Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies by Paul Noe, Joy H. Wang, Kyu Chung, Zhiyong Cheng, Jessica J. Field, Xiaomeng Shen, Stephanie C. Casey, Christa L. Cortesio, Cinthia V. Pastuskovas, Hyewon Phee, Kristin V. Tarbell, Jackson G. Egen, Amy-Jo Casbon

“…Our results reveal a role of cDC1s in ADA generation and highlight the potential ADA challenges with targeting immunostimulatory agents to this cellular compartment.…”
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Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies by Tram M. Ta, Sajjaf Malik, Elizabeth M. Anderson, Amber D. Jones, Amber D. Jones, Jocelyn Perchik, Maryann Freylikh, Luca Sardo, Zackary A. Klase, Zackary A. Klase, Taisuke Izumi

“…Memory CD4+ T cell subsets are regarded as the predominant cellular compartment of the HIV reservoir, but monocytes and derivative macrophages or dendritic cells also play a role in the persistent virus infection. …”
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Characterization and expression analysis of MATEs in Cannabis sativa L. reveals genes involving in cannabinoid synthesis by Sifan Wang, Xue Cao, Xiangxiao Meng, Maimaiti Aili, Qin Dou, Yan Wang, Atia Tul Wahab, Shilin Chen, Wei Sun, Huihua Wan, Weiqiang Chen, Weiqiang Chen

“…MATEs could have the potential to translocate cannabinoids or their synthetic intermediates to cellular compartment, thus protecting them from unwanted modifications and cytotoxicity. …”
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The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

“…High-resolution MALDI imaging further reveals that BTZ-043 diffuses and accumulates in the cellular compartment, and fully penetrates the necrotic center. …”
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The immune response to Covid-19 mRNA vaccination among Lymphoma patients receiving anti-CD20 treatment by Edina Komlodi-Pasztor, Edina Komlodi-Pasztor, Marta Escarra-Senmarti, Danielle A. Bazer, Aastha Bhatnagar, Carlos A. Perez Heydrich, Marcus Messmer, Marcus Messmer, Richard F. Ambinder, Douglas E. Gladstone, Douglas E. Gladstone, Laura Clayton, Amy Goodrich, Laura Schoch, Nina Wagner-Johnston, Christopher J. VandenBussche, Christopher J. VandenBussche, Peng Huang, Matthias Holdhoff, Maximillian Rosario

“…We assayed for vaccine “take” in the humoral (IgG and IgA) and cellular compartment. Here, we show that short-term and long-term development of IgG and IgA antibodies directed toward COVID-19 spike protein are reduced in these patients compared to healthy controls. …”
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Elementary Growth Modes provide a molecular description of cellular self-fabrication. by Daan H de Groot, Josephus Hulshof, Bas Teusink, Frank J Bruggeman, Robert Planqué

“…The phenotype of a cell is only extended with one more EGM whenever growth becomes limited by an additional biophysical constraint, such as a limited solvent capacity of a cellular compartment. The theory presented here extends recent results on Elementary Flux Modes: the minimal building blocks of cellular growth models that lack the self-fabrication aspect. …”
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Evaluation of novel beverage formulations for hydration enhancement in humans by Tinsley Grant M., Siedler Madelin R., Rodriguez Christian, Harty Patrick S., Stratton Matthew T., White Sarah J., Keith Dale S., Green Jacob J., Boykin Jake R., Williams Abegale D., DeHaven Brielle, Brojanac Alexandra, Tinoco Ethan

“…The primary bioimpedance outcomes were phase angle at 50 kHz, resistance of the extra-cellular compartment (R0), and resistance of the intracellular compartment (Ri). …”
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Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales by Suse Seidemann, Suse Seidemann, Florian Salomon, Florian Salomon, Karl B. Hoffmann, Karl B. Hoffmann, Karl B. Hoffmann, Thomas Kurth, Ivo F. Sbalzarini, Ivo F. Sbalzarini, Ivo F. Sbalzarini, Ivo F. Sbalzarini, Ivo F. Sbalzarini, Robert Haase, Robert Haase, Marius Ader, Marius Ader

“…The functionality of photoreceptors, rods, and cones is highly dependent on their outer segments (POS), a cellular compartment containing highly organized membranous structures that generate biochemical signals from incident light. …”
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Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions by Zhou, Hufeng, Gao, Shangzhi, Nguyen, Nam Ninh, Fan, Mengyuan, Jin, Jingjing, Liu, Bing, Zhao, Liang, Xiong, Geng, Tan, Min, Li, Shijun, Wong, Limsoon

“…We compare our stringent homology-based approach to a conventional homology-based approach for predicting host-pathogen PPIs, based on cellular compartment distribution analysis, disease gene list enrichment analysis, pathway enrichment analysis and functional category enrichment analysis. …”
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Development of small-molecule reporters for fluorescence imaging of enzymes function and application by Cheong, Haolun

“…Hence, in this thesis, I had utilized the advantages of optical imaging to design various new novel and sensitive fluorescent reporter capable of visualizing selected enzyme, furin and β-lactamase that have similar catalytic activities, at the target cellular compartment. Furin is located at different organelle and each location contributed to different biological roles in the pathological condition. …”
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Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD by Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mueller, Zane Zeier

“…By deleting NPM1 sub-cellular localization signals, we found that PR binds NPM1 regardless of the cellular compartment to which NPM1 was directed. Deletion of the NPM1 acidic loop motif, known to engage other arginine-rich proteins, abrogated PR and NPM1 binding. …”
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SCGN deficiency results in colitis susceptibility by Luis F Sifuentes-Dominguez, Haiying Li, Ernesto Llano, Zhe Liu, Amika Singla, Ashish S Patel, Mahesh Kathania, Areen Khoury, Nicholas Norris, Jonathan J Rios, Petro Starokadomskyy, Jason Y Park, Purva Gopal, Qi Liu, Shuai Tan, Lillienne Chan, Theodora Ross, Steven Harrison, K Venuprasad, Linda A Baker, Da Jia, Ezra Burstein

“…Altogether, these studies demonstrate that functional deficiency in SCGN can result in intestinal inflammation and implicates the neuroendocrine cellular compartment in IBD.…”
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Structure, Function and Regulation of the Hsp90 Machinery by Jing Li, Johannes Buchner

Subjects: “…while Hsp90β is constitutively expressed. [13] Hsp90 analogues also exist in other cellular compartments such as Grp94 in the endoplasmic reticulum…”
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Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation by Kevin Baßler, Wataru Fujii, Theodore S. Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D. Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Lorenzo Bonaguro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Rainer Knoll, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Charlotte Kröger, Elena De Domenico, Elena De Domenico, Matthias Becker, Matthias Becker, Kristian Händler, Kristian Händler, Christian T. Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Heidi Theis, Michael Kraut, Michael Kraut, Marc H. Wadsworth, Marc H. Wadsworth, Travis K. Hughes, Humberto J. Ferreira, Emily Hinkley, Emily Hinkley, Ines H. Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K. Shalek, Alex K. Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Marc Beyer, Marc Beyer, Patrick Baum, Nir Yosef, Nir Yosef, Nir Yosef, Nir Yosef, Anna C. Aschenbrenner, Anna C. Aschenbrenner, Anna C. Aschenbrenner, Thomas Ulas, Thomas Ulas, Thomas Ulas, Jan Hasenauer, Jan Hasenauer, Fabian J. Theis, Fabian J. Theis, Dirk Skowasch, Joachim L. Schultze, Joachim L. Schultze, Joachim L. Schultze

“…Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. …”
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Bioinformatics as a Tool for Assessing the Quality of Sub-Cellular Proteomic Strategies and Inferring Functions of Proteins: Plant Cell Wall Proteomics as a Test Case by Hélène San Clemente, Rafael Pont-Lezica, Elisabeth Jamet

“…Bioinformatics is used at three different steps of proteomic studies of sub-cellular compartments. First one is protein identification from mass spectrometry data. …”
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Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine by Ioana Alesutan, Katharina Musculus, Tatsiana Castor, Kousi Alzoubi, Jakob Voelkl, Florian Lang

“…Known effects of NH4Cl include alkalinization of acidic cellular compartments. The present study explored whether osteo-/chondrogenic signaling could be influenced by alkalinization of acidic cellular compartments following inhibition of the vacuolar H+ ATPase with bafilomycin A1 or following dissipation of the pH gradient across the membranes of acidic cellular compartments with methylamine. …”
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Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection. by Kamal L Nahas, Viv Connor, Katharina M Scherer, Clemens F Kaminski, Maria Harkiolaki, Colin M Crump, Stephen C Graham

“…Herpes simplex virus-1 (HSV-1) is a large, enveloped DNA virus and its assembly in the cell is a complex multi-step process during which viral particles interact with numerous cellular compartments such as the nucleus and organelles of the secretory pathway. …”
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Reading the Evolution of Compartmentalization in the Ribosome Assembly Toolbox: The YRG Protein Family. by Pablo Mier, Antonio J Pérez-Pulido, Emmanuel G Reynaud, Miguel A Andrade-Navarro

“…Here, we propose the use of molecular markers specific to cellular compartments to set up a framework to advance the understanding of this complex intracellular process. …”
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When fixation creates fiction by Judith Miné-Hattab

“…A chemical regularly used to image cells can dramatically alter the way cellular compartments called condensates look under the microscope.…”
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Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology by Sarah Aldosari, Maan Awad, Elizabeth O. Harrington, Frank W. Sellke, M. Ruhul Abid

“…Recent studies have shown that interaction between ROS in different sub-cellular compartments plays a crucial role in determining the outcomes (beneficial vs. deleterious) of ROS exposures on the vascular system. …”
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