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Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal ultrasound imaging (part 1): nomenclature, diagnostic accuracy and associated anomalies
Published 2016“…Only isolated cases of posterior fossa anomalies – defined as having no cerebral or extracerebral additional anomalies detected on ultrasound examination – were included in the analysis. …”
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22
Machine learning based feature extraction from EEG signals for brain-computer interface
Published 2018“…The EEG signal is a testing record which is utilized to reflect the electrical activity of brain cells in the cerebral cortex. By analyzing and transferring EEG signals to computer with BCI, brain activity can be translated and interpreted into instructions and commands for computer. …”
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Final Year Project (FYP) -
23
Inflammatory biomarkers and motoric cognitive risk syndrome: multicohort survey
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Journal Article -
24
Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer
Published 2024“…Here, we model this ecosystem by growing glioblastoma into long-term cultured human cortical organoids that contain the major neuroglial cell types found in the cerebral cortex. Single-cell RNA-seq analysis suggests that, compared to matched gliomasphere models, glioblastoma cortical organoids (GCO) more faithfully recapitulate the diversity and expression programs of malignant cell states found in patient tumors. …”
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25
Specific maternal brain responses to their own child’s face : an fMRI meta-analysis
Published 2019“…Viewing their own child is associated with enhanced cerebral activation in cortical and subcortical regions including the midbrain, amygdala, striatum, ventrolateral prefrontal cortex, and insula. …”
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Journal Article -
26
Using surface markers to describe the kinematics of the medial longitudinal arch in a longitudinal study of flexible flat feet and health-related quality of life
Published 2023“…Initially, it was applied to participants with cerebral palsy, to observe if it could characterise the MLA in feet with complex deformity and variable walking patterns. …”
Thesis -
27
CT perfusion for lesion-symptom mapping in large vessel occlusion ischemic stroke
Published 2024“…Time to maximal contrast (Tmax) prolongation was defined as >6 s, and penumbra as the difference between Tmax and ischemic core (relative cerebral blood flow<30%). Voxel-lesion-symptom mapping was performed using sparse canonical correlation analysis. …”
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28
Dynamic B0 field shimming for improving pseudo-continuous arterial spin labeling at 7 Tesla
Published 2024“…We evaluated both 2D and 3D variants of our method, comparing their performance against the established global frequency offset and optimal encoding scheme (OES)-based corrections. Cerebral blood flow (CBF) maps were quantified before and after corrections, and CBF values from different methods were compared across the whole brain, white matter, and grey matter regions. …”
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29
Edible bird’s nest mitigates histological alterations in the cortexes of rats’ brains subjected to lead toxicity
Published 2024“…The objective of this research was to evaluate EBN’s neuroprotective role on the cerebral and cerebellar cortexes of lead acetate-exposed adult female rats. …”
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30
Improved virtual keyboard design for P300-based brain-computer interface
Published 2009“…Amyotrophic lateral sclerosis (ALS), brainstem stroke, brain or spinal cord injury, cerebral palsy, muscular dystrophies, multiple sclerosis, and numerous other diseases impair the neural pathways that control muscles or impair the muscles themselves. …”
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Final Year Project (FYP) -
31
Neural and psychological correlates of stuttering
Published 2025“…In the second study, we investigated the incomplete cerebral dominance theory by analysing data from the same fMRI studies in four different speech and language tasks. …”
Thesis -
32
Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia
Published 2022“…This study thus aims to investigate the DNA methylation landscape in a chronic cerebral hypoperfusion (CCH) mouse model of VaD. As a nexus between the gene-environment interaction, intermittent fasting (IF) was introduced as a prophylactic intervention. …”
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Journal Article -
33
The role of p53 and ASPP2 in neurodegenerative disease
Published 2015“…Also, LPS induces nuclear ASPP2 <em>in vivo</em> at the blood-cerebral spinal fluid-barrier (BCSFB), the brain's barrier to inflammation. …”
Thesis -
34
Feature extraction from EEG signals and regularization for brain-computer interface
Published 2020“…The main motivation behind MI-BCI is to improve life of people with different neuromuscular disorders such as amyotrophic lateral sclerosis, cerebral palsy, stroke, or spinal cord injury, as well as to help them with rehabilitation. …”
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Thesis-Doctor of Philosophy -
35
The effect of the amyloid-beta peptide on the fluidity of cell membranes : a study by fluorescence correlation spectroscopy
Published 2017“…One of the key factors thought lead to AD is the aggregation of the amyloid-beta (Aβ) in susceptible brain regions, namely the cerebral cortex and hippocampus. Aβ is thought to interact with the cell membrane, perturbing its structure and organization, thus changing the fluidity and normal function of the cell membrane, leading to detrimental effects on the cells. …”
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Thesis -
36
Transcriptome analysis of ischemic stroke recovery induced by neural stem cell preconditioned with baicalein-enriched fraction of oroxylum indicum
Published 2024“…A total of 15 Sprague-Dawley (SD) rats were injected with endothelin-1 (ET-1) to occlude the middle cerebral artery (MCA) blood vessel inside the brain, mimicking the ischemic stroke disease in human. …”
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Thesis -
37
Biomarkers and cognition study, Singapore (BIOCIS): protocol, study design, and preliminary findings
Published 2024“…Mean age and education is 61.32 years and 14.34 years respectively with 39.8% males. 47.9 % of the cohort are employed and 32.06% have a family history of dementia. The prevalence of cerebral small vessel disease is 90.2% with a mean modified Fazekas white matter hyperintensity score of 4.1. …”
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Journal Article