Prospective Evaluation of Quality of Life and Functional Outcomes after Carbon Ion Radiotherapy for Inoperable Bone and Soft Tissue Sarcomas by Shuichiro Komatsu, Masahiko Okamoto, Shintaro Shiba, Takuya Kaminuma, Shohei Okazaki, Hiroki Kiyohara, Takashi Yanagawa, Takashi Nakano, Tatsuya Ohno

“…The main site of primary disease was the pelvis (70.5%), and the most common pathologic diagnosis was chordoma (45.9%). The 3-year overall survival and local control rates were 87.8% and 83.8%, respectively. …”
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Acinic cell carcinoma of parotid gland metastasis to left cavernous sinus: a case report and review of literature by Xiao-yan LIN, Ying-hua SONG, Jia-yao WANG

“…This case was difficult to differentiate from other primary intracalvarium tumors, including papillary meningioma, papillary tumor of choroid plexus, papillary ependymoma, papillary glioneuronal tumors as well as chordoma. According to the medical history and the comparison of histomorphology and immunophenotyping between parotid gland tumor cells and left cavernous sinus tumor cells, the final diagnosis was metastatic papillary parotid acinar cell carcinoma of the left cavernous sinus. …”
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Diagnostics of <i>IDH1/2</i> Mutations in Intracranial Chondroid Tumors: Comparison of Molecular Genetic Methods and Immunohistochemistry by Vyacheslav Varachev, Anastasia Shekhtman, Dmitrii Guskov, Dmitrii Rogozhin, Alexander Zasedatelev, Tatiana Nasedkina

“…The detection of <i>IDH1</i> mutations in chordoma (2/15) and osteosarcoma (2/7) suggested the need for a revised diagnosis. …”
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Quantitative proteomic studies addressing unmet clinical needs in sarcoma by Elizabeth A. Connolly, Elizabeth A. Connolly, Peter S. Grimison, Peter S. Grimison, Lisa G. Horvath, Lisa G. Horvath, Phillip J. Robinson, Roger R. Reddel

“…These studies traverse a range of histological subtypes including chordoma, Ewing sarcoma, gastrointestinal stromal tumors, leiomyosarcoma, liposarcoma, malignant peripheral nerve sheath tumors, myxofibrosarcoma, rhabdomyosarcoma, synovial sarcoma, osteosarcoma, and undifferentiated pleomorphic sarcoma. …”
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Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy by A. Muscato, A. Muscato, A. Muscato, L. Arsini, L. Arsini, G. Battistoni, L. Campana, D. Carlotti, D. Carlotti, F. De Felice, A. De Gregorio, A. De Gregorio, M. De Simoni, M. De Simoni, C. Di Felice, Y. Dong, G. Franciosini, G. Franciosini, M. Marafini, M. Marafini, I. Mattei, R. Mirabelli, R. Mirabelli, S. Muraro, M. Pacilio, L. Palumbo, L. Palumbo, V. Patera, V. Patera, A. Schiavi, A. Schiavi, A. Sciubba, A. Sciubba, M. Schwarz, S. Sorbino, V. Tombolini, M. Toppi, M. Toppi, G. Traini, A. Trigilio, A. Trigilio, A. Sarti, A. Sarti

“…In this paper, the case of two patients affected by a chordoma and a meningioma, respectively, treated with protons in Trento (IT) is presented. …”
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Large-Scale assessment of ChatGPT's performance in benign and malignant bone tumors imaging report diagnosis and its potential for clinical applications by Fan Yang, Dong Yan, Zhixiang Wang

“…Four cases of spinal chordoma were misdiagnosed as spinal tuberculosis. …”
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Endoscopic endonasal approaches to the skull base tumors: minimally-invasive approach with achievement of radicality. Our experience by Orest I. Palamar, Andriy P. Huk, Ruslan V. Aksyonov, Dmytro I. Okonskyi, Dmytro S. Teslenko

“…Tumor location and pathology: tumors in pterygopalatine fossa (paraganglioma, carcinoma, neurilemmoma, neurofibroma, chondrosarcoma) — 10 (25.6 %), pituitary adenomas with sphenoid sinus and/or parasellar extension — 14 (35.9 %), sphenoid sinus tumors (carcinoma, neurilemmoma, fibrous dysplasia, angiofibroma, esthesioneuroblastoma) — 8 (20.5 %), petroclival tumors — 6 (15.4 %): hemangiopericytoma — 1, clival tumors — 5 (chordoma), sella turcica lesion with posterior clinoid recess extension (osteoma) – 1 (2.5 %). …”
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Receptor Tyrosine Kinase Inhibitors for the Treatment of Recurrent and Unresectable Bone Sarcomas by Víctor Albarrán, María Luisa Villamayor, Jesús Chamorro, Diana Isabel Rosero, Javier Pozas, María San Román, Juan Carlos Calvo, Patricia Pérez de Aguado, Jaime Moreno, Patricia Guerrero, Carlos González, Coral García de Quevedo, Pablo Álvarez-Ballesteros, María Ángeles Vaz

“…Although the development of TKIs for other primary bone tumors is less advanced, preclinical data and early trials have begun to show their potential benefit in advanced Ewing sarcoma (ES) and rarer bone tumors (chondrosarcoma, chordoma, giant cell tumor of bone, and undifferentiated pleomorphic sarcoma). …”
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A novel three dimensional-printed biomechanically evaluated patient-specific sacral implant in spinopelvic reconstruction after total en bloc sacrectomy by Zhaorui Lv, Zhaorui Lv, Jianmin Li, Zhiping Yang, Xin Li, Qiang Yang, Zhenfeng Li

“…There were 7 cases of chordoma, 3 cases of osteosarcoma, 1 case of chondrosarcoma and 1 case of undifferentiated pleomorphic sarcoma. …”
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Thoracoabdominal Aortic Replacement Together with Curative Oncological Surgery in Retroperitoneal and Spinal Tumours by Brigitta M. Lutz, Klaus-Dieter Schaser, Jurgen Weitz, Johanna Kirchberg, Hagen Fritzsche, Alexander C. Disch, Albert Busch, Steffen Wolk, Christian Reeps

“…Five consecutive patients were enrolled between 2016 and 2020, suffering from cancer of unknown primary, pleomorphic carcinoma, chordoma, rhabdoid sarcoma, and endometrial cancer metastasis. …”
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Hearing Loss in Cancer Patients with Skull Base Tumors Undergoing Pencil Beam Scanning Proton Therapy: A Retrospective Cohort Study by Barbara Bachtiary, Dorothe Veraguth, Nicolaas Roos, Flurin Pfiffner, Dominic Leiser, Alessia Pica, Marc Walser, Stefanie von Felten, Damien C. Weber

“…Included patients were treated for chordoma (n = 24), chondrosarcoma (n = 9), head and neck tumors (n = 9), or meningioma (n = 3), with a mean tumor dose of 71.1 Gy (RBE) (range, 52.0–77.8), and a mean dose of 37 Gy (RBE) (range, 0.0–72.7) was delivered to the cochleas. …”
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Effects of nuclear interaction corrections and trichrome fragment spectra modelling on dose and linear energy transfer distributions in carbon ion radiotherapy by Alessia Bazani, Jacob Brunner, Stefania Russo, Antonio Carlino, Daniel Simon Colomar, Walter Ikegami Andersson, Mario Ciocca, Markus Stock, Piero Fossati, Ester Orlandi, Lars Glimelius, Silvia Molinelli, Barbara Knäusl

“…Four treatment sites were analysed: six prostate adenocarcinoma, ten head and neck, nine locally advanced pancreatic adenocarcinoma and five sacral chordoma. The FLUKA and clinical plans were compared in terms of DRBE deviations for D98%, D50%, D2% for the clinical target volume (CTV) and D50% in ring-like dose regions retrieved from isodose curves in base RS plans. …”
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Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis by Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou, Xiaohu Wang

“…Of the 897 BSs patients who received carbon ion radiotherapy in the studies, 526 patients had chordoma, 255 patients had chondrosarcoma, 112 patients had osteosarcoma, and 4 patients had other sarcomas. …”
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Initial clinical applications treating pediatric and adolescent patients using MR-guided radiotherapy by Margaret M. Kozak, David Crompton, Brandie A. Gross, Lyndsay Harshman, David Dickens, Jeffrey Snyder, Andrew Shepard, Joël St-Aubin, David Dunkerley, Daniel Hyer, John M. Buatti

“…The clinical applications of MRgRT included Wilms tumor with unresectable IVC thrombus (n=1), Ewing sarcoma (primary and metastatic, n=3), recurrent diffuse intrinsic pontine glioma (DIPG, n=2), nasopharyngeal carcinoma (n=1), clival chordoma (n=1), primitive neuroectodermal tumor of the pancreas (n=1), recurrent gluteo-sacral germ cell tumor (n=1), C-spine ependymoma (n=1), and posterior fossa ependymoma (n=1). …”
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More than Five Decades of Proton Therapy: A Bibliometric Overview of the Scientific Literature by Maria Giulia Vincini, Mattia Zaffaroni, Marco Schwarz, Giulia Marvaso, Federico Mastroleo, Stefania Volpe, Luca Bergamaschi, Giovanni Carlo Mazzola, Giulia Corrao, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Daniela Alterio

“…Among disease types, prostate cancer is followed by chordoma, head and neck, and breast cancer. The change in trend themes demonstrated the fast evolution of hotspots in PT; among the most recent trends, the appearance of flash, radiomics, <i>relative biological effectiveness (RBE)</i>, and <i>linear energy transfer (LET)</i> deserve to be highlighted. …”
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Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression [Retraction] by He J, Guan J, Liao S, Wu Z, Liu B, Mo H, Yuan Z

“…RETRACTED ARTICLE: Long Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression. …”
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COVID-19 cases and their outcome among patients with uncommon co-existing illnesses: A lesson from Northern India by D. Himanshu Reddy, Virendra Atam, Priyanka Rai, Farman Khan, Saurabh Pandey, Hardeep Singh Malhotra, Kamlesh Kumar Gupta, Satyendra Kumar Sonkar, Rajeev Verma, Kauser Usman, Shyam Chand Chaudhary, Satyendra Kumar Sonkar, Vivek Kumar, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, M.L. Patel, D. Himanshu, Ajay Kumar, Sudhir Kr Verma, Medhavi Gautam, Harish Gupta, Satish Kumar, Deepak Baghchandanani, Ambuj Yadav, M. Lamba, Amit Kumar, Suhail, Rati Prabha, Darshan Bajaj, Abhishek Bahadur Singh, Mayank Mahendra, Gaurav Kumar, Narendra Kumar, Bal Krishna Ojha, Rajeev Verma, Dhananjay Kumar Verma, Vinod Kumar, Suresh Singh, Shivam Gupta, Mohammad Hashim, Kuldeep Verma, Akriti Bhardwaj, Anurag Chaudhary, Himanshu Chaudhan, Kaustubh, Kinjalk Dubey, Naveen Kumar, Rituraj, Janmajay Kumar, Somesh Srivastav, Shiv Paratap Singh, Sunita Kumari, Sudham Srivastave, Jyoti Verma, Mohmmad Ahmad Hussain, Ammar Sabir Siddiqui, Azher Rizvi, Chitranshu Pancholi, Deepak Sharma, Deepak Kumar Verma, David Zothansanga, Kuldeep Singh, Prashant Kumar Singh, Rahul Kumar, Vipin Raj Bharti, Shahnawaz Ali Ansari, Vivek Kumar, Monika Kallani, Harish Bharti, Ankita Singh, Avirup Majumdar, Neeraj Verma, Mayank Mishra, Pankaj Kumar Gupta, Shubhanshu Shivhare, Mudit Kotwal, Prashant Mahar, Praduman Mall, Krishnapal Singh Parmar, Guddoo Kumar

“…Group B included- organ transplant (27.8%), autoimmune [myasthenia gravis, polymyositis, psoriasis] (22.6%), haematologic [Haemophilia, ITP, Aplastic anaemia, APML, CML] (27.8%), uncommon malignancies [disseminated sacral chordoma and GTN] (11.1%) and snakebite (11.1%). Serum Procalcitonin was not helpful for diagnosis of bacterial infection in COVID-19 disease. …”
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Trombose venosa profunda e sua relação com trombofilias e neoplasias: estudo retrospectivo Deep venous thrombosis and its relationship with thrombophilias and malignancies: retrosp... by Ana Vieira Baptista, Luís Antunes, Joana Moreira, Ricardo Pereira, Anabela Gonçalves, Gabriel Anacleto, João Alegrio, Manuel Fonseca, Óscar Gonçalves, Albuquerque Matos

“…The protocol for screening for thrombophilia and malignancy was applied to 65 patients (73,0%), being detected congenital thrombophilias in 41 patients (63,1%), two cases of antiphospholipid antibody syndrome (APS), one case of monoclonal gammopathy, one of lung cancer and one of sacral chordoma. 49 of the patients subjected to the protocols (75,4%) were referred to the Hematology Clinic for evaluation and in 40 of those patients (81,6%) was suggested keeping oral anticoagulation for more than 12 months. …”
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Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bon... by Bradford S. Hoppe, Ivy A. Petersen, Benjamin K. Wilke, Todd A. DeWees, Reiko Imai, Eugen B. Hug, Maria Rosaria Fiore, Jürgen Debus, Piero Fossati, Shigeru Yamada, Ester Orlandi, Qing Zhang, Cihang Bao, Katharina Seidensaal, Byron C. May, Anna C. Harrell, Matthew T. Houdek, Laura A. Vallow, Peter S. Rose, Michael G. Haddock, Jonathan B. Ashman, Krista A. Goulding, Steven Attia, Sunil Krishnan, Anita Mahajan, Robert L. Foote, Nadia N. Laack, Sameer R. Keole, Chris J. Beltran, Eric M. Welch, Mohammed Karim, Safia K. Ahmed

“…Participants must have an Eastern Cooperative Oncology Group Performance Status score of two or less, newly diagnosed disease, and histopathologic confirmation of pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone involvement, or non-RMS soft tissue sarcoma with bone involvement. …”
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Radiotherapy of other sellar lesions. by Karavitaki, N

“…It is particularly important in the therapeutic algorithm of craniopharyngiomas and meningiomas and has also been used in chordomas/chordosarcomas and less commonly, in other lesions. …”