Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells. by Elnaz Farahbakhshian, Monique M Verstegen, Trudi P Visser, Sima Kheradmandkia, Dirk Geerts, Shazia Arshad, Noveen Riaz, Frank Grosveld, Niek P van Til, Jules P P Meijerink

“…To test the ability to expand HSCs in vitro prior to transplantation, two growth factor cocktails containing stem cell factor, thrombopoietin, fms-related tyrosine kinase-3 ligand (STF) or stem cell factor, thrombopoietin, insulin-like growth factor-2, fibroblast growth factor-1 (STIF) either with or without the addition of angiopoietin-like protein-3 (Angptl3) were used. …”
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Cone snail species off the Brazilian coast and their venoms: a review and update by Helena B. Fiorotti, Suely G. Figueiredo, Fabiana V. Campos, Daniel C. Pimenta

“…By swiftly harpooning and injecting their prey and predators with such deadly cocktails, the slow-moving cone snails guarantee their survival in the harsh, competitive marine environment. …”
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Molecular Detection and Genotyping of Human Papilloma Virus Infections in Iraqi Patients with Esophageal Carcinoma. by Intisar M. Jumaa, Saad H. Mohammed Ali, Tural Y. Bakir, Delaram M. M. Ardalan

“…The molecular detection methods for HPV detection and genotyping were performed by in situ hybridization using cocktailed- and specific high- risk HPV DNA probes, respectively. …”
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Identification of <i>Aethina tumida</i> Kir Channels as Putative Targets of the Bee Venom Peptide Tertiapin Using Structure-Based Virtual Screening Methods by Craig A. Doupnik

“…Identifying individual venom components and their target(s) with mechanism of action is now attainable to understand comprehensively the effectiveness of venom cocktails and how they collectively function in the defense and predation of an organism. …”
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Furniture Environment in Today’s Conditions: Challenges and Opportunities by Pavlykivska Olha I., Kamyshnykova Evelina V., Halyniak Lesia O.

“…As part of charitable activities, the company produced a flammable mixture for Molotov cocktails, barrier road devices «hedgehogs», sewed «plate carriers», blankets and pillows, fabricated the economy-class «student beds». …”
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Availability and consumption of different alcoholic beverages and use of drinking contexts among adolescents in three Mexican cities by Mallie J. Paschall, Christopher L. Ringwalt, Joel W. Grube, Ted Miller, Kenneth R. Warren, Virginia Gidi, Deborah A. Fisher, Allison Goldberg

“…Objectives: This descriptive study examined alcohol consumption, perceived availability, and purchase of different types of alcoholic beverages (i.e., beer, wine, tequila, other spirits, pre-mixed cocktails, alcohol energy drinks, homemade alcohol), and drinking contexts. …”
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A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. by John Lok Man Law, Chao Chen, Jason Wong, Darren Hockman, Deanna M Santer, Sharon E Frey, Robert B Belshe, Takaji Wakita, Jens Bukh, Christopher T Jones, Charles M Rice, Sergio Abrignani, D Lorne Tyrrell, Michael Houghton

“…Although a cure for HCV is on the near horizon, emerging drug cocktails will be expensive, associated with side-effects and resistance making a global vaccine an urgent priority given the estimated high incidence of infection around the world. …”
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Structural and Computational Studies of the SARS-CoV-2 Spike Protein Binding Mechanisms with Nanobodies: From Structure and Dynamics to Avidity-Driven Nanobody Engineering by Gennady Verkhivker

“…The review is focused on the analysis of mechanisms underlying synergistic binding of multivalent nanobodies that can be superior to single nanobodies and conventional nanobody cocktails in combating escape mutations by effectively leveraging binding avidity and allosteric cooperativity. …”
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Comparative Assay of Glutathione S- Transferase (GSTs) Activity of Excretory-Secretory Materials and Somatic Extract of Fasciola spp Parasites by Heshmatollah Alirahmi, Ali Farahnak, Taghi Golmohamadi, Mohammad Reza Esharghian

“…In order to assay the enzyme activity, excretory-secretory and somatic extracts in the form of cocktails (potassium phosphate buffer, reduced glutathione and 1-chloro-2,4-dinitrobenzene substrates) were prepared and their absorbance recorded for 5 minutes at 340 nm. …”
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Bile salt metabolism is not the only factor contributing to Clostridioides (Clostridium) difficile disease severity in the murine model of disease by Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce

“…Animals given only the five antibiotic cocktails showed only transient colonization and no disease. …”
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Comparative secretome analyses of two <it>Trichoderma reesei </it>RUT-C30 and CL847 hypersecretory strains by Lignon Sabrina, Mollé Daniel, Jan Gwénaël, Dolla Alain, Margeot Antoine, Herpoël-Gimbert Isabelle, Mathis Hughes, Sigoillot Jean-Claude, Monot Frédéric, Asther Marcel

“…Comparison of protein patterns in both strains highlighted many unexpected differences between cellulase cocktails. The results demonstrate that 2D electrophoresis is a promising tool for studying cellulase production profiles, whether for industrial characterization of an entire secretome or for a more fundamental study on cellulase expression at genome-wide scale.…”
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In vivo expressed biologics for infectious disease prophylaxis: rapid delivery of DNA-based antiviral antibodies by Chasity D. Andrews, Yaoxing Huang, David D. Ho, Rachel A. Liberatore

“…Furthermore, the development of mAb cocktails can provide a faster route to developing a robust medical intervention than searching for a single, outstanding mAb. …”
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Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy by Nader El-Sayes, Alyssa Vito, Karen Mossman

“…These multi-therapy regimens have long been a mainstay of clinical oncology with chemotherapy cocktails but are more recently being investigated in the emerging landscape of immunotherapy. …”
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Factors affecting phage development and anti-phage defence systems in Staphylococcus aureus by Igor Eduardo Astudillo Skliarova

“…The knowledge of factors affecting phage infection will improve the design of phage therapies or the formulation of phage cocktails. Furthermore, drugs inhibiting those factors could be developed and implemented in phage adjunctive therapies. …”
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DEVELOPMENT OF PROTEIN FOAMER TECHNOLOGY FOR USE IN SPORTS NUTRITION by Krumlikov V.Y., Izgarysheva N.V., Pozo-Dengra J., Kriger O.V.

“…The product has a high content of essential amino acids and can be recommended as a protein component of the protein cocktails for sports nutrition. Production of protein foam concentrates with a high content of protein from secondary raw materials (pig blood plasma) is a good way to improve the quality of functional foods using a low cost process.…”
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Design and feasibility testing of a novel group intervention for young women who binge drink in groups. by Linda Irvine, Iain K Crombie, Vivien Swanson, Elena D Dimova, Ambrose J Melson, Tracey M Fraser, Rosaline Barbour, Peter M Rice, Sheila Allan

“…Components of the intervention were woven around fun activities, such as making alcohol free cocktails. Women were followed up four months after the intervention was delivered.…”
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Cost of Manufacturing for Recombinant Snakebite Antivenoms by Timothy Patrick Jenkins, Andreas Hougaard Laustsen

“…Notably, according to our calculations, it appears that such next-generation antivenoms based on cocktails of monoclonal immunoglobulin Gs (IgGs) could be manufacturable at a comparable or lower cost to current plasma-derived antivenoms, which are priced at USD 13-1120 per treatment. …”
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Morphologically distinct Escherichia coli bacteriophages differ in their efficacy and ability to stimulate cytokine release in vitro by Mohammadali eKhan Mirzaei, Yeneneh eHaileselassie, Marit eNavis, Callum eCooper, Eva eSverremark-Ekström, Anders S Nilsson

“…In order to address concerns over safety and the poorly understood pharmacokinetics of phages and their associated cocktails, immunological characterization is required. …”
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Combinatorial peptide-based epitope mapping from Ebola virus DNA vaccines and infections reveals residue-level determinants of antibody binding by Daniel R. Ripoll, Daniel A. J. Mitchell, Lesley C. Dupuy, Anders Wallqvist, Connie Schmaljohn, Sidhartha Chaudhury

“…One of the therapeutic approaches for treating EBOV infection focus largely on cocktails of monoclonal antibodies (mAbs) that bind to specific regions of the EBOV glycoprotein (GP) and neutralize the virus. …”
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Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting. by David J Kahler, Faizzan S Ahmad, Anita Ritz, Haiqing Hua, Dorota N Moroziewicz, Andrew A Sproul, Carmen R Dusenberry, Linshan Shang, Daniel Paull, Matthew Zimmer, Keren A Weiss, Dieter Egli, Scott A Noggle

“…This technique prospectively isolates fully reprogrammed iPSCs, and depletes both parental and "contaminating" partially reprogrammed fibroblasts, thereby substantially reducing the time and reagents required to generate iPSC lines without the use of defined small molecule cocktails. FACS derived iPSC lines express common markers of pluripotency, and possess spontaneous differentiation potential in vitro and in vivo. …”
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