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2561
Genetic diversity analysis in a mini core collection of Damask rose (Rosa damascena Mill.) germplasm from Iran using URP and SCoT markers
Published 2021-09-01“…This involved the use of universal rice primers (URP) and start codon targeted (SCoT) molecular markers. Results Fourteen URP and twelve SCoT primers amplified 268 and 216 loci, with an average of 19.21 and 18.18 polymorphic fragments per primer, respectively. …”
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2562
An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.
Published 2014-10-01“…This eliminates the 3'-splice junction of exon 17, creates an alternate splice site immediately downstream in which the processed mRNA contains a frame shift, and generates a premature stop codon predicted to truncate approximately 50% of the protein. …”
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2563
The complete mitochondrial genome of Dysgonia stuposa (Lepidoptera: Erebidae) and phylogenetic relationships within Noctuoidea
Published 2020-03-01“…The newly sequenced mitogenome contained some common features reported in other Erebidae species, e.g., an A+T biased nucleotide composition and a non-canonical start codon for cox1 (CGA). Like other insect mitogenomes, the D. stuposa mitogenome had a conserved sequence ‘ATACTAA’ in an intergenic spacer between trnS2 and nad1, and a motif ‘ATAGA’ followed by a 20 bp poly-T stretch in the A+T rich region. …”
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2564
Characterization, Comparison of Four New Mitogenomes of Centrotinae (Hemiptera: Membracidae) and Phylogenetic Implications Supports New Synonymy
Published 2022-01-01“…All PCGs start with ATN, except for <i>nad5</i> (start with TTG), and stop with TAA or the incomplete stop codon T, except for <i>nad2</i> and <i>cytb</i> (terminate with TAG). …”
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2565
Identification of Missense <i>ADGRV1</i> Mutation as a Candidate Genetic Cause of Familial Febrile Seizure 4
Published 2020-09-01“…As a result, a heterozygous c.2039A>G of the <i>ADGRV1</i> gene leading to a codon change of aspartic acid to glycine at the position 680 (rs547076322) was identified. …”
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2566
Unilateral follicular variant of papillary thyroid carcinoma with unique <it>KRAS</it> mutation in struma ovarii in bilateral ovarian teratoma: a rare case report
Published 2012-06-01“…</p> <p>Normal and cancerous thyroid tissues were tested for <it>BRAF</it> and <it>RAS</it> mutations by direct sequencing, and for <it>RET/PTC</it> rearrangements by RT-PCR/Southern blotting. A <it>KRAS</it> codon 12 mutation, the GGT → GTT transversion, corresponding to the Gly → Val amino acid change was identified in the absence of other genetic alterations commonly found in PTC.…”
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2567
Comparative Mitogenomics in <i>Hyalella</i> (Amphipoda: Crustacea)
Published 2021-02-01“…<i>Hyalella</i> mitochondrial genomes show the typical AT-richness and strong nucleotide bias among codon sites and strands of pancrustaceans. Protein-coding sequences are biased towards AT-rich codons, with a preference for leucine and serine amino acids. …”
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2568
Bioprocess optimization of interferon β-1-a in Pichia pastoris and its improved inhibitory effect against hepatocellular carcinoma cells
Published 2022-03-01“…In the present study, we aimed to improve the expression level of INF-β-1a by Pichia pastoris using optimization of culture conditions. The codon-optimized INF-β- 1a gene was cloned into pPICZαA plasmid under the control of alcohol oxidase I (AOX1) promoter. …”
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2569
Overexpression of the novel MATE fluoroquinolone efflux pump FepA in Listeria monocytogenes is driven by inactivation of its local repressor FepR.
Published 2014-01-01“…The frame-shift mutation was responsible for the introduction of a premature stop codon resulting in an inactive truncated protein. …”
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2570
Complete Mitochondrial Genome Sequence, Characteristics, and Phylogenetic Analysis of <i>Oenanthe javanica</i>
Published 2023-08-01“…A total of 87 SSR (simple sequence repeat) loci were detected, with 99% composed of palindrome repeats and forward repeats, while no complementary repeats were identified. Codon preference analysis indicated that watercress prefers to use codons encoding leucine, isoleucine, and serine with a preference for A/U-ending codons. …”
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2571
Mitochondrial Genomes of <i>Hestina persimilis</i> and <i>Hestinalis nama</i> (Lepidoptera, Nymphalidae): Genome Description and Phylogenetic Implications
Published 2021-08-01“…These two mitogenomes have the typical composition, including 37 genes and a control region. The start codons of the protein-coding genes (PCGs) in the two mitogenomes are the typical codon pattern ATN, except CGA in the <i>cox1</i> gene. …”
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2572
Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: <it>in vitro </it>and <it>in vivo </it>studies
Published 2011-04-01“…</p> <p>Results</p> <p>The plant-codon-optimized hIGF-I was introduced into rice via <it>Agrobacterium</it>-mediated transformation. …”
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2573
Intraductal oncocytic papillary neoplasm arising in Peutz-Jeghers Syndrome bile duct: a unique case report
Published 2022-12-01“…Next-generation sequencing (NGS) revealed other than STK11 germline mutation, the tumor also harbors GNAS somatic mutation at codon 478 and EGFR amplification. Conclusion To our knowledge, this is the first report of IOPN arising in PJS. …”
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2574
Description and complete mitochondrial genome of Atkinsoniella zizhongi sp. nov. (Hemiptera: Cicadellidae: Cicadellinae) from China and its phylogenetic implications
Published 2022-09-01“…All of the PCGs were determined to have the typical stop codon TAA or TAG, while COX2 and ND5 ended with incomplete termination codons T and TA, respectively. …”
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2575
Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring
Published 2017-04-01“…Hemoglobin Constant Spring (HbCS, HBA2: c.427T>C) is a common nondeletional α-thalassemia resulting from a nucleotide substitution at the termination codon of the HBA2 gene. Homozygosity for HbCS is characterized with mild anemia, jaundice, and splenomegaly. …”
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2576
A novel baculovirus-derived promoter with high activity in the baculovirus expression system
Published 2016-06-01“…The strongest promoter activity was defined by a 120 nt sequence upstream of the ATG start codon for the orf46 gene. On average, GFP expression under this new promoter was more than two fold higher than the expression obtained with the standard polyhedrin (polh) promoter. …”
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2577
Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones
Published 2023-11-01“…A third nearly intact provirus, with a stop codon in Pol, was integrated into an intergenic site. …”
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2578
Renal Cell Carcinoma with Cardiac Metastases: A Case Report and Review of the Literature
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2579
<i>C</i>-Terminal Fragment of Vitellogenin II, a Potential Yolkin Polypeptide Complex Precursor Protein—Heterologous Expression, Purification, and Immunoregulatory Activity
Published 2021-07-01“…The ygp40 coding sequence was codon optimized, successfully expressed in the <i>E. coli</i> system, and purified from inclusion bodies with a yield of about 1.1 mg/L of culture. …”
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2580
Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development.
Published 2022-01-01“…The whnl mutation, mapped on Chromosome 15, is due to a 7-bp insertion identified in the 3' region of exon 9 in the Krt90 gene (formerly Riken cDNA 4732456N10Rik), and is predicted to result in a frameshift that changes serine 476 to arginine and subsequently introduces 36 novel amino acids into the protein before a premature stop codon (p. Ser476ArgfsTer36). By immunohistochemistry the normal KRT90 protein is expressed in the nail matrix and nail bed in control mice where lesions are located in mutant mice. …”
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