Kupffer cell polarization, or cytokine release were induced by orally administered SiO₂ particles. …”
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T Regulatory Cell-Associated Tolerance Induction by High-Dose Immunoglobulins in an HLA-Transgenic Mouse Model of Pemphigus by Christoph Hudemann, Jochen Hoffmann, Enno Schmidt, Michael Hertl, Rüdiger Eming

“…This prompted us to study T- and B- cell polarization by IVIg in a human-Dsg3-dependent mouse model for PV. …”
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Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination by Laura Di Blasio, Paolo A. Gagliardi, Alberto Puliafito, Luca Primo

“…The aim of this review is to summarize the various mechanisms by which PDK1 controls the cell migration process, from cell polarization to actin cytoskeleton and focal adhesion regulation, and finally, to discuss the evidence supporting a role for PDK1 in cancer cell invasion and dissemination.…”
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Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia by Mohammad Sadeghi, Leili Aghebati-Maleki, Sina Abbaszadeh, Sina Rasoulzadeh, Abbas Ali Hosseinpour Feizi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh

“…According to several studies, the mammalian target of rapamycin (mTOR), which mediates several biological processes in cells, including cell survival, autophagy, cell polarization, etc, is highly involved in cancer progression, chemoresistance, and relapse. …”
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Preparation of PtNi@SDC core-shell nanoparticles by one-pot solvothermal synthesis by Quek, Kenneth Kai Wen

“…Therefore, it was used as the cathode material for the fuel cell polarization test, and also as the core in the hydrothermal synthesis of platinum-nickel core, samaria-doped ceria shell (PtNi@SDC) nanoparticle catalyst. …”
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Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis by Ali Mahmoud Hashemi, Shiva Solahaye Kahnamouii, Hassan Agajani, Khalil Frozannia, Alireza Pournasrollah, Rasoul Sadeg, Heidarali Esmaeeli, Yosef Gadimi, Ebrahim Razmpa

“…The results showed the reduction of TLR4 pathway and Th17 cell polarization. Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients’ cultured T cells were increased after stimulation with HMGB-1 following employing quercetin. …”
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The Role of Glycosyltransferases in Colorectal Cancer by Cecilia Fernández-Ponce, Noelia Geribaldi-Doldán, Ismael Sánchez-Gomar, Roberto Navarro Quiroz, Linda Atencio Ibarra, Lorena Gomez Escorcia, Ricardo Fernández-Cisnal, Gustavo Aroca Martinez, Francisco García-Cózar, Elkin Navarro Quiroz

“…Therefore, glycosylation in CRC can affect cell migration, cell–cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease. …”
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Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. by April Kaur Randhawa, Muki S Shey, Alana Keyser, Blas Peixoto, Richard D Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A Hanekom, Thomas R Hawn, South African Tuberculosis Vaccine Initiative Team

“…These data support a mechanism where TLR1/6 polymorphisms modulate TH1 T-cell polarization through genetic regulation of monocyte IL-10 secretion in the absence of IL-12. …”
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Testosterone Propionate Promotes Proliferation and Viability of Bone Marrow Mesenchymal Stem Cells while Preserving Their Characteristics and Inducing Their Anti-Cancer Efficacy by Başak Aru, Tuba Akdeniz, Hüsniye Dağdeviren, Gizem Gürel, Gülderen Yanıkkaya Demirel

“…The results showed that, apart from promoting mesenchymal stem cells’ polarization and increasing their cytotoxicity on K562 cells, testosterone propionate did not alter differentiation capacities of bone marrow-derived mesenchymal stem cells and certain cell surface markers, but led to a significant increase in HLA-DR expression. …”
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Fusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis by Hui Liu, Yuxuan Liu, Wei Fan, Bing Fan

“…F. nucleatum-infected RAW264.7 cells polarized to the M1 phenotype, and this was accompanied by inflammatory cytokine production. …”
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Targeting interleukin 4 and interleukin 13: a novel therapeutic approach in bullous pemphigoid by Fangyuan Chen, Yiman Wang, Xinyi Chen, Nan Yang, Li Li

“…However, before this novel therapy can be approved for regular usage, further studies are needed concerning the long-term safety and systemic usage of IL-4/13 monoclonal antibody treatment in BP.KEY MESSAGESBP is an autoimmune skin disease with Th2-mediated autoimmune response involvement.As typical Th2 cytokines, IL-4 and IL-13 may contribute to the pathogenesis of BP in multiple ways, such as promoting Th2 cell polarization, driving the immunoglobulin class switching, recruiting eosinophils and basophils, and inducing pruritus.As a promising therapeutic approach for BP, IL-4/13 antagonists have shown satisfactory outcomes in preliminary clinical studies.…”
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Human peripheral blood mononuclear cells display a temporal evolving inflammatory profile after myocardial infarction and modify myocardial fibroblasts phenotype by Elodie Miquelestorena-Standley, Ana Valéria Vinhais da Silva, Marina Monnier, Stéphanie Chadet, Marie Piollet, Audrey Héraud, Roxane Lemoine, Thomas Bochaton, Geneviève Derumeaux, Sébastien Roger, Fabrice Ivanes, Denis Angoulvant

“…Expression level of P2RY11 and genes involved in tolerogenic profile of dendritic cells and T cell polarization were evaluated by RT-PCR. P2Y11 protein expression was assessed by flow cytometry. …”
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