Secondary pulmonary alveolar proteinosis: a single-center retrospective study (a case series and literature review) by Dongmei Zhang, Xinlun Tian, Ruie Feng, Xiaobei Guo, Peng Wang, Yusen Situ, Yi Xiao, Kai-Feng Xu

“…Hematological disorders, including myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML), and pulmonary tuberculosis (TB) infection were the underlying diseases. …”
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The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways by Yang X, Wu X, Wu X, Huang L, Song J, Yuan C, He Z, Li Y

“…Xinmei Yang,1– 3 Xijun Wu,4 Xiaosen Wu,5 Lei Huang,1,2 Jingrui Song,1,2 Chunmao Yuan,1,2 Zhixu He,3,6 Yanmei Li1,2 1State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People’s Republic of China; 2The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guizhou Medical University, Guiyang, 550014, People’s Republic of China; 3Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guiyang, 550004, People’s Republic of China; 4Department of Laboratory, The Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang, 550023, People’s Republic of China; 5FuRong Tobacco Research Station, Xiangxi Autonomous Prefecture Tobacco Company Yongshun Branch, Yongshun, 416700, People’s Republic of China; 6Department of Pediatrics, Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, People’s Republic of ChinaCorrespondence: Yanmei Li, State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People’s Republic of China, Tel/Fax +86 85183805081, Email liyanmei518@hotmail.com Zhixu He, Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guiyang, 550004, People’s Republic of China, Tel/Fax +86 13595019670, Email hzx@gmc.edu.cnPurpose: Chronic myelogenous leukemia (CML) is a hematological malignancy with increased proliferation of cells of the myeloid series. …”
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Cytotoxic, anti-proliferative and apoptotic effects of zerumbone on human and mouse leukemic cell lines by Hamid, Asmah

“…In this study, the cytotoxic effect of ZER was tested against different types of cell lines including leukemia cells such as WEHI- 3B (mouse myelomonocytic leukemia), HL-60 (human promyelocytic leukemia), CEM-SS (human T-lymphoblastic leukemia) and K-562 (human chronic myelogenous leukemia/ erythroleukemia), using the standard MTT assay. …”
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Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient by Xin Chen, Bichen Wang, Aiming Pang, Weiping Yuan, Erlie Jiang, Yajing Chu, Sizhou Feng, Mingzhe Han

“…Although CSF3R point mutations (eg, T618I) are emerging as key players in chronic neutrophilic leukemia/atypical chronic myelogenous leukemia , the significance of rarer CSF3R mutations is unknown. …”
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Direct Polyphenol Attachment on the Surfaces of Magnetite Nanoparticles, Using <i>Vitis vinifera</i>, <i>Vaccinium corymbosum</i>, or <i>Punica granatum</i> by Ana E. Matías-Reyes, Margarita L. Alvarado-Noguez, Mario Pérez-González, Mauricio D. Carbajal-Tinoco, Elizabeth Estrada-Muñiz, Jesús A. Fuentes-García, Libia Vega-Loyo, Sergio A. Tomás, Gerardo F. Goya, Jaime Santoyo-Salazar

“…A cell viability assessment was conducted via the MTT and NRu tests to estimate the metabolic and lysosomal activities of the MNPs@polyphenols in K562 (chronic myelogenous leukemia, ATCC) cells.…”
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<i>ABL</i> Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo by Shu-Huey Chen, Yao-Yu Hsieh, Huey-En Tzeng, Chun-Yu Lin, Kai-Wen Hsu, Yun-Shan Chiang, Su-Mei Lin, Ming-Jang Su, Wen-Shyang Hsieh, Chia-Hwa Lee

“…Chronic myelogenous leukemia (CML) is the most common type of leukemia in adults, and more than 90% of CML patients harbor the abnormal Philadelphia chromosome (Ph) that encodes the BCR-ABL oncoprotein. …”
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In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury by Enrica Federti, Alessandro Matte, Antonio Recchiuti, Francesca Garello, Alessandra Ghigo, Wassim El Nemer, Enzo Terreno, Angela Amoresano, Domenico Mattoscio, Franco Turrini, Christophe Lebouef, Anne Janin, Antonella Pantaleo, Roberta Russo, Mickael Marin, Iana Iatcencko, Veronica Riccardi, Angela Siciliano, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi

“…Here, we show that imatinib, an oral tyrosine kinase inhibitor developed for the treatment of chronic myelogenous leukemia, acts as multimodal therapy targeting signal transduction pathways involved in the pathogenesis of both anemia and inflammatory vasculopathy of humanized murine model for SCD. …”
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Bloodstream gram-negative bacterial infections in adult patients with leukemia: A retrospective review of medical records in a tertiary care hospital in Western Saudi Arabia by Reyan Merdad, Almuhanad Alyami, Ahmed Basalim, Abdulrahman Alzahrani, Ahmed Aldainiy, Abdullah Awadh, Enas Ghulam, Fayssal Farahat

“…In a multivariable analysis, patients with acute myeloid leukemia and acute lymphoid leukemia were significantly more likely to acquire GNB BSI (p = 0.01), while patients with chronic myelogenous leukemia and chronic lymphocytic leukemia had a lower likelihood of developing GNB BSI. …”
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A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain by Gyun Jee Song, Gyun Jee Song, Md Habibur Rahman, Mithilesh Kumar Jha, Mithilesh Kumar Jha, Deepak Prasad Gupta, Deepak Prasad Gupta, Sung Hee Park, Jae-Hong Kim, Sun-Hwa Lee, In-Kyu Lee, Taebo Sim, Taebo Sim, Yong Chul Bae, Won-Ha Lee, Kyoungho Suk

“…It was developed as a new class of anti-cancer drug to treat resistant chronic myelogenous leukemia. Recent studies suggest that c-Abl inhibition would provide a neuroprotective effect in animal models of Parkinson’s disease as well as in clinical trials. …”
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Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells by Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus

“…In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). …”
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Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumor... by Xuechao Liu, Guangfeng Wang, Xianglei Yan, Haibo Qiu, Ping Min, Miaoyi Wu, Chunyang Tang, Fei Zhang, Qiuqiong Tang, Saijie Zhu, Miaozhen Qiu, Wei Zhuang, Douglas D. Fang, Zhiwei Zhou, Dajun Yang, Yifan Zhai

“…HQP1351, an orally bioavailable multikinase BCR-ABL inhibitor, is currently in clinical trials for the treatment of T315I mutant chronic myelogenous leukemia (CML), but the potential application in imatinib-resistant GISTs carrying secondary KIT mutations has not been explored. …”
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Dynamics of Minimal Residual Disease in Neuroblastoma Patients by Suguru Uemura, Toshiaki Ishida, Khin Kyae Mon Thwin, Nobuyuki Yamamoto, Akihiro Tamura, Kenji Kishimoto, Daiichiro Hasegawa, Yoshiyuki Kosaka, Nanako Nino, Kyaw San Lin, Satoru Takafuji, Takeshi Mori, Kazumoto Iijima, Noriyuki Nishimura

“…In contrast to the tumor-specific gene-rearrangement-positive acute lymphoblastic leukemia (ALL) and the oncogenic fusion-gene-positive chronic myelogenous leukemia (CML) and several solid tumors, the clinical significance of MRD remains to be established in neuroblastoma. …”
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OUTCOMES OF PEDIATRIC HEMATOPOIETIC STEM CELL TRANSPLANTS (HSCT) PERFORMED IN BRAZIL BETWEEN 2008 AND 2019 by A Seber, A Gomes, LE Daudt, JF Fernandes, LG Darrigo-Junior, A Siminone, CC Silva, N Hamerschlak, CS Bonfim

“…Pediatric myelodysplastic syndrome and chronic myelogenous leukemia had overall survival over 80%. Severe aplastic anemia was the most common non-malignant HSCT indication and the results with matched related and unrelated transplants are excellent, > 85% survival. …”
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Betulin, a Newly Characterized Compound in <i>Acacia auriculiformis</i> Bark, Is a Multi-Target Protein Kinase Inhibitor by Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach

“…The effect of betulin on the cell viability of doxorubicin-resistant K562R chronic myelogenous leukemia cells was then verified to investigate its putative use as an anti-cancer compound. …”
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A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling by Yanesko Fernandes Bella, Carlos Rocha Oliveira, José Roberto Mateus-Silva, Maysa Alves Rodrigues Brandao-Rangel, Anamei Silva-Reis, Juliana de Melo Batista Santos, Regiane Albertini, Rodrigo Alvaro Brandao Lopes-Martins, Luis Vicente Franco de Oliveira, Rodolfo P. Vieira

“…In the present study, the effects of two doses (5 ug/mL and 10 ug/mL) of Immunity-6™, a phytocomplex composed by beta-glucan, green tea (Camelia sinensis), chamomile (Matricaria chamomilla), and ascorbic acid (vitamin C) was tested in vitro, using chronic myelogenous leukemia cell line (K-562; 5 ×104/mL/well), which were challenged with lipopolysaccharide (LPS; 1 ug/mL) for 24 h. …”
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Bioactive Lipids as Chronic Myeloid Leukemia’s Potential Biomarkers for Disease Progression and Response to Tyrosine Kinase Inhibitors by Felipe Campos de Almeida, Maria G. Berzoti-Coelho, Diana Mota Toro, Diana Mota Toro, Maira da Costa Cacemiro, Vitor Leonardo Bassan, Gabriel Dessotti Barretto, Pedro Manoel Marques Garibaldi, Leonardo Carvalho Palma, Lorena Lobo de Figueiredo-Pontes, Lorena Lobo de Figueiredo-Pontes, Carlos Arterio Sorgi, Lucia Helena Faciolli, Luiz Gustavo Gardinassi, Fabíola Attié de Castro, Fabíola Attié de Castro

“…Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that expresses the Philadelphia chromosome and constitutively activated Bcr-Abl tyrosine kinase in hematopoietic progenitor cells. …”
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Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis by Shilpa Kuttikrishnan, Shilpa Kuttikrishnan, Tariq Masoodi, Gulab Sher, Ajaz A. Bhat, Kalyani Patil, Tamam El-Elimat, Nicholas H. Oberlies, Cedric J. Pearce, Mohmmad Haris, Mohmmad Haris, Aamir Ahmad, Aamir Ahmad, Feras Q. Alali, Shahab Uddin, Shahab Uddin, Shahab Uddin

“…Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic myelogenous leukemia (CML). However, the molecular mechanism of the FOXM1/BUB1B regulatory network and the role of Neosetophomone-B (NSP-B) in leukemia remains unclear. …”
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Genetic polymorphism in high hbf anemic pregnant women and the effect of stem cell factor and erythropoietin-treated K562 cells on erk signaling of mapk pathway by Za'ror, Yousef Saeed Mohammad Abu

“…K562 human chronic myelogenous leukemia cells, on the other hand, have an embryonic HbF phenotype and are widely used as a screening model for HbF inducers. …”
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Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia by Lijing Wang, Shuchen Gu, Fenfang Chen, Yi Yu, Jin Cao, Xinran Li, Chun Gao, Yanzhen Chen, Shuchong Yuan, Xia Liu, Jun Qin, Bin Zhao, Pinglong Xu, Tingbo Liang, Hongyan Tong, Xia Lin, Xin-Hua Feng

“…Here, we show that the oncogenic BCR-ABL1 of chronic myelogenous leukemia (CML) and the cellular ABL1 tyrosine kinases phosphorylate and inactivate Smad4 to block antiproliferative TGF-β signaling. …”
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RECURRENT ISOLATED CENTRAL NERVOUS SYSTEM BLAST CRISIS IN A PATIENT WITH CHRONIC MYELOID LEUKEMIA IN COMPLETE MOLECULAR REMISSION AND PREVIOUS TRAUMATIC CEREBROSPINAL FLUID FISTULA... by FGL Nunes, F Malagutti, MEP Antoniolli, GG Rodrigues, LOVD Reis, RCS Alves, JS Almeida, TC Bortolheiro, RD Cançado, AC Kneese

“…Backgroud: Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder characterized by presence of the Philadelphia (Ph) chromosome. …”
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