Color change kinetics and total carotenoid content of pumpkin as affected by drying tempearture by Onwude, Daniel I., Hashim, Norhashila, Janius, Rimfiel, Mat Nawi, Nazmi, Abdan, Khalina

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Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders by Asraa Faris, Cheah, Pike See, Ling, King-Hwa

“…A single nucleotide polymorphism at the pro-region of the BDNF gene (rs6265) has been reported to alter the amino acid from valine to methionine at codon 66 and was associated with neuropsychiatric disorders in several studies. …”

Structure prediction of a thermostable SR74 α-Amylase from Geobacillus stearothermophilus expressed in CTG-clade yeast Meyerozyma guilliermondii strain SO by Lim, Si Jie, Muhd Noor, Noor Dina, Salleh, Abu Bakar, Oslan, Siti Nurbaya

“…However, the CUG ambiguity present in the strain SO has possibly altered the amino acid residues in SR74 amylase wild type (WT) encoded by CUG the codon from the leucine to serine. From the multiple sequence alignment, six mutations were found in recombinant SR74 α-amylase (rc). …”

Nucleotide variations of 9‑cis‑epoxycarotenoid dioxygenase 2 (NCED2) and pericarp coloration genes (Rc and Rd) from upland rice varieties by Hamzah, Muazr Amer, Mohd Kasim, Nur Aini, Shamsuddin, Athirah, Mustafa, Nadia, Mohamad Rusli, Norliana Izzati, Teh, Chui Yao, Ho, Chai Ling

“…Our findings demonstrated that all the upland rice varieties analyzed have a Rd gene which encodes a complete dihydroflavonol-4-reductase without early translational termination codon irrespective of their pericarp colors. However, the upland rice varieties with white pericarps were found to have a defective Rc gene with a 14-base deletion at exon 7 which could disrupt the function of a positive regulator of proanthocyanidin biosynthesis. …”
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A study of peroxisome proliferator activated receptor gamma (PPARy) gene variant in relation to physical activity and fat intake among primary school Malay children in Kota Bharu,... by Rahman, Aiman Nadia Akmar

“…The missense mutation of Proline to Alanine at codon 12 (Pro12Ala) of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) is one of the most critical genetic factors predisposing to positive energy balance that may lead to development of obesity. …”
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Danger theory metaphor in artificial immune system for system call data by Anjum Iqbal, Anjum Iqbal

“…This study aims to contribute for the domain proposing a novel metaphor DASTON (DAnger Susceptible daTa codON). The effort completes four objectives; framework for abstracting immunology inspired computational metaphor, mechanism for DASTON abstraction, verifying existence of DASTON through benchmark data, and discovering novel biological property bio fitness for computational metaphors. …”
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Characterization and Phylogenetic Analyses of the Complete Mitochondrial Genome of Sugarcane (<i>Saccharum</i> spp. Hybrids) Line A1 by Dinggang Zhou, Ying Liu, Jingzuo Yao, Ze Yin, Xinwen Wang, Liping Xu, Youxiong Que, Ping Mo, Xiaolan Liu

“…Chromosome 2 includes 18 genes in total, which contains 13 PCGs (four <i>nad</i> genes, three <i>rps</i> genes, two <i>atp</i> genes, one <i>ccm</i> gene, one <i>cob</i> gene, one <i>cox</i> gene and one <i>rpl</i> gene) and five non-coding genes (tRNA genes). Analysis of codon usage of 35 PCGs showed that codon ending in A/U was preferred. …”
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Increased mutation efficiency of CRISPR/Cas9 genome editing in banana by optimized construct by Sen Zhang, Shaoping Wu, Chunhua Hu, Qiaosong Yang, Tao Dong, Ou Sheng, Guiming Deng, Weidi He, Tongxin Dou, Chunyu Li, Chenkang Sun, Ganjun Yi, Fangcheng Bi

“…The application of this promoter and banana codon-optimized Cas9 in CRISPR/Cas9 cassette resulted in a fourfold increase in mutation efficiency compared with the previous CRISPR/Cas9 cassette for banana. …”
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Indications for Percutaneous Ultrasound-Guided Renal Biopsy and Complications Associated with it: An Observational Study by Mohammad Ashraf Bhat, Shahid Sulayman, Manzoor Ahmad Parry, Muzaffar Maqsood Wani, Imtiyaz Ahmad Wani

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Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis. by Emmanuel Dias-Neto, Diana N Nunes, Ricardo J Giordano, Jessica Sun, Gregory H Botz, Kuan Yang, João C Setubal, Renata Pasqualini, Wadih Arap

“…Sequences obtained by qPhage plus pyrosequencing were similar to a dataset produced from conventional Sanger-sequenced transducing-units (TU), with no biases due to GC content, codon usage, and amino acid or peptide frequency. …”
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Filaggrin gene mutation in pediatric patients with atopic dermatitis: A look into Indian gene pool, a pilot study by K A Rajeshwari, Merin M Thomas, Geetha Nagaraj

“…Only 5 of the detected 22 amino acid changes H2507Q, L2481S, K2444E, E2398Q, and S2366T have been previously reported and are not clinically significant; however, in one patient a stop codon was detected (S2366STOP). P2238N, R2239W, and V2243L detected in 70% of the samples and S2231E detected in 67% of the patient samples have not been reported so far and their clinical significance is yet to be analyzed. …”
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A Single Nonsynonymous Substitution in the RNA-Dependent RNA Polymerase of <i>Potato virus Y</i> Allows the Simultaneous Breakdown of Two Different Forms of Antiviral Resistance in... by Benoît Moury, Thierry Michon, Vincent Simon, Alain Palloix

“…Inoculations by grafting resulted in the selection of PVY mutants breaking PM949 resistance and, less efficiently, <i>Pvr4</i>–mediated resistance. The codon substitution E₄₇₂K in the NIb cistron of PVY, which was shown previously to be sufficient to break <i>Pvr4</i> resistance, was also sufficient to break PM949 resistance, a rare example of cross-pathogenicity effect. …”
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Analysis of the Mitogenomes of Two Helotid Species Provides New Insights into the Phylogenetic Relationship of the Basal Cucujoidea (Insecta: Coleoptera) by Jing Liu, Yuhang Yang, Zihan Yan, Haishan Wang, Ming Bai, Chengmin Shi, Jing Li

“…After comparing the mt genomes of <i>H. thoracica</i> and <i>H. yehi</i>, we observed the gene arrangement, codon usage patterns, base content, and RNA secondary structures of both species to be similar, which has also been noted in other Coleoptera insects. …”
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A Single Base Insertion in <i>F9</i> Causing Hemophilia B in a Family of Newfoundland–Parti Standard Poodle Hybrid Dogs by Henrike Kuder, Liubov Sandzhieva-Vuzzo, Alexandra Kehl, Jonathan M. Rappaport, Elisabeth Müller, Urs Giger

“…Sequencing the <i>F9</i> exons revealed a single nucleotide insertion resulting in a frameshift in the last exon (NM_001003323.2:c.821_822insA), predicted to result in a premature stop codon (NP_001003323.1:p.Asn274LysfsTer23) with a loss of 178 of 459 amino acids. …”
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Enhancing explainable SARS-CoV-2 vaccine development leveraging bee colony optimised Bi-LSTM, Bi-GRU models and bioinformatic analysis by Dilber Uzun Ozsahin, Zubaida Said Ameen, Abdurrahman Shuaibu Hassan, Auwalu Saleh Mubarak

“…The developed multi-epitope vaccine is non-toxic and highly antigenic. Codon adaptation, cloning, gel electrophoresis assess genomic sequence, protein composition, expression and purification while docking and IMMSIM servers simulate interactions and immunological response, respectively. …”
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eIF3 Interacts with Selenoprotein mRNAs by Hassan Hayek, Gilbert Eriani, Christine Allmang

“…The synthesis of selenoproteins requires the co-translational recoding of an in-frame UGASec codon. Interactions between the Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2) in the 3′untranslated region (3′UTR) of selenoprotein mRNAs enable the recruitment of the selenocysteine insertion machinery. …”
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The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes by Hilal Yeter-Alat, Naïma Belgareh-Touzé, Emmeline Huvelle, Josette Banroques, N. Kyle Tanner

“…Ded1 is a yeast DEAD-box protein, the functional ortholog of mammalian DDX3, that is considered important for the scanning efficiency of the 48S pre-initiation complex ribosomes to the AUG start codon. We used a modified PAR-CLIP technique, which we call quicktime PAR-CLIP (qtPAR-CLIP), to crosslink Ded1 to 4-thiouridine-incorporated RNAs in vivo using UV light centered at 365 nm. …”
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Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia. by Matthew J Grigg, Bridget E Barber, Jutta Marfurt, Mallika Imwong, Timothy William, Elspeth Bird, Kim A Piera, Ammar Aziz, Usa Boonyuen, Christopher J Drakeley, Jonathan Cox, Nicholas J White, Qin Cheng, Tsin W Yeo, Sarah Auburn, Nicholas M Anstey

“…RESULTS:Fourteen non-synonymous mutations were detected, with the most common being at codon T91P (10.2%) and R34L (10.0%), resulting in 21 different genotypes, including the wild-type, 14 single mutants, and six double mutants. …”
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Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain by Abdoulaye Diane, David Pierce, Sandra E. Kelly, Sharon Sokolik, Faye Borthwick, Miriam Jacome-Sosa, Rabban Mangat, JESUS MIGUEL PRADILLO, Stuart McRae Allan, Megan R. Ruth, Catherine J. Field, Rebecca Hutcheon, Petra Rocic, James C. Russell, Donna F Vine, Spencer D. Proctor

“…In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. …”
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RARE UNSTABLE ALPHA GLOBIN VARIANT HB TAYBE (HBA1:C.118_120DELACC) WITH HBA2 POLY A MUTATIONS, CAUSES TO HEMOLYTIC ANEMIA IN TWO CASES FROM AZERBAIJAN by AghaRza Aghayev, Khuraman Jafarova, Afsana Mammadova, Zenfira Mirzeyeva, Valeh Huseynov

“…Others may be due to ins/del in the α-globin, one of them Hb-Taybe caused deletion of Thr residue at codon 40 of the HBA1. We report, for the first time, 2 cases with hemolytic anemia due to the presence of Hb-Taybe in trans with HBA2 poly-A mutations. …”
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