Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway by Mingyue Sheng, Mingyue Sheng, Xun Chen, Xun Chen, Yan Yu, Yan Yu, Qi Wu, Junping Kou, Junping Kou, Gangling Chen, Gangling Chen

“…Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian rhythms that affects multiple molecular, cellular, and physiology pathways that control susceptibility, injury, and recovery in the neurological disorders. …”
Get full text

Acid pH Strategy Adaptation through <i>NRG1</i> in <i>Ustilago maydis</i> by José Alejandro Sánchez-Arreguin, José Ruiz-Herrera, F. de Jesus Mares-Rodriguez, Claudia Geraldine León-Ramírez, Lino Sánchez-Segura, Patricio Adrián Zapata-Morín, Jordan Coronado-Gallegos, Elva Teresa Aréchiga-Carvajal

“…Four of the seven genes included <i>WCO1</i> codifying PAS domain ( These has been shown as the key structural motif involved in protein-protein interactions of the circadian clock, and it is also a common motif found in signaling proteins, where it functions as a signaling sensor) domains sensors of blue light, two of the three previously reported to encode opsins, one vacuolar and non-pH-responsive, and another one whose role in the acid pH response was already known. …”
Get full text

Circadian control of ConA-induced acute liver injury and inflammatory response via Bmal1 regulation of Junb by Zhaiyi Liu, Jiayang Zhang, Shuyao Li, Hui Wang, Baoyin Ren, Jiazhi Li, Zhiyue Bao, Jiaxin Liu, Meina Guo, Guangrui Yang, Lihong Chen

“…However, the significance of the circadian clock in autoimmune hepatitis (AIH), which is characterised by immune-mediated hepatocyte destruction and extensive inflammatory cytokine production, remains unclear. …”
Get full text

In vitro and in vivo investigation into the role of lysine specific demethylases in the molecular circadian oscillator by Shepherd, H

“…</p> <p>LSD1 and LSD2 were found to interact with circadian clock proteins <em>in vitro</em>. The LSD1 mutations were found to decrease the ability of LSD1 to bind to its primary cofactor CoREST and to CLOCK, BMAL1 and PER1 and PER2. …”

Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding induced nonalcoholic steatohepatitis alleviation by Jiafeng Xia, Wanru Guo, Ming Hu, Xiuyuan Jin, Sitong Zhang, Boqiang Liu, Hangyuan Qiu, Kaicen Wang, Aoxiang Zhuge, Shengjie Li, Zhongkang Ji, Lanjuan Li, Kaijin Xu

“…ABSTRACTWith the drive of the endogenous circadian clock and external cues such as feeding behavior, the microbial community generates rhythmic oscillations in composition and function. …”
Get full text

Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes? by Carolina López-Cano, Liliana Gutiérrez-Carrasquilla, Ferran Barbé, Enric Sánchez, Marta Hernández, Raquel Martí, Vicky Ceperuelo-Mallafre, Mireia Dalmases, Sonia Fernández-Veledo, Joan Vendrell, Cristina Hernández, Rafael Simó, Albert Lecube

“…Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. We examined whether the expression of Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α relates to changes in the expression of clock genes (Period homolog proteins (PER)1, PER2, PER3, Retinoid-related orphan receptor alpha (RORA), Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), Circadian locomotor output cycles kaput (CLOCK), and Cryptochrome proteins (CRY) 1 and CRY2) in patients with type 2 diabetes. …”
Get full text

BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma by Shuai-Jun Chen, Yi Huang, Fan Yu, Xiao Feng, Yuan-Yi Zheng, Qian Li, Qian Niu, Ye-Han Jiang, Li-Qin Zhao, Meng Wang, Pei-Pei Cheng, Lin-Jie Song, Li-Mei Liang, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye

“…The aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) is a major circadian clock transcriptional activator that is also extensively expressed in peripheral tissues and plays a crucial role in organ and tissue metabolism. …”
Get full text

The Quasimesenchymal Pancreatic Ductal Epithelial Cell Line PANC-1—A Useful Model to Study Clonal Heterogeneity and EMT Subtype Shifting by Hendrik Ungefroren, Isabel Thürling, Benedikt Färber, Tanja Kowalke, Tanja Fischer, Leonardo Vinícius Monteiro De Assis, Rüdiger Braun, Darko Castven, Henrik Oster, Björn Konukiewitz, Ulrich Friedrich Wellner, Hendrik Lehnert, Jens-Uwe Marquardt

“…Interestingly, the different EMT phenotypes were found to segregate with differences in tumorigenic potential in vitro, as measured by colony forming and invasive activities, and in circadian clock function. Moreover, the individual clones the phenotypes of which remained stable upon prolonged culture also responded differently to treatment with transforming growth factor (TGF)β1 in regard to regulation of growth and individual TGFβ target genes, and to culture conditions that favour ductal-to-endocrine transdifferentiation as a more direct measure for cellular plasticity. …”
Get full text

Genome and evolution of Prosopis alba Griseb., a drought and salinity tolerant tree legume crop for arid climates by Wenqian Kong, Min Liu, Peter Felker, Mauricio Ewens, Cecilia Bessega, Carolina Pometti, Jinpeng Wang, Peng Xu, Jia Teng, Jinyu Wang, Xiyin Wang, Yuannian Jiao, Magdy S. Alabady, Françoise Thibaud‐Nissen, Patrick Masterson, Xin Qiao, Andrew H. Paterson

“…The 50 most expanded gene families include many that are involved in ion homeostasis, perhaps related to drought and/or salt adaptation, together with photosynthetic genes carbonic anhydrase (CA), malate dehydrogenase (MDH) and malic enzyme and gene families involved in circadian clock systems, synthesis of brassinosteroids, auxin and gibberellin. …”
Get full text

Systematic analysis of a Monoterpene synthase from bangun-bangun (Plectranthus amboinicus lour. spreng) by Ashaari, Nur Suhanawati

“…Transcript expression analysis revealed that PamTps1 was up-regulated in leaves (42-fold of expression level) instead of stems which were associated with linalool emission following a diurnal rhythm regulated by circadian clock of the plant. Homology modelling of PamTps1 was predicted using BPPS (1N24) with 67 % sequence identity as a template. …”
Get full text

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise by Ana P. Pinto, Vitor R. Muñoz, Alisson L. da Rocha, Rafael L. Rovina, Gustavo D. Ferrari, Luciane C. Alberici, Fernando M. Simabuco, Fernando M. Simabuco, Giovana R. Teixeira, Giovana R. Teixeira, José R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva, Adelino S. R. da Silva

“…Also, IL-6 is interconnected to circadian clock-related inflammation and can be suppressed by the nuclear receptor subfamily 1, group D, member 1 (Nr1d1, protein product REV-ERBα). …”
Get full text

The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specif... by Brooke M. Van Loh, Alexandra M. Yaw, Joseph A. Breuer, Brooke Jackson, Duong Nguyen, Krystal Jang, Fabiola Ramos, Emily V. Ho, Laura J. Cui, Dominique L. M. Gillette, Lorenzo F. Sempere, Michael R. Gorman, Michael R. Gorman, Karen J. Tonsfeldt, Karen J. Tonsfeldt, Pamela L. Mellon, Pamela L. Mellon, Hanne M. Hoffmann, Hanne M. Hoffmann

“…On a molecular level, the shortening of the SCN period was driven, at least partially, by a direct regulatory role of VAX1 on the circadian clock genes Bmal1 and Per2. Interestingly, Vax1Vip females presented with increased expression of arginine vasopressin (Avp) in the paraventricular nucleus, which resulted in increased circulating corticosterone. …”
Get full text

Defining the age-dependent and tissue-specific circadian transcriptome in male mice by Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser

“…Summary: Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. …”
Get full text

Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD by Manuel Johanns, Joel T. Haas, Violetta Raverdy, Jimmy Vandel, Julie Chevalier-Dubois, Loic Guille, Bruno Derudas, Benjamin Legendre, Robert Caiazzo, Helene Verkindt, Viviane Gnemmi, Emmanuelle Leteurtre, Mehdi Derhourhi, Amélie Bonnefond, Philippe Froguel, Jérôme Eeckhoute, Guillaume Lassailly, Philippe Mathurin, François Pattou, Bart Staels, Philippe Lefebvre

“…Background &amp; Aims: Liver homeostasis is ensured in part by time-of-day-dependent processes, many of them being paced by the molecular circadian clock. Liver functions are compromised in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), and clock disruption increases susceptibility to MASLD progression in rodent models. …”
Get full text

Circadian miR-218-5p targets gene CA2 to regulate uterine carbonic anhydrase activity during egg shell calcification by Xiaxia Du, Zhifu Cui, Zifan Ning, Xun Deng, Felix Kwame Amevor, Gang Shu, Xiaoqi Wang, Zhichao Zhang, Yaofu Tian, Qing Zhu, Yan Wang, Diyan Li, Yao Zhang, Xiaoling Zhao

“…ABSTRACT: MicroRNAs (miRNAs) are involved in regulating the circadian clock. In our previous work, miR-218-5p was found to be a circadian miRNA in the chicken uterus, but its role in the eggshell formation process was not clear. …”
Get full text

Circadian Rhythm Alteration of the Core Clock Genes and the Lipid Metabolism Genes Induced by High-Fat Diet (HFD) in the Liver Tissue of the Chinese Soft-Shelled Turtle (<i>Trionyx... by Li Liu, Lingli Liu, Shiming Deng, Li Zou, Yong He, Xin Zhu, Honghui Li, Yazhou Hu, Wuying Chu, Xiaoqing Wang

“…The mechanism might be regulated by 17 circadian clock genes and 18 fat metabolism genes, together with a high-fat diet (HFD). …”
Get full text

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms by Rebecca C Schugar, Christy M Gliniak, Lucas J Osborn, William Massey, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Danny Orabi, Robert N Helsley, Amanda L Brown, Amy Burrows, Chelsea Finney, Kevin K Fung, Frederick M Allen, Daniel Ferguson, Anthony D Gromovsky, Chase Neumann, Kendall Cook, Amy McMillan, Jennifer A Buffa, James T Anderson, Margarete Mehrabian, Maryam Goudarzi, Belinda Willard, Tytus D Mak, Andrew R Armstrong, Garth Swanson, Ali Keshavarzian, Jose Carlos Garcia-Garcia, Zeneng Wang, Aldons J Lusis, Stanley L Hazen, Jonathan Mark Brown

“…This study underscores the relationship between microbe and host metabolism and provides evidence that gut microbe-derived trimethylamine (TMA) is a key regulator of the host circadian clock. This work also demonstrates that gut microbe-targeted enzyme inhibitors have potential as anti-obesity therapeutics.…”
Get full text

Exploring circadian rhythms, food intake, and their interactions in marine invertebrates by Berger, Cory Ailin

“…Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. …”
Get full text

Identification of Rhythmically Expressed LncRNAs in the Zebrafish Pineal Gland and Testis by Shital Kumar Mishra, Taole Liu, Han Wang

Get full text

Thousands of oscillating LncRNAs in the mouse testis by Shital Kumar Mishra, Taole Liu, Han Wang

Get full text