Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation by Katarzyna Kopycka, Ben C. Maddison, Kevin C. Gough

“…Here, the effectiveness of ovine rPrP mutants at codon 136 and peptides derived from this region were assessed for their ability to inhibit PrPSc replication, using protein misfolding cyclic amplification (PMCA). …”
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Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas by Larissa Rodrigues Gomes, Aline Lavigne, Patrícia Brasil, Cassio Leonel Peterka, Didier Ménard, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz

“…A single mutation was observed at codon C383G in pvdhps gene (SGKAV, 48%). CONCLUSION No evidence of molecular signatures associated with P. vivax resistance to SP was observed in the Brazilian samples.…”
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Diversity of the Genes Implicated in Algerian Patients Affected by Usher Syndrome. by Samia Abdi, Amel Bahloul, Asma Behlouli, Jean-Pierre Hardelin, Mohamed Makrelouf, Kamel Boudjelida, Malek Louha, Ahmed Cheknene, Rachid Belouni, Yahia Rous, Zahida Merad, Djamel Selmane, Mokhtar Hasbelaoui, Crystel Bonnet, Akila Zenati, Christine Petit

“…The deleterious consequences of a missense mutation of CDH23 (p.Asp1501Asn) and the in-frame single codon deletion in USH1G (p.Ala397del) on the corresponding proteins were predicted from the solved 3D-structures of extracellular cadherin (EC) domains of cadherin-23 and the sterile alpha motif (SAM) domain of USH1G/sans, respectively. …”
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Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V by Alexandra Viktoria Busley, Mandy Kleinsorge, Lukas Cyganek

“…Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. …”
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An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis by Olugbenga S. Onile, Adeyinka I. Fadahunsi, Ameerah A. Adekunle, Bolaji F. Oyeyemi, Chiaka I. Anumudu

“…A 3D structure of the vaccine construct was predicted, followed by disulphide engineering for stability, codon adaptation and in silico cloning for proper expression and molecular protein–protein docking of vaccine construct in the vector against toll-like receptor 4 receptor, respectively. …”
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A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia. by Travis J Wiles, J Paul Norton, Sara N Smith, Adam J Lewis, Harry L T Mobley, Sherwood R Casjens, Matthew A Mulvey

“…In CFT073, neaT appears to be unameliorated, having an exceptionally A+T-rich composition along with a notably altered codon bias. These data suggest that neaT was recently brought into the proteobacterial pan-genome from an extra-phyletic source. …”
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A Fungal Conserved Gene from the Basidiomycete Hebeloma cylindrosporum Is Essential for Efficient Ectomycorrhiza Formation by Jeanne Doré, Roland Marmeisse, Jean-Philippe Combier, Gilles Gay

“…Molecular analyses showed that the single-copy disrupting T-DNA was integrated 6,884 bp downstream from the start codon, of an open reading frame potentially encoding a 3,096-amino-acid-long protein. …”
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Comparative and phylogenetic analyses of nine complete chloroplast genomes of Orchidaceae by Likuan Liu, Jingxuan Du, Zhihua Liu, Wenming Zuo, Zhenglei Wang, Jinping Li, Yang Zeng

“…Following that, topics such as analysis of selection pressure, codon usage, amino acid frequencies, repeated sequences, and reverse repeat contraction and expansion are covered. …”
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The first complete mitochondrial genome of Matsucoccidae (Hemiptera, Coccoidea) and implications for its phylogenetic position by Kai Hu, Sanpeng Yu, Niannian Zhang, Maojuan Tian, Qiming Ban, Zhongliang Fan, Jiansheng Qiu

“…All PCGs were initiated by the ATN start codons and ended with the TAA/G or single T-- stop codons. …”
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The First Two Complete Mitochondrial Genomes of Neoephemeridae (Ephemeroptera): Comparative Analysis and Phylogenetic Implication for Furcatergalia by Ran Li, Zhenxing Ma, Changfa Zhou

“…Two neoephemerid mitogenomes had a similar gene size, base composition, and codon usage of protein-coding genes (PCGs), and the sequenced gene arrangements were consistent with the putative ancestral insect mitogenomes as understood today. …”
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Estimating the protein burden limit of yeast cells by measuring the expression limits of glycolytic proteins by Yuichi Eguchi, Koji Makanae, Tomohisa Hasunuma, Yuko Ishibashi, Keiji Kito, Hisao Moriya

“…Some proteins had low expression limits that were explained by their localization and metabolic perturbations. The codon usage should be highly optimized to trigger the protein-burden effect, even under strong transcriptional induction. …”
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Cloning and Expression of a Novel GH134 β-Mannanase Gene from Thermophilic Fungus Rhizopus microsporus and Its Application in Juice Processing by LIU Xue, HAN Pu, CHEN Wei, TIAN Hongtao, GU Xinxi

“…The cloned RmMan134 gene had a total length of 552 bp without introns, encoding 183 amino acids and one stop codon. The expressed enzyme was composed of one signal peptide sequence of 19 amino acid residues and the catalytic region of the GH134 family. …”
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BglBricks: A flexible standard for biological part assembly by Dueber John E, Anderson J Christopher, Leguia Mariana, Wu Gabriel C, Goler Jonathan A, Arkin Adam P, Keasling Jay D

“…In particular, the system is not suitable for the construction of protein fusions due to an unfavorable scar sequence that encodes an in-frame stop codon.</p> <p>Results</p> <p>Here, we present a similar but new composition standard, called BglBricks, that addresses the scar translation issue associated with the original standard. …”
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Complex and simple translational readthrough signals in pea enation mosaic virus 1 and potato leafroll virus, respectively. by Tamari Chkuaseli, K Andrew White

“…Different essential viral proteins are translated via programmed stop codon readthrough. Pea enation mosaic virus 1 (PEMV1) and potato leafroll virus (PLRV) are related positive-sense RNA plant viruses in the family Solemoviridae, and are type members of the Enamovirus and Polerovirus genera, respectively. …”
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Structural Characteristics of Mitochondrial Genomes of Eight Treehoppers (Hemiptera: Membracidae: Centrotinae) and Their Phylogenetic Implications by Haijun Bai, Jinrui Zhang, Christopher H. Dietrich, Yiping Li, Xiangqun Yuan

“…Phylogenetic analyses were conducted using both maximum likelihood and Bayesian inference methods based on three separate nucleotide sequence datasets in which RNA gene sequences and/or third codon positions were either included or excluded from the concatenated protein-coding gene alignments. …”
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Mutation detection and prenatal diagnosis of XLHED pedigree by Yao Lin, Wei Yin, Zhuan Bian

“…The mutation, c.172-173insGG, which leads to an immediate premature stop codon in exon one caused severe structural changes of EDA. …”
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Association of GSTP1 Ile-105-Val Gene Polymorphism with Response to Treatment Among Iraqi Chronic Myeloid Leukaemia Patients by Atyab Abdul Hameed Alaqidi, Maysem Mouayad Alwash

“…Method: A ‘PCR-RFLP’ assay was implemented to detect the polymorphic variants of codon 105 GSTP1 gene of forty Iraqi CML patients in chronic phase referring to the National Center of Haematology in the period between November 2017 and July 2018. …”
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Nucleic acid amplification-based HER2I655V molecular detection for breast cancer by Bugi Ratno Budiarto, Pimpin Utama Pohan, Desriani

“…Single Nucleotide Polymorphism at codon 655 of HER2 gene has been extensively evaluated for its role as a susceptible biomarker for breast cancer development and the contradictive result of its role has been a debate among researchers as evidenced from case-control studies. …”
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Severe congenital thrombocytopenia and platelet dysfunction due to novel WAS gene mutation: case report by Darjan Kardum, Borna Biljan, Marijana Arambašić

“…This mutation produces a frameshift, with substitution of aspartic acid for glycine at position 502 of the protein, and causes a downstream stop-loss codon. Clinically, the infant displayed severe thrombocytopenia and thrombasthenia, in the absence of other WAS-related traits (i.e., immune deficiency, eczema). …”
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Genome-wide survey of cold stress regulated alternative splicing in Arabidopsis thaliana with tiling microarray. by Noam Leviatan, Noam Alkan, Dena Leshkowitz, Robert Fluhr

“…The majority of cold regulated alternative splicing introduced a premature termination codon (PTC) into the transcripts creating potential targets for degradation by the nonsense mediated mRNA decay (NMD) process. …”
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