Development of a local bacterial isolate expressing cyclodextrin glycosyltransferase through molecular cloning approaches by Ramli, Norhayati

“…The recognition of TTG as a start codon was assisted by the presence of Shine-Dalgarno sequence, which located at 6 bp upstream from the initiation codon. …”
Get full text

PRODUCTION OF L-TRYPTOPHAN BY MUTANTS OF CORYNEBACTERIUM GLUTAMICUM by Hamies Mohamed, Ghada El Nady, A. Ali, A. Abdel-Razik, S. Ibrahim

“…To detect and compare the difference between the parent strains and the muted strains genetically two molecular markers were used start codon targeted polymorphism (SCoT) and Inter-simple sequence repeats (ISSR). …”
Get full text

Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia by Xiaohui Tao, Tian Xu, Li Liu, Xiaoyun Lin, Zhenlin Zhang, Hua Yue

“…Thr193GlyfsX13) in the NR0B1 (nuclear receptor subfamily 0, group B, member 1) gene, resulting in a premature stop codon due to a frameshift mutation. During treatment and follow-up, the proband did not respond well to bisphosphonate and developed atypical femoral fractures. …”
Get full text

Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability by Leon Y Chan, Christopher F Mugler, Stephanie Heinrich, Pascal Vallotton, Karsten Weis

“…Here, we combine non-invasive transcriptome-wide mRNA production and stability measurements with selective and acute perturbations to demonstrate that mRNA degradation is tightly coupled to the regulation of translation, and that a competition between translation initiation and mRNA decay -but not codon optimality or elongation- is the major determinant of mRNA stability in yeast. …”
Get full text

Landscape and progress of global COVID-19 vaccine development by Hui-Yao Huang, Shu-Hang Wang, Yu Tang, Wei Sheng, Chi-Jian Zuo, Da-Wei Wu, Hong Fang, Qiong Du, Ning Li

Get full text

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases by Emilia Zarembska, Klaudia Ślusarczyk, Małgorzata Wrzosek

“…The C677T polymorphism, which results in the conversion of valine to alanine at codon 222, is associated with reduced activity and an increased thermolability of the enzyme. …”
Get full text

Methylmercury-Mediated Oxidative Stress and Activation of the Cellular Protective System by Masatake Fujimura, Fusako Usuki

“…Furthermore, MeHg-induced intracellular selenium deficiency due to the greater affinity of MeHg for selenohydryl groups and selenides leads to failure in the recoding of a UGA codon for selenocysteine and results in the degradation of antioxidant selenoenzyme mRNA by nonsense-mediated mRNA decay. …”
Get full text

The complete mitochondrial genome of Anthrenus museorum (Coleoptera: Bostrichiformia: Dermestidae) from China by Yangyang Liu, Yaoyao Dong, Zhenglong Ye, Siyong Wu, Guoyong Li

“…The typical ATN start codon was observed in all PCGs, except for ND3 (TTG), and all 13 PCGs showed three types of stop codons (TAA, TAG, and T-). …”
Get full text

Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry by Hindmarsh Patrick L, Laimins Laimonis A

“…In contrast, modification of the codons in the capsid genes to ones more commonly used in cellular genes resulted in high-level synthesis. …”
Get full text

Wnt/β-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis by Gayatri D Shirolkar, Sara Pasic, Jully Gogoi-Tiwari, Manoj K Bhat, John K Olynyk, Arun Dharmarajan, Janina EE Tirnitz-Parker

Get full text

Comprehensive quantitative modeling of translation efficiency in a genome‐reduced bacterium by Marc Weber, Adrià Sogues, Eva Yus, Raul Burgos, Carolina Gallo, Sira Martínez, Maria Lluch‐Senar, Luis Serrano

“…We found that, although the initiation rate varied over 160‐fold among genes, most of the known factors had little impact on translation efficiency. Local codon elongation rates could not be fully explained by the adaptation to tRNA abundances, which varied over 100‐fold among tRNA isoacceptors. …”
Get full text

Genetic mapping revealed that the Pun2 gene in Capsicum chacoense encodes a putative aminotransferase by Shieun Yi, Do-Gyeong Lee, Seungki Back, Ju-Pyo Hong, Siyoung Jang, Koeun Han, Byoung-Cheorl Kang

“…This mutation resulted in the generation of an early stop codon, resulting in a truncated mutant lacking the PLP binding site, which is critical for pAMT enzymatic activity. …”
Get full text

Junctional epidermolysis bullosa: genotype-phenotype correlations by Alexey A. Kubanov, Vadim V. Chikin, Arfenya E. Karamova, Ekaterina S. Monchakovskaya

“…The correlation between severe types of junctional epidermolysis bullosa and mutations resulting in premature stop codon generation and complete absence of protein expression has been described. …”
Get full text

Separating the effects of mutation and selection in producing DNA skew in bacterial chromosomes by Morton Brian R, Morton Richard A

“…First, it quantifies the role of mutation in generating skew so that its effect on composition, for example codon bias, can be assessed. Second, it provides an objective method for locating origin and terminus, one that is based on chromosome-wide accumulation of leading <it>vs </it>lagging strand nucleotide differences. …”
Get full text

Molecular evaluation of E198A SNP in the iso-type 1 β – tubulin gene of Haemonchus contortus isolated from sheep in Al-Diwanyiah, Iraq by Akram M. Amana, Mansoor J. Alkhaled

“…This study investigated the benzimidazole resistance in <em>Haemonchus contortus</em> parasitic nematodes from sheep from October 2021 to December 2022 in Al-Diwanyiah city/Iraq, and samples were processed at the laboratory of Parasitology in Veterinary Medicine College of Al-Qadissyiah University through the detection of E198A mutation and SNP polymorphism of the β-tubulin gene at this codon position. Ninety adult <em>H. contortus</em> samples were collected from the abomasum of sheep (n = 400) and then tested by qPCR and tetra-primer ARMS-PCR. …”
Get full text

Molecular epidemiology and disease severity of human respiratory syncytial virus in Vietnam. by Dinh Nguyen Tran, Thi Minh Hong Pham, Manh Tuan Ha, Thi Thu Loan Tran, Thi Kim Huyen Dang, Lay-Myint Yoshida, Shoko Okitsu, Satoshi Hayakawa, Masashi Mizuguchi, Hiroshi Ushijima

“…One GA2 genotype strain had a premature stop codon which shortened the G protein length. RSV infection was significantly associated with younger age and higher severity score than those without. …”
Get full text

Exon Shuffling and Origin of Scorpion Venom Biodiversity by Xueli Wang, Bin Gao, Shunyi Zhu

“…In this work, we analyzed the exon-intron structures of an array of scorpion venom protein-encoding genes and unexpectedly found that nearly all of these genes possess a phase-1 intron (one intron located between the first and second nucleotides of a codon) near the cleavage site of a signal sequence despite their mature peptides remarkably differ. …”
Get full text

Experimental Confirmation of a Whole Set of tRNA Molecules in Two Archaeal Species by Yoh-ichi Watanabe, Yutaka Kawarabayasi

“…Based on the genomic sequences for most archaeal species, only one tRNA gene (isodecoder) is predicted for each triplet codon. This observation promotes analysis of a whole set of tRNA molecules and actual splicing patterns of interrupted tRNA in one organism. …”
Get full text

The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia by Ceren Acar, sukru Kartalci

“…The most commonly studied polymorphism in COMT gene is rs4680 and it causes a valine methionine conversion at codon 158. The association studies on this polymorphism in different populations gave both positive and negative results. …”
Get full text

Caracterização molecular de uma família com nem2a e suas implicações clínicas. by M C Lemos, F Carrilho, F J Rodrigues, M Cavalheiro, F J Regateiro, M M Ruas

“…RET gene mutations were screened for in affected individuals and their offspring by PCR-RFLP techniques.Genetic testing revealed a point mutation at codon 634 (TGC>TGG), in the heterozygous state, in all affected individuals. …”
Get full text