Identification of Laboratory Biomarkers for Early Detection and Clinical Management of Post-Acute Syndrome Among Survivors of the 2013–2016 West Africa Ebola Outbreak in Sier... by Guetiya Wadoum RE, Sevalie S, Baimba Kargbo M, Clarke A, Bangura S, Kargbo M, Sesay HM, Kamara AH, Bangura J, Kamara AF, Allieu S, Rogers H, Mattei M, Colizzi V, Montesano C, Momoh EJJ

“…Finally, there was a significant (p < 0.05) association between hematological (Hb, PCV, MCV, MCH), biochemical (ALT, CREA, C-kinase, T-cholesterol, triglycerides) parameters and the risk of developing severe complications.Conclusion: We recommend clinicians closely monitor Hb, PCV, MCV, MCH, ALT, CREA, C-kinase, T-cholesterol, triglycerides and lymphocytes as clinically relevant laboratory biomarkers to identify survivors at higher risk of developing severe post-acute syndrome upon discharge from Ebola treatment unit including headache, abdominal pain, chest pain, ocular complication, arthralgia, hearing difficulty and erectile dysfunction which can impact health-related quality of life among Ebola survivors.Keywords: Ebola virus disease, hematological, immunological, biochemical, biomarkers, post-acute syndrome…”
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A Machine-Learning Model for the Prognostic Role of C-Reactive Protein in Myocarditis by Anna Baritussio, Chun-yan Cheng, Giulia Lorenzoni, Cristina Basso, Stefania Rizzo, Monica De Gaspari, Francesco Fachin, Andrea Silvio Giordani, Honoria Ocagli, Elena Pontara, Maria Grazia Peloso Cattini, Elisa Bison, Nicoletta Gallo, Mario Plebani, Giuseppe Tarantini, Sabino Iliceto, Dario Gregori, Renzo Marcolongo, Alida Linda Patrizia Caforio

“…Abnormal CRP was reported in 288 patients, mainly with CS myocarditis (<i>p</i> < 0.001), recent viral infection, shorter symptoms duration (<i>p</i> = 0.001), chest pain (<i>p</i> < 0.001), better functional class at diagnosis (<i>p</i> = 0.018) and higher troponin I values (<i>p</i> < 0.001). …”
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Predictors of Long COVID in Patients without Comorbidities: Data from the Polish Long-COVID Cardiovascular (PoLoCOV-CVD) Study by Michał Chudzik, Joanna Lewek, Joanna Kapusta, Maciej Banach, Piotr Jankowski, Agata Bielecka-Dabrowa

“…The LC group also had significantly more symptoms during the acute phase of COVID-19, and they suffered significantly more often from dyspnoea (48 vs. 33%), fatigue (72 vs. 63%), chest pain (50 vs. 36%), leg muscle pain (41 vs. 32%), headache (66 vs. 52%), arthralgia (44 vs. 25%), and chills (34 vs. 25%). …”
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Extended radical resection and chest wall reconstruction for a pulmonary sarcomatoid carcinoma: a case report by Yingzhi Zhao, Shaohua Xie, Haoqian Zheng, Kaixin Zhang, Xin Gao, Wenwu Liu, Wei Dai, Hongfan Yu, Qiuling Shi, Bin Hu, Qiang Li, Tianpeng Xie, Xing Wei

“…Case presentation A 58-year-old male patient with a nodule in the right upper lobe that had been identified on physical examination 2 years before presentation presented to our hospital with a recent cough, expectoration, and chest pain. Imaging revealed a mass in the right upper lobe that had invaded the chest wall. …”
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Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative... by Omar Yaxmehen Bello-Chavolla, Carlos A. Fermín-Martínez, Daniel Ramírez-García, Arsenio Vargas-Vázquez, Luisa Fernández-Chirino, Martín Roberto Basile-Alvarez, Paulina Sánchez-Castro, Alejandra Núñez-Luna, Neftali Eduardo Antonio-Villa

“…The most common persistent symptoms were fatigue, musculoskeletal pain, headache, cough, loss of smell or taste, fever, post-exertional malaise, brain fog, anxiety, and chest pain. PASC was present in 21.21% (95% CI 19.74–22.68) of subjects with previously diagnosed COVID-19. …”
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Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID by Kazuki Tokumasu, Hiroyuki Honda, Naruhiko Sunada, Yasue Sakurada, Yui Matsuda, Koichiro Yamamoto, Yasuhiro Nakano, Toru Hasegawa, Yukichika Yamamoto, Yuki Otsuka, Hideharu Hagiya, Hitomi Kataoka, Keigo Ueda, Fumio Otsuka

“…The most frequent symptoms in ME/CFS patients were general fatigue and post-exertional malaise (89.4% of the patients), headache (34.0%), insomnia (23.4%), dysosmia (21.3%) and dysgeusia (19.1%). Dizziness, chest pain, insomnia and headache were characteristic symptoms related to ME/CFS. …”
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POST-COVID-19-syndrome in young healthy women: myth or reality? by Tatiana E. Belokrinitskaya, Nataly I. Frolova, Viktor A. Mudrov, Kristina A. Kargina, Evgeniya A. Shametova, Chimita Tch. Zhamyanova, Shakhnozakhon R. Osmonova

“…Only patients with COVID-19 reported cough (43.6%), shortness of breath (26.5%), chest pain (18.2%), weight loss (18.8%), hair loss (60.8%); in the comparison group, these symptoms were not reported; p20.001. …”
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Clinical Observation of Dingxiang Guanshitong Hanhua Pills Alone and Its Combination with Fugui Guanshitong Granules in the Treatment of Advanced Esophageal Cancer by ZHENG Yuling, ZHANG Yaling, LIU Huaimin, XU Yanchao, JIA Xiaolin, LI Junsai, HE Wenlong, TONG Xinduo, QIN Shanwen, ZHANG Lihan

“…The survival rate after 6 weeks of treatment, Quality of Life (QOL) score, Karnofsky Performance Status (KPS) score, TCM syndrome score (dysphagia, poststernal chest pain, mucus vomiting, loss of appetite, fatigue) before and after treatment of the three groups were compared, and safety evaluation was conducted. …”
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A New Clinical Prediction Rule for Infective Endocarditis in Emergency Department Patients With Fever: Definition and First Validation of the CREED Score by Marcello Covino, Antonio De Vita, Alessia d'Aiello, Salvatore Emanuele Ravenna, Aureliano Ruggio, Lorenzo Genuardi, Benedetta Simeoni, Andrea Piccioni, Giuseppe De Matteis, Rita Murri, Antonio Maria Leone, Andrea Flex, Antonio Gasbarrini, Giovanna Liuzzo, Massimo Massetti, Francesco Franceschi

“…The CREED score included 12 variables: male sex, anemia, dialysis, pacemaker, recent hospitalization, recent stroke, chest pain, specific infective diagnosis, valvular heart disease, valvular prosthesis, previous endocarditis, and clinical signs of suspect endocarditis. …”
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Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong by Gilbert T. Chua, Sabrina Tsao, Mike Yat Wah Kwan, Tak Ching Yu, Agnes Sze Yin Leung, Ka Wah Li, Calvin Chit Kwong Chow, Wai Hung Ku, Janette Kwok, Kelvin K. W. To, Yu Lung Lau, Francisco Tsz Tsun Lai, Ian Chi Kei Wong, Patrick Ip

“…After discharge, 10 patients (35.7%) reported symptoms, including occasional chest pain, shortness of breath, reduced exercise tolerance, and recurrent vasovagal near-syncope. …”
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A machine learning model for diagnosing acute pulmonary embolism and comparison with Wells score, revised Geneva score, and Years algorithm by Linfeng Xi, Han Kang, Mei Deng, Wenqing Xu, Feiya Xu, Qian Gao, Wanmu Xie, Rongguo Zhang, Min Liu, Zhenguo Zhai, Chen Wang, Xiangxiang Pan, Peifang Wei

“…The ML models were constructed using eight clinical features, including D-dimer, cardiac troponin T (cTNT), arterial oxygen saturation, heart rate, chest pain, lower limb pain, hemoptysis, and chronic heart failure. …”
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Predictive Factors of Mortality in Patients with Severe COVID-19 Treated in the Intensive Care Unit: A Single-Center Study in Vietnam by Sy Duong-Quy, Duc Huynh-Truong-Anh, Thanh Nguyen-Thi-Kim, Tien Nguyen-Quang, Thuy Tran-Ngoc-Anh, Nam Nguyen-Van-Hoai, Mai Do-Thi-Thu, Thanh Nguyen-Chi, Toi Nguyen-Van, Tram Tang-Thi-Thao, Anh Nguyen-Tuan, Quan Nguyen-Hoang, Phung Hoang-Phi-Tuyet, Giap Vu-Van, Hieu Nguyen-Lan, Chuong Nguyen-Hong, Sy Dinh-Ngoc, Dung Truong-Viet, Vinh Nguyen-Nhu, Thai Nguyen-Duy

“…Results Common clinical symptoms of severe and critical COVID-19 included shortness of breath (97.4%), fatigue (89.4%), cough (76.8%), chest pain (47.7%), loss of smell (48.3%), loss of taste (39.1%), and headache (21.2%). …”
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Impact of cardiorespiratory rehabilitation program on submaximal exercise capacity of Tunisian male patients with post-COVID19: A pilot study by Emna Toulgui, Wafa Benzarti, Chiraz Rahmani, Sana Aissa, Ines Ghannouchi, Asma Knaz, Amani Sayhi, Sana Sellami, Khaoula Mahmoudi, Sonia Jemni, Imene Gargouri, Abdelaziz Hayouni, Walid Ouanes, Achraf Ammar, Achraf Ammar, Achraf Ammar, Helmi Ben saad

“…Post-COVID19 patients suffer from persistent respiratory, cardiovascular, neurological, and musculoskeletal health complaints such as dyspnea, chest pain/discomfort, and fatigue. In Tunisia, the potential benefits of a cardiorespiratory rehabilitation program (CRRP) after COVID19 remain unclear. …”
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Spontaneous Pneumomediastinum: Hamman Syndrome by Tushank Chadha, BS, Ethan Kunstadt, MD

“…Macklin and Macklin were the first to note the pathogenesis of the syndrome and explained that the common denominator to spontaneous pneumomediastinum was that increased alveolar pressure leads to alveolar rupture.3 Common clinical findings for spontaneous pneumomediastinum include: chest pain, dyspnea, cough, and emesis.4 The condition is not always readily recognized on initial presentation in part for its rare incidence, estimated to be approximately 1 in every 44,500 ED patients3and also because of the non-specific presenting symptoms. …”
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Description of a new clinical syndrome: thoracic constriction without evidence of the typical funnel-shaped depression—the "invisible" pectus excavatum by Anna Hohneck, Uzair Ansari, Michèle Natale, Karsten Wittig, Daniel Overhoff, Philipp Riffel, Michael Boettcher, Ibrahim Akin, Daniel Duerschmied, Theano Papavassiliu

“…The most common symptoms at presentation were palpitations (41%), followed by dyspnea (24%) and atypical chest pain (14%). Three patients (3%) had atrial fibrillation or atrial flutter. …”
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Influenza pandêmica A (H1N1) 2009: fatores de risco para o internamento Pandemic influenza A (H1N1) 2009: risk factors for hospitalization by Luana Lenzi, Ângela Maron de Mello, Lineu Roberto da Silva, Mônica Holtz Cavichiolo Grochocki, Roberto Pontarolo

“…The risk factors for hospitalization were age (20-29 years), African or Indigenous ethnicity, presence of specific comorbidities (heart disease, lung disease, kidney disease, hemoglobinopathy, immunosuppression, diabetes, obesity, puerperium, and smoking), a high number of comorbidities, and specific symptoms (dyspnea, diarrhea, vomiting, chest pain, hemoptysis, pneumonia, and wheezing). Higher levels of education and early use of oseltamivir were found to be protective factors. …”
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Mean Platelet Volume as a Predictor of Coronary Artery Disease Severity and its Association With Coronary Artery Calcification by Itshak Amsalem MD, Elad Asher MD, MHA, FESC, Inbar Blaufeld BMSc, Rafael Hitter MD, Nir Levi MD, Louay Taha MD, Fauzi Fadi Shaheen MD, Hani Karameh MD, MRCP, Tomer Maller MD, Nimrod Perel MD, Yoed Steinmetz MD, Mohammad Karmi MD, Kamal Hamayel MD, Mohammed Manassra MD, Talya Wolak MD, Michael Glikson MD, FACC, FESC, Arik Wolak MD

“…Only patients evaluated for chest pain were included. The Multi-Ethnic Study of Atherosclerosis (MESA) CAC calculator was used to categorize patients CCS by age, gender, and ethnicity to CAC severity percentiles (<50, 50-74, 75-89, ≥90). …”
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Evolocumab attenuate pericoronary adipose tissue density via reduction of lipoprotein(a) in type 2 diabetes mellitus: a serial follow-up CCTA study by Meng-Meng Yu, Xin Zhao, Yin-Yin Chen, Xin-Wei Tao, Jun-Bo Ge, Hang Jin, Meng-Su Zeng

“…Results A total of 170 T2DM patients with stable chest pain were included [(mean age 64 ± 10.6 [range 40–85] years; 131 men). …”
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Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice by Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu, Chang Ma, Sjaak Philipsen, Qunye Zhang, Jianmin Yang, Feng Xu, Cheng Zhang, Yun Zhang, Wencheng Zhang

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High-Sensitivity Cardiac Troponin T and the Diagnosis of Cardiovascular Disease in the Emergency Room: The Importance of Combining Cardiovascular Biomarkers with Clinical Data by Michele Golino, Jacopo Marazzato, Federico Blasi, Matteo Morello, Valentina Chierchia, Cristina Cadonati, Federica Matteo, Claudio Licciardello, Martina Zappa, Walter Ageno, Alberto Passi, Fabio Angeli, Roberto De Ponti

“…On the other hand, only chest pain (OR: 22.91, 95% CI: 3.97–132.32, <i>p</i> < 0.01) and eGFR (OR: 1.04, 95% CI: 1.004–1.083, <i>p</i> = 0.03) were associated with the ACS diagnosis. …”
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