Construction of a molecular inflammatory predictive model with histone modification-related genes and identification of CAMK2D as a potential response signature to infliximab in ul... by Shuyu Ye, Shuyu Ye, Yongqing Lyu, Libin Chen, Libin Chen, Yiwei Wang, Yiwei Wang, Yue He, Yue He, Quansi Li, Quansi Li, Li Tian, Li Tian, Fen Liu, Fen Liu, Xiaoyan Wang, Xiaoyan Wang, Feiyan Ai, Feiyan Ai

“…Histone modifications regulate chromosome structure and gene expression, resulting in effects on inflammatory and immune responses. …”
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Novel Brassica hybrids with different resistance to Leptosphaeria maculans reveal unbalanced rDNA signal patterns by Szwarc Justyna, Niemann Janetta, Kaczmarek Joanna, Majka Joanna, Bocianowski Jan

“…In this study, we aimed to correlate the field resistance of selected Brassica hybrids to blackleg with chromosomal structure revealed by Fluorescence in situ hybridization. …”
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Current Understanding of Molecular Phase Separation in Chromosomes by Je-Kyung Ryu, Da-Eun Hwang, Jeong-Mo Choi

“…Finally, we discuss a recent phase separation model, termed bridging-induced phase separation (BIPS), which can explain the formation of local chromosome structures.…”
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Identification of complex and cryptic chromosomal rearrangements by optical genome mapping by Shanshan Shi, Peizhi Huang, Ruiling Yan, Ruiman Li

“…Conclusions Our study confirmed OGM as a robust alternative approach to karyotyping for the detection of chromosomal structural rearrangements, including CCRs and cryptic translocations.…”
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Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues by Vinícius G. Contessoto, Olga Dudchenko, Erez Lieberman Aiden, Peter G. Wolynes, José N. Onuchic, Michele Di Pierro

“…Here the authors perform physical simulations to study the genome architecture of Aedes aegypti, which reveal an ensemble of 3D chromosomal structures that are folded over and partially condensed, resembling liquid crystalline properties.…”
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Chromosome study of patients recovering from chronic lymphocytic leukemia by Haider Mohamed Abdel Aziz, Sada Jasim Abdulameer, Tariq Daoud Salman

“…The number is normal and the chromosomal structure is also normal compared to normal and other cases. …”
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A Decision Support System Based on Neural Network and Genetic Algorithm: Case Study of Breast Cancer by Fatemeh Ahouz, Azadeh Bastani, Amin Golabpour

“…Conclusion: The proposed chromosomal structure is able to derive optimal NN architecture. …”
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Chromosome 5P of Agropyron cristatum induces chromosomal translocation by disturbing homologous chromosome pairing in a common wheat background by Haiming Han, Xinyuan Ma, Zhen Wang, Kai Qi, Wenjing Yang, Weihua Liu, Jinpeng Zhang, Shenghui Zhou, Yuqing Lu, Xinming Yang, Xiuquan Li, Lihui Li

“…Aberrant meiosis was associated with chromosomal structural variation, and aberrant meiotic behavior was observed in wheat–A. cristatum 5P monosomic and disomic addition lines, suggesting that the effect of chromosome 5P was independent of the number of chromosome 5P copies. …”
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Structural rearrangements as a recurrent pathogenic mechanism for SETBP1 haploinsufficiency by V. Alesi, S. Genovese, M. C. Roberti, E. Sallicandro, S. Di Tommaso, S. Loddo, V. Orlando, D. Pompili, C. Calacci, V. Mei, E. Pisaneschi, M. V. Faggiano, A. Morgia, C. Mammì, G. Astrea, R. Battini, M. Priolo, M. L. Dentici, R. Milone, A. Novelli

“…Abstract Chromosomal structural rearrangements consist of anomalies in genomic architecture that may or may not be associated with genetic material gain and loss. …”
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Identification of Recurrent Chromosome Breaks Underlying Structural Rearrangements in Mammary Cancer Cell Lines by Natalie C. Senter, Andrew McCulley, Vladimir A. Kuznetsov, Wenyi Feng

“…In order to address the extent to which chromosomal structural rearrangement breakpoints correlate with recurrent DNA double-strand breaks (DSBs), we simultaneously mapped chromosome structural variation breakpoints (using whole-genome DNA-seq) and spontaneous DSB formation (using Break-seq) in the estrogen receptor (ER)-positive breast cancer cell line MCF-7 and a non-cancer control breast epithelium cell line MCF-10A. …”
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The effects of estrogen induction therapy on pubertal presentations in turner syndrome patients by Yi-Chen Lee, Chi-Yu Huang, Chao-Hsu Lin, Bi-Wen Cheng, Shih-Kang Huang, Shu-Nin Yeh, Yann-Jinn Lee, Wei-Hsin Ting

“…Sixty-six patients were enrolled and distributed into 45,X monosomy group, X chromosome structural abnormalities group and X mosaicism group. …”
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Immune checkpoints represent a promising breakthrough in targeted therapy and prognosis of myelodysplastic syndrome by Xinyu Guo, Shunjie Yu, Xiaotong Ren, Lijuan Li

“…Myelodysplastic syndrome (MDS) is a hematological malignancy of undetermined etiology, possibly linked to chromosomal structural alterations, genetic mutations, presentation and carcinogenicity of variant antigens on cell surface, and the generation of pro-inflammatory microenvironment in the bone marrow. …”
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A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma by Laura Hardwick

“…As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but differences in study cohorts and/or tumour heterogeneity can lead to discordant results regarding the nature of specific genes affected. …”
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Genomic instability is an early event in aluminium-induced tumorigenesis by Mandriota, SJ, Tenan, M, Nicolle, A, Jankowska, JD, Ferrari, P, Tille, J-C, Durin, M-A, Green, CM, Tabruyn, S, Moralli, D, Sappino, A-P

“…We demonstrate that AlCl3 rapidly increases chromosomal structural abnormalities in mammary epithelial cells, while we failed to detect direct modulation of specific mRNA pathways. …”

Recent insights into mechanisms preventing ectopic centromere formation by Qianhua Dong, Jinpu Yang, Jinxin Gao, Fei Li

“…The centromere is a specialized chromosomal structure essential for chromosome segregation. …”
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Understanding Spatial Genome Organization: Methods and Insights by Vijay Ramani, Jay Shendure, Zhijun Duan

“…Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures has yielded much new information. It is becoming increasingly clear, for example, that interphase chromosomes form stable, multilevel hierarchical structures. …”
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The complete chloroplast genome sequence of Garcinia anomala (Clusiaceae) from Yunnan Province, China by Biying Yue, Jipu Shi

“…The chloroplast genome is 156,774 bp in length and has a typical quadripartite chromosomal structure. The genome is divided into a pair of inverted repeat regions (IR) of 27,053 bp, one small single-copy (SSC) region of 17,082 bp and a large single copy (LSC) region of 85,586 bp. …”
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New techniques for genetic development of a class of fuzzy controllers by Leitch, D, Probert, P

“…We use an analysis of GA's by Altenberg to determine a performance measure that demonstrates that our coding scheme and reordering operator improve the ability of the GA to organize itself and evolve chromosomal structures that not only produce high scores, but improve the search efficiency of the genetic operators. …”

Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis by Stefano J. Mandriota, Mirna Tenan, Adeline Nicolle, Julia D. Jankowska, Paolo Ferrari, Jean-Christophe Tille, Mary-Anne Durin, Catherine M. Green, Sebastien Tabruyn, Daniela Moralli, André-Pascal Sappino

“…We demonstrate that AlCl₃ rapidly increases chromosomal structural abnormalities in mammary epithelial cells, while we failed to detect direct modulation of specific mRNA pathways. …”
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The human Y and inactive X chromosomes similarly modulate autosomal gene expression by Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page

“…Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects. Studying sex chromosome structural anomalies, promoters of Xi- and Y-responsive genes, and CRISPR inhibition, we traced part of this shared effect to homologous transcription factors—ZFX and ZFY—encoded by Chr X and Y. …”
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