Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34⁺ Cells, Potentially through Downregulation of ROS Production and Activation of the Src-Lyn-p11... by Ga-Bin Park, Min-Jung Kim, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han, Ho Sup Lee, Daejin Kim, Jee-Yeong Jeong

“…There have been efforts to overcome this limitation by using various cytokine cocktails and antioxidants. In this study, we investigated the effects of echinochrome A (Ech A)-a well-established and non-toxic antioxidant-on the ex vivo expansion of HSPCs by analyzing a CD34⁺ cell population and their biological functions. …”
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Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment by Jacob J. Zulk, Justin R. Clark, Samantha Ottinger, Mallory B. Ballard, Marlyd E. Mejia, Vicki Mercado-Evans, Emmaline R. Heckmann, Belkys C. Sanchez, Barbara W. Trautner, Anthony W. Maresso, Kathryn A. Patras

“…These results have implications for developing cocktails of phage with multiple different bacterial targets, of which each is evaded only at the cost of bacterial fitness.…”
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Pectobacterium carotovorum Phage vB_PcaM_P7_Pc Is a New Member of the Genus Certrevirus by Kishani N. Naligama, Anupama P. Halmillawewa

“…Further, the selection of taxonomically different phages for the formulation of phage cocktails in biocontrol applications is critical to combat potential bacterial resistance development. …”
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A genomic perspective on the potential of termite-associated Cellulosimicrobium cellulans MP1 as producer of plant biomass-acting enzymes and exopolysaccharides by Nguyen Thi-Hanh Vu, Tung Ngoc Quach, Xuan Thi-Thanh Dao, Ha Thanh Le, Chi Phuong Le, Lam Tung Nguyen, Lam Tung Le, Cuong Cao Ngo, Ha Hoang, Ha Hoang Chu, Quyet-Tien Phi

“…Background Lignocellulose is a renewable and enormous biomass resource, which can be degraded efficiently by a range of cocktails of carbohydrate-active enzymes secreted by termite gut symbiotic bacteria. …”
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Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454 by Nikolay P. Arbatsky, Anastasiya A. Kasimova, Alexander S. Shashkov, Mikhail M. Shneider, Anastasiya V. Popova, Dmitry A. Shagin, Andrey A. Shelenkov, Yuliya V. Mikhailova, Yurii G. Yanushevich, Ruth M. Hall, Yuriy A. Knirel, Johanna J. Kenyon

“…Capsular polysaccharide (CPS) is a primary receptor for many lytic bacteriophages, and thus knowledge of the chemical structures of CPS produced by the species will underpin the identification of suitable phages for therapeutic cocktails. However, recent research has shown that some isolates carry additional genes outside of the CPS biosynthesis K locus, which can modify the CPS structure. …”
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Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2 by Jessica Wagoner, Shawn Herring, Tien-Ying Hsiang, Aleksandr Ianevski, Scott B. Biering, Shuang Xu, Markus Hoffmann, Stefan Pöhlmann, Michael Gale, Tero Aittokallio, Joshua T. Schiffer, Judith M. White, Stephen J. Polyak

“…Our findings therefore bode well for the development of oral drug cocktails for at home use at the first sign of an infection by a coronavirus or other emerging viral pathogens.…”
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Comparative Study of the Myocardium of Patients from Four COVID-19 Waves by Lubov Borisovna Mitrofanova, Igor Aleksandrovich Makarov, Andrey Nikolaevich Gorshkov, Andrey Leonidovich Runov, Maxim Sergeevich Vonsky, Maria Mikhailovna Pisareva, Andrey Borisovich Komissarov, Taiana Alekseevna Makarova, Qingli Li, Tatiana Leonidovna Karonova, Alexandra Olegovna Konradi, Evgeny Vladimirovich Shlaykhto

“…We also did immunofluorescent staining of three myocardial specimens using VP1/SARS-CoV-2 antibody cocktails. Further, we ran RT-ddPCR analysis for 14 RNA samples extracted from paraffin-embedded myocardium. …”
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Phage resistance formation and fitness costs of hypervirulent Klebsiella pneumoniae mediated by K2 capsule-specific phage and the corresponding mechanisms by Miran Tang, Zeyu Huang, Xiaodong Zhang, Jingchun Kong, Beibei Zhou, Yijia Han, Yi Zhang, Lijiang Chen, Tieli Zhou

“…Our study suggests that K2-specific phage has the potential to function as an antivirulence agent, or a part of phage cocktails combined with phages targeting phage-resistant bacteria, against hvKP-relevant infections.…”
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Alcohol Exclusion Laws and Its Drawbacks by William Ngo

“…Liquor containing high percentages of alcohol, such as Everclear which contains up to 190 proofs, are often masked by sweeteners and flavorings. Cocktails like these can cause a person to become dangerously intoxicated without their realization or intention. …”
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