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2361
The marker choice: Unexpected resolving power of an unexplored CO1 region for layered DNA barcoding approaches.
Published 2017-01-01“…In contrast, the amplification of the "Folmer region" using the universal primers was difficult and the third codon positions of this fragment have experienced nucleotide substitution saturation. …”
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Article -
2362
Genomic Insights into the Rice Blast Fungus through Estimation of Gene Emergence Time in Phylogenetic Context
Published 2018-10-01“…Our phylostrata-wide analysis of genes revealed that genes in the same phylostratum tend to be similar in many physical and functional characteristics such as gene length and structure, GC contents, codon adaptation index, and level of transcription, which correlates with biological functions in evolutionary context. …”
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Article -
2363
A Modelling Framework Linking Resource-Based Stochastic Translation to the Optimal Design of Synthetic Constructs
Published 2021-01-01“…We show how our framework can be used to link a synthetic construct’s modular design (promoter, ribosome binding site (RBS) and codon composition) to protein yield during continuous culture, with a particular focus on the effects of low-efficiency codons and their impact on ribosomal queues. …”
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Article -
2364
Detection of Testicular Metastasis from Renal Cell Carcinoma on PSMA-PET Scan
Published 2024-03-01Get full text
Article -
2365
Characterization of complete mitochondrial genome of Pogonophryne albipinna (Perciformes: Artedidraconidae)
Published 2020-01-01“…Except for ATP6 gene and COI (GTG), 11 genes begin with the typical start codon, while incomplete stop codons (T– –) were identified in COII, ND4, and CytB. …”
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Article -
2366
Cloning and Comparative Studies of Seaweed Trehalose-6-Phosphate Synthase Genes
Published 2010-07-01“…PyTPS encodes a protein of 908 amino acids before a stop codon, and has a calculated molecular mass of 101,591 Daltons. …”
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Article -
2367
An engineered bacterium auxotrophic for an unnatural amino acid: a novel biological containment system
Published 2015-09-01“…This synthetic auxotrophy was achieved by conditional production of the antidote protein against the highly toxic enzyme colicin E3. An amber stop codon was inserted in the antidote gene. The translation of the antidote mRNA was controlled by a translational switch using amber-specific 3-iodo-L-tyrosine incorporation. …”
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Article -
2368
Propagation of a De Novo Gene under Natural Selection: Antifreeze Glycoprotein Genes and Their Evolutionary History in Codfishes
Published 2021-11-01“…In three select species representing different AFGP-bearing clades, we analyzed all AFGP gene family members and the broader scale <i>AFGP</i> genomic regions in detail. Codon usage analyses suggest that motif duplication produced the intragenic AFGP tripeptide coding repeats, and rapid sequence divergence post-duplication stabilized the recombination-prone long repetitive coding region. …”
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Article -
2369
Reduction in noise-induced functional loss of the cochleae in mice with pre-existing cochlear dysfunction due to genetic interference of prestin.
Published 2014-01-01“…To address this question, a genetic model of prestin dysfunction in mice was created by inserting an internal ribosome entry site (IRES)-CreERT2-FRT-Neo-FRT cassette into the prestin locus after the stop codon. Homozygous mice exhibit a threshold elevation of auditory brainstem responses with large individual variation. …”
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Article -
2370
Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome
Published 2007-11-01“…The second had a mutation causing a premature stop codon (Q47X) in the Fas gene and the Y446C substitution in caspase-10. …”
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Article -
2371
Two interesting cases of a rare haemoglobin variant – Haemoglobin J Meerut with varied clinical presentations
Published 2023-01-01“…It results from mutation at codon 120 of the α globin gene changing the alanine to glutamic acid. …”
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Article -
2372
The complete mitochondrial genome of Dudusa sphingiformis (Lepidoptera: Notodontidae) and phylogenetic analysis
Published 2021-10-01“…Almost all the PCGs initiated with typical ATN codons, except for cox1 with CGA. Among them, nine PCGs terminated with TAA or TAG, while other four PCGs (cox1, cox2, nad5, and nad4) with incomplete stop codon T. …”
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Article -
2373
The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils.
Published 2006-12-01“…Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products. …”
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Article -
2374
The complete mitochondrial genome of the blue runner, Caranx crysos (Mitchill, 1815) (Teleostei: Carangidae)
Published 2021-04-01“…The circular mitogenome encoded a typical 37 genes, including 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (12S rRNA and 16S rRNA), and 22 tRNA genes. An unusual start codon (GTG) was identified for the COX1 gene, and incomplete stop codons (T–/TA–) were found in seven genes, including ND2, ND3, ND4, COX2, COX3, ATP6, and CytB. …”
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Article -
2375
NMR study of eukaryotic translation termination
Published 2013“…Exact mechanism of stop codon recognition by class I release factor eRF1 and the cooperative role of class II release factor eRF3 remain obscure. …”
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Thesis -
2376
Molecular phylogeny of horseshoe crab using mitochondrial Cox1 gene as a benchmark sequence
Published 2010“…The observed mean Genetic Distance (GD) value was higher in 3rd codon position in all the selected group of organisms. …”
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Proceeding Paper -
2377
Molecular phylogeny of horseshoe crab
Published 2011“…The observed mean Genetic Distance (GD) value was higher in 3rd codon position in all the selected group of organisms. …”
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Article -
2378
A ribosomopathy reveals decoding defective ribosomes driving human dysmorphism.
Published 2017“…The amino acid substitutions lie in two highly conserved loop regions of uS12 with known roles in maintaining the accuracy of mRNA codon translation. Primary cells revealed one substitution severely impaired OGFOD1-dependent hydroxylation of a neighboring proline residue resulting in 40S ribosomal subunits that were blocked from polysome formation. …”
Journal article -
2379
Allelic variation in normal human FBN1 expression in a family with Marfan syndrome: a potential modifier of phenotype?
Published 2003“…This suggested that allelic variation in normal FBN1 expression might occur in MFS families, and have potential clinical implications particularly for those with premature termination codon (PTC) mutations who usually display low levels of expression from the mutant allele due to nonsense-mediated decay (NMD). …”
Journal article -
2380
A stretched conformation of DNA with a biological role?
Published 2017“…Because a triplet is the length of a gene codon, we speculate that the structural physics of nucleic acids may have biased the evolution of recombinase proteins to exploit triplet base stacks and also the genetic code.…”
Journal article