Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination by Paolo Marzano, Simone Balin, Sara Terzoli, Sara Terzoli, Silvia Della Bella, Silvia Della Bella, Valentina Cazzetta, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Immo Prinz, Francesca Calcaterra, Francesca Calcaterra, Clara Di Vito, Assunta Cancellara, Assunta Cancellara, Michela Calvi, Michela Calvi, Anna Carletti, Sara Franzese, Sara Franzese, Alessandro Frigo, Alessandro Frigo, Ahmed Darwish, Ahmed Darwish, Antonio Voza, Antonio Voza, Joanna Mikulak, Domenico Mavilio, Domenico Mavilio

“…Based on scRNA/TCR-seq data related to regulatory signals induced by the vaccine, we used computational approaches for the functional pathway enrichment analysis (Reactome), dynamics of the effector cell-polarization (RNA Velocity and CellRank), and cell-cell communication (NicheNet).ResultsWe identified MAIT cells as an important source of TNF across circulating lymphocytes in response to repeated SARS-CoV-2 BNT162b2 vaccination. …”
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Polarization of Human Monocyte-Derived Cells With Vitamin D Promotes Control of Mycobacterium tuberculosis Infection by Jagadeeswara Rao Muvva, Venkata Ramanarao Parasa, Maria Lerm, Mattias Svensson, Susanna Brighenti

“…We studied the phenotype and ability of human monocyte-derived cells polarized with active vitamin D [1,25(OH)2D3] to control intracellular Mtb infection compared with polarization of conventional subsets, classical M1 or alternative M2.Methods: Human blood-derived monocytes were treated with active vitamin D or different cytokines to obtain 1,25(OH)2D3-polarized as well as M1- and M2-like cells or fully polarized M1 and M2 subsets. …”
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CoO_x-Fe₃O₄/N-rGO Oxygen Reduction Catalyst for Anion-Exchange Membrane Fuel Cells by Ramesh K. Singh, John C. Douglin, Lanjie Jiang, Karam Yassin, Simon Brandon, Dario R. Dekel

“…Finally, we quantified the various cell polarization losses as a function of cathode catalyst loadings to obtain insights for future work with AEMFCs based on this catalyst. …”
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The 3D-Printed Ordered Bredigite Scaffold Promotes Pro-Healing of Critical-Sized Bone Defects by Regulating Macrophage Polarization by Xuan Y, Li L, Zhang C, Zhang M, Cao J, Zhang Z

“…In vitro, the BRT-O scaffolds facilitated RWA264.7 cells polarization to pro-healing M2 macrophage phenotype, whereas the BRT-R and β-TCP scaffolds stimulated more pro-inflammatory M1-type macrophages. …”
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Microenvironmental regulation of T-cells in pulmonary hypertension by Lydie Plecitá-Hlavatá, Andrea Brázdová, Andrea Brázdová, Monika Křivonosková, Monika Křivonosková, Cheng-Jun Hu, Cheng-Jun Hu, Tzu Phang, Jan Tauber, Min Li, Hui Zhang, Konrad Hoetzenecker, Slaven Crnkovic, Slaven Crnkovic, Grazyna Kwapiszewska, Grazyna Kwapiszewska, Kurt R. Stenmark

“…To determine whether metabolic reprogramming of PH-Fibs was directly contributing to the effects of PH-Fibs conditioned media on T-cell polarization, we treated PH-Fibs with the HDAC inhibitor SAHA, which was previously shown to normalize metabolic status and examined the effects of the conditioned media. …”
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Comparative Immune Response after Vaccination with SOBERANA^® 02 and SOBERANA^® plus Heterologous Scheme and Natural Infection in Young Children by Rocmira Pérez-Nicado, Chiara Massa, Laura Marta Rodríguez-Noda, Anja Müller, Rinaldo Puga-Gómez, Yariset Ricardo-Delgado, Beatriz Paredes-Moreno, Meiby Rodríguez-González, Marylé García-Ferrer, Ilianet Palmero-Álvarez, Aniurka Garcés-Hechavarría, Daniel G. Rivera, Yury Valdés-Balbín, Vicente Vérez-Bencomo, Dagmar García-Rivera, Barbara Seliger

“…In contrast to low levels of IL-4, high levels of IL-2, IL-6, IFN-γ, and IL-10 suggest a predominant Th1 cell polarization. Cytotoxic-related proteins granzyme A and B, perforin, and granulin were also found in the supernatant after S1 stimulation in both vaccinated and recovered children. (4) Conclusions: Vaccination with the heterologous scheme of SOBERANA^® 02/SOBERANA^® Plus induces a stronger antibody and cellular immune response compared to natural infections in young children.…”
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Deciphering the mechanism of Tinospora cordifolia extract on Th17 cells through in-depth transcriptomic profiling and in silico analysis by Amrita Nandan, Amrita Nandan, Amrita Nandan, Vishwas Sharma, Prodyot Banerjee, Kannan Sadasivam, Subramanian Venkatesan, Subramanian Venkatesan, Bhavana Prasher, Bhavana Prasher, Bhavana Prasher

“…For the first time, in-depth genome-wide expression profiling of T. cordifolia treated naive CD4+ T cells, polarized to Th17 cells, suggests the broad-spectrum activity of T. cordifolia. …”
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Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization by Zachary S Morris, KyungMann Kim, Paul M Sondel, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Ishan Chakravarty, Thomas C Havighurst, Erin J Nystuen

“…MPL favorably reprogrammed the irradiated tumor-immune microenvironment toward M1 macrophage and Th1 TBET+CD4+ T cell polarization. Furthermore, MPL significantly increased intratumoral expression of several Th1-associated and M1-associated proinflammatory cytokines. …”
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Features of immune response in different phenotypes of chronic obstructive pulmonary disease by M. V. Antonyuk, E. E. Mineeva, V. V. Knyshova, A. V. Urenko, T. I. Vitkina, T. P. Novgorodtseva, T. A. Gvozdenko

“…Progression of the disease, broncho-obstructive disorders and hyperinflation are associated with increased levels of cytokines that provide cell polarization along the Th17 pathway. Determination of COPD phenotype and the type of immune response already at an early stage of the disease will enable prediction of its course and justify the choice of phenotype-oriented therapy.…”
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Mass Transport Limitations in Electrochemical Conversion of CO₂ to Formic Acid at High Pressure by Selvaraj Chinnathambi, Mahinder Ramdin, Thijs J. H. Vlugt

“…To complete the analysis, we simulated the full cell polarization curve and fitted with the experimental data.…”
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MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis by Liu Y, Zhao N, Xu Q, Deng F, Wang P, Dong L, Lu X, Xia L, Wang M, Chen Z, Zhou J, Zuo D

“…The presence of MBL during Th17 cell polarization significantly limited aryl hydrocarbon receptor (AhR) expression and suppressed the signal transducer and activator of transcription 3 (STAT3) phosphorylation. …”
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