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2221
Antisense Peptide Technology for Diagnostic Tests and Bioengineering Research
Published 2021-08-01“…This phenomenon is closely related to the structure of the standard genetic code table, and at the same time, is unrelated to the direction of its codon sequence translation. The concept of <i>complementary peptide interaction</i> is discussed, and its possible applications to diagnostic tests and bioengineering research are summarized. …”
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2222
Chromosomal periodicity and positional networks of genes in Escherichia coli
Published 2010-01-01“…Here, we find that genes with a highly biased codon composition and characterizing a functional core in Escherichia coli K12 show to be periodically distributed along the arcs, suggesting an encoded three‐dimensional genomic organization helping functional activities among which are translation and, possibly, transcription. …”
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2223
Novel Mutations in The Coding Region of The Third Exon of Myostatin (MSTN) Gene in Madura Cattle
Published 2023-04-01“…Among the identified novel mutations, one mutation in c.1301G/T caused a stop codon for the TT genotype cattle. However, no cattle carried the TT genotype. …”
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2224
Microbial divergence and evolution. The case of anammox bacteria
Published 2024-02-01“…The apparent evolution of the HDH genes in these anammox bacteria is highly related to the diversification of the anammox clades and their genomes as pointed by phylogenomics, their GC content and codon usage profile. This study represents a clear case where bacterial evolution presents a paralleled genome, gene and species diversification through time from a common ancestor; a scenario that most times is masked by a web-like phylogeny and the huge complexity within the prokaryotes. …”
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2225
The complete mitochondrial genome of record-breaking migrant Arctic tern (Sterna paradisaea)
Published 2019-07-01“…The analysis of mitochondrial DNA (mtDNA) base composition, codon usage, and genome arrangement patterns can provide insight into metabolic pathways and evolutionary history. …”
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2226
Caracterización de polimorfismos en el gen pfmdr1 en aislados clínicos de p. Falciparum en Colombia
Published 2004-02-01“…La mutación Asn-86-Try en este gen, se ha relacionado con resistencia a CQ y con sensibilidad a MQ, HF y ART, mientras que la presencia del codón silvestre Asp-1246 se ha relacionado con resistencia a estos últimos antimaláricos (2).…”
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2227
Complete mitochondrial genome of a golden orb-web spider Trichonephila clavata (Chelicerata, Arachnida) from South Korea
Published 2023-07-01“…The phylogenetic trees using the maximum likelihood (ML) method were reconstructed with nucleotides (without 3rd codon position) and amino acids from 13 PCGs, respectively, which consistently confirmed that T. clavata (Subfamily Nephilinae) from South Korea and China are clustered together, distinctly separated from the other subfamily Araneinae in the monophyletic family Araneidae.…”
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2228
Tissue-specific differences in human transfer RNA expression.
Published 2006-12-01“…Relative tRNA abundance exhibits a statistically significant correlation to the codon usage of a collection of highly expressed, tissue-specific genes in a subset of tissues or tRNA isoacceptors. …”
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2229
Conjugation of proteins by installing BIO-orthogonally reactive groups at their N-termini.
Published 2012-01-01“…In the second step, the N-terminus of the engineered protein was modified in vivo with bio-orthogonally functional groups by reassigning functional methionine surrogates such as L-homopropargylglycine and L-azidohomoalanine into the first methionine codon of the engineered internal methionine-free GFP. …”
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2230
The first complete mitochondrial genome of the hawkmoth Marumba saishiuana (Lepidoptera: Sphingidae) and insights into its phylogenetic position
Published 2022-08-01“…Most of 13 PCGs initiate with the standard start codon of ATN, except cox1, which starts with CGA. …”
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2231
Complete mitochondrial genome of Penaeus acehensis (Crustacea, Decapoda, Penaeidae) from Aceh province, Indonesia
Published 2018-07-01“…Incomplete stop codon (T- -) was found in five genes including COX2, COX3, NAD5, NAD4, and NAD4L. …”
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2232
Whole exome sequencing identifies a mutation in thrombomodulin as the genetic cause of a suspected platelet disorder in a family with normal platelet function
Published 2017-08-01“…This sequence change results in a stop codon (p.Cys537Stop) and truncation of the protein and has been previously described in two other families with bleeding events which suggests it may be a recurrent mutation. …”
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2233
Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code
Published 2020-03-01“…The Elongation Factor-Tu GTPase anticodon-codon latch that checks the accuracy of translation appears to have evolved at about the eight amino acid to ~16 amino acid stage. …”
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2234
Hunting for a cure: the therapeutic potential of gene therapy in Duchenne muscular dystrophy
Published 2014“…This review focuses on several main strategies in gene therapy, including truncated dystrophin gene transfer via viral vectors, antisense mediated exon skipping to restore the reading frame, and read-through of translation stop codons. An exon skipping agent, eteplirsen, and a termination codon read drug, ataluren, are currently the most promising therapies. …”
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2235
Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.
Published 2000“…Five different germline mutations were detected in DPC4; three of these were deletions, one a single base substitution creating a stop codon, and one a missense change. None of these patients had distinguishing clinical features. …”
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2236
Viral vectored transmission blocking vaccines against Plasmodium falciparum
Published 2010“…Materials and methods: Protein sequences for each of the antigens were codon optimised for expression in humans and cloned into shuttle vectors, which were then recombined with the parental virus and purified to obtain virus expressing the antigen of interest. …”
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2237
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants
Published 2017“…Out of a total of five positively selected SNPs, four represented nonsense mutations resulting in stop codons, three of these in a single ApiAP2 transcription factor gene, and one in SRPK1. …”
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2238
Transposon insertion in a serine-specific minor tRNA coding sequence affects intraperitoneal survival of Haemophilus influenzae in the infant rat model.
Published 2010“…Among 25 different paraquat-sensitive mutants only one mutant harbouring a Tn-insertion within the tRNA-Ser1 gene specific for the rare serine codon UCC, was highly attenuated for intraperitoneal infectivity. …”
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2239
Co-inheritance of Hb Pak Num Po, a novel alpha1 gene mutation, and alpha0 thalassemia associated with transfusion-dependent Hb H disease.
Published 2004“…Extensive molecular analyses of the alpha globin genes and their regulatory sequence (HS-40) revealed that both patients are compound heterozygotes for alpha0 thalassemia (--(SEA)) and a novel point mutation, a thymidine insertion after codon 131 of the alpha1 gene. The resulting frameshift gives rise to a highly unstable alpha globin chain, which we refer to as "Hb Pak Num Po," containing an additional 34 amino acids. …”
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2240
Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.
Published 2013“…A number of potential therapies have been investigated for the treatment of this disease including utrophin upregulation, 'stop-codon read through' aminoglycosides and adeno-associated virus gene replacement as well as stem cell therapy. …”
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