A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome by Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhöfer, Mariann Gyöngyösi, Klaus G. Schmetterer, Christopher Gerner

“…Summary: To investigate long COVID-19 syndrome (LCS) pathophysiology, we performed an exploratory study with blood plasma derived from three groups: 1) healthy vaccinated individuals without SARS-CoV-2 exposure; 2) asymptomatic recovered patients at least three months after SARS-CoV-2 infection and; 3) symptomatic patients at least 3 months after SARS-CoV-2 infection with chronic fatigue syndrome or similar symptoms, here designated as patients with long COVID-19 syndrome (LCS). …”
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Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset by Sophie Steiner, Sonya C. Becker, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Sandra Bauer, Madlen Löbel, Anna B. Stittrich, Anna B. Stittrich, Patricia Grabowski, Carmen Scheibenbogen, Carmen Scheibenbogen

“…In this study, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients and controls were genotyped for five immune gene SNPs in tyrosine phosphatase non-receptor type 22 (PTPN22, rs2476601), cytotoxic T-lymphocyte-associated protein 4 (CTLA4, rs3087243), tumor necrosis factor (TNF, rs1800629 and rs1799724), and interferon regulatory factor 5 (IRF5, rs3807306), which are among the most important risk variants for autoimmune diseases. …”
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Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants by Peter Hanlon, MSc, Barbara I Nicholl, PhD, Bhautesh Dinesh Jani, PhD, Duncan Lee, PhD, Ross McQueenie, PhD, Frances S Mair, ProfMD

“…The top five long-term conditions associated with frailty were multiple sclerosis (OR 15·3; 99·75% CI 12·8–18·2); chronic fatigue syndrome (12·9; 11·1–15·0); chronic obstructive pulmonary disease (5·6; 5·2–6·1); connective tissue disease (5·4; 5·0–5·8); and diabetes (5·0; 4·7–5·2). …”
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Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events by Kazuki Tokumasu, Manami Fujita-Yamashita, Naruhiko Sunada, Yasue Sakurada, Koichiro Yamamoto, Yasuhiro Nakano, Yui Matsuda, Yuki Otsuka, Toru Hasegawa, Hideharu Hagiya, Hiroyuki Honda, Fumio Otsuka

“…Serious complications included myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), sarcoidosis, aseptic meningitis, neuromyelitis optica spectrum disorders (NMOSDs), tendon adhesions, and idiopathic thrombocytopenia. …”
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Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness by Alexander E. Boruch, Jacob B. Lindheimer, Jacob V. Ninneman, Glenn R. Wylie, Thomas Alexander, Jacquelyn C. Klein-Adams, Aaron J. Stegner, Nicholas P. Gretzon, Bishoy Samy, Michael J. Falvo, Dane B. Cook

“…Previous investigations in other CMI populations (i.e., Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) have reported associations between PEM and expression of genes coding for adrenergic, metabolic, and immune function. …”
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Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity by Fereshteh Jahanbani, Justin Cyril Sing, Rajan Douglas Maynard, Shaghayegh Jahanbani, Janet Dafoe, Whitney Dafoe, Nathan Jones, Kelvin J. Wallace, Azuravesta Rastan, Holden T. Maecker, Hannes L. Röst, Michael P. Snyder, Ronald W. Davis

“…IntroductionMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) presents substantial challenges in patient care due to its intricate multisystem nature, comorbidities, and global prevalence. …”
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Physical health of Post-9/11 U.S. Military veterans in the context of Healthy People 2020 targeted topic areas: Results from the Comparative Health Assessment Interview Research St... by Yasmin S. Cypel, Dawne Vogt, Shira Maguen, Paul Bernhard, Elizabeth Lowery, William J. Culpepper, Irvine Armand-Gibbs, Aaron I. Schneiderman

“…Adjusted odds ratios (AORs) for musculoskeletal and hearing disorders, traumatic brain injury, and chronic fatigue syndrome (CFS) were 3–6 times higher in veterans versus nonveterans (p < 0.001). …”
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Characteristics of patients with panic disorder attended in primary care during the COVID-19 pandemic: A cross-sectional multicenter study by Miquel Roca, Antonio Torres Villamor, Vicente Gasull Molinera, Margarita Gili

“…A high level of stress (Holmes–Rahe scale > 300), concomitant chronic fatigue syndrome and irritable bowel disease, and having financial difficulties in the past 6 months were associated with factors of panic disorder. …”
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Cognitive symptoms after COVID-19 by M. Altuna, Mª.B. Sánchez-Saudinós, A. Lleó

“…Post–COVID-19 cognitive symptoms share common features with those described in chronic fatigue syndrome, including a similar profile with affective symptoms. …”
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Typing myalgic encephalomyelitis by infection at onset: A DecodeME study [version 4; peer review: 2 approved] by Andy Devereux-Cooke, Simon J. McGrath, Emma Northwood, Sian Leary, Pippa Stacey, Anna Redshaw, Jim Wilson, Claire Tripp, Isabel Lewis, Sonya Chowdhury, Sumy V. Baby, Øyvind Almelid, Hannes Becher, Tom Baker, Malgorzata Clyde, Thibaud Boutin, John Ireland, Diana Garcia, Ewan McDowall, Shona M. Kerr, Gemma L. Samms, David Perry, Jareth C. Wolfe, Veronique Vitart, Chris P. Ponting, Andrew D. Bretherick

“…Background: People with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. …”
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Identification of transient receptor potential melastatin 3 proteotypic peptides employing an efficient membrane protein extraction method for natural killer cells by Chandi T. Magawa, Chandi T. Magawa, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Cassandra Balinas, Cassandra Balinas, Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Kiran Thapaliya, Kiran Thapaliya, Leighton Barnden, Leighton Barnden, Rebekah Maksoud, Rebekah Maksoud, Rebekah Maksoud, Breanna Weigel, Breanna Weigel, Breanna Weigel, Penny A. Rudd, Lara J. Herrero, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik

“…This will facilitate genetic analysis of membrane proteins known as transient receptor potential melastatin 3 (TRPM3) ion channels in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) research.Methods: Two protocols, internally identified as Protocol 1 and 2, were adapted and optimized for high yield protein extraction. …”
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Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 by L. V. Shogenova, Thi Tuet Truong, N. O. Kryukova, K. A. Yusupkhodzhaeva, D. D. Pozdnyakova, T. G. Kim, A. V. Chernyak, Е. N. Kalmanova, O. S. Medvedev, T. A. Kuropatkina, S. D. Varfolomeev, A. M. Ryabokon, O. А. Svitich, M. P. Kostinov, Ibaraki Kunio, Maehara Hiroki, A. G. Chuchalin

“…This randomized controlled parallel prospective study included 60 COVID-19 survivors with post-COVID-19 syndrome (ICD-10: U09.9) during the recovery period, with clinical manifestations of chronic fatigue syndrome (CFS), who received standard therapy in accordance with the management protocol of patients with CFS (ICD-10: G93.3): physiotherapy and medication therapy with drugs containing magnesium, B vitamins and L-carnitine. …”
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Fighting Post-COVID and ME/CFS – development of curative therapies by Carmen Scheibenbogen, Judith Theresia Bellmann-Strobl, Judith Theresia Bellmann-Strobl, Judith Theresia Bellmann-Strobl, Cornelia Heindrich, Kirsten Wittke, Elisa Stein, Christiana Franke, Harald Prüss, Harald Prüss, Hannah Preßler, Marie-Luise Machule, Heinrich Audebert, Carsten Finke, Hanna Gwendolyn Zimmermann, Hanna Gwendolyn Zimmermann, Hanna Gwendolyn Zimmermann, Birgit Sawitzki, Birgit Sawitzki, Christian Meisel, Christian Meisel, Markus Toelle, Anne Krueger, Anna C. Aschenbrenner, Joachim L. Schultze, Joachim L. Schultze, Joachim L. Schultze, Marc D. Beyer, Marc D. Beyer, Markus Ralser, Markus Ralser, Michael Mülleder, Leif Erik Sander, Frank Konietschke, Friedemann Paul, Friedemann Paul, Friedemann Paul, Silvia Stojanov, Lisa Bruckert, Dennis M. Hedderich, Franziska Knolle, Gabriela Riemekasten, Maria J. G. T. Vehreschild, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Uta Behrends, Uta Behrends, Uta Behrends, Susen Burock

“…There is an overlap of symptoms and pathomechanisms of PCS with postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). No curative therapies are available for ME/CFS or PCS. …”
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Post-COVID condition or “long COVID”, return-to work, and occupational health research by Alexis Descatha, Bradley A Evanoff, Marc Fadel

“…Strategies promoting return to work for those with post-COVID-19 conditions will need to be implemented and could be comparable to programs developed for other chronic conditions, since post-COVID conditions share some similarities to post-intensive care syndrome, fibromyalgia, and chronic fatigue syndrome (15, 33, 34). These patients have better outcomes following integrative health approach that combines traditional medical management, non-pharmacological treatments including physical therapy, and behavior and lifestyle changes (35, 36). …”
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The report of the Chief Medical Officer's CFS/ME working group: what does it say and will it help? by Sharpe, M

“…Chronic fatigue syndrome (CFS) sometimes known as myalgic encephalomyelitis or encephalopathy (ME) has long been a controversial topic. …”

Non-pharmacological approaches to treatment. by Sharpe, M

“…Chronic fatigue syndrome (CFS) as currently defined overlaps with other syndromes including chronic pain, fibromyalgia, anxiety and depression. …”

Non-pharmacological approaches to treatment. by Sharpe, M

“…Chronic fatigue syndrome (CFS) as currently defined overlaps with other syndromes including chronic pain, fibromyalgia, anxiety and depression. …”