Clinical Trial Design in Alzheimer's Disease by Seyed Mehrdad Savar, Niayesh Mohebbi

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Clinical Trial Exclusion Criteria Affect Trial Inclusivity by Race and Sex by Robert J. Stanton, Yasmin N. Aziz, Heidi Sucharew, Mary Haverbusch, David J. Robinson, Elisheva Coleman, Felipe De Los Rios La Rosa, Stacie Demel, Simona Ferioli, Jason Mackey, Adam Jasne, Tracy E. Madsen, Eva Mistry, Sabreena Slavin, Michael Star, Kyle Walsh, Daniel Woo, Pooja Khatri, Joseph Broderick, Brett Kissela, Dawn O. Kleindorfer

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Biomarkers navigate drug development: Pharmacology, effectiveness and safety by Daohong Chen

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Design and implementation of an adaptive confirmatory trial in Japanese patients with palmoplantar pustulosis by Richuan Zheng, Yoichi M. Ito, Motonari Yunoki, Kazuki Minoda, Soyoku Nobeyama

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A comparison of clinical development pathways to advance tuberculosis regimen development by V. Chang, P. P. J. Phillips, M. Z. Imperial, P. Nahid, R. M. Savic

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Estimating vaccine efficacy during open-label follow-up of COVID-19 vaccine trials based on population-level surveillance data by Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes

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Looking ahead in early-phase trial design to improve the drug development process: examples in oncology by Alyssa M. Vanderbeek, Robert A. Redd, Steffen Ventz, Lorenzo Trippa

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Optimal trial design selection: a comparative analysis between two-arm and three-arm trials incorporating network meta-analysis for evaluating a new treatment by Fangshu Ye, Chong Wang, Annette M. O’Connor

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Connecting a disconnected trial network with a new trial: optimizing the estimation of a comparative effect in a network meta-analysis by Lauren McKeen, Paul Morris, Chong Wang, Max D. Morris, Annette M. O’Connor

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Pulmonary hypertension in interstitial lung disease: Clinical trial design and endpoints: A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Dev... by Steven D. Nathan, Peter Fernandes, Mitchell Psotka, Patrizio Vitulo, Lucilla Piccari, Katerina Antoniou, Sylvia M. Nikkho, Norman Stockbridge

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How do study design features and participant characteristics influence willingness to participate in clinical trials? Results from a choice experiment by Caitlin Thomas, Sarah Mulnick, Nicolas Krucien, Kevin Marsh

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Intramuscular ketamine vs. midazolam for rapid risk-reduction in suicidal, depressed emergency patients: Clinical trial design and rationale by Sumra Sajid, Ryan E. Lawrence, Hanga C. Galfalvy, John G. Keilp, Vivek K. Moitra, J. John Mann, Michael F. Grunebaum

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Why Is There No Cure for Tinnitus? by Don J. McFerran, Don J. McFerran, David Stockdale, Ralph Holme, Charles H. Large, David M Baguley, David M Baguley, David M Baguley, David M Baguley

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Patients’ preferences for selection of endpoints in cardiovascular clinical trials by Robert D. Chow, Kashmira P. Wankhedkar, Mihriye Mete

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COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps by Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi

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Shaping a research agenda to ensure a successful European health technology assessment: insights generated during the inaugural convention of the European access academy by Elaine Julian, Mira Pavlovic, Oriol Sola-Morales, Fabrizio Gianfrate, Mondher Toumi, Heiner C. Bucher, Christian Dierks, Wolfgang Greiner, Peter Mol, Jean-François Bergmann, Tomas Salmonson, Ansgar Hebborn, Mathilde Grande, Antonella Cardone, Jörg Ruof

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A randomized triple-blind controlled clinical trial evaluation of sitagliptin in the treatment of patients with non-alcoholic fatty liver diseases without diabetes by Azam Doustmohammadian, Ahmad Nezhadisalami, Fahimeh Safarnezhad Tameshke, Nima Motamed, Mansooreh Maadi, Mohammad Farahmand, Masoudreza Sohrabi, Cain C. T. Clark, Hossein Ajdarkosh, Amir Hossein Faraji, Mehdi Nikkhah, Elham Sobhrakhshankhah, Ramin Ebrahimi, Farhad Zamani

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Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak by Pauline Manchon, Drifa Belhadi, France Mentré, Cédric Laouénan

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Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV by Minhee Kang, Jennifer C. Price, Marion G. Peters, Sharon R. Lewin, Mark Sulkowski

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Simulations for designing and interpreting intervention trials in infectious diseases by M. Elizabeth Halloran, Kari Auranen, Sarah Baird, Nicole E. Basta, Steven E. Bellan, Ron Brookmeyer, Ben S. Cooper, Victor DeGruttola, James P. Hughes, Justin Lessler, Eric T. Lofgren, Ira M. Longini, Jukka-Pekka Onnela, Berk Özler, George R. Seage, Thomas A. Smith, Alessandro Vespignani, Emilia Vynnycky, Marc Lipsitch

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