The role of medullary dorsal horn circuits in the diurnal regulation of nociception by Zirpel, F

“…Furthermore, molecular experiments revealed the presence of a local circadian clock in the MDH. Recordings from wildtype and clock gene knockout mice point towards intramedullary mechanisms governing the response to capsaicin. …”

Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway by Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli

“…Overall, our results show an altered expression of circadian genes accompanying heme biosynthesis disorders and confirm the need to deepen the knowledge of the mechanisms through which the alteration of the circadian clock circuitry could take part in determining signs and symptoms of porphyria patients and then again could represent a target for innovative therapeutic strategies.…”
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E4BP4 Coordinates Circadian Control of Cognition in Delirium by Min Chen, Li Zhang, Mingting Shao, Jianhao Du, Yifei Xiao, Fugui Zhang, Tianpeng Zhang, Yifang Li, Qianqian Zhou, Kaisheng Liu, Zhigang Wang, Baojian Wu

“…These findings define a causal role of clock dysfunction in delirium development and indicate E4bp4 as a regulator of cognition at the crosstalk between circadian clock and delirium.…”
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Grape-Seed Procyanidin Extract (GSPE) Seasonal-Dependent Modulation of Glucose and Lipid Metabolism in the Liver of Healthy F344 Rats by Romina M. Rodríguez, Marina Colom-Pellicer, Jordi Blanco, Enrique Calvo, Gerard Aragonès, Miquel Mulero

“…These differential effects, which were also reflected in some plasmatic parameters (i.e., glucose and triglycerides) and hormones (corticosterone and melatonin), were also associated with significant changes in the expression of several hepatic circadian clock genes (<i>Bmal1</i>, <i>Cry1</i>, and <i>Nr1d1</i>) and ER stress genes (<i>Atf6</i>, <i>Grp78</i>, and <i>Chop</i>). …”
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Differential Response of MYB Transcription Factor Gene Transcripts to Circadian Rhythm in Tea Plants (<i>Camellia sinensis</i>) by Zhihang Hu, Nan Zhang, Zhiyuan Qin, Jinwen Li, Ni Yang, Yi Chen, Jieyu Kong, Wei Luo, Aisheng Xiong, Jing Zhuang

“…The circadian clock refers to the formation of a certain rule in the long-term evolution of an organism, which is an invisible ‘clock’ in the body of an organism. …”
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The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in <i>Drosophila</i> by Ahmed M. Alsehli, Sifang Liao, Mohamed H. Al-Sabri, Lukas Vasionis, Archana Purohit, Neha Behare, Laura E. Clemensson, Michael J. Williams, Helgi B. Schiöth

“…Interestingly, loss of <i>Hmgcr</i> in the PI does not affect circadian rhythm, suggesting that Hmgcr regulates sleep by pathways distinct from the circadian clock. Taken together, these findings suggest that Hmgcr activity in the PI is essential for proper sleep homeostasis in flies.…”
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Bibliometric and visual analysis of time-restricted eating by Shuai Wang, Shuai Wang, Xiaoxiao Lin, Yihong Guan, Jinyu Huang

“…There were four indicating research directions, and the keywords of the green cluster were time-restricted feeding, metabolism, circadian clock, and circadian rhythm. The keywords of the blue cluster were obesity, health, diet, and food intake. …”
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Precise Editing of the <i>OsPYL9</i> Gene by RNA-Guided Cas9 Nuclease Confers Enhanced Drought Tolerance and Grain Yield in Rice (<i>Oryza sativa</i> L.) by Regulating Circadian Rh... by Babar Usman, Gul Nawaz, Neng Zhao, Shanyue Liao, Yaoguang Liu, Rongbai Li

“…Most of the DEPs related to circadian clock rhythm, drought response, and reactive oxygen species were upregulated in the mutant plants. …”
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Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Here we showed that the circadian clock protein BMAL1 in hepatocytes is both necessary and sufficient to protect against ALD by mitigating ferroptosis. …”
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Comparative Transcriptome Analysis of Gene Expression and Regulatory Characteristics Associated with Different Vernalization Periods in <i>Brassica rapa</i> by Yun Dai, Shujiang Zhang, Xiao Sun, Guoliang Li, Lingyun Yuan, Fei Li, Hui Zhang, Shifan Zhang, Guohu Chen, Chenggang Wang, Rifei Sun

“…The analysis indicated that transcripts related to the plant hormone signal transduction, starch and sucrose metabolism, photoperiod and circadian clock, and vernalization pathways changed notably at different vernalization periods. …”
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The nature and distribution of putative non-functional alleles suggest only two independent events at the origins of Astyanax mexicanus cavefish populations by Maxime Policarpo, Laurent Legendre, Isabelle Germon, Philippe Lafargeas, Luis Espinasa, Sylvie Rétaux, Didier Casane

“…Results Using the published genomes of 47 Astyanax cavefish from la Cueva de El Pachón, El Sótano de la Tinaja, La Cueva Chica and El Sótano de Molino, we searched for putative loss-of-function mutations in previously defined sets of genes, i.e., vision, circadian clock and pigmentation genes. Putative non-functional alleles for four vision genes were identified. …”
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Regulatory Networks of Flowering Genes in <i>Angelica sinensis</i> during Vernalization by Mimi Luo, Xiaoxia Liu, Hongyan Su, Meiling Li, Mengfei Li, Jianhe Wei

“…According to functional annotation, 104 co-expressed genes were classified into six categories: FLC expression (22; e.g., <i>VILs</i>, <i>FCA</i> and <i>FLK</i>), sucrose metabolism (12; e.g., <i>TPSs</i>, <i>SUS3</i> and <i>SPSs</i>), hormone response (18; e.g., <i>GID1B</i>, <i>RAP2s</i> and <i>IAAs</i>), circadian clock (2; i.e., <i>ELF3</i> and <i>COR27</i>), downstream floral integrators and meristem identity (15; e.g., <i>SOC1</i>, <i>AGL65</i> and <i>SPLs</i>) and cold response (35; e.g., <i>PYLs</i>, <i>ERFs</i> and <i>CORs</i>). …”
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Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome by Florent Gobert, Alexandra Corneyllie, Hélène Bastuji, Christian Berthomier, Marc Thevenet, Jonas Abernot, Véronique Raverot, Frédéric Dailler, Claude Guérin, Claude Gronfier, Jacques Luauté, Fabien Perrin

“…Abstract Fluctuations of consciousness and their rhythmicities have been rarely studied in patients with a disorder of consciousness after acute brain injuries. 24-h assessment of brain (EEG), behaviour (eye-opening), and circadian (clock-controlled hormones secretion from urine) functions was performed in acute brain-injured patients. …”
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Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice by Bradley B. Jamieson, Aleisha M. Moore, Dayanara B. Lohr, Simone X. Thomas, Lique M. Coolen, Michael N. Lehman, Rebecca E. Campbell, Richard Piet, Richard Piet

“…In rodents, the preovulatory surge is triggered by these hormonal cues and coincident timing signals from the central circadian clock in the suprachiasmatic nucleus (SCN). …”
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The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes by Luise Fuhr, Mónica Abreu, Annalucia Carbone, Rukeia El-Athman, Fabrizio Bianchi, Mikko O. Laukkanen, Gianluigi Mazzoccoli, Angela Relógio

“…In the current work we utilized fibroblasts isolated from tubulovillous adenoma, which has high risk for malignant transformation, to study the interaction between benign tumour stroma and the circadian clock machinery. We explored the role of the biological clock in this interplay taking advantage of an experimental model, represented by the co-culture of colon cancer cells with normal fibroblasts or tumour-associated fibroblasts, isolated from human colorectal tumour specimens. …”
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The impact of a self-selected time restricted eating intervention on eating patterns, sleep, and late-night eating in individuals with obesity by Stacey L. Simon, Jennifer Blankenship, Emily N. C. Manoogian, Satchidananda Panda, Douglas G. Mashek, Lisa S. Chow

“…All participants logged oral intake using the myCircadian Clock mobile application throughout the entire intervention. …”
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Associations of sleep disorders with all-cause and cause-specific mortality in cancer survivors: a cross-sectional analysis of the NHANES 2005–2016 by Jingying Nong, Jinzhuo Tong, Ruotian Wang, Kejian Shi, Yi Zhang

“…Abstract Background The circadian clock and endoplasmic reticulum stress signaling play important roles in oncogenesis and development of cancer. …”
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Pilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome by Iwona Świątkiewicz, Celestyna Mila-Kierzenkowska, Alina Woźniak, Karolina Szewczyk-Golec, Jarosław Nuszkiewicz, Joanna Wróblewska, Paweł Rajewski, Simone J. P. M. Eussen, Kristine Færch, Emily N. C. Manoogian, Satchidananda Panda, Pam R. Taub

“…Dietary intake, sleep, activity and wellbeing will be monitored with the myCircadianClock application and questionnaires. Adherence to TRE defined as the proportion of days recorded with app during the monitored intervention in which participants satisfied 10-h TRE is the primary outcome. …”
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Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica) by L. Dalle Carbonare, A. Basile, L. Rindi, F. Bulleri, H. Hamedeh, S. Iacopino, V. Shukla, D. A. Weits, L. Lombardi, A. Sbrana, L. Benedetti-Cecchi, B. Giuntoli, F. Licausi, E. Maggi

“…We first monitored the fluctuations of putative circadian-clock genes over a period of 24 h along the ALAN gradient. …”
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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection by Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar Vasudevan, Aarti Jagannath

“…Here we show that sleep deprivation profoundly alters the transcriptional landscape of the lung, causing the suppression of both innate and adaptive immune systems, disrupting the circadian clock, and activating genes implicated in SARS-CoV-2 replication, thereby generating a lung environment that could promote viral infection and associated disease pathogenesis. …”
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