Genome sequencing and transcriptome analysis of Trichoderma reesei QM9978 strain reveals a distal chromosome translocation to be responsible for loss of vib1 expression and loss of... by Christa Ivanova, Jonas Ramoni, Thiziri Aouam, Alexa Frischmann, Bernhard Seiboth, Scott E. Baker, Stéphane Le Crom, Sophie Lemoine, Antoine Margeot, Frédérique Bidard

“…During the last 50 years, the ascomycete Trichoderma reesei, the main source of industrial cellulase and hemicellulase cocktails, has been subjected to several rounds of classical mutagenesis with the aim to obtain higher production levels. …”
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A genomic perspective on the potential of termite-associated Cellulosimicrobium cellulans MP1 as producer of plant biomass-acting enzymes and exopolysaccharides by Nguyen Thi-Hanh Vu, Tung Ngoc Quach, Xuan Thi-Thanh Dao, Ha Thanh Le, Chi Phuong Le, Lam Tung Nguyen, Lam Tung Le, Cuong Cao Ngo, Ha Hoang, Ha Hoang Chu, Quyet-Tien Phi

“…Background Lignocellulose is a renewable and enormous biomass resource, which can be degraded efficiently by a range of cocktails of carbohydrate-active enzymes secreted by termite gut symbiotic bacteria. …”
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Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454 by Nikolay P. Arbatsky, Anastasiya A. Kasimova, Alexander S. Shashkov, Mikhail M. Shneider, Anastasiya V. Popova, Dmitry A. Shagin, Andrey A. Shelenkov, Yuliya V. Mikhailova, Yurii G. Yanushevich, Ruth M. Hall, Yuriy A. Knirel, Johanna J. Kenyon

“…Capsular polysaccharide (CPS) is a primary receptor for many lytic bacteriophages, and thus knowledge of the chemical structures of CPS produced by the species will underpin the identification of suitable phages for therapeutic cocktails. However, recent research has shown that some isolates carry additional genes outside of the CPS biosynthesis K locus, which can modify the CPS structure. …”
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Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2 by Jessica Wagoner, Shawn Herring, Tien-Ying Hsiang, Aleksandr Ianevski, Scott B. Biering, Shuang Xu, Markus Hoffmann, Stefan Pöhlmann, Michael Gale, Tero Aittokallio, Joshua T. Schiffer, Judith M. White, Stephen J. Polyak

“…Our findings therefore bode well for the development of oral drug cocktails for at home use at the first sign of an infection by a coronavirus or other emerging viral pathogens.…”
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Comparative Study of the Myocardium of Patients from Four COVID-19 Waves by Lubov Borisovna Mitrofanova, Igor Aleksandrovich Makarov, Andrey Nikolaevich Gorshkov, Andrey Leonidovich Runov, Maxim Sergeevich Vonsky, Maria Mikhailovna Pisareva, Andrey Borisovich Komissarov, Taiana Alekseevna Makarova, Qingli Li, Tatiana Leonidovna Karonova, Alexandra Olegovna Konradi, Evgeny Vladimirovich Shlaykhto

“…We also did immunofluorescent staining of three myocardial specimens using VP1/SARS-CoV-2 antibody cocktails. Further, we ran RT-ddPCR analysis for 14 RNA samples extracted from paraffin-embedded myocardium. …”
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Phage resistance formation and fitness costs of hypervirulent Klebsiella pneumoniae mediated by K2 capsule-specific phage and the corresponding mechanisms by Miran Tang, Zeyu Huang, Xiaodong Zhang, Jingchun Kong, Beibei Zhou, Yijia Han, Yi Zhang, Lijiang Chen, Tieli Zhou

“…Our study suggests that K2-specific phage has the potential to function as an antivirulence agent, or a part of phage cocktails combined with phages targeting phage-resistant bacteria, against hvKP-relevant infections.…”
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Cellulase and xylanase-producing Trichoderma Asperellum and Rhizopus Oryzae for effective saccharification of oil palm frond leaves by solid-state fermentation by Ezeilo, Uchenna Regina

“…Thermal and pH stability tests for their enzyme cocktails revealed half-lives for UC1 CMCase, FPase, ß-glucosidase and xylanase to be 15.18, 4.06, 17.47, 15.16 h at 60 °C, as well as 64.59, 25.14, 68.59 and 19.20 h at pH 4.0; UC2 - 5.13, 1.48, 18.81, 9.23 h when incubated at 60 °C and 27.55, 12.23, 18.26, 4.43 h at pH 4.0. …”
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Alcohol Exclusion Laws and Its Drawbacks by William Ngo

“…Liquor containing high percentages of alcohol, such as Everclear which contains up to 190 proofs, are often masked by sweeteners and flavorings. Cocktails like these can cause a person to become dangerously intoxicated without their realization or intention. …”
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