AID function in somatic hypermutation and class switch recombination by Yu Kefei

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Parp3 negatively regulates immunoglobulin class switch recombination. by Isabelle Robert, Léa Gaudot, Mélanie Rogier, Vincent Heyer, Aurélia Noll, Françoise Dantzer, Bernardo Reina-San-Martin

“…Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by the recruitment of activation-induced cytidine deaminase (AID) to immunoglobulin loci and by the subsequent generation of DNA lesions, which are differentially processed to mutations during SHM or to double-stranded DNA break intermediates during CSR. …”
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Onychomadesis in a Patient with Immunoglobulin Class Switch Recombination Deficiency by Mojgan Safari, Nima Rezaei, Mehrdad Hajilooi, Asghar Aghamohammadi, Qiang Pan-Hammarstrom, Lennart Hammarstrom

Subjects: “…Class switch recombination Hyper IgM Syndrome…”
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AIDing chromatin and transcription-coupled orchestration of immunoglobulin class switch recombination by Bharat eVaidyanathan, Bharat eVaidyanathan, Wei-Feng eYen, Wei-Feng eYen, Joseph ePucella, Joseph ePucella, Jayanta eChaudhuri, Jayanta eChaudhuri, Jayanta eChaudhuri

“…Secondary diversification of the antibody repertoire upon antigenic challenge, in the form of immunoglobulin heavy chain (IgH) class switch recombination (CSR) endows mature, naïve B cells in peripheral lymphoid organs with a limitless ability to mount an optimal humoral immune response, thus expediting pathogen elimination. …”
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PP4 is essential for germinal center formation and class switch recombination in mice. by Ming-Yu Chen, Ya-Ping Chen, Ming-Sian Wu, Guanni-Yi Yu, Wen-Jye Lin, Tse-Hua Tan, Yu-Wen Su

“…Basal levels of serum Igs of all isotypes were strongly reduced in CD23(cre)PP4(F/F) mice, and their B cells showed a reduced efficiency of class switch recombination (CSR) in vitro upon stimulation by LPS or LPS plus IL-4. …”
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IgH 3' regulatory region increases ectopic class switch recombination. by Sandrine Le Noir, Amélie Bonaud, Bastien Hervé, Audrey Baylet, François Boyer, Sandrine Lecardeur, Zeliha Oruc, Christophe Sirac, Michel Cogné

“…DNA lesions inflicted by activation-induced deaminase (AID) instrumentally initiate the processes reshaping immunoglobulin genes in mature B-cells, from local somatic hypermutation (SHM) to junctions of distant breaks during class switch recombination (CSR). It remains incompletely understood how these divergent outcomes of AID attacks are differentially and temporally focused, with CSR strictly occurring in the Ig heavy chain (IgH) locus while SHM concentrates on rearranged V(D)J regions in the IgH and Ig light chain loci. …”
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Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses by Helena Kuri-Magaña, Helena Kuri-Magaña, Leonardo Collado-Torres, Leonardo Collado-Torres, Andrew E. Jaffe, Andrew E. Jaffe, Andrew E. Jaffe, Andrew E. Jaffe, Humberto Valdovinos-Torres, Marbella Ovilla-Muñoz, Juan Téllez-Sosa, Laura C. Bonifaz, Jesús Martínez-Barnetche

Subjects: “…Class Switch Recombination…”
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The immunoglobulin heavy chain super enhancer controls class switch recombination in developing B cells by Audrey Dauba, Emmanuelle Näser, Dylan Andrieux, Michel Cogné, Yves Denizot, Ahmed Amine Khamlichi

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Comprehensive FISH probe design tool applied to imaging human immunoglobulin class switch recombination. by Jakub Nedbal, Philip S Hobson, David J Fear, Rainer Heintzmann, Hannah J Gould

“…This novel technique offers the possibility of gaining unprecedented insight into the molecular mechanisms involved in class switch recombination.…”
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Novel CD40LG Mutation in Two Cousins With Immunoglobulin Class Switch Recombinant Deficiency by Shahnaz Armin, Keyvan Ramezani, Bibi Shahin Shamsian, Zahra Chavoshzadeh, Maryam Eghbali, Alireza Zare Bidoki, Maryam Sadr, Mehrnaz Mesdaghi, Hooshang Gorjipour, Sepideh Razi, Nima Rezaei

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Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination by Hongchang Zhao, Stella R Hartono, Kirtney Mae Flores de Vera, Zheyuan Yu, Krishni Satchi, Tracy Zhao, Roger Sciammas, Lionel Sanz, Frédéric Chédin, Jacqueline Barlow

Subjects: “…class switch recombination…”
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B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation by Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Pietro Di Lucia, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John D. Crispino, Ziv Shulman

“…Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. …”
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Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination by Xikui Sun, Xikui Sun, Jingning Bai, Jingning Bai, Jiejie Xu, Jiejie Xu, Xiaoli Xi, Mingyu Gu, Mingyu Gu, Chengming Zhu, Hongman Xue, Chun Chen, Junchao Dong, Junchao Dong, Junchao Dong

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Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination. by Fernando Grigera, Alfonso Bellacosa, Amy L Kenter

“…Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the post-transcriptional level of several MMR proteins, including MutS homologue 2 (MSH2). …”
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HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression by Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum

“…Summary: B cells generate functionally different classes of antibodies through class-switch recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to join the DNA breaks at the donor and acceptor switch (S) regions. …”
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ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. by Tina A Müller, Kefei Yu, Robert P Hausinger, Katheryn Meek

“…To assess ALKBH1's role in class switch recombination, splenic B cells were isolated from Alkbh1(-/-) and Alkbh1(+/+) mice and subjected to switching from IgM to IgG1. …”
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P628: HIGH THROUGHPUT IMMUNOGENETIC EVIDENCE FOR EXTENSIVE IN VIVO CLASS SWITCH RECOMBINATION EVENTS IN CLL by E. Sofou, A. Agathangelidis, A.-M. Antoniadou, E. Georgiou, M. Papaioannou, N. Pechlivanis, F. Psomopoulos, K. Stamatopoulos, A. Chatzidimitriou

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Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination by Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi

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TLR9 signaling in B cells determines class switch recombination to IgG2a by Jegerlehner, A, Maurer, P, Bessa, J, Hinton, H, Kopf, M, Bachmann, M

TLR9 signaling in B cells determines class switch recombination to IgG2a. by Jegerlehner, A, Maurer, P, Bessa, J, Hinton, H, Kopf, M, Bachmann, M

“…Although IgG2a is the most potent Ab isotype in the host response to viral and bacterial infections, the regulation of class switch recombination to IgG2a in vivo is not yet well understood. …”