Physiologically based modelling of cerebral autoregulation by Wang, Y

“…<p>The human brain requires sufficient and continuous blood supply to maintain healthy function. Cerebral autoregulation (CA), a highly complex mechanism, plays a crucial role in achieving this function. …”

Modeling the mechanisms of non-neurogenic dynamic cerebral autoregulation by van Zijl, N, Banerjee, A, Payne, SJ

“…Objective: Dynamic cerebral autoregulation (dCA) refers to a collection of mechanisms that act to maintain steady state cerebral blood flow (CBF) near constant despite changes in arterial blood pressure (ABP), but which is known to become impaired in various cerebrovascular diseases. …”

Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis by Kioko, M, Mwangi, S, Njunge, JM, Berkley, JA, Bejon, P, Abdi, AI

“…However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. …”

The chronic cerebral hypoperfusion model induces proinflammatory cascades in Alzheimer's disease by Abedi, Zahra, Basri, Hamidon, Hassan, Zurina, Inche Mat, Liyana Najwa, Khaza’ai, Huzwah, Mohd Ali, Razana

“…Cerebral neuroinflammation has emerged as a significant pathway contributing to the progression of Alzheimer's disease (AD) pathology. …”
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Lower serum uric acid and impairment of right cerebral hemisphere structural brain networks are related to depressive symptoms in cerebral small vessel disease: a cross-sectional study by Yu, Lei, Yi, Ming, Guo, Jiayu, Li, Jinbiao, Zeng, Huixing, Cui, Liqian, Xu, Xiangming, Liu, Gang, Fan, Yuhua, Zeng, Jinsheng, Xing, Shihui, Chen, Yicong, Wang, Meng, Tan, Shuangquan, Jin, Leow Yi, Kumar, Dilip, Vipin, Ashwati, Ann, Soo See, Fatin Zahra Binte Zailan, Sandhu, Gurveen Kaur, Kandiah, Nagaendran, Dang, Chao

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Automated detection of cerebral microbleeds on MR images using knowledge distillation framework by Sundaresan, V, Arthofer, C, Zamboni, G, Murchison, AG, Dineen, RA, Rothwell, PM, Auer, DP, Wang, C, Miller, KL, Tendler, BC, Alfaro-Almagro, F, Sotiropoulos, SN, Sprigg, N, Griffanti, L, Jenkinson, M

“…<p><b>Introduction:</b> Cerebral microbleeds (CMBs) are associated with white matter damage, and various neurodegenerative and cerebrovascular diseases. …”

Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow by Sun, J, Zelaya, F, Sendt, K, McQueen, G, Gillespie, AL, Lally, J, Howes, OD, Barker, GJ, McGuire, P, MacCabe, JH, Egerton, A

“…PET and SPECT studies in treatment-resistant schizophrenia (TRS) have revealed significant alterations in regional cerebral blood flow (CBF) during clozapine treatment, which may vary according to the clinical response. …”

HELMET: a hybrid machine learning framework for real-time prediction of edema trajectory in large middle cerebral artery stroke by Phillips, E, O'Donoghue, O, Zhang, Y, Tsimpos, P, Mallinger, LA, Chatzidakis, S, Pohlmann, J, Du, Y, Kim, I, Song, J, Brush, B, Smirnakis, S, Ong, CJ, Orfanoudaki, A

“…Malignant cerebral edema occurs when brain swelling displaces and compresses vital midline structures within the first week of a large middle cerebral artery stroke. …”

Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory by Faizy, TD, Yedavalli, V, Salim, HA, Lakhani, DA, Musmar, B, Adeeb, N, Essibayi, MA, Daraghma, M, El Naamani, K, Henninger, N, Sundararajan, SH, Kuhn, AL, Khalife, J, Ghozy, S, Scarcia, L, Yeo, LL, Tan, BY, Regenhardt, RW, Heit, JJ, Cancelliere, NM, Rouchaud, A, Fiehler, J, Sheth, SA, Puri, AS, Dmytriw, AA

“…Only patients with occlusion of the distal branches (M2 and M3) of the middle cerebral artery territory were included. Unsuccessful MT was defined as a modified Thrombolysis in Cerebral Infarction score of 0–2a. …”

Population-specific adaptation in malaria-endemic regions of Asia by Gusareva, Elena S., Lorenzini, Paolo Alberto, Nurul Adilah Ramli, Ghosh, Amit Gourav, Kim, Hie Lim

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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol by Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

“…The primary endpoint will be change in cerebral glucose uptake, measured using [18F]FDG positron emission tomography. …”
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G-induced loss of consciousness for fighter pilots by Foo, Jonathan Zhi Bao.

“…Using data from Model 6, the relationship between cerebral blood flow and the G-load factor could be established.…”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. …”
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Auditory to Visual Cross-Modal Adaptation for Emotion: Psychophysical and Neural Correlates by Wang, Xiaodong, Guo, Xiaotao, Chen, Lin, Liu, Yijun, Goldberg, Michael E., Xu, Hong

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Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…The main argument for the FDA approvals is a presumed therapy-induced removal of cerebral amyloid deposits. Lecanemab and donanemab are also thought to cause some statistical delay in the determination of cognitive decline. …”
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REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells by Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…In this study, we identified and investigated the role of REST-target genes in human brain tissues, cerebral organoids, and neural cells in Down syndrome. …”
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Telerobotic neurovascular interventions with magnetic manipulation by Kim, Yoonho, Genevriere, Emily, Harker, Pablo, Choe, Jaehun, Balicki, Marcin, Regenhardt, Robert W, Vranic, Justin E, Dmytriw, Adam A, Patel, Aman B, Zhao, Xuanhe

“…We further demonstrate telerobotically assisted therapeutic procedures including coil embolization and clot retrieval thrombectomy for treating cerebral aneurysms and ischemic stroke, respectively. …”
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Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…Instead, higher plasma choline was significantly associated with poor cognition (adjusted mean difference: -0.170 [95% confidence interval (CI) -0.297;-0.043]), brain atrophy and more markers of cerebral small vessel disease, such as white matter hyperintensity volume (0.237 [95% CI: 0.076;0.397]). …”

Predictive modeling of g-induced loss of consciousness for entertainment theme parks by Hariharan Anushya.

“…This in turn causes low oxygen consumption by the brain finally resulting in brain ischemia. Hence the cerebral blood flow is an important parameter in the prediction of G-LOC.…”
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The effects of fasting on acute ischemic infarcts in the rat by Schneider, AM, Buchan, AM, Couch, Y

“…These findings suggest that fasting may be a beneficial non-pharmacological additive therapeutic option for cerebral ischemia, potentially by reducing inflammation in the acute stage of the disease.…”