A candidate gene identification strategy utilizing mouse to human big-data mining: “3R-tenet” in COPD genetic research by Sangeetha Vishweswaraiah, Leema George, Natarajan Purushothaman, Koustav Ganguly

“…The genes were also assessed for replication of the associations and expression in COPD−/mouse cigarette smoke exposed lung tissues using other datasets. …”
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Assessing Information Available for Health Professionals and Potential Participants on Lung Cancer Screening Program Websites: Cross-sectional Study by Rachael H Dodd, Chenyue Zhang, Ashleigh R Sharman, Julie Carlton, Ruijin Tang, Nicole M Rankin

“…The US Preventive Services Task Force (USPSTF) updated recommendations for lung cancer screening in 2021, adjusting the age of screening to 50 years (from 55 years) and reducing the number of pack-years used to estimate total firsthand cigarette smoke exposure to 20 (from 30). With many individuals using the internet to find health care information, it is important to understand what information is available for individuals contemplating lung cancer screening. …”
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Significant role of circRNA BBS9 in chronic obstructive pulmonary disease via miRNA-103a-3p/BCL2L13 by Pujian Guo, Jing Lu, Yu Lei

“…Methods Real-time quantitative reverse transcription PCR (qRT-PCR) was performed to determine the levels and the linkages of circRNA BBS9, miRNA-103a-3p, and BCL2L13 in cigarette smoke extract (CSE)-treated human pulmonary microvascular endothelial cells (HPMECs). …”
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Evaluation of Thirdhand Smoke Exposure after Short Visits to Public Facilities (Noraebang and Internet Cafés): A Prospective Cohort Study by Myung-Bae Park, Boram Sim

“…We evaluated whether a short stay in a facility with smoke-related substances that adhere to the surrounding environment would expose individuals to THS even if they do not smell or are directly exposed to cigarette smoke. We confirmed that even two relatively short stays (approximately 2 h each) in a facility in which people had previously smoked can lead to THS exposure.…”
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Low dose cadmium exposure regulates miR-381–ANO1 interaction in airway epithelial cells by Pooja Singh, Fu Jun Li, Kevin Dsouza, Crystal T Stephens, Huaxiu Zheng, Abhishek Kumar, Mark T. Dransfield, Veena B Antony

“…Abstract Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death worldwide. Cigarette smoke which has approximately 2–3 µg of Cadmium (Cd) per cigarette contributes to the environmental exposure and development and severity of COPD. …”
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Short-Term Benefits of Smoking Cessation Improve Respiratory Function and Metabolism in Smokers by Pezzuto A, Ricci A, D'Ascanio M, Moretta A, Tonini G, Calabrò N, Minoia V, Pacini A, De Paolis G, Chichi E, Carico E, Tammaro A

“…Aldo Pezzuto,1 Alberto Ricci,1 Michela D’Ascanio,1 Alba Moretta,1 Giuseppe Tonini,2 Noemi Calabrò,1 Valeria Minoia,1 Alessia Pacini,1 Giuliana De Paolis,1 Eleonora Chichi,1 Elisabetta Carico,3 Antonella Tammaro4 1Department of Cardiovascular and Respiratory Sciences, S Andrea Hospital, Sapienza University, Rome, Italy; 2Oncology Department, Campus Bio-Medico University, Rome, Italy; 3Clinical and Molecular Medicine Department, S Andrea Hospital, Sapienza University, Rome, Italy; 4Department of Neuroscience- NESMOS, S.Andrea Hospital, Sapienza University, Rome, ItalyCorrespondence: Aldo Pezzuto, Email aldo.pezzuto@uniroma1.itBackground: Cigarette smoke exposure is the main preventable cause of chronic obstructive pulmonary disease (COPD). …”
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ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke by Traganos Frank, Gietl Diana, Jorgensen Ellen, Huang Xuan, Tanaka Toshiki, Darzynkiewicz Zbigniew, Albino Anthony P

“…We have recently reported that brief exposure of human pulmonary adenocarcinoma A549 cells or normal human bronchial epithelial cells (NHBE) to cigarette smoke (CS) induced phosphorylation of H2AX.</p> <p>Results</p> <p>We report here that H2AX phosphorylation in A549 cells induced by CS was accompanied by activation of ATM, as revealed by ATM phosphorylation on <it>Ser</it>1981 (ATM-S1981^P) detected immunocytochemically and by Western blotting. …”
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An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma by Maya-Liliana Avramescu, Christian Potiszil, Tak Kunihiro, Kazunori Okabe, Eizo Nakamura

“…However, smokers’ AFBs experienced a more uniform Fe-supply within the lung environment compared to non-smokers, likely due to Fe complexation from cigarette smoke, yielding denser, smaller and more Fe-rich AFBs. …”
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Human Leukocyte Antigen (HLA) Haplotype Does Not Influence the Inflammatory Pattern of Duodenal Lymphocytosis Linked to Irritable Bowel Syndrome by Giuseppe Losurdo, Alessia Todeschini, Floriana Giorgio, Domenico Piscitelli, Antonio Giangaspero, Enzo Ierardi, Alfredo Di Leo

“…DQ2-8 positive subjects had similar levels compared to negative ones for tTG2, IFNγ, TLR2, and MyD88. Cigarette smoke did not influence molecular expression in our study. …”
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Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes by Subroto Chatterjee, Amrita Balram, Wendy Li

“…The convergence of multiple physiologically relevant external stimuli/agonists—platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), stress, cigarette smoke/nicotine, tumor necrosis factor-α (TNF-α), and in particular, oxidized low-density lipoprotein (ox-LDL)—on β-1,4 galactosyltransferase results in its phosphorylation or activation, via a “turn-key” reaction, generating LacCer. …”
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MicroRNA miR-627-5p restrains pulmonary artery smooth muscle cell dysfunction by targeting MAP 2 K4 and PI3K/AKT signaling by Ting Li, Xiaoqin Tan, Yuexia Huang, Jun Cui, Fan Chen, Ying Xiong

“…Our study intends to evaluate whether miR-627-5p affects cigarette smoke extract (CSE)-induced aberrant biological behaviors of PASMCs. …”
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Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway by Lidan Jia, Xuefang Liu, Xinguang Liu, Qingzhou Guan, Yange Tian, Jiansheng Li, Peng Zhao

“…BEAS-2B epithelial cells were exposed to cigarette smoke extract (CSE) to determine the effect of BYF on epithelial barrier function. …”
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Association between Smoking and Urine Indole Levels Measured by a Commercialized Test by Masataka Mine, Nobuyuki Masaki, Takumi Toya, Takayuki Namba, Yuji Nagatomo, Bonpei Takase, Takeshi Adachi

“…On the other hand, cigarette smoke contains indoles, which could also change the urine indole levels. …”
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Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD by Mario Cazzola, Clive P. Page, Jadwiga A. Wedzicha, Bartolome R. Celli, Antonio Anzueto, Maria Gabriella Matera

“…It can be triggered by oxidant air pollutants and cigarette smoke and/or by endogenous reactive oxygen species (ROS) released from mitochondria and activated inflammatory, immune and epithelial cells in the airways, together with a reduction in endogenous antioxidants such as glutathione (GSH). …”
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Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study by Annika Jaitner, Marc Vaudel, Krasimira Tsaneva-Atanasova, Pål R. Njølstad, Bo Jacobsson, Jack Bowden, Stefan Johansson, Rachel M. Freathy

“…Using the number of cigarettes smoked per day in the first trimester as the exposure, the causal effect on placental weight was 11 g [95%CI: 1,21] per cigarette per day. …”
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Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease by Wenhua Wang, Huaihuai Peng, Menghao Zeng, Jie Liu, Guibin Liang, Zhihui He

“…Methods COPD mice model was induced by cigarette smoke exposure and EPCs were injected intravenously to investigate their effects on COPD mice. …”
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In Vitro Profiling of Toxicity Effects of Different Environmental Factors on Skin Cells by Minghui Fu, Yingxin Yang, Xiaolan Zhang, Bingli Lei, Tian Chen, Yuanqi Chen

“…This study aimed to investigate the cytotoxic effects of different environmental factors, including cooking oil fumes (COFs), haze (PM_2.5), and cigarette smoke (CS), on epidermal HaCaT cells and dermal fibroblast (FB) cells. …”
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The Evaluation Of The Effects Of Passive Smoking On Children's Health With Detection Of Urine Cotinine Levels by Nermin Dindar Badem, İlknur Bostancı, Medine Aysin Tasar, Dilek Kahvecioğlu, Yıldız Bilge Dallar

“…This finding suggests that families are biased towards reporting smoking cessation alongside their sick children and those children are also exposed to cigarette smoke in out-of-home settings.…”
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A pilot randomised trial of a brief virtual reality scenario in smokers unmotivated to quit: Assessing the feasibility of recruitment. by Olga Perski, Trupti Jambharunkar, Jamie Brown, Dimitra Kale

“…The mean (SD) age of participants was 34.4 (12.1) years, with 46.7% identifying as female. The mean (SD) cigarettes smoked per day was 9.8 (7.2). The intervention (86.7%, 95% CI = 69.3%-96.2%) and control (93.3%, 95% CI = 77.9%-99.2%) scenarios were rated as acceptable. …”
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El cigarrillo: implicaciones para la salud by Manuel Antonio Ballén, Andrés Jagua Gualdrón, Deisy Lorena Álvarez, Alejandro Rincón

“…Se emplearon en la búsqueda las palabras clave "Cigarette Smoke", "Cancer AND smoke", "COPD AND smoke", "Nicotine Dependence". …”
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