I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs by Magdalena Strachowska, Karolina Gronkowska, Maciej Sobczak, Marika Grodzicka, Sylwia Michlewska, Kinga Kołacz, Tuhin Sarkar, Joanna Korszun, Maksim Ionov, Agnieszka Robaszkiewicz

“…Importantly, I-CBP112 treated cancer cells polarized human macrophages into proinflammatory phenotypes. …”
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Monocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability by Juan López-Relaño, Juan López-Relaño, Beatriz Martín-Adrados, Beatriz Martín-Adrados, Irene Real-Arévalo, Irene Real-Arévalo, Javier Lozano-Bartolomé, Javier Lozano-Bartolomé, Beatriz Abós, Beatriz Abós, Silvia Sánchez-Ramón, Bárbara Alonso, Manuel Gómez del Moral, Manuel Gómez del Moral, Eduardo Martínez-Naves, Eduardo Martínez-Naves

“…Mixed lymphocyte reaction experiments showed that L-DCs could stimulate naïve CD4 T-cells, polarizing them toward a predominant Th1 phenotype. …”
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A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells by Thomas Quast, Karolin Zölzer, Donald Guu, Luis Alvarez, Carsten Küsters, Eva Kiermaier, U. Benjamin Kaupp, Waldemar Kolanus

“…The microfluidic approach allows us to generate soluble gradients with high spatio-temporal precision and to analyze actin dynamics, cell polarization, and persistent directional migration in both static and dynamic environments. …”
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Ovalbumin-Induced Epithelial Activation Directs Monocyte-Derived Dendritic Cells to Instruct Type 2 Inflammation in T Cells Which Is Differentially Modulated by 2′-Fucosyllactose a... by Marit Zuurveld, Pien C.J. Kiliaan, Sophie E.L. van Grinsven, Gert Folkerts, Johan Garssen, Belinda van’t Land, Linette E.M. Willemsen

“…Allergic sensitization starts with epithelial cell activation driving dendritic cells (DCs) to instruct T helper 2 (Th2) cell polarization. Food allergens trigger intestinal epithelial cell (IEC) activation. …”
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Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An... by Pravin Parajuli, Kuppan Gokulan, Sangeeta Khare

“…Sodium arsenite, sodium arsenate, dimethyl arsenic acid sodium salt (DMA^V), and disodium methyl arsonate hydrate (MMA^V) were assessed for their effects on intestinal permeability by measuring the change in trans-epithelial electrical resistance (TEER) of T-84 cells. Polarized T-84 cells exposed to 12.8 µM of sodium arsenite from the basolateral side showed a marked reduction in TEER. …”
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Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization by Xianwei Huang, Xiong Liu, Jiaqi Zeng, Penghui Du, Xiaodong Huang, Jiyan Lin

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The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo by Karilyn E. Sant, Jason M. Hansen, Larissa M. Williams, Nancy L. Tran, Jared V. Goldstone, John J. Stegeman, Mark E. Hahn, Alicia Timme-Laragy

“…Redox signaling is important for embryogenesis, guiding pathways that govern processes crucial for embryo patterning, including cell polarization, proliferation, and apoptosis. Exposure to pro-oxidants during this period can be deleterious, resulting in altered physiology, teratogenesis, later-life diseases, or lethality. …”
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Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis by Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun, Qintai Yang

“…This study aimed to determine the combined effects of these three receptor signals on the T cell-polarizing function of DCs in AR patients.MethodsMonocyte-derived DCs (mo-DCs) were generated and stimulated with Toll-like receptor (TLR) 1–9 ligands. …”
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Electrochemical engineering of low-cost and high-power redox flow batteries by Milshtein, Jarrod D. (Jarrod David)

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Inhibition of IFN-[gamma] promoter function by site-specific methylation by Jones, Brendan T. (Brendan Taber)

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Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer by Wenzhe Gao, Dongjie Chen, Dongjie Chen, Dongjie Chen, Dongjie Chen, Jixing Liu, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu

“…We classified patients into two distinct RNA modification patterns (WM_Score_high and _low), The WM_Score_high subgroup was correlated with worse prognosis, Th2/Th17 cell polarization and oncogenic pathways (e.g. EMT, TGF-β, and mTORC1 signaling pathways), whereas the WM_Score_low subgroup associated with favorable survival rate and Th1 cell trend. …”
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AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway by Ying Zhang, Yanyan Pan, Peiyi Zhang, Fang Wang, Ying Han, Kailin Li, Wen Jiang, Jue Wang, Yun Luan, Qian Xin

“…The inhibitory effect of tapinarof on Tfh cells was further verified in the in vitro Tfh cell polarization experiment. Realtime qPCR revealed that tapinarof repressed the expression of Tfh signature genes. …”
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Proton-conducting ceramics for water electrolysis and hydrogen production at elevated pressure by C. Herradon, L. Le, C. Meisel, J. Huang, C. Chmura, Y.D. Kim, C. Cadigan, R. O’Hayre, N.P. Sullivan

“…Increasing the operating pressure from 2.1 to 12.6 bara enables a 40% overall decrease in the over-potential required to drive electrolysis at 500 mA cm−2, with a 33% decrease in the cell ohmic resistance and a 60% decrease in the cell polarization resistance. Faradaic efficiency is also found to increase with operating pressure. …”
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Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models by Paulo C Rodriguez, Zhihua Chen, Y Ann Chen, Lilit Karapetyan, Jiannong Li, Manali S Phadke, Jessica K Mandula, Peter A Forsyth, Keiran S M Smalley

“…In anti-PD-1+LAG-3 treated tumors, CD4+T cell depletion was associated with fewer activated (CD69+) CD8+T cells and impaired IFNγ release but, conversely, increased numbers of activated CD8+T cells and IFNγ release in anti-PD-1+CTLA-4 treated tumors.Conclusions Together these studies suggest that these two clinically relevant immune checkpoint inhibitor (ICI) combinations have differential effects on CD4+T cell polarization, which in turn, impacted cytotoxic CD8+T cell function. …”
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Identification of gut dysbiosis in axial spondyloarthritis patients and improvement of experimental ankylosing spondyloarthritis by microbiome-derived butyrate with immune-modulati... by Hong Ki Min, Hyun Sik Na, Hyun Sik Na, Hyun Sik Na, Hyun Sik Na, JooYeon Jhun, JooYeon Jhun, JooYeon Jhun, Seon-Yeong Lee, Seon-Yeong Lee, Sun Shim Choi, Go Eun Park, Jeong Su Lee, Jeong Su Lee, Jeong Su Lee, Jeong Su Lee, In Gyu Um, In Gyu Um, In Gyu Um, In Gyu Um, Seung Yoon Lee, Seung Yoon Lee, Seung Yoon Lee, Seung Yoon Lee, Hochan Seo, Tae-Seop Shin, Yoon-Keun Kim, Jennifer Jooha Lee, Seung-Ki Kwok, Mi-La Cho, Mi-La Cho, Mi-La Cho, Mi-La Cho, Sung-Hwan Park

“…Butyrate reduced CD4+ IL-17A+ T cell differentiation and osteoclastogenesis.DiscussionWe found that CD4+ IL-17A+ T cell polarization was reduced, when F. prausnitzii or butyrate were introduced into curdlan-induced SpA mice or CD4+ T cells of axSpA patient. …”
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IL-2–mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish by Kete Ai, Kang Li, Xinying Jiao, Yu Zhang, Jiaqi Li, Qian Zhang, Xiumei Wei, Jialong Yang

“…Moreover, IFN-γ binds to its receptors IFNγR1 and IFNγR2 and further initiates a STAT1/T-bet axis-mediated positive feedback loop to stabilize the Th1 cell polarization in tilapia. These findings demonstrate that, prior to the emergence of tetrapods, the bony fish Nile tilapia had already evolved Th1 cells to fight intracellular bacterial infection, and support the notion that IL-2–mTORC1 signaling coordinates the STAT1/T-bet axis to determine Th1 cell fate, which is an ancient mechanism that has been programmed early during vertebrate evolution. …”
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Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds by Bong-Sung Kim, Pathricia V. Tilstam, Katrin Springenberg-Jung, Arne Hendrick Boecker, Corinna Schmitz, Daniel Heinrichs, Soo Seok Hwang, Jan Philipp Stromps, Bergita Ganse, Ruedger Kopp, Matthias Knobe, Juergen Bernhagen, Norbert Pallua, Richard Bucala

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Depletion of Lipocalin 2 (LCN2) in Mice Leads to Dysbiosis and Persistent Colonization with Segmented Filamentous Bacteria by Patrick Klüber, Steffen K. Meurer, Jessica Lambertz, Roman Schwarz, Silke Zechel-Gran, Till Braunschweig, Sabine Hurka, Eugen Domann, Ralf Weiskirchen

“…Finally, the ileum of <i>Lcn2</i> null mice displayed a high abundance of segmented filamentous bacteria, which are intimately associated with the mucosal cell layer, provoking epithelial antimicrobial responses and affecting T-helper cell polarization.…”
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Vitamin D Status and Immune Response in Hospitalized Patients with Moderate and Severe COVID-19 by Tatiana L. Karonova, Igor V. Kudryavtsev, Ksenia A. Golovatyuk, Arthur D. Aquino, Olga V. Kalinina, Alena T. Chernikova, Ekaterina K. Zaikova, Denis A. Lebedev, Ekaterina S. Bykova, Alexey S. Golovkin, Evgeny V. Shlyakhto

“…We demonstrate that the serum 25(OH)D level ≤ 11.4 ng/mL is associated with the stimulation of Th2 and the downregulation of Th17 cell polarization of the adaptive immunity in patients with COVID-19.…”
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Philadelphia chromosome-negative myeloproliferative chronic neoplasms: is clonal hematopoiesis the main determinant of autoimmune and cardio-vascular manifestations? by Giovanni Fulvio, Giovanni Fulvio, Chiara Baldini, Marta Mosca, Antonello di Paolo, Guido Bocci, Giuseppe Alberto Palumbo, Emma Cacciola, Paola Migliorini, Rossella Cacciola, Sara Galimberti

“…However, DNMT3A mutations induce pro-inflammatory T-cell polarization and activate the inflammasome complex, while TET2 downregulation leads to endothelial cell autophagy and inflammatory factor upregulation. …”
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