Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S] by Tara Ann Burns, Marimuthu Subathra, Paola Signorelli, Young Choi, Xiaofeng Yang, Yong Wang, Maristella Villani, Kapil Bhalla, Daohong Zhou, Chiara Luberto

“…To examine if dysregulated SMS contributes to leukemogenesis, we measured SMS activity in several leukemic cell lines and found that it is highly elevated in K562 chronic myelogenous leukemia (CML) cells. The increased SMS in K562 cells was caused by the presence of Bcr-abl, a hallmark of CML; stable expression of Bcr-abl elevated SMS activity in HL-60 cells while inhibition of the tyrosine kinase activity of Bcr-abl with Imatinib mesylate decreased SMS activity in K562 cells. …”
Get full text

Bosutinib stimulates macrophage survival, phagocytosis, and intracellular killing of bacteria by da Silva, Ronni A. G., Stocks, Claudia J., Hu, Guangan, Kline, Kimberly A., Chen, Jianzhu

“…Here, we show that bosutinib, an FDA-approved chemotherapeutic for treating chronic myelogenous leukemia, does not possess any antibiotic activity but enhances macrophage responses to bacterial infection. …”
Get full text

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions by Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Hao Tan, Jiong, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G., Fullwood, Melissa Jane

“…We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. …”
Get full text
Get full text

Development of a Transplantable GFP+ B-Cell Lymphoma Tumor Cell Line From MHC-Defined Miniature Swine: Potential for a Large Animal Tumor Model by Marian Schenk, Abraham J. Matar, Abraham J. Matar, Isabel Hanekamp, Robert J. Hawley, Christene A. Huang, Christene A. Huang, Raimon Duran-Struuck, Raimon Duran-Struuck

“…Two tumor cell lines, post-transplant lymphoproliferative disease (PTLD) 13271 and chronic myelogenous leukemia (CML) 14736, were previously established from the Massachusetts General Hospital (MGH) miniature swine herd. …”
Get full text

Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation by Osvaldo Contreras, Maximiliano Villarreal, Enrique Brandan

“…Nilotinib is a second-generation FDA-approved TKI designed to overcome Imatinib resistance and intolerance in patients with chronic myelogenous leukemia (CML). Interestingly, TKIs have also been shown to be an efficient treatment for several non-malignant disorders such fibrotic diseases, including those affecting skeletal muscles. …”
Get full text

Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism by Mohammad Raish, Ajaz Ahmad, Mudassar Shahid, Yousef A. Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffar Iqbal, Naushad Ali, Khalid M. Alkharfy, Fahad I. Al-Jenoobi

“…Dasatinib (DAS), a narrow-therapeutic index drug, Bcr-Abl, and Src family kinases multitarget inhibitor have been approved for chronic myelogenous leukemia (CML) and Ph-positive acute lymphocytic leukemia (Ph+ ALL). …”
Get full text

The survival of patients enrolled in a global direct-to-patient cancer medicine donation program: The Glivec International Patient Assistance Program (GIPAP) by Chukwuemeka A. Umeh, Pat Garcia-Gonzalez, David Tremblay, Richard Laing

“…Background: The Glivec International Patient Assistance Program (GIPAP) is a unique direct-to-patient program that provides imatinib (Glivec) at no cost to eligible patients in low- and middle-income countries (LMICs) with chronic myelogenous leukemia (CML) or gastrointestinal stromal tumor (GIST). …”
Get full text

Unrelated Donor Bone Marrow Transplants in Children by Alfred Grovas, Stephen A. Feig, Sheryl O'rourke, Leonard Valentino, Fran Wiley, Lynne Hunt, Elliot M. Landaw, James Gajewski

“…Eligible diagnosis included acute leukemia (AL) (n = 15), chronic myelogenous leukemia (CML) (n = 4), myelodysplastic syndrome (MDS) (n = 3), and severe aplastic anemia (SAA) (n = 2). …”
Get full text

Herb-drug interaction: Effect of sinapic acid on the pharmacokinetics of dasatinib in rats by Mudassar Shahid, Ajaz Ahmad, Mohammad Raish, Yousef A Bin Jardan, Khalid M. Alkharfy, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffer Iqbal, Naushad Ali, Fahad I. Al-Jenoobi

“…Dasatinib (DAS) is a narrow therapeutic index drug and novel oral multitarget inhibitor of tyrosine kinase and approved for the first-line therapy for chronic myelogenous leukemia (CML) and Philadelphia chromosome (Ph + ) acute lymphoblastic leukemia (ALL). …”
Get full text

Efficacy and safety of switching to flumatinib in patients with chronic myeloid leukemia who have not achieved optimal response or are intolerant to TKI treatment by YANG Songfan, YANG Songfan, WEN Qin, ZHANG Ying

“…Objective To observe the efficacy and safety of flumatinib conversion in chronic myelogenous leukemia-chronicphase (CML-CP) patients with suboptimal TKI response or intolerance. …”
Get full text

BCR-ABL triggers a glucose-dependent survival program during leukemogenesis through the suppression of TXNIP by Lin Feng, Ruxin Ding, Xuan Qu, Yuanchun Li, Tong Shen, Lei Wang, Ruikai Li, Juan Zhang, Yi Ru, Xin Bu, Yang Wang, Min Li, Wenqi Song, Liangliang Shen, Pengxia Zhang

“…Abstracts Imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but the primary and acquired imatinib resistance remains the big hurdle. …”
Get full text

The effects of photodynamic therapy on leukemia cells mediated by KillerRed, a genetically encoded fluorescent protein photosensitizer by Meng Yuan, Chengcheng Liu, Jiao Li, Wenpeng Ma, Xiaozhuo Yu, Ping Zhang, Yanhong Ji

“…In this study, we aimed to investigate the effects of KillerRed-mediated PDT on chronic myelogenous leukemia K562 cells, acute monocytic leukemia NB4 cells, and acute monocytic leukemia THP1 cells. …”
Get full text

The Complement Cascade as a Mediator of Human Malignant Hematopoietic Cell Trafficking by Anna Lenkiewicz, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Bing Xu, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak

“…By contrast, human myeloid and lymphoid leukemia cell lines and clonogenic blasts from chronic myelogenous leukemia (CML) and acute myelogenous leukemia (AML) patients respond to C3 and C5 cleavage fragments by chemotaxis and increased adhesion. …”
Get full text

Heteroleptic Copper(II) Complexes Containing an Anthraquinone and a Phenanthroline as Synthetic Nucleases and Potential Anticancer Agents by Ívina P. de Souza, Júlia R. L. Silva, Amanda O. Costa, Jennifer T. J. Freitas, Renata Diniz, Rodrigo B. Fazzi, Ana M. da Costa Ferreira, Elene C. Pereira-Maia

“…The complexes inhibited the growth of chronic myelogenous leukemia and human squamous carcinoma cells with low IC₅₀ values, complex <b>1</b> being the most effective.…”
Get full text

New Values of <i>Teucrium</i> species: <i>in Vitro</i> Study of Cytotoxic Activities of Secondary Metabolites by Milan S. STANKOVIĆ, Tatjana Lj. MITROVIĆ, Ivana Z. MATIĆ, Marina D. TOPUZOVIĆ, Slaviša M. STAMENKOVIĆ

“…<p class=MsoNormal style='text-align:justify;text-indent:14.2pt'><span style='font-size:10.0pt;font-family:"Garamond Premr Pro","serif";mso-bidi-font-family:"Garamond Premr Pro Subh";color:black;mso-ansi-language:EN-GB'>The cytotoxicity of seven <i style='mso-bidi-font-style:normal'>Teucrium </i>species, a long time ago used as a food spices, for beverages and teas preparing, as well as therapeutics for digestive and respiratory diseases, were examined against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human chronic myelogenous leukemia K562 and human breast adenocarcinoma MDA-MB-361 cells. …”
Get full text

Restriction-Assembly: A Solution to Construct Novel Adenovirus Vector by Xiaojuan Guo, Yangyang Sun, Juan Chen, Xiaohui Zou, Wenzhe Hou, Wenjie Tan, Tao Hung, Zhuozhuang Lu

“…Interestingly, SAdV1XE3-CGA could propagate in human chronic myelogenous leukemia K562 cells. The E1 region was similarly modified to generate E1/E3-deleted replication-defective virus SAdV1-EG. …”
Get full text

Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential by Vladimir A. Kozlov, Diana V. Aleksanyan, Svetlana G. Churusova, Aleksandr A. Spiridonov, Ekaterina Yu. Rybalkina, Evgenii I. Gutsul, Svetlana A. Aksenova, Alexander A. Korlyukov, Alexander S. Peregudov, Zinaida S. Klemenkova

“…The pincer complexes exhibit remarkable cytotoxicity against several solid and blood cancer cell lines, including human colorectal carcinoma (HCT116), breast cancer (MCF7), prostate adenocarcinoma (PC3), chronic myelogenous leukemia (K562), multiple plasmacytoma (AMO1), and acute lymphoblastic leukemia (H9), with the dimethylamino-substituted derivative being particularly effective. …”
Get full text

Correlation of the transcription factors IRF4 and BACH2 with the abnormal NFATC1 expression in T cells from chronic myeloid leukemia patients by Yikai Zhang, Xiangbo Zeng, Xianfeng Zha, Jing Lai, Guangxiao Tan, Shaohua Chen, Xibao Yu, Yangqiu Li, Ling Xu

“…In order to clarify the mechanisms leading to the T cell dysfunction, we characterized the gene expression profile of T cells from chronic myelogenous leukemia (CML) patients by microarray analysis and investigated the related regulating pathway.Methods We employed gene expression profiling, bioinformatics and real-time quantitative reverse transcription PCR (RT-qPCR) to detect genes differentially expressed in CML patients versus healthy donors.Results There were 1704 genes differentially expressed between CD3+ T cells from CML patients and healthy donors, including 868 up-regulated genes and 836 down-regulated genes, which mostly related to T cell functional pathways. …”
Get full text

A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells by Jiajia Xin, Huijie Zhang, Dandan Yin, Ning An, Yaozhen Chen, Jinmei Xu, Jing Zhang, Zhixin Liu, Yongsheng Liu, Wen Yin, Mingkai Li, Xingbin Hu

“…With the development of tyrosine kinase inhibitor (TKI) resistance, finding the novel effective chemotherapeutic agent is of seminal importance for chronic myelogenous leukemia (CML) treatment. This study aims to find the effective anti-leukemic candidates and investigate the possible underlying mechanism. …”
Get full text

Antimicrobial activity against periodontopathogenic bacteria, antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica by Elif Burcu Bali, Leyla Açık, Gülçin Akca, Meral Sarper, Mualla Pınar Elçi, Ferit Avcu, Mecit Vural

“…Additionally, cytotoxic activity of the extracts on androgen-insensitive prostate cancer, androgen-sensitive prostate cancer, chronic myelogenous leukemia and acute promyelocytic leukemia human cancer cell lines were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. …”
Get full text