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2501
Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation
Published 2023-03-01“…Here, the effectiveness of ovine rPrP mutants at codon 136 and peptides derived from this region were assessed for their ability to inhibit PrPSc replication, using protein misfolding cyclic amplification (PMCA). …”
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2502
Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas
Published 2019-02-01“…A single mutation was observed at codon C383G in pvdhps gene (SGKAV, 48%). CONCLUSION No evidence of molecular signatures associated with P. vivax resistance to SP was observed in the Brazilian samples.…”
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2503
Diversity of the Genes Implicated in Algerian Patients Affected by Usher Syndrome.
Published 2016-01-01“…The deleterious consequences of a missense mutation of CDH23 (p.Asp1501Asn) and the in-frame single codon deletion in USH1G (p.Ala397del) on the corresponding proteins were predicted from the solved 3D-structures of extracellular cadherin (EC) domains of cadherin-23 and the sterile alpha motif (SAM) domain of USH1G/sans, respectively. …”
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2504
Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V
Published 2023-06-01“…Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. …”
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2505
An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis
Published 2020-10-01“…A 3D structure of the vaccine construct was predicted, followed by disulphide engineering for stability, codon adaptation and in silico cloning for proper expression and molecular protein–protein docking of vaccine construct in the vector against toll-like receptor 4 receptor, respectively. …”
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2506
A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia.
Published 2013-02-01“…In CFT073, neaT appears to be unameliorated, having an exceptionally A+T-rich composition along with a notably altered codon bias. These data suggest that neaT was recently brought into the proteobacterial pan-genome from an extra-phyletic source. …”
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2507
A Fungal Conserved Gene from the Basidiomycete Hebeloma cylindrosporum Is Essential for Efficient Ectomycorrhiza Formation
Published 2014-10-01“…Molecular analyses showed that the single-copy disrupting T-DNA was integrated 6,884 bp downstream from the start codon, of an open reading frame potentially encoding a 3,096-amino-acid-long protein. …”
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2508
Comparative and phylogenetic analyses of nine complete chloroplast genomes of Orchidaceae
Published 2023-12-01“…Following that, topics such as analysis of selection pressure, codon usage, amino acid frequencies, repeated sequences, and reverse repeat contraction and expansion are covered. …”
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2509
The first complete mitochondrial genome of Matsucoccidae (Hemiptera, Coccoidea) and implications for its phylogenetic position
Published 2022-11-01“…All PCGs were initiated by the ATN start codons and ended with the TAA/G or single T-- stop codons. …”
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2510
The First Two Complete Mitochondrial Genomes of Neoephemeridae (Ephemeroptera): Comparative Analysis and Phylogenetic Implication for Furcatergalia
Published 2021-11-01“…Two neoephemerid mitogenomes had a similar gene size, base composition, and codon usage of protein-coding genes (PCGs), and the sequenced gene arrangements were consistent with the putative ancestral insect mitogenomes as understood today. …”
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2511
Estimating the protein burden limit of yeast cells by measuring the expression limits of glycolytic proteins
Published 2018-08-01“…Some proteins had low expression limits that were explained by their localization and metabolic perturbations. The codon usage should be highly optimized to trigger the protein-burden effect, even under strong transcriptional induction. …”
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2512
Cloning and Expression of a Novel GH134 β-Mannanase Gene from Thermophilic Fungus Rhizopus microsporus and Its Application in Juice Processing
Published 2023-08-01“…The cloned RmMan134 gene had a total length of 552 bp without introns, encoding 183 amino acids and one stop codon. The expressed enzyme was composed of one signal peptide sequence of 19 amino acid residues and the catalytic region of the GH134 family. …”
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2513
BglBricks: A flexible standard for biological part assembly
Published 2010-01-01“…In particular, the system is not suitable for the construction of protein fusions due to an unfavorable scar sequence that encodes an in-frame stop codon.</p> <p>Results</p> <p>Here, we present a similar but new composition standard, called BglBricks, that addresses the scar translation issue associated with the original standard. …”
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2514
Complex and simple translational readthrough signals in pea enation mosaic virus 1 and potato leafroll virus, respectively.
Published 2022-09-01“…Different essential viral proteins are translated via programmed stop codon readthrough. Pea enation mosaic virus 1 (PEMV1) and potato leafroll virus (PLRV) are related positive-sense RNA plant viruses in the family Solemoviridae, and are type members of the Enamovirus and Polerovirus genera, respectively. …”
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2515
Structural Characteristics of Mitochondrial Genomes of Eight Treehoppers (Hemiptera: Membracidae: Centrotinae) and Their Phylogenetic Implications
Published 2023-07-01“…Phylogenetic analyses were conducted using both maximum likelihood and Bayesian inference methods based on three separate nucleotide sequence datasets in which RNA gene sequences and/or third codon positions were either included or excluded from the concatenated protein-coding gene alignments. …”
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2516
Mutation detection and prenatal diagnosis of XLHED pedigree
Published 2017-08-01“…The mutation, c.172-173insGG, which leads to an immediate premature stop codon in exon one caused severe structural changes of EDA. …”
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2517
Association of GSTP1 Ile-105-Val Gene Polymorphism with Response to Treatment Among Iraqi Chronic Myeloid Leukaemia Patients
Published 2018-12-01“…Method: A ‘PCR-RFLP’ assay was implemented to detect the polymorphic variants of codon 105 GSTP1 gene of forty Iraqi CML patients in chronic phase referring to the National Center of Haematology in the period between November 2017 and July 2018. …”
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2518
Nucleic acid amplification-based HER2I655V molecular detection for breast cancer
Published 2019-04-01“…Single Nucleotide Polymorphism at codon 655 of HER2 gene has been extensively evaluated for its role as a susceptible biomarker for breast cancer development and the contradictive result of its role has been a debate among researchers as evidenced from case-control studies. …”
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2519
Severe congenital thrombocytopenia and platelet dysfunction due to novel WAS gene mutation: case report
Published 2022-12-01“…This mutation produces a frameshift, with substitution of aspartic acid for glycine at position 502 of the protein, and causes a downstream stop-loss codon. Clinically, the infant displayed severe thrombocytopenia and thrombasthenia, in the absence of other WAS-related traits (i.e., immune deficiency, eczema). …”
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2520
Genome-wide survey of cold stress regulated alternative splicing in Arabidopsis thaliana with tiling microarray.
Published 2013-01-01“…The majority of cold regulated alternative splicing introduced a premature termination codon (PTC) into the transcripts creating potential targets for degradation by the nonsense mediated mRNA decay (NMD) process. …”
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