Proteome Profiling of Exosomes Purified from a Small Amount of Human Serum: The Problem of Co-Purified Serum Components by Mateusz Smolarz, Monika Pietrowska, Natalia Matysiak, Łukasz Mielańczyk, Piotr Widłak

“…In this set of exosome-related proteins, there were 45 species associated with the GO cellular compartment term “extracellular exosome”. …”
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Nucleocapsid Protein (N) of <i>Peste des petits ruminants</i> Virus (PPRV) Interacts with Cellular Phosphatidylinositol-3-Kinase (PI3K) Complex-I and Induces Autophagy by Yash Chaudhary, Juhi Jain, Sharad Kumar Gaur, Prabhakar Tembhurne, Shanmugam Chandrasekar, Muthuchelvan Dhanavelu, Sharvan Sehrawat, Rajeev Kaul

“…The PPRV-N protein can specifically interact with VPS34 of the PI3K complex-I and colocalize with the proteins of PI3K complex-I in the same sub-cellular compartment, that is, in the cytoplasm. These interactions do not affect the intracellular localization of the different host proteins. …”
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On-chip analysis of glycolysis and mitochondrial respiration in human induced pluripotent stem cells by Stefanie Fuchs, Ruben W.J. van Helden, Maury Wiendels, Mees N.S. de Graaf, Valeria V. Orlova, Christine L. Mummery, Berend J. van Meer, Torsten Mayr

“…Microfluidic devices, also called Organs-on-Chip (OoC), allow complex engineering of the cellular compartment, yielding designs in which microfluidic flow can be precisely controlled. …”
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Analysis of IAV Replication and Co-infection Dynamics by a Versatile RNA Viral Genome Labeling Method by Dou, Dan, Hernández-Neuta, Iván, Wang, Hao, Östbye, Henrik, Qian, Xiaoyan, Thiele, Swantje, Resa-Infante, Patricia, Kouassi, Nancy Mounogou, Sender, Vicky, Hentrich, Karina, Mellroth, Peter, Henriques-Normark, Birgitta, Gabriel, Gülsah, Nilsson, Mats, Daniels, Robert

“…Genome delivery to the proper cellular compartment for transcription and replication is a primary goal of viruses. …”
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The association of protein-bound methionine sulfoxide with proteomic basis for aging in beech seeds by Ewa Marzena Kalemba, Kris Gevaert, Francis Impens, Sara Dufour, Anna Czerwoniec

“…Functional analyses based on gene ontology annotations revealed that nucleic acid binding activity (molecular function), ribosome organization or biogenesis and transmembrane transport (cellular processes), translational proteins (protein class) and membranous anatomical entities (cellular compartment) were affected in aged seeds. To verify whether MetO, the oxidative posttranslational modification of proteins that can be reversed via the action of methionine sulfoxide reductase (Msr) enzymes, is involved in the aging of beech seeds, we identified and quantified 226 MetO-containing proteins, among which 9 and 19 exhibited significantly up- and downregulated MetO levels, respectively, in beech seeds under long-term storage conditions. …”
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Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope by Christian E. Lamm, Katrin Link, Sabrina Wagner, Jens Milbradt, Manfred Marschall, Uwe Sonnewald

“…In all eukaryotic cells, the nucleus forms a prominent cellular compartment containing the cell’s nuclear genome. …”
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Estrous cycle state-dependent renewal of appetitive behavior recruits unique patterns of Arc mRNA in female rats by Emily N. Hilz, Laura A. Agee, Donyun Jun, Marie-H. Monfils, Marie-H. Monfils, Hongjoo J. Lee, Hongjoo J. Lee

“…In this experiment that effect is replicated and extended upon to understand how the estrous cycle may modulate contextual representation at the neuronal population level to drive renewal.MethodsEstrous cycle stage [i.e., proestrus (P, high hormone) or metestrus/diestrus (M/D, low hormone)] was considered during two important learning and behavioral expression windows: at extinction training and during long-term memory (LTM)/renewal testing. Cellular compartment analysis of temporal activity using fluorescence in situ hybridization (catFISH) for Arc mRNA was conducted after the distinct context-stimulus exposures.ResultsRats in P during context-dependent extinction training but in a different stage of the estrous cycle during LTM and renewal testing (P-different) were shown to exhibit more renewal of conditioned foodcup (but not conditioned orienting) behavior compared to rats in other estrous cycle groups. …”
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Polymeric nanoparticles and organic fluorophores for cancer sensing and therapy by Ang, Chung Yen

“…Therefore, the detection in the rise of GSH level in the cellular compartment could serve as an early indication of cancer. …”
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Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12 by Y. Maurice Morillon, Zhen Su, Jeffrey Schlom, John W. Greiner

“…Conclusions These findings provide strong evidence that the systemic administration of an immunocytokine consisting of a tumor-targeting Ig through recognition of DNA and DNA-histone complexes coupled to muIL-12 can effectively target the bladder TME; this significantly reduces the myeloid cellular compartment and reverts an immunosuppressive to an immunopermissive TME, ultimately resulting in antitumor effects. …”
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Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen by Arjen Gebraad, Roope Ohlsbom, Juho J. Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Caroline A. Heckman, Susanna Miettinen

“…Mesenchymal stem/stromal cells (MSCs) are self-renewing and multipotent progenitors, which constitute the main cellular compartment of the bone marrow stroma. Because MSCs have an important role in the pathogenesis of multiple myeloma, it is essential to know if novel drugs target MSCs. …”
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Plasticity-Related Activity in the Hippocampus, Anterior Cingulate, Orbitofrontal, and Prefrontal Cortex Following a Repeated Treatment with D₂/D₃ Agonist Qui... by Hana Brozka, Daniela Alexova, Dominika Radostova, Martina Janikova, Branislav Krajcovic, Štěpán Kubík, Jan Svoboda, Ales Stuchlik

“…The expression of IEGs <i>Arc</i> and <i>Homer1a</i> was determined using cellular compartment analysis of temporal activity by fluorescence in situ hybridization. …”
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<it>In vitro </it>and <it>in vivo </it>plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid... by Wood Paul L, Khan M Amin, Smith Tara, Ehrmantraut Greg, Jin Wei, Cui Wei, Braverman Nancy E, Goodenowe Dayan B

“…In contrast, only limited plasmalogen replacement was observed in PMD lymphocytes suggesting that the effects of protein misfolding and accumulation in the ER negatively affect processing of plasmalogen precursors in this cellular compartment.</p>…”
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Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement by Aleksandra Zielińska, Abigail Savietto, Anabela de Sousa Borges, Denis Martinez, Melanie Berbon, Joël R Roelofsen, Alwin M Hartman, Rinse de Boer, Ida J Van der Klei, Anna KH Hirsch, Birgit Habenstein, Marc Bramkamp, Dirk-Jan Scheffers

“…The bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. …”
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A genetic model for in vivo proximity labelling of the mammalian secretome by Rui Yang, Amanda S. Meyer, Ilia A. Droujinine, Namrata D. Udeshi, Yanhui Hu, Jinjin Guo, Jill A. McMahon, Dominique K. Carey, Charles Xu, Qiao Fang, Jihui Sha, Shishang Qin, David Rocco, James Wohlschlegel, Alice Y. Ting, Steven A. Carr, Norbert Perrimon, Andrew P. McMahon

“…Enzyme-catalysed proximity labelling enables the identification of proteins within a specific cellular compartment. Here, we report a BirA*G3 mouse strain that enables CRE-dependent promiscuous biotinylation of proteins trafficking through the endoplasmic reticulum. …”
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TACI Isoforms Regulate Ligand Binding and Receptor Function by Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Andrea Cerutti, Andrea Cerutti, Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles

“…Both TACI isoforms are detectable in the endosomal cellular compartment where they co-localize with MyD88, TRAF6, and the activated 65 kDa form of TLR9, depending on a conserved intracellular TACI sequence. …”
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Salt Stress-Induced Structural Changes Are Mitigated in Transgenic Tomato Plants Over-Expressing Superoxide Dismutase by Liliya R. Bogoutdinova, Elena M. Lazareva, Inna A. Chaban, Neonila V. Kononenko, Tatyana Dilovarova, Marat R. Khaliluev, Ludmila V. Kurenina, Alexander A. Gulevich, Elena A. Smirnova, Ekaterina N. Baranova

“…The engineering of transgenic plants with higher production of ROS-scavenging enzyme in plant cells could protect the integrity of such a fine intracellular structure as the cytoskeleton and each cellular compartment. We analyzed the morphological changes in root tip cells caused by the application of iso-osmotic NaCl and Na₂SO₄ solutions to tomato plants harboring an introduced superoxide dismutase gene. …”
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Photobiomodulation and Growth Factors in Dentistry: A Systematic Review by Gianna Dipalma, Angelo Michele Inchingolo, Assunta Patano, Irene Palumbo, Mariafrancesca Guglielmo, Irma Trilli, Anna Netti, Irene Ferrara, Fabio Viapiano, Alessio Danilo Inchingolo, Gianfranco Favia, Leonardo Dongiovanni, Andrea Palermo, Francesco Inchingolo, Luisa Limongelli

“…By stimulating the cellular compartment, photobiomodulation promotes cell proliferation, enabling tissue restoration after dental extractions, periodontal surgical treatments, or the management of traumatic oral injuries. …”
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Thioredoxin (Trxo1) interacts with proliferating cell nuclear antigen (PCNA) and its overexpression affects the growth of tobacco cell culture by Aingeru Calderón, Ana Ortiz-Espín, Raquel Iglesias-Fernández, Pilar Carbonero, Federico Vicente Pallardó, Francisca Sevilla, Ana Jiménez

“…Thus, very little is known about the function of Trxs in this cellular compartment. Previously, we studied the intracellular localization of PsTrxo1 and confirmed its presence in mitochondria and, interestingly, in the nucleus under standard growth conditions. …”
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Biological Barriers for Drug Delivery and Development of Innovative Therapeutic Approaches in HIV, Pancreatic Cancer, and Hemophilia A/B by Emre Basar, Henry Mead, Bennett Shum, Ingrid Rauter, Cihan Ay, Adriane Skaletz-Rorowski, Norbert H. Brockmeyer

“…Depending on a disease’s pathophysiology, the involved tissues, cell populations, and cellular components, drugs often have to overcome several biological barriers to reach their target cells and become effective in a specific cellular compartment. Human biological barriers are incredibly diverse and include multiple layers of protection and obstruction. …”
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Intracellular chloride and hydrogen ion dynamics in the nervous system by Raimondo, J

“…This process is shown to be dependent upon the level of activity of the GABAAR, the post-synaptic cells membrane potential and the cellular compartment into which the Cl- flows. These principles were extended to demonstrate that popular optogenetic strategies for silencing neural activity have different effects upon GABAAR transmission. …”