The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis by Sakine Rezaie Kahkhaie, Khadije Rezaie Keikhaie

“…DNA molecule is the most important cellular compartment damaged by ionizing radiation. On the other hand, the ability of irradiated cells to repair the damaged DNA is very low. …”
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Preparation of Outer Membrane Vesicles from Myxococcus xanthus by James Berleman, Marcin Zemla, Jonathan Remis, Manfred Auer

“…Outer membrane vesicles (OMVs) represent a unique sub-cellular compartment of bacteria that may act as a scaffold for various extracellular activities, including intercellular signaling. …”
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Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue. by Tifini L Batts, Emi Sasaki, Mayzie Miller, Joshua Sparago, Rudy W Bauer, Daniel Paulsen, Bonnie Boudreaux, Chin-Chi Liu, Stephanie D Byrum, Andrea N Johnston

“…Remarkably, 6 (19%) of the upregulated proteins are correlated to non-hepatobiliary neuroendocrine neoplasia and 16 (50%) are functionally annotated within the exosome cellular compartment key to neuroendocrine signaling. Twenty-six (21%) downregulated proteins are enriched in metabolic pathways consistent with alterations in cancer. …”
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An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. by Stephan, A, Vaughan, S, Shaw, M, Gull, K, McKean, P

“…Constructing a eukaryotic cilium/flagellum is a demanding task requiring the transport of proteins from their cytoplasmic synthesis site into a spatially and environmentally distinct cellular compartment. The clear potential hazard is that import of aberrant proteins could seriously disable cilia/flagella assembly or turnover processes. …”

Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli by Huiyi Chen, Katsuyuki Shiroguchi, Hao Ge, Xiaoliang Sunney Xie

“…Abstract An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria. Here, we report a genome‐wide RNA degradation study in Escherichia coli using RNA‐seq, and present evidence that the stereotypical exponential RNA decay curve obtained using initiation inhibitor, rifampicin, consists of two phases: residual RNA synthesis, a delay in the interruption of steady state that is dependent on distance relative to the mRNA's 5′ end, and the exponential decay. …”
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A modular cloning (MoClo) toolkit for reliable intracellular protein targeting in the yeast Saccharomyces cerevisiae by Pavel Simakin, Christian Koch, Johannes M. Herrmann

“…Furthermore, we optimized the subcellular targeting by controlling expression levels using a collection of different promoter cassettes; the MoClo strategy allows it to generate arrays of expression plasmids in parallel to optimize gene expression levels and reliable targeting for each given protein and cellular compartment. Thus, the MoClo strategy enables the generation of protein-expressing yeast plasmids that accurately target proteins of interest to various cellular compartments.…”
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Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. by Yan Meng, Yi Qian, Li Gao, Ling-Bo Cai, Yu-Gui Cui, Jia-Yin Liu

“…PRDX4 monitors the oxidative burden within cellular compartment and reduces hydrogen peroxide and alkyl hydroperoxide related to oxidative stress and apoptosis. …”
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Sub-cellular Proteomics of Medicago truncatula by Jeonghoon eLee, Zhentian eLei, Bonnie eWatson, Lloyd W. Sumner

“…Thus, efficient protocols for sub-cellular fraction, purification, and enrichment are necessary for each cellular compartment. In addition, protein extraction, solubilization, separation, and digestion prior to mass spectral identification are important to enhance the detection of low abundance proteins and to increase the overall detectable proportion of the sub-cellular proteome. …”
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Heat Shock Proteins (HSPs) Inducers for Stress Management in Agricultural Crops by Shivendu Pratap Singh Solanki, S. G. Telkar, Shashikant Sharma, Kunzang Lamo, Joy Kumar Dey

“…Binding of HSP with particular polypeptide within sub cellular compartment avoids denaturation of many proteins at high temperatures. …”
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Ratiometric fluorescence-imaging assays of plant membrane traffic using polyproteins. by Samalova, M, Fricker, M, Moore, I

“…Here the 20 residue self-cleaving 2A peptide from Foot and Mouth Disease Virus was used to construct polyproteins that expressed a trafficked marker in fixed stoichiometry with a reference protein in a different cellular compartment. Various pairs of compartments were simultaneously targeted. …”

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. by Nathalie Britzen-Laurent, Michael Bauer, Valeria Berton, Nicole Fischer, Adrian Syguda, Simone Reipschläger, Elisabeth Naschberger, Christian Herrmann, Michael Stürzl

“…Specifically, GBP-1 recruited GBP-5 and GBP-2 into its own cellular compartment and GBP-5 repositioned GBP-2. In addition, GBP-1, GBP-2 and GBP-5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner. …”
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Physiological and Proteomic Changes in the Apoplast Accompany Leaf Senescence in Arabidopsis by Maria L. Borniego, Maria C. Molina, Juan J. Guiamét, Dana E. Martinez

“…The apoplast, i.e. the cellular compartment external to the plasma membrane, undergoes important changes during senescence. …”
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Simplified method to predict mutual interactions of human transcription factors based on their primary structure. by Sebastian Schmeier, Boris Jankovic, Vladimir B Bajic

“…TFs that function in the same cellular compartment (nucleus) and in the same type of molecular process (transcription initiation). …”
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Regulating Subcellular Metal Homeostasis: the Key to Crop Improvement by Khurram Bashir, Sultana Rasheed, Sultana Rasheed, Takanori Kobayashi, Motoaki Seki, Motoaki Seki, Motoaki Seki, Naoko Kishi Nishizawa

“…Thus, any change in the metal profile of a cellular compartment significantly affects metabolism. Different subcellular compartments are suggested to be linked through complex retrograde signaling networks to regulate cellular metal homeostasis. …”
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Comparative rates of evolution in endosymbiotic nuclear genomes by Keeling Patrick J, Rogers Matthew B, Patron Nicola J

“…We compared the evolutionary rates of genes from nuclear, nucleomorph, and plastid genomes, all of which encode proteins that function in the same cellular compartment, the plastid, and are thus subject to similar selection pressures. …”
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Genetically Encoded Fluorescent Biosensors for Biomedical Applications by Vera S. Ovechkina, Suren M. Zakian, Sergey P. Medvedev, Kamila R. Valetdinova

“…Real-time monitoring of drug action in a specific cellular compartment, organ, or tissue type; the ability to screen at the single-cell resolution; and the elimination of false-positive results caused by low drug bioavailability that is not detected by in vitro testing methods are a few of the obvious benefits of using genetically encoded fluorescent biosensors in drug screening. …”
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Restricted expression of Epstein-Barr virus latent genes in murine B cells derived from embryonic stem cells. by Magdalena Zychlinska, Heidrun Herrmann, Ursula Zimber-Strobl, Wolfgang Hammerschmidt

“…EBV efficiently infects human B cells and persists in this cellular compartment latently. EBV-infected B cells become activated and growth transformed, express a characteristic set of viral latent genes, and acquire the status of proliferating lymphoblastoid cell lines in vitro. …”
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Activity-Dependent Fluctuations in Interstitial [K⁺]: Investigations Using Ion-Sensitive Microelectrodes by Hana Beswick-Jones, Amy J. Hopper, Angus M. Brown

“…In the course of action potential firing, all axons and neurons release K⁺ from the intra- cellular compartment into the interstitial space to counteract the depolarizing effect of Na⁺ influx, which restores the resting membrane potential. …”
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Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation by Chen, J, Cao, Y, Markelc, B, Kaeppler, J, Vermeer, JAF, Muschel, RJ

“…Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling in a different cellular compartment of the tumor, the cancer cells themselves. …”

Selectable Markers and Reporter Genes for Engineering the Chloroplast of Chlamydomonas reinhardtii by Lola Esland, Marco Larrea-Alvarez, Saul Purton

“…Expression of foreign genes in the chloroplast is particularly advantageous as: (i) accumulation of product in this sub-cellular compartment minimises potential toxicity to the rest of the cell; (ii) genes can integrate at specific loci of the chloroplast genome (plastome) by homologous recombination; (iii) the high ploidy of the plastome and the high-level expression of chloroplast genes can be exploited to achieve levels of recombinant protein as high as 5% total cell protein; (iv) the lack of any gene silencing mechanisms in the chloroplast ensures stable expression of transgenes. …”
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