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The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis
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Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.
Published 2023-01-01“…Compensation is a defining principle of a true circadian clock, where its approximately 24-hour period length is relatively unchanged across environmental conditions. …”
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Circadian Clock Contributes to Modulate Salinity Stress-Responsive Antioxidative Mechanisms and Chloroplast Proteome in <i>Spinacia oleracea</i>
Published 2023-02-01“…In the presence of dawn and dusk, the circadian clock-based defense mechanism was observed using the genotypes “Delhi Green” and “Malav Jyoti.” …”
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Interactions between Core Elements of the <i>Botrytis cinerea</i> Circadian Clock Are Modulated by Light and Different Protein Domains
Published 2022-05-01“…Altogether, the results revealed the complexity of protein–protein interactions occurring between the core elements of the <i>B. cinerea</i> circadian clock.…”
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Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock
Published 2023-05-01“…Three major hypotheses were proposed on the origin and mechanisms of regulation of ∼12-h rhythms, namely, that they are not cell-autonomous and controlled by a combination of the circadian clock and environmental cues, that they are regulated by two anti-phase circadian transcription factors in a cell autonomous manner, or that they are established by a cell-autonomous ∼12-h oscillator.Methods: To distinguish among these possibilities, we performed a post hoc analysis of two high temporal resolution transcriptome dataset in animals and cells lacking the canonical circadian clock.Results: In both the liver of BMAL1 knockout mice and Drosophila S2 cells, we observed robust and prevalent ∼12-h rhythms of gene expression enriched in fundamental processes of mRNA and protein metabolism that show large convergence with those identified in wild-type mice liver. …”
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PER, a Circadian Clock Component, Mediates the Suppression of MMP-1 Expression in HaCaT Keratinocytes by cAMP
Published 2018-03-01Subjects: “…skin circadian clock…”
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Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons
Published 2023-08-01“…Here, through an unbiased survey, we show that the binding motif of Bmal1, a central transcription factor of the circadian clock, is enriched in differentially hydroxymethylated regions (DhMRs) of mouse DRG after peripheral lesion. …”
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Current Insights into m<sup>6</sup>A RNA Methylation and Its Emerging Role in Plant Circadian Clock
Published 2023-01-01“…A deeper understanding of the mechanism of m<sup>6</sup>A RNA regulation and its role in plant circadian clocks will contribute to a greater understanding of the plant circadian clock.…”
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Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction
Published 2022-07-01“…PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. …”
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Acute HDM exposure shows time-of-day and sex-based differences in the severity of lung inflammation and circadian clock disruption
Published 2023-11-01“…However, how the lung circadian clock influences time-of-day response and sex-based differences in house dust mite (HDM)-induced airway inflammation and remodeling has not been thoroughly investigated. …”
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Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol.
Published 2023-01-01“…Finally, we will use computational tools to predict optimal time intervals for physical performance based on the above-described data, thereby retrieving valuable data on the circadian clock as a key factor for health maintenance and optimization.…”
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The effects of SN Ps in the regions of positioning RNA polymerase II on the TBP/promoter affinity in the genes of human circadian clock
Published 2016-01-01“…Genetic variability in the genes of circadian clock is manifested as the phenotypic variability of physiological functions and behavior as well as disorders of the function of not only the clock but also other systems, leading to the development of a pathologies. …”
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Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
Published 2021-10-01Subjects: Get full text
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Daylight exposure and circadian clocks in broilers: part I—photoperiod effect on broiler behavior, skeletal health, and fear response
Published 2023-12-01“…Environmental photoperiod and related circadian clock, the 24-h L-D cycle, are important factors in maintaining productive performance, pathophysiological homeostasis, and psychological reaction in humans and animals. …”
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Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function
Published 2020-02-01Subjects: “…circadian clock…”
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The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach).
Published 2023-10-01“…Circadian clocks in terrestrial animals are encoded by molecular feedback loops involving the negative regulators PERIOD, TIMELESS or CRYPTOCHROME2 and positive transcription factors CLOCK and BMAL1/CYCLE. …”
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The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells
Published 2021Journal article