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2621
Genome-wide polysomal analysis of a yeast strain with mutated ribosomal protein S9
Published 2007-08-01“…Read-through analysis did not reveal any increase in read-through of a premature stop codon by the mutant strain.</p> <p>Conclusion</p> <p>The ribosomal protein rpS9 appears to be involved in the translation of many mRNAs, since altering its C terminus led to a significant change in ribosomal association of many mRNAs. …”
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2622
Kaposi’s Sarcoma-Associated Herpesvirus ORF7 Is Essential for Virus Production
Published 2021-05-01“…Here, we investigated the role of ORF7 during KSHV lytic replication by generating two types of ORF7 knock-out (KO) mutants (frameshift-induced and stop codon-induced ORF7 deficiency), KSHV BAC16, and its revertants. …”
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2623
Role of ribosome recycling factor in natural termination and translational coupling as a ribosome releasing factor.
Published 2023-01-01“…These in vivo and in vitro studies indicate that RRF releases ribosomes from mRNA at the termination codon of u-ORF. Furthermore, the non-dissociable ribosomes read downstream from AUG of UAAUG with RRF in vitro. …”
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2624
Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer’s and Creutzfeldt–Jakob Disease: A Micromorphological Pilot Study on 20 Brains
Published 2021-02-01“…The AD ABC score according to the NIA-Alzheimer’s association guidelines, and prion protein subtype with codon 129 methionine–valine (M/V) polymorphisms in sCJD, while representing key characteristics of these diseases, did not correlate with the morphology of the Aβ/PrP<sup>Sc</sup> co-aggregates. …”
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2625
Molecular Detection of Dapsone and Rifampicin Resistance on Mycobacterium leprae from Leprosy Patients in East Java
Published 2010-03-01“…From 70 isolates for folP gene examination, there were 3 isolates which had mutation in the amino acid at codon 53; 2 cases Threonin (ACC) became Alanin (GCC) and 1 case Threonin (ACC) became Arginin (AGA). …”
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2626
Virulence Structure and Genetic Diversity of <i>Blumeria graminis</i> f. sp. <i>avenae</i> from Different Regions of Europe
Published 2022-05-01“…<i>avenae</i> was assessed based on 80 single-spore isolates collected in different European countries such as Poland (40 isolates), Germany (10), Finland (10), Czech Republic (10) and Ireland (10) using ISSR (<i>Inter-Simple Sequence Repeats</i>) and SCoT (<i>Start Codon Targeted</i>) markers. This work demonstrated differences in virulence of <i>B. graminis</i> f. sp. …”
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2627
Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages
Published 2024-02-01“…Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to alternative genetic codes (e.g., the UAG stop-codon is reassigned to glutamine) while infecting hosts with the standard bacterial code. …”
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2628
A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.
Published 2014-04-01“…The LINE-1 insertion is predicted to insert a premature stop codon within the homeodomain of DLX6. This prompted the sequencing of DLX5 and DLX6 in a human cohort with CP, where a missense mutation within the highly conserved DLX5 homeobox of a patient with PRS was identified. …”
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2629
An insight into the sialotranscriptome of the West Nile mosquito vector, <it>Culex tarsalis</it>
Published 2010-01-01“…The average amino acid identity among salivary proteins is 70.1%, while that for housekeeping proteins is 91.2% (P < 0.05), and the codon volatility of secreted proteins is significantly higher than those of housekeeping proteins. …”
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2630
Forward genetic studies reveal LsAPRR2 as a key gene in regulating the green color of pericarp in bottle gourd (Lagenaria siceraria)
Published 2023-02-01“…Cloning and sequence comparison of the two parental LsAPRR2 promoter regions indicated 11 bases insertion and 8 SNPs mutations in the region -991~-1033, upstream of the start codon in white bottle gourd. Proof of GUS reporting system, Genetic variation in this fragment significantly reduced the expression of LsAPRR2 in the pericarp of white bottle gourd. …”
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2631
16-membered ring macrolides and erythromycin induce ermB expression by different mechanisms
Published 2022-06-01“…Abstract Background Ribosome stalling on ermBL at the tenth codon (Asp) and mRNA stabilization are believed to be mechanisms by which erythromycin (Ery) induces ermB expression. …”
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2632
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2633
The Complete Mitochondrial Genome of Four Hylicinae (Hemiptera: Cicadellidae): Structural Features and Phylogenetic Implications
Published 2020-12-01“…Among 13 protein-coding genes, most show typical ATN start codons and TAR (TAA/TAG) or an incomplete stop codon T–, and several genes start by TTG/GTG. …”
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2634
A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation
Published 2015-11-01“…These IRESs require an RNA pseudoknot that mimics a codon-anticodon interaction and contains a conformationally dynamic loop. …”
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2635
TERTmonitor—qPCR Detection of <i>TERTp</i> Mutations in Glioma
Published 2023-08-01“…Telomerase promoter (TERTp) mutations are frequently observed in various types of tumours and commonly characterised by two specific hotspots located at positions −124 and −146 upstream of the start codon. They enhance <i>TERTp</i> activity, resulting in increased TERT expression. …”
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2636
Genetic engineering and raising temperature enhance recombinant protein production with the cdna1 promoter in Trichoderma reesei
Published 2022-10-01“…Here, we identified that the region 600- to 700-bp upstream of the start codon is critical for the efficiency of the cdna1 promoter. …”
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2637
Identification of H-2d Restricted T Cell Epitope of Foot-and-mouth Disease Virus Structural Protein VP1
Published 2011-09-01“…</p> <p>Results</p> <p>A codon-optimized expression method was adopted for effective expression of VP1 protein in colon bacillus. …”
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2638
Antisense Oligonucleotide-Mediated Splice Switching: Potential Therapeutic Approach for Cancer Mitigation
Published 2021-11-01“…AOs can also be used to induce splice switching, where the expression of an oncogenic protein can be inhibited by the induction of a premature stop codon. In general, AOs are modified chemically to increase their stability and binding affinity. …”
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2639
Sustainable recovery of MBNL activity in autoregulatory feedback loop in myotonic dystrophy
Published 2022-12-01“…The genetic construct contains an MBNL1-coding sequence separated by the fragment of ATP2A1 pre-mRNA with an MBNL-sensitive alternative exon containing stop codon in the reading frame of MBNL1. Inclusion of this exon leads to the arrangement of an inactive form of the protein, but exclusion gives rise to fully active MBNL1. …”
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2640
Application of reverse vaccinology to design a multi-epitope subunit vaccine against a new strain of Aeromonas veronii
Published 2022-08-01“…Finally, using Escherichia coli K12 as a model, codon optimization yielded ideal GC content and a higher CAI value, which was then included in the cloning vector pET2+ (a). …”
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